Extension and limits of the network of coupled motions correlated to hydride transfer in dihydrofolate reductase

Journal of the American Chemical Society

Volumn 136, Issue 6, 2014, Pages 2575-2582

  Singh, Priyanka ^a   Sen, Arundhuti ^a,b   Francis, Kevin ^a   Kohen, Amnon ^a  

^a E11 SSH   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; MODELS, MOLECULAR; TEMPERATURE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84894148788     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja411998h     Document Type: Article

References (58)

1. Hammes, G. G.; Benkovic, S. J.; Hammes-Schiffer, S. Biochemistry 2011, 50, 10422-10430
2. Fersht, A. Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding; W.H. Freeman: New York, 1999.
3. Nagel, Z. D.; Klinman, J. P. Nat. Chem. Biol. 2009, 5, 543-550
4. Hay, S.; Scrutton, N. S. Nat. Chem. 2012, 4, 161-168
5. Cheatum, C.; Kohen, A. In Dynamics in Enzyme Catalysis; Klinman, J.; Hammes-Schiffer, S., Eds.; Springer: Berlin, 2013; Vol. 337, pp 1-39.
6. Klinman, J. P.; Kohen, A. Annu. Rev. Biochem. 2013, 82, 471-496
7. Sen, A.; Kohen, A. In Quantum Tunneling in Enzyme Catalyzed Reactions; Allemann, R.; Scrutton, N., Eds.; Royal Society of Chemistry: London, 2009; pp 161-178.
8. Roston, D.; Islam, Z.; Kohen, A. Molecules 2013, 18, 5543-5567
9. Lee, J.; Goodey, N. M. Chem. Rev. 2011, 111, 7595-7624
10. Hammes-Schiffer, S.; Benkovic, S. J. Annu. Rev. Biochem. 2006, 75, 519-541
11. Sawaya, M. R.; Kraut, J. Biochemistry 1997, 36, 586-603
12. Fierke, C. A.; Johnson, K. A.; Benkovic, S. J. Biochemistry 1987, 26, 4085-4092
13. Bystroff, C.; Kraut, J. Biochemistry 1991, 30, 2227-2239
14. Falzone, C. J.; Wright, P. E.; Benkovic, S. J. Biochemistry 1994, 33, 439-442
15. Li, L.; Falzone, C. J.; Wright, P. E.; Benkovic, S. J. Biochemistry 1992, 31, 7826-7833
16. McElheny, D.; Schnell, J. R.; Lansing, J. C.; Dyson, H. J.; Wright, P. E. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 5032-5037
17. Antikainen, N. M.; Smiley, R. D.; Benkovic, S. J.; Hammes, G. G. Biochemistry 2005, 44, 16835-16843
18. Chen, S.; Wang, L.; Fahmi, N. E.; Benkovic, S. J.; Hecht, S. M. J. Am. Chem. Soc. 2012, 134, 18883-18885
19. Boehr, D. D.; McElheny, D.; Dyson, H. J.; Wright, P. E. Science 2006, 313, 1638-1642
20. Suel, G. M.; Lockless, S. W.; Wall, M. A.; Ranganathan, R. Nat. Struct. Mol. Biol. 2003, 10, 59-69
21. Wong, K. F.; Selzer, T.; Benkovic, S. J.; Hammes-Schiffer, S. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 6807-6812
22. Radkiewicz, J. L.; Brooks, C. L. J. Am. Chem. Soc. 2000, 122, 255-231
23. Agarwal, P. K.; Billeter, S. R.; Rajagopalan, P. T.; Benkovic, S. J.; Hammes-Schiffer, S. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 2794-2799
24. Rod, T. H.; Radkiewicz, J. L.; Brooks, C. L. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 6980-6985
25. Wang, L.; Goodey, N. M.; Benkovic, S. J.; Kohen, A. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 15753-15758
26. Wagner, C. R.; Huang, Z.; Singleton, S. F.; Benkovic, S. J. Biochemistry 1995, 34, 15671-15680
27. Rajagopalan, P. T. R.; Stefan, L.; Benkovic, S. J. Biochemistry 2002, 41, 12618-12628
28. Wang, L.; Goodey, N. M.; Benkovic, S. J.; Kohen, A. Philos. Trans. R. Soc., B 2006, 361, 1307-1315
29. Wang, L.; Tharp, S.; Selzer, T.; Benkovic, S. J.; Kohen, A. Biochemistry 2006, 45, 1383-1392
30. Sikorski, R. S.; Wang, L.; Markham, K. A.; Rajagopalan, P. T.; Benkovic, S. J.; Kohen, A. J. Am. Chem. Soc. 2004, 126, 4778-4779
31. Klinman, J. P. In Quantum Tunneling in Enzyme Catalyzed Reactions; Allemann, R.; Scrutton, N., Eds.; Royal Society of Chemistry: London, 2009; pp 132-160.
32. Kohen, A. In Isotopes Effects in Chemistry and Biology; Taylor and Francis: Boca Raton, FL, 2006; pp 743-764.
33. Hammes-Schiffer, S. Acc. Chem. Res. 2005, 39, 93-100
34. Nagel, Z. D.; Klinman, J. P. Chem. Rev. 2010, 110, PR41-PR67
35. Wang, Z.; Roston, D.; Kohen, A. In Advances in Protein Chemistry and Structural Biology; Christov, C.; Karabencheva-Christova, T., Eds.; Academic Press: New York, 2012; Vol. 87, pp 155-180.
36. Luk, L. Y. P.; Javier Ruiz-Pernía, J.; Dawson, W. M.; Roca, M.; Loveridge, E. J.; Glowacki, D. R.; Harvey, J. N.; Mulholland, A. J.; Tuñón, I.; Moliner, V.; Allemann, R. K. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 16344-16349
37. Ruiz-Pernia, J. J.; Luk, L. Y. P.; García-Meseguer, R.; Martí, S.; Loveridge, E. J.; Tuñón, I.; Moliner, V.; Allemann, R. K. J. Am. Chem. Soc. 2013, 135, 18689-18696
38. Francis, K.; Stojković, V.; Kohen, A. J. Biol. Chem. 2013, 288, 35961-35968
39. Liu, C. T.; Hanoian, P.; French, J. B.; Pringle, T. H.; Hammes-Schiffer, S.; Benkovic, S. J. Proc. Natl. Acad. Sci. U.S.A. 2013, 10159-10164
40. Stojković, V.; Perissinotti, L. L.; Willmer, D.; Benkovic, S. J.; Kohen, A. J. Am. Chem. Soc. 2012, 134, 1738-1745
41. Hammes-Schiffer, S.; Watney, J. B. Philos. Trans. R. Soc., B 2006, 361, 1365-1373
42. Wong, K. F.; Watney, J. B.; Hammes-Schiffer, S. J. Phys. Chem. B 2004, 108, 12231-12241
43. Cameron, C. E.; Benkovic, S. J. Biochemistry 1997, 36, 15792-15800
44. Miller, G. P.; Benkovic, S. J. Biochemistry 1998, 37, 6327-6335
45. Agrawal, N.; Kohen, A. Anal. Biochem. 2003, 322, 179-184
46. Markham, K. A.; Sikorski, R. S.; Kohen, A. Anal. Biochem. 2004, 322, 26-32
47. Markham, K. A.; Sikorski, R. S.; Kohen, A. Anal. Biochem. 2004, 325, 62-67
48. McCracken, J. A.; Wang, L.; Kohen, A. Anal. Biochem. 2003, 324, 131-136
49. Sen, A.; Yahashiri, A.; Kohen, A. Biochemistry 2011, 50, 6462-6468
50. Yahashiri, A.; Sen, A.; Kohen, A. J. Labelled Compd. Radiopharm. 2009, 52, 463-466
51. Northrop, D. B. In Enzyme Mechanism from Isotope Effects; CRC Press: Boca Raton, FL, 1991; p 181-202.
52. Cook, P. F.; Cleland, W. W.; Taylor and Francis Group LLC: New York, NY, 2007; p 253-324.
53. Cleland, W. W. In Enzyme Mechanism from Isotope Effects; CRC Press: Boca Raton, FL, 1991; p 247-268.
54. Cleland, W. W. In Isotope Effects in Chemistry and Biology; CRC Press: Boca Raton, FL, 2006.
55. Roston, D.; Cheatum, C. M.; Kohen, A. Biochemistry 2012, 51, 6860-6870
56. Liu, C. T.; Hanoian, P.; French, J. P.; Pringle, T. H.; Hammes-Schiffer, S.; Benkovic, S. J. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 10159-10164
57. Arora, K.; Brooks, C. L., III. J. Am. Chem. Soc. 2009, 131, 5642-5647
58. Rod, T. H.; Brooks, C. L. J. Am. Chem. Soc. 2003, 125, 8718-8719