Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signaling

Toxicology and Applied Pharmacology

Volumn 271, Issue 2, 2013, Pages 239-248

  Son, Young Ok ^a   Pratheeshkumar, Poyil ^a   Wang, Lei ^a   Wang, Xin ^a   Fan, Jia ^a   Kim, Dong Hern ^a   Lee, Ju Yeon ^a   Zhang, Zhuo ^a   Lee, Jeong Chae ^a,b   Shi, Xianglin ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Chonbuk National University   (South Korea)

Author keywords

catenin; Carcinogenesis; Cell transformation; Cr(VI); Reactive oxygen species (ROS)

Indexed keywords

BETA CATENIN; CATALASE; CHROMIUM; GLYCOGEN SYNTHASE KINASE 3BETA; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SIGNAL PEPTIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHAGY; BRONCHUS MUCOSA; CANCER TISSUE; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CELL STIMULATION; CELL SURVIVAL; CELL TRANSFORMATION; COLONY FORMATION; CONTROLLED STUDY; EPITHELIUM CELL; FOOD DEPRIVATION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MEDIATOR; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

Β-CATENIN; 5,5-DIMETHYL-1-PYRROLINE-1-OXIDE; CARCINOGENESIS; CAT; CATALASE; CELL TRANSFORMATION; COX-2; CR(VI); CYCLOOXYGENASE-2; DMEM; DMPO; DULBECCO'S MODIFIED EAGLE'S MEDIUM; ELECTRON SPIN RESONANCE; ESR; FBS; FETAL BOVINE SERUM; HIF-1Α; HYPOXIA-INDUCIBLE TRANSCRIPTION FACTOR-1Α; LC3; MAMMALIAN TARGET OF RAPAMYCIN; MATRIX METALLOPROTEINASES; MICROTUBULE-ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; MMPS; MTOR; REACTIVE OXYGEN SPECIES; REACTIVE OXYGEN SPECIES (ROS); ROS; SOD; SUPEROXIDE DISMUTASE; VASCULAR ENDOTHELIAL GROWTH FACTOR; VEGF;

ANIMALS; BETA CATENIN; BLOTTING, WESTERN; CARCINOGENS; CELL LINE, TUMOR; CELL MOVEMENT; CHROMIUM; CLONE CELLS; ELECTRON SPIN RESONANCE SPECTROSCOPY; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, NUDE; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PLASMIDS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84880437876     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.04.036     Document Type: Article

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