A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways

Pain

Volumn 155, Issue 12, 2014, Pages 2560-2567

  Janes, Kali ^a   Esposito, Emanuela ^b   Doyle, Timothy ^a   Cuzzocrea, Salvatore ^b   Tosh, Dillip K ^c   Jacobson, Kenneth A ^c   Salvemini, Daniela ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MESSINA   (Italy)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

A3; Adenosine; Chemotherapy induced peripheral; Neuroinflammation; Neuropathic pain; Neuropathy; Paclitaxel; Spinal cord

Indexed keywords

6 ETHYL 2 PHENYL 4 PROPYL 3 PYRIDINECARBOXYLIC ACID 5 THIOCARBOXYLIC ACID 5 ETHYL 3 PROPYL ESTER; 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; GLUTAMATE AMMONIA LIGASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PACLITAXEL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA; VESICULAR GLUTAMATE TRANSPORTER 1; ADENOSINE; ADENOSINE A3 RECEPTOR AGONIST; ANTINEOPLASTIC AGENT; CYTOKINE; EXCITATORY AMINO ACID TRANSPORTER 2; N(6)-(3-IODOBENZYL)-5'-N-METHYLCARBOXAMIDOADENOSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SLC1A2 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; MALE; NEUROPATHIC PAIN; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENETICS; GLIA; HYPERALGESIA; METABOLISM; NEURALGIA; OXIDATION REDUCTION REACTION; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; SPINAL CORD; SPRAGUE DAWLEY RAT;

ADENOSINE; ADENOSINE A3 RECEPTOR AGONISTS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CYTOKINES; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID TRANSPORTER 2; HYPERALGESIA; MALE; NADP; NEURALGIA; NEUROGLIA; NF-KAPPA B; OXIDATION-REDUCTION; PACLITAXEL; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SPINAL CORD; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84918532342     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2014.09.016     Document Type: Article

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