Extramotor involvement in ALS: PET studies with the GABA(A) ligand [11C]flumazenil

Brain

Volumn 123, Issue 11, 2000, Pages 2289-2296

  Lloyd, C M ^a,b   Richardson, M P ^b,c   Brooks, D J ^b,c   Al Chalabi, A ^a   Leigh, P N ^a,d  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Amyotrophic lateral sclerosis; Extramotor cortex; PET; 11C flumazenil

Indexed keywords

FLUMAZENIL;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BRAIN BLOOD FLOW; CLINICAL ARTICLE; FEMALE; GABAERGIC TRANSMISSION; GLUCOSE METABOLISM; HUMAN; LIGAND BINDING; MALE; NERVE DEGENERATION; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; RECEPTOR DENSITY; SENSORIMOTOR CORTEX; SENSORY CORTEX;

EID: 0033765916     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/123.11.2289     Document Type: Article

References (62)

1. A positron emission tomography study of frontal lobe function (verbal fluency) in amyotrophic lateral sclerosis
2. Frontal lobe dysfunction in amyotrophic lateral sclerosis: A PET study
3. Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis
4. Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS)
5. 3D acquisition and reconstruction in positron emission tomography
6. El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis
7. The central nervous system in motor neurone disease
8. The 'dying back' process. A common denominator in many naturally occurring and toxic neuropathies
9. Adult onset motor neuron disease: Worldwide mortality, incidence and distribution since 1950
10. Deux nouveaux cas de sclerose amyotrophique suivis d'autopsie
11. Nonverbal visual attention, but not recognition memory of learning, processes are impaired in motor neurone disease
12. Pathology of motor system disorder
13. Spectral analysis of dynamic PET studies
14. Lowered cerebral glucose utilization in amyotrophic lateral sclerosis
15. Neuropsychological study of motor neuron disease
16. Amyotrophic lateral sclerosis: Origin and extent of the upper motor neuron lesion
17. Motor neuron disease in a defined English population: Estimates of incidence and mortality
18. The origin of corticospinal projections from the premotor areas in the frontal lobe
19. Calbindin D-28k and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis
20. Hereditary spastic paraparesis with dementia, amyotrophy and peripheral neuropathy. A neuropathological study
21. Stereotaxic summation analysis of human cerebral benzodiazepine binding maps
22. The relationship between global and local changes in PET scans
23. Assessing the significance of focal activations using their spatial extent
24. Spatial registration and normalization of images
25. Statistical parametric maps in functional imaging: A general linear approach
26. Cognitive impairment in motor neuron disease
27. Neuropsychological, electroencephalogram and brain computed tomography findings in motor neuron disease
28. Unchanged total number of neurons in motor cortex and neocortex in amyotrophic lateral sclerosis: A stereological study
29. Cognitive and memory deficits in untreated Parkinson's disease and amyotrophic lateral sclerosis patients: A comparative study
30. Cortical motor-sensory hypometabolism in amyotrophic lateral sclerosis: A PET study
31. Total manifestations of amyotrophic lateral sclerosis in the totally locked-in state
32. Cerebral glucose utilization in motor neuron disease
33. The pathology of amyotrophic lateral sclerosis
34. Dementia and motor neuron disease: Morphometric, biochemical and Golgi studies
35. Amyotrophic lateral sclerosis and its association with dementia, parkinsonism and other neurological disorders: A review
36. Stereology: A practical primer for neuropathology
37. Parvalbumin and calbindin D-28K in the human motor system and in motor neurone disease
38. Motor neuron disease inclusion dementia
39. Involvement of the frontotemporal lobe and limbic system in amyotrophic lateral sclerosis: As assessed by serial computed tomography and magnetic resonance imaging
40. The relationship between abnormalities of cognitive function and cerebral activation in amyotrophic lateral sclerosis. A neuropsychological and positron emission tomography study
41. Cortical function in amyotrophic lateral sclerosis. A positron emission tomography study
42. Frontal lobe atrophy in motor neuron diseases
43. 3H-flumazenil autoradiography in hippocampal sclerosis
44. Compartmental analysis of [11C] flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography
45. Electromyographic studies in amyotrophic lateral sclerosis
46. Amyotrophic lateral sclerosis: A clinicoanatomic study of 53 cases
47. Frontal lobe function in amyotrophic lateral sclerosis: A neuropsychologic and positron emission tomography study
48. An automated system based on solid phase extraction and HPLC for the routine determination in plasma of unchanged [11C]-L-deprenyl; [11C]diprenorphine; [11C]flumazenil; [11C]raclopride; and [11C]Schering 23390
49. Prevalence and correlates of neuropsychological deficits in amyotrophic lateral sclerosis
50. Synthesis of an ethyl 8-fluoro-5,6-dihydro-5-[11C]methyl-6-oxo-4H-imidazo[1,5-a] [1,4]benzodiazepine-3-carboxylate (RO 15.1788-11C): A specific radioligand for the in vivo study of central benzodiazepine receptors by positron emission tomography
51. Presenile dementia combined with amyotrophy: A review of 34 Japanese cases
52. Frontal lobe dementia and motor neuron disease
53. Brain glutamate deficiency in amyotrophic lateral sclerosis
54. Benzodiazepine receptors in focal epilepsy with cortical dysgenesis: An 11C-flumazenil PET study
55. 11C-flumazenil PET in neocortical epilepsy
56. ANALYZE: A software system for biomedical image analysis. First Conference on Visualisation in Biomedical Computing
57. Nerve fibre degeneration in the brain in amyotrophic lateral sclerosis
58. Physical performance of a new positron tomograph for brain imaging with retractable septa
59. Cerebral blood flow and oxygen metabolism in progressive dementia associated with amyotrophic lateral sclerosis
60. Focal reductions of cerebral blood flow in amyotrophic lateral sclerosis: A [99mTc]-d,1-HMPAO SPECT study
61. Free amino acids in motor cortex of amyotrophic lateral sclerosis