메뉴 건너뛰기




Volumn 40, Issue 1, 2015, Pages e46-e52

PET in multiple sclerosis

Author keywords

Molecular imaging; Multiple sclerosis; PET

Indexed keywords

4 AMINOBUTYRIC ACID; CANNABINOID; CARBON 11; CARRIER PROTEIN; FLUMAZENIL C 11; FLUORINE 18; MYELIN; RADIOLIGAND;

EID: 84917708943     PISSN: 03639762     EISSN: 15360229     Source Type: Journal    
DOI: 10.1097/RLU.0000000000000359     Document Type: Article
Times cited : (20)

References (78)
  • 1
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372:1502-1517.
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 2
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: Results of an international survey
    • Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology. 1996;46:907-911.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 3
    • 34548633861 scopus 로고    scopus 로고
    • Primary-progressive multiple sclerosis
    • Miller DH, Leary SM. Primary-progressive multiple sclerosis. Lancet Neurol. 2007;6:903-912.
    • (2007) Lancet Neurol , vol.6 , pp. 903-912
    • Miller, D.H.1    Leary, S.M.2
  • 4
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: An immune or neurodegenerative disorder?
    • Trapp BD, Nave KA. Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci. 2008;31:247-269.
    • (2008) Annu Rev Neurosci , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 5
    • 78751502845 scopus 로고    scopus 로고
    • PET imaging in multiple sclerosisV current status and future applications
    • Kiferle L, Politis M, Muraro PA, et al. PET imaging in multiple sclerosisV current status and future applications. Eur J Neurol. 2011;18:226-231.
    • (2011) Eur J Neurol , vol.18 , pp. 226-231
    • Kiferle, L.1    Politis, M.2    Muraro, P.A.3
  • 6
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996;19:312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 7
    • 34248392684 scopus 로고    scopus 로고
    • Microglial activation and its implications in the brain diseases
    • Dheen ST, Kaur C, Ling EA. Microglial activation and its implications in the brain diseases. Curr Med Chem. 2007;14:1189-1197.
    • (2007) Curr Med Chem , vol.14 , pp. 1189-1197
    • Dheen, S.T.1    Kaur, C.2    Ling, E.A.3
  • 8
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: Unique stimuli, specialized responses
    • Ransohoff RM, Perry VH. Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol. 2009;27:119-145.
    • (2009) Annu Rev Immunol , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 9
    • 0029981358 scopus 로고    scopus 로고
    • Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor
    • Suzumura A, Sawada M, Marunouchi T. Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor. Brain Res. 1996;713:192-198.
    • (1996) Brain Res , vol.713 , pp. 192-198
    • Suzumura, A.1    Sawada, M.2    Marunouchi, T.3
  • 10
    • 0033169233 scopus 로고    scopus 로고
    • Interleukin-1beta inducible nitric oxide synthase and nuclear factor-kappa B are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferongamma injection
    • Hartlage-Rübsamen M, Lemke R, Schliebs R. Interleukin-1beta, inducible nitric oxide synthase, and nuclear factor-kappa B are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferongamma injection. J Neurosci Res. 1999;57:388-398.
    • (1999) J Neurosci Res , vol.57 , pp. 388-398
    • Hartlage-Rübsamen, M.1    Lemke, R.2    Schliebs, R.3
  • 11
    • 14944385354 scopus 로고    scopus 로고
    • Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors
    • Floden AM, Li S, Combs CK. Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. J Neurosci. 2005;25:2566-2575.
    • (2005) J Neurosci , vol.25 , pp. 2566-2575
    • Floden, A.M.1    Li, S.2    Combs, C.K.3
  • 12
    • 0036850086 scopus 로고    scopus 로고
    • Visualising microglial activation in vivo
    • Banati RB. Visualising microglial activation in vivo. Glia. 2002;40:206-217.
    • (2002) Glia , vol.40 , pp. 206-217
    • Banati, R.B.1
  • 13
    • 0348109489 scopus 로고    scopus 로고
    • Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: Evidence from activated microglial cells in vitro
    • Wilms H, Claasen J, Röhl C, et al. Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro. Neurobiol Dis. 2003;14:417-424.
    • (2003) Neurobiol Dis , vol.14 , pp. 417-424
    • Wilms, H.1    Claasen, J.2    Röhl, C.3
  • 14
    • 0024204730 scopus 로고
    • Imaging of human brain lesions with an omega 3 site radioligand
    • Benavides J, Cornu P, Dennis T, et al. Imaging of human brain lesions with an omega 3 site radioligand. Ann Neurol. 1988;24:708-712.
    • (1988) Ann Neurol , vol.24 , pp. 708-712
    • Benavides, J.1    Cornu, P.2    Dennis, T.3
  • 15
    • 0032585663 scopus 로고    scopus 로고
    • [11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis
    • Banati RB, Goerres GW, Myers R, et al. [11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis. Neurology. 1999;53:2199-2203.
    • (1999) Neurology , vol.53 , pp. 2199-2203
    • Banati, R.B.1    Goerres, G.W.2    Myers, R.3
  • 16
    • 0033768486 scopus 로고    scopus 로고
    • The peripheral benzodiazepine binding site in the brain in multiple sclerosis: Quantitative in vivo imaging of microglia as a measure of disease activity
    • Banati RB, Newcombe J, Gunn RN, et al. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain. 2000;123:2321-2337.
    • (2000) Brain , vol.123 , pp. 2321-2337
    • Banati, R.B.1    Newcombe, J.2    Gunn, R.N.3
  • 17
    • 0030970058 scopus 로고    scopus 로고
    • Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis
    • Benveniste EN. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med (Berl). 1997;75:165-173.
    • (1997) J Mol Med (Berl) , vol.75 , pp. 165-173
    • Benveniste, E.N.1
  • 18
    • 0038293470 scopus 로고    scopus 로고
    • PET visualization of microglia in multiple sclerosis patients using [11C]PK11195
    • Debruyne JC, Versijpt J, Van Laere KJ, et al. PET visualization of microglia in multiple sclerosis patients using [11C]PK11195. Eur J Neurol. 2003;10: 257-264.
    • (2003) Eur J Neurol , vol.10 , pp. 257-264
    • Debruyne, J.C.1    Versijpt, J.2    Van Laere, K.J.3
  • 19
    • 20144384091 scopus 로고    scopus 로고
    • Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: A correlative study
    • Versijpt J, Debruyne JC, Van Laere KJ, et al. Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study. Mult Scler. 2005;11:127-134.
    • (2005) Mult Scler , vol.11 , pp. 127-134
    • Versijpt, J.1    Debruyne, J.C.2    Van Laere, K.J.3
  • 20
    • 0034842126 scopus 로고    scopus 로고
    • Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    • Peterson JW, Bö L,Mörk S, et al. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol. 2001;50:389-400.
    • (2001) Ann Neurol , vol.50 , pp. 389-400
    • Peterson, J.W.1    Bö, L.2    Mörk, S.3
  • 21
    • 27644552194 scopus 로고    scopus 로고
    • Cortical demyelination and diffuse white matter injury in multiple sclerosis
    • Kutzelnigg A, Lucchinetti CF, Stadelmann C, et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain. 2005;128: 2705-2712.
    • (2005) Brain , vol.128 , pp. 2705-2712
    • Kutzelnigg, A.1    Lucchinetti, C.F.2    Stadelmann, C.3
  • 22
    • 48849116689 scopus 로고    scopus 로고
    • Grey matter pathology in multiple sclerosis
    • Geurts JJ, Barkhof F. Grey matter pathology in multiple sclerosis. Lancet Neurol. 2008;7:841-851.
    • (2008) Lancet Neurol , vol.7 , pp. 841-851
    • Geurts, J.J.1    Barkhof, F.2
  • 23
    • 78249280011 scopus 로고    scopus 로고
    • A gradient of neuronal loss and meningeal inflammation in multiple sclerosis
    • Magliozzi R, Howell OW, Reeves C, et al. A gradient of neuronal loss and meningeal inflammation in multiple sclerosis. Ann Neurol. 2010;68:477-493.
    • (2010) Ann Neurol , vol.68 , pp. 477-493
    • Magliozzi, R.1    Howell, O.W.2    Reeves, C.3
  • 24
    • 84866117533 scopus 로고    scopus 로고
    • Increased PK11195 PET binding in the cortex of MS patients correlates with disability
    • Politis M, Gianneti P, Su P, et al. Increased PK11195 PET binding in the cortex of MS patients correlates with disability. Neurology. 2012;79:523-530.
    • (2012) Neurology , vol.79 , pp. 523-530
    • Politis, M.1    Gianneti, P.2    Su, P.3
  • 25
    • 84862764134 scopus 로고    scopus 로고
    • Decreased microglial activation in MS patients treated with glatiramer acetate
    • Ratchford JN, Endres CJ, Hammoud DA, et al. Decreased microglial activation in MS patients treated with glatiramer acetate. J Neurol. 2012;259:1199-1205.
    • (2012) J Neurol , vol.259 , pp. 1199-1205
    • Ratchford, J.N.1    Endres, C.J.2    Hammoud, D.A.3
  • 26
    • 84903394463 scopus 로고    scopus 로고
    • Decreased microglial activation precedes stabilization of disability in multiple sclerosis patients treated with natalizumab
    • (Meeting Abstracts 1). 004
    • Politis M, Giannetti P, Niccolini F, et al. Decreased microglial activation precedes stabilization of disability in multiple sclerosis patients treated with natalizumab. Neurology. 2013;80(Meeting Abstracts 1):S21. 004
    • (2013) Neurology , vol.80 , pp. S21
    • Politis, M.1    Giannetti, P.2    Niccolini, F.3
  • 27
    • 35649010838 scopus 로고    scopus 로고
    • Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsingVremitting experimental autoimmune encephalomyelitis
    • Rasmussen S, Wang Y, Kivisäkk P, et al. Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsingVremitting experimental autoimmune encephalomyelitis. Brain. 2007;130:2816-2829.
    • (2007) Brain , vol.130 , pp. 2816-2829
    • Rasmussen, S.1    Wang, Y.2    Kivisäkk, P.3
  • 28
    • 20044376483 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis repressed by microglial paralysis
    • Heppner FL, Greter M, Marino D, et al. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med. 2005;11:146-152.
    • (2005) Nat Med , vol.11 , pp. 146-152
    • Heppner, F.L.1    Greter, M.2    Marino, D.3
  • 29
    • 36549056962 scopus 로고    scopus 로고
    • Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: Preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients
    • Vas A, Shchukin Y, Karrenbauer VD, et al. Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients. J Neurol Sci. 2008;264:9-17.
    • (2008) J Neurol Sci , vol.264 , pp. 9-17
    • Vas, A.1    Shchukin, Y.2    Karrenbauer, V.D.3
  • 30
    • 79960594561 scopus 로고    scopus 로고
    • Translocator protein PET imaging for glial activation in multiple sclerosis
    • Oh U, Fujita M, Ikonomidou VN, et al. Translocator protein PET imaging for glial activation in multiple sclerosis. J Neuroimmune Pharmacol. 2011; 6:354-361.
    • (2011) J Neuroimmune Pharmacol , vol.6 , pp. 354-361
    • Oh, U.1    Fujita, M.2    Ikonomidou, V.N.3
  • 31
    • 38949112843 scopus 로고    scopus 로고
    • Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation
    • Fujita M, Imaizumi M, Zoghbi SS, et al. Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation. Neuroimage. 2008;40:43-52.
    • (2008) Neuroimage , vol.40 , pp. 43-52
    • Fujita, M.1    Imaizumi, M.2    Zoghbi, S.S.3
  • 32
    • 33845752145 scopus 로고    scopus 로고
    • Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [(11)C]DAA1106
    • Ikoma Y, Yasuno F, Ito H, et al. Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [(11)C]DAA1106. J Cereb Blood Flow Metab. 2007;27:173-184.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 173-184
    • Ikoma, Y.1    Yasuno, F.2    Ito, H.3
  • 33
    • 58149303036 scopus 로고    scopus 로고
    • Nuclear imaging of neuroinflammation: A comprehensive review of [11C]PK11195 challengers
    • Chauveau F, Boutin H, Van Camp N, et al. Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers. Eur J Nucl Med Mol Imaging. 2008;35:2304-2319.
    • (2008) Eur J Nucl Med Mol Imaging , vol.35 , pp. 2304-2319
    • Chauveau, F.1    Boutin, H.2    Van Camp, N.3
  • 34
    • 54149105539 scopus 로고    scopus 로고
    • Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106
    • Yasuno F, Ota M, Kosaka J, et al. Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106. Biol Psychiatry. 2008;64:835-841.
    • (2008) Biol Psychiatry , vol.64 , pp. 835-841
    • Yasuno, F.1    Ota, M.2    Kosaka, J.3
  • 35
    • 0025856850 scopus 로고
    • Brain kinetics and specific binding of [11C]PK 11195 to omega 3 sites in baboons: Positron emission tomography study
    • Petit-Taboué MC, Baron JC, Barré L, et al. Brain kinetics and specific binding of [11C]PK 11195 to omega 3 sites in baboons: positron emission tomography study. Eur J Pharmacol. 1991;200:347-351.
    • (1991) Eur J Pharmacol , vol.200 , pp. 347-351
    • Petit-Taboué, M.C.1    Baron, J.C.2    Barré, L.3
  • 36
    • 34648822769 scopus 로고    scopus 로고
    • In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors
    • Boutin H, Chauveau F, Thominiaux C, et al. In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors. Glia. 2007;55:1459-1468.
    • (2007) Glia , vol.55 , pp. 1459-1468
    • Boutin, H.1    Chauveau, F.2    Thominiaux, C.3
  • 37
    • 84875912433 scopus 로고    scopus 로고
    • Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brainVa PET study in control subjects
    • Jučaite A, Cselényi Z, Arvidsson A, et al. Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brainVa PET study in control subjects. EJNMMI Res. 2012;2:15.
    • (2012) EJNMMI Res , vol.2 , pp. 15
    • Jučaite, A.1    Cselényi, Z.2    Arvidsson, A.3
  • 38
    • 65349120620 scopus 로고    scopus 로고
    • Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain
    • Cosenza-Nashat M, Zhao ML, Suh HS, et al. Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol Appl Neurobiol. 2008;35:306-328.
    • (2008) Neuropathol Appl Neurobiol , vol.35 , pp. 306-328
    • Cosenza-Nashat, M.1    Zhao, M.L.2    Suh, H.S.3
  • 39
    • 84888365501 scopus 로고    scopus 로고
    • 18F]PBR111 binding is increate in lesional and perilesional white matter of MS patients
    • 18F]PBR111 binding is increate in lesional and perilesional white matter of MS patients. J Nucl Med. 2013;54:82.
    • (2013) J Nucl Med , vol.54 , pp. 82
    • Colasanti, A.1    Guo, Q.2    Muhlert, N.3
  • 40
    • 33748074810 scopus 로고    scopus 로고
    • A novel fluorescent probe that is brain permeable and selectively binds to myelin
    • Wu C, Tian D, Feng Y, et al. A novel fluorescent probe that is brain permeable and selectively binds to myelin. J Histochem Cytochem. 2006;54:997-1004.
    • (2006) J Histochem Cytochem , vol.54 , pp. 997-1004
    • Wu, C.1    Tian, D.2    Feng, Y.3
  • 41
    • 56249096579 scopus 로고    scopus 로고
    • Molecular probes for imaging myelinated white matter in CNS
    • Wu C, Wei J, Tian D, et al. Molecular probes for imaging myelinated white matter in CNS. J Med Chem. 2008;51:6682-6688.
    • (2008) J Med Chem , vol.51 , pp. 6682-6688
    • Wu, C.1    Wei, J.2    Tian, D.3
  • 42
    • 70949100119 scopus 로고    scopus 로고
    • In vivo quantification of myelin changes in the vertebrate nervous system
    • Wang Y, Wu C, Caprariello AV, et al. In vivo quantification of myelin changes in the vertebrate nervous system. J Neurosci. 2009;29:14663-14669.
    • (2009) J Neurosci , vol.29 , pp. 14663-14669
    • Wang, Y.1    Wu, C.2    Caprariello, A.V.3
  • 43
    • 79955379054 scopus 로고    scopus 로고
    • 11C]-2-(4′-methylaminophenyl)- 6-hydroxybenzothiazole
    • 11C]-2-(4′-methylaminophenyl)- 6-hydroxybenzothiazole. Ann Neurol. 2011; 69:673-680.
    • (2011) Ann Neurol , vol.69 , pp. 673-680
    • Stankoff, B.1    Freeman, L.2    Aigrot, M.S.3
  • 44
    • 0019829069 scopus 로고
    • Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose
    • Sokoloff L. Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose. J Cereb Blood Flow Metab. 1981;1:7-36.
    • (1981) J Cereb Blood Flow Metab , vol.1 , pp. 7-36
    • Sokoloff, L.1
  • 45
    • 0032904685 scopus 로고    scopus 로고
    • Energetics of functional activation in neural tissues
    • Sokoloff L. Energetics of functional activation in neural tissues. Neurochem Res. 1999;24:321-329.
    • (1999) Neurochem Res , vol.24 , pp. 321-329
    • Sokoloff, L.1
  • 46
    • 0026487739 scopus 로고
    • Relationship between corpus callosum atrophy and cerebral metabolic asymmetries in multiple sclerosis
    • Pozzilli C, Fieschi C, Perani D, et al. Relationship between corpus callosum atrophy and cerebral metabolic asymmetries in multiple sclerosis. J Neurol Sci. 1992;112:51-57.
    • (1992) J Neurol Sci , vol.112 , pp. 51-57
    • Pozzilli, C.1    Fieschi, C.2    Perani, D.3
  • 47
    • 0003140697 scopus 로고    scopus 로고
    • Functional basis of memory impairment in multiple sclerosis: A[18F]FDG PET study
    • Paulesu E, Perani D, Fazio F, et al. Functional basis of memory impairment in multiple sclerosis: a[18F]FDG PET study. Neuroimage. 1996;4:87-96.
    • (1996) Neuroimage , vol.4 , pp. 87-96
    • Paulesu, E.1    Perani, D.2    Fazio, F.3
  • 48
    • 0030873086 scopus 로고    scopus 로고
    • Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: A 18F-fluorodeoxyglucose positron emission tomography study
    • Roelcke U, Kappos L, Lechner-Scott J, et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxyglucose positron emission tomography study. Neurology. 1997;48:1566-1571.
    • (1997) Neurology , vol.48 , pp. 1566-1571
    • Roelcke, U.1    Kappos, L.2    Lechner-Scott, J.3
  • 49
    • 0033551541 scopus 로고    scopus 로고
    • A longitudinal study of cerebral glucose metabolism MRI and disability in patients with MS
    • Blinkenberg M, Jensen CV, Holm S, et al. A longitudinal study of cerebral glucose metabolism, MRI, and disability in patients with MS. Neurology. 1999;53:149-153.
    • (1999) Neurology , vol.53 , pp. 149-153
    • Blinkenberg, M.1    Jensen, C.V.2    Holm, S.3
  • 50
    • 84555219841 scopus 로고    scopus 로고
    • Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: An exploratory study
    • Blinkenberg M, Mathiesen HK, Tscherning T, et al. Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study. Neurol Res. 2012;34:52-58.
    • (2012) Neurol Res , vol.34 , pp. 52-58
    • Blinkenberg, M.1    Mathiesen, H.K.2    Tscherning, T.3
  • 51
    • 0031808530 scopus 로고    scopus 로고
    • Clinical significance of reduced cerebral metabolism in multiple sclerosis: A combined PET and MRI study
    • Sun X, Tanaka M, Kondo S, et al. Clinical significance of reduced cerebral metabolism in multiple sclerosis: a combined PET and MRI study. Ann Nucl Med. 1998;12:89-94.
    • (1998) Ann Nucl Med , vol.12 , pp. 89-94
    • Sun, X.1    Tanaka, M.2    Kondo, S.3
  • 52
    • 34548446421 scopus 로고    scopus 로고
    • Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis
    • Xu H, Cheng CL, Chen M, et al. Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis. J Leukoc Biol. 2007;82:532-541.
    • (2007) J Leukoc Biol , vol.82 , pp. 532-541
    • Xu, H.1    Cheng, C.L.2    Chen, M.3
  • 53
    • 0037440415 scopus 로고    scopus 로고
    • Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide
    • Facchinetti F, Del Giudice E, Furegato S, et al. Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide. Glia. 2003;41:161-168.
    • (2003) Glia , vol.41 , pp. 161-168
    • Facchinetti, F.1    Del Giudice, E.2    Furegato, S.3
  • 54
    • 39649086708 scopus 로고    scopus 로고
    • Therapeutic potential of CB2 targeting in multiple sclerosis
    • Docagne F, Mestre L, Loría F, et al. Therapeutic potential of CB2 targeting in multiple sclerosis. Expert Opin Ther Targets. 2008;12:185-195.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 185-195
    • Docagne, F.1    Mestre, L.2    Loría, F.3
  • 56
    • 0029094470 scopus 로고
    • Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    • Galiègue S, Mary S, Marchand J, et al. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem. 1995;232:54-61.
    • (1995) Eur J Biochem , vol.232 , pp. 54-61
    • Galiègue, S.1    Mary, S.2    Marchand, J.3
  • 57
    • 0035191240 scopus 로고    scopus 로고
    • Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation
    • Carlisle SJ, Marciano-Cabral F, Staab A, et al. Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation. Int Immunopharmacol. 2002;2:69-82.
    • (2002) Int Immunopharmacol , vol.2 , pp. 69-82
    • Carlisle, S.J.1    Marciano-Cabral, F.2    Staab, A.3
  • 58
    • 0242304878 scopus 로고    scopus 로고
    • Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
    • Pryce G, Ahmed Z, Hankey DJ, et al. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain. 2003;126(Pt 10):2191-2202.
    • (2003) Brain , vol.126 , pp. 2191-2202
    • Pryce, G.1    Ahmed, Z.2    Hankey, D.J.3
  • 59
    • 26844448746 scopus 로고    scopus 로고
    • Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli
    • Maresz K, Carrier EJ, Ponomarev ED, et al. Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli. J Neurochem. 2005;95:437-445.
    • (2005) J Neurochem , vol.95 , pp. 437-445
    • Maresz, K.1    Carrier, E.J.2    Ponomarev, E.D.3
  • 61
    • 33847420442 scopus 로고    scopus 로고
    • Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis
    • Benito C, Romero JP, Tolón RM, et al. Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. J Neurosci. 2007;27:2396-2402.
    • (2007) J Neurosci , vol.27 , pp. 2396-2402
    • Benito, C.1    Romero, J.P.2    Tolón, R.M.3
  • 62
    • 34547486580 scopus 로고    scopus 로고
    • 11C-JHU75528: A radiotracer for PET imaging of CB1 cannabinoid receptors
    • Horti AG, Fan H, Kuwabara H, et al. 11C-JHU75528: a radiotracer for PET imaging of CB1 cannabinoid receptors. J Nucl Med. 2006;47:1689-1696.
    • (2006) J Nucl Med , vol.47 , pp. 1689-1696
    • Horti, A.G.1    Fan, H.2    Kuwabara, H.3
  • 63
    • 36949015804 scopus 로고    scopus 로고
    • The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain
    • Yasuno F, Brown AK, Zoghbi SS, et al. The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain. Neuropsychopharmacology. 2008;33:259-269.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 259-269
    • Yasuno, F.1    Brown, A.K.2    Zoghbi, S.S.3
  • 64
    • 68749088245 scopus 로고    scopus 로고
    • Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand
    • Terry GE, Liow JS, Zoghbi SS, et al. Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand. Neuroimage. 2009;48:362-370.
    • (2009) Neuroimage , vol.48 , pp. 362-370
    • Terry, G.E.1    Liow, J.S.2    Zoghbi, S.S.3
  • 65
    • 77952092564 scopus 로고    scopus 로고
    • Kinetic analysis of the cannabinoid-1 receptor PET tracer [(18)F]MK-9470 in human brain
    • Sanabria-Bohórquez SM, Hamill TG, Goffin K, et al. Kinetic analysis of the cannabinoid-1 receptor PET tracer [(18)F]MK-9470 in human brain. Eur J Nucl Med Mol Imaging. 2010;37:920-933.
    • (2010) Eur J Nucl Med Mol Imaging , vol.37 , pp. 920-933
    • Sanabria-Bohórquez, S.M.1    Hamill, T.G.2    Goffin, K.3
  • 66
    • 58249122563 scopus 로고    scopus 로고
    • Evaluation of [11C]PipISB and [18F]PipISB in monkey as candidate radioligands for imaging brain cannabinoid type-1 receptors in vivo
    • Finnema SJ, Donohue SR, Zoghbi SS, et al. Evaluation of [11C]PipISB and [18F]PipISB in monkey as candidate radioligands for imaging brain cannabinoid type-1 receptors in vivo. Synapse. 2009;63:22-30.
    • (2009) Synapse , vol.63 , pp. 22-30
    • Finnema, S.J.1    Donohue, S.R.2    Zoghbi, S.S.3
  • 67
    • 67349092220 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of carbon-11- and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging
    • Evens N, Muccioli GG, Houbrechts N, et al. Synthesis and biological evaluation of carbon-11- and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging. Nucl Med Biol. 2009;36:455-465.
    • (2009) Nucl Med Biol , vol.36 , pp. 455-465
    • Evens, N.1    Muccioli, G.G.2    Houbrechts, N.3
  • 68
    • 77955323562 scopus 로고    scopus 로고
    • Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)
    • Horti AG, Gao Y, Ravert HT, et al. Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2). Bioorg Med Chem. 2010;18:5202-5207.
    • (2010) Bioorg Med Chem , vol.18 , pp. 5202-5207
    • Horti, A.G.1    Gao, Y.2    Ravert, H.T.3
  • 69
    • 84880331685 scopus 로고    scopus 로고
    • Whole-body biodistribution and radiation dosimetry of the cannabinoid type 2 receptor ligand [11C]-NE40 in healthy subjects
    • Ahmad R, Koole M, Evens N, et al. Whole-body biodistribution and radiation dosimetry of the cannabinoid type 2 receptor ligand [11C]-NE40 in healthy subjects. Mol Imaging Biol. 2013;15:384-390.
    • (2013) Mol Imaging Biol , vol.15 , pp. 384-390
    • Ahmad, R.1    Koole, M.2    Evens, N.3
  • 70
    • 0033765916 scopus 로고    scopus 로고
    • Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil
    • Lloyd CM, Richardson MP, Brooks DJ, et al. Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil. Brain. 2000; 123:2289-2296.
    • (2000) Brain , vol.123 , pp. 2289-2296
    • Lloyd, C.M.1    Richardson, M.P.2    Brooks, D.J.3
  • 71
    • 12144277744 scopus 로고    scopus 로고
    • A case of multiple sclerosis with homonymous hemianopia examined by positron emission tomography
    • Murai H, Kiyosawa M, Suzuki Y, et al. A case of multiple sclerosis with homonymous hemianopia examined by positron emission tomography. Jpn J Ophthalmol. 2004;48:591-593.
    • (2004) Jpn J Ophthalmol , vol.48 , pp. 591-593
    • Murai, H.1    Kiyosawa, M.2    Suzuki, Y.3
  • 72
    • 0035924320 scopus 로고    scopus 로고
    • Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage
    • Ohta A, Sitkovsky M. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature. 2001;414:916-920.
    • (2001) Nature , vol.414 , pp. 916-920
    • Ohta, A.1    Sitkovsky, M.2
  • 74
    • 0032587884 scopus 로고    scopus 로고
    • Dysregulation of adenosine A1 receptormediated cytokine expression in peripheral blood mononuclear cells from multiple sclerosis patients
    • Mayne M, Shepel PN, Jiang Y, et al. Dysregulation of adenosine A1 receptormediated cytokine expression in peripheral blood mononuclear cells from multiple sclerosis patients. Ann Neurol. 1999;45:633-639.
    • (1999) Ann Neurol , vol.45 , pp. 633-639
    • Mayne, M.1    Shepel, P.N.2    Jiang, Y.3
  • 75
    • 0034743760 scopus 로고    scopus 로고
    • Adenosine A2A receptor activation reduces proinflammatory events and decreases cell death following intracerebral hemorrhage
    • Mayne M, Fotheringham J, Yan HJ, et al. Adenosine A2A receptor activation reduces proinflammatory events and decreases cell death following intracerebral hemorrhage. Ann Neurol. 2001;49:727-735.
    • (2001) Ann Neurol , vol.49 , pp. 727-735
    • Mayne, M.1    Fotheringham, J.2    Yan, H.J.3
  • 76
    • 48249097173 scopus 로고    scopus 로고
    • CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis
    • Mills JH, Thompson LF, Mueller C, et al. CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2008;105:9325-9330.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9325-9330
    • Mills, J.H.1    Thompson, L.F.2    Mueller, C.3
  • 77
    • 84883740885 scopus 로고    scopus 로고
    • Increased adenosine A2A-receptor binding in the brain of progressive multiple sclerosis patients detected using [11C]TMSX-PET
    • Rissanen E, Virta J, Helin S, et al. Increased adenosine A2A-receptor binding in the brain of progressive multiple sclerosis patients detected using [11C]TMSX-PET. J Cereb Blood Flow Metab. 2013;33:1394-1401.
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 1394-1401
    • Rissanen, E.1    Virta, J.2    Helin, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.