Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [11C]DAA1106

Journal of Cerebral Blood Flow and Metabolism

Volumn 27, Issue 1, 2007, Pages 173-184

  Ikoma, Yoko ^a   Yasuno, Fumihiko ^a   Ito, Hiroshi ^a   Suhara, Tetsuya ^a   Ota, Miho ^a,b   Toyama, Hinako ^c   Fujimura, Yota ^a,d   Takano, Akihiro ^a   Maeda, Jun ^a   Zhang, Ming Rong ^a,e   Nakao, Ryuji ^a   Suzuki, Kazutoshi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e 141 0032   (Japan)

Author keywords

11C DAA1106; Binding potential; Distribution volume; Peripheral benzodiazepine receptor; Positron emission tomography

Indexed keywords

(N 5 FLUORO 2 PHENOXYPHENYL) N (2 HYDROXY 5 METHOXYBENZYL)ACETAMIDE C 11; (N 5 FLUORO 2 PHENOXYPHENYL) N (2,5 DIMETHOXYBENZYL)ACETAMIDE C 11; BENZODIAZEPINE RECEPTOR; DAA 1106; DAA 1123; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BINDING AFFINITY; BRAIN REGION; CALCULATION; CORRELATION ANALYSIS; DISTRIBUTION VOLUME; DRUG TISSUE LEVEL; HUMAN; HUMAN EXPERIMENT; NOISE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RELIABILITY; SIMULATION;

ACETAMIDES; ADULT; AGED; ALGORITHMS; BRAIN; DATA INTERPRETATION, STATISTICAL; FEMALE; HUMANS; LEAST-SQUARES ANALYSIS; MALE; MIDDLE AGED; MODELS, STATISTICAL; PHENYL ETHERS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, GABA-A;

EID: 33845752145     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600325     Document Type: Article

References (38)

1. Anholt RR, De Souza EB, Oster-Granite ML, Snyder SH (1985) Peripheral-type benzodiazepine receptors: autoradiographic localization in whole-body sections of neonatal rats. J Pharmacol Exp Ther 233:517-26
2. Anholt RR, Pedersen PL, De Souza EB, Snyder SH (1986) The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J Biol Chem 261:576-83
3. Antkiewicz-Michaluk L, Guidotti A, Krueger KE (1988) Molecular characterization and mitochondrial density of a recognition site for peripheral-type benzodiazepine ligands. Mol Pharmacol 34:272-8
4. 3H]PK11195 binding to activated microglia. J Neurocytol 26:77-82
5. Banati RB, Newcombe J, Gunn RN, Cagnin A, Turkheimer F, Heppner F et al (2000) The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain 123:2321-37
6. 3H]PK 11195, an isoquinoline carboxamide derivative: kinetic studies and autoradiographic localization. J Neurochem 41:1744-50
7. Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE et al (2001) In-vivo measurement of activated microglia in dementia. Lancet 358:461-7
8. Carson RE (1993) PET parameter estimation using linear integration methods: bias and variability consideration. In: Quantification of brain function: tracer kinetics and image analysis in brain PET (Uemura K, Lassen NA, Jones T, Kanno I, eds), Amsterdam: Elsevier Science Publishers B.V., 499-507
9. Chaki S, Funakoshi T, Yoshikawa R, Okuyama S, Okubo T, Nakazato A et al (1999) Binding characteristics of [3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors. Eur J Pharmacol 371:197-204
10. 11C]PK11195 in normalhuman brain and application in multiple sclerosis patients. Acta Neurol Belg 102:127-35
11. 11C]PK11195. Eur J Neurol 10:257-64
12. Eriksson L, Holte S, Bohm C, Kesselberg M, Hovander B (1988) Automated blood sampling systems for positron emission tomography. IEEE Trans Nucl Sci 35:703-7
13. Feng D, Huang SC, Wang Z, Ho D (1996) An unbiased parametric imaging algorithm for nonuniformly sampled biomedical system parameter estimation. IEEE Trans Med Imag 15:512-8
14. Feng D, Wang ZZ, Huang SC (1993) A study on statistically reliable and computationally efficient algorithms for the measurement of local cerebral blood flow with positron emission tomography. IEEE Trans Med Imag 12:182-8
15. Gavish M, Bachman I, Shoukrun R, Katz Y, Veenman L, Weisinger G et al (1999) Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev 51:629-50
16. 11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy. Neurology 61:686-9
17. 11C](R)-PK11195 positron emission tomography. Am J Roentgenol 176:1016-8
18. Groom GN, Junck L, Foster NL, Frey KA, Kuhl DE (1995) PET of peripheral benzodiazepine binding sites in the microgliosis of Alzheimer's disease. J Nucl Med 36:2207-10
19. Ichise M, Toyama H, Innis RB, Carson RE (2002) Strategies to improve neuroreceptor parameter estimation by linear regression analysis. J Cereb Blood Flow Metab 22:1271-81
20. Ikoma Y, Toyama H, Uemura K, Kimura Y, Senda M, Uchiyama A (2001) Evaluation of the reliability of parameter estimates in the compartment model analysis by using the fitting error. In: Physiological imaging of the brain with PET (Gjedde A, Hansen SB, Knudsen GM, Paulson OB, eds), New York: Academic Press, 91-5
21. Jayakumar AR, Panickar KS, Norenberg MD (2002) Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells. J Neurochem 83:1226-34
22. 11C]PK11195 brain studies. J Cereb Blood Flow Metab 25:842-51
23. Kuhlmann AC, Guilarte TR (2000) Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethylene neurotoxicity. J Neurochem 74:1694-704
24. Le Fur G, Perrier ML, Vaucher N, Imbault F, Flamier A, Benavides J et al (1983) Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide. I. In vitro studies. Life Sci 32:1839-47
25. Logan J, Fowler JS, Volkow ND, Ding YS, Wang GJ, Alexoff DL (2001) A strategy for removing the bias in the graphical analysis method. J Cereb Blood Flow Metab 21:307-20
26. 11C-methyl]-(-)-cocaine PET studied in human subjects. J Cereb Blood Flow Metab 10:740-7
27. 11C]DAA1106 for PET: an imaging tool for glial cells in the brain. Synapse 52:283-91
28. Millet P, Delforge J, Pappata S, Syrota A, Cinotti L (1996) Error analysis on parameter estimates in the ligand-receptor model: application to parameter imaging using PET data. Phys Med Biol 41:2739-56
29. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ (1984) A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 15:217-27
30. 3H]PK 11195 binding in rat cerebral cortex followinga local ischaemic lesion. J Cereb Blood Flow Metab 11:314-22
31. Okubo T, Yoshikawa R, Chaki S, Okuyama S, Nakazato A (2004) Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives asnovel peripheral benzodiazepine receptor ligands. Bioorg Med Chem 12:423-38
32. Okuyama S, Chaki S, Yoshikawa R, Ogawa S, Suzuki Y, Okubo T et al (1999) Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106. Life Sci 64:1455-64
33. 11C]PK1195. Neurology 55:1052-4
34. 3H] Ro5-4864 to benzodiazepine binding sites in the rat cerebral cortex. Eur J Pharmacol 71:173-5
35. 3H]Ro 5-4864 in rat brain and kidney. J Pharmacol Exp Ther 225:61-9
36. Stephenson DT, Schober DA, Smalstig EB, Mincy RE, Gehlert DR, Clemens JA. (1995) Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat. J Neurosci 15:5263-74
37. Yasuno F, Hasnine AH, Suhara T, Ichimiya T, Sudo Y, Inoue M et al (2002) Template-based method for multiple volumes of interest of human brain PET images. Neuroimage 6(Part 1):577-86
38. 11C]DAA1106: radiosynthesis and in vivo binding to peripheral benzodiazepine receptors in mouse brain. Nucl Med Biol 30:513-9