Aging and injury: Alterations in cellular energetics and organ function

Aging and Disease

Volumn 5, Issue 2, 2014, Pages 101-108

  Poulose, Ninu ^a   Raju, Raghavan ^a  

^a AUGUSTA UNIVERSITY   (United States)

Author keywords

Aging; Hemorrhage; Hypoxia; Ischemia; Mitochondria; Sirt1

Indexed keywords

EID: 84916940622     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: 10.14336/AD.2014.0500101     Document Type: Review

References (81)

1. Ferrucci L, Giallauria F, Guralnik JM (2008). Epidemiology of aging. Radiologic clinics of North America, 46: 643-652, 5.
2. Mishra RP, Oviedo-Orta E, Prachi P, Rappuoli R, Bagnoli F (2012). Vaccines and antibiotic resistance. Current opinion in microbiology, 15: 596-602
3. NIA (2011). Global Health and Aging.
4. Kinsella K, He W (2008) An aging world: 2008 International population reports
5. CDC (2013) National Vital Statistics Reports
6. Zhaurova K (2008). Genetic causes of adult-onset disorders. Nature education, 1: 49
7. Curry N, Hopewell S, Doree C, Hyde C, Brohi K, Stanworth S (2011). The acute management of trauma hemorrhage: a systematic review of randomized controlled trials. Critical care, 15: R92
8. Thompson HJ, McCormick WC, Kagan SH (2006). Traumatic brain injury in older adults: epidemiology, outcomes, and future implications. Journal of the American Geriatrics Society, 54: 1590-1595
9. Gong Y, Hua Y, Keep RF, Hoff JT, Xi G (2004). Intracerebral hemorrhage: effects of aging on brain edema and neurological deficits. Stroke; a journal of cerebral circulation, 35: 2571-2575
10. Gong Y, Xi GH, Keep RF, Hoff JT, Hua Y (2005). Aging enhances intracerebral hemorrhage-induced brain injury in rats. Acta neurochirurgica. Supplement, 95: 425-427
11. Lesnefsky EJ, Gallo DS, Ye J, Whittingham TS, Lust WD (1994). Aging increases ischemia-reperfusion injury in the isolated, buffer-perfused heart. The Journal of laboratory and clinical medicine, 124: 843-851
12. Okaya T, Blanchard J, Schuster R, Kuboki S, Husted T, Caldwell CC, et al. (2005). Age-dependent responses to hepatic ischemia/reperfusion injury. Shock, 24: 421-427
13. Zingarelli B, Hake PW, O'Connor M, Burroughs TJ, Wong HR, Solomkin JS, et al. (2009). Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma. Critical care medicine, 37: 1978-1987
14. Anderson S, Eldadah B, Halter JB, Hazzard WR, Himmelfarb J, Horne FM, et al. (2011). Acute kidney injury in older adults. Journal of the American Society of Nephrology: JASN, 22: 28-38
15. Mees ST, Gwinner M, Marx K, Faendrich F, Schroeder J, Haier J, et al. (2008). Influence of sex and age on morphological organ damage after hemorrhagic shock. Shock, 29: 670-674
16. King RW, Plewa MC, Buderer NM, Knotts FB (1996). Shock index as a marker for significant injury in trauma patients. Academic emergency medicine: official journal of the Society for Academic Emergency Medicine, 3: 1041-1045
17. Zarzaur BL, Croce MA, Fischer PE, Magnotti LJ, Fabian TC (2008). New vitals after injury: shock index for the young and age x shock index for the old. The Journal of surgical research, 147: 229-236
18. Rani M, Schwacha MG (2012). Aging and the pathogenic response to burn. Aging and disease, 3: 171-180
19. Nacionales DC, Gentile LF, Vanzant E, Lopez MC, Cuenca A, Cuenca AG, et al. (2014). Aged mice are unable to mount an effective myeloid response to sepsis. Journal of immunology, 192: 612-622
20. Franceschi C, Bonafe M, Valensin S (2000). Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine, 18: 1717-1720
21. Swift ME, Burns AL, Gray KL, DiPietro LA (2001). Age-related alterations in the inflammatory response to dermal injury. The Journal of investigative dermatology, 117: 1027-1035
22. Lucas DT, Szweda LI (1998). Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction. Proceedings of the National Academy of Sciences of the United States of America, 95: 510-514
23. Korzick DH, Lancaster TS (2013). Age-related differences in cardiac ischemia-reperfusion injury: effects of estrogen deficiency. Pflugers Archiv: European journal of physiology, 465: 669-685
24. Tani M, Suganuma Y, Hasegawa H, Shinmura K, Ebihara Y, Hayashi Y, et al. (1997). Decrease in ischemic tolerance with aging in isolated perfused Fischer 344 rat hearts: relation to increases in intracellular Na+ after ischemia. Journal of molecular and cellular cardiology, 29: 3081-3089
25. Tani M, Honma Y, Takayama M, Hasegawa H, Shinmura K, Ebihara Y, et al. (1999). Loss of protection by hypoxic preconditioning in aging Fischer 344 rat hearts related to myocardial glycogen content and Na+ imbalance. Cardiovascular research, 41: 594-602
26. van den Munckhof I, Riksen N, Seeger JP, Schreuder TH, Borm GF, Eijsvogels TM, et al. (2013). Aging attenuates the protective effect of ischemic preconditioning against endothelial ischemia-reperfusion injury in humans. American journal of physiology. Heart and circulatory physiology, 304: H1727-1732
27. Jian B, Yang S, Chen D, Zou L, Chatham JC, Chaudry I, et al. (2011). Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury. Molecular medicine, 17: 542-549
28. Lakatta EG (1990). Changes in cardiovascular function with aging. European heart journal, 11 Suppl C: 22-29
29. Gardin JM, Arnold AM, Bild DE, Smith VE, Lima JA, Klopfenstein HS, et al. (1998). Left ventricular diastolic filling in the elderly: the cardiovascular health study. The American journal of cardiology, 82: 345-351
30. Olivetti G, Melissari M, Capasso JM, Anversa P (1991). Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circulation research, 68: 1560-1568
31. Domenighetti AA, Wang Q, Egger M, Richards SM, Pedrazzini T, Delbridge LM (2005). Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure. Hypertension, 46: 426-432
32. Yamamoto T, Sadoshima J (2011). Protection of the heart against ischemia/reperfusion by silent information regulator 1. Trends in cardiovascular medicine, 21: 27-32
33. Judge S, Leeuwenburgh C (2007). Cardiac mitochondrial bioenergetics, oxidative stress, and aging. American journal of physiology. Cell physiology, 292: C1983-1992
34. Hoare M, Das T, Alexander G (2010). Ageing, telomeres, senescence, and liver injury. Journal of hepatology, 53: 950-961
35. Kupiec-Weglinski JW, Busuttil RW (2005). Ischemia and reperfusion injury in liver transplantation. Transplantation proceedings, 37: 1653-1656
36. Wang JH, Behrns KE, Leeuwenburgh C, Kim JS (2012). Critical role of autophage in ischemia/reperfusion injury to aged livers. Autophagy, 8: 140-141
37. Kuboki S, Schuster R, Blanchard J, Pritts TA, Wong HR, Lentsch AB (2007). Role of heat shock protein 70 in hepatic ischemia-reperfusion injury in mice. American journal of physiology. Gastrointestinal and liver physiology, 292: G1141-1149
38. Matsutani T, Kang SC, Miyashita M, Sasajima K, Choudhry MA, Bland KI, et al. (2007). Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged mice. American journal of physiology. Gastrointestinal and liver physiology, 292: G268-274
39. Wang JH, Ahn IS, Fischer TD, Byeon JI, Dunn WA, Jr., Behrns KE, et al. (2011). Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Gastroenterology, 141: 2188-2199 e2186
40. Li L, Messina JL (2009). Acute insulin resistance following injury. Trends in endocrinology and metabolism: TEM, 20: 429-435
41. Li L, Thompson LH, Zhao L, Messina JL (2009). Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury. Endocrinology, 150: 24-32
42. Onyszchuk G, He YY, Berman NE, Brooks WM (2008). Detrimental effects of aging on outcome from traumatic brain injury: a behavioral, magnetic resonance imaging, and histological study in mice. Journal of neurotrauma, 25: 153-171
43. Gupta RK, Prasad S (2013). Early down regulation of the glial Kir4.1 and GLT-1 expression in pericontusional cortex of the old male mice subjected to traumatic brain injury. Biogerontology, 14: 531-541
44. Sun D, Colello RJ, Daugherty WP, Kwon TH, McGinn MJ, Harvey HB, et al. (2005). Cell proliferation and neuronal differentiation in the dentate gyrus in juvenile and adult rats following traumatic brain injury. Journal of neurotrauma, 22: 95-105
45. Sun D, McGinn M, Hankins JE, Mays KM, Rolfe A, Colello RJ (2013). Aging- and injury-related differential apoptotic response in the dentate gyrus of the hippocampus in rats following brain trauma. Frontiers in aging neuroscience, 5: 95
46. Bates K, Vink R, Martins R, Harvey A (2013). Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain. Neurobiology of aging
47. Kang H, Lichtman JW (2013). Motor axon regeneration and muscle reinnervation in young adult and aged animals. The Journal of neuroscience: the official journal of the Society for Neuroscience, 33: 19480-19491
48. Drechsler S, Weixelbaumer K, Raeven P, Jafarmadar M, Khadem A, van Griensven M, et al. (2012). Relationship between age/gender-induced survival changes and the magnitude of inflammatory activation and organ dysfunction in post-traumatic sepsis. PloS one, 7: e51457
49. Close GL, Kayani A, Vasilaki A, McArdle A (2005). Skeletal muscle damage with exercise and aging. Sports medicine, 35: 413-427
50. Mandavia D, Newton K (1998). Geriatric trauma. Emergency medicine clinics of North America, 16: 257-274
51. Nomellini V, Gomez CR, Gamelli RL, Kovacs EJ (2009). Aging and animal models of systemic insult: trauma, burn, and sepsis. Shock, 31: 11-20
52. Bratic A, Larsson NG (2013). The role of mitochondria in aging. The Journal of clinical investigation, 123: 951-957
53. Harman D (1972). The biologic clock: the mitochondria? Journal of the American Geriatrics Society, 20: 145-147
54. Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, et al. (2000). Extension of life-span with superoxide dismutase/catalase mimetics. Science, 289: 1567-1569
55. Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, et al. (2005). Extension of murine life span by overexpression of catalase targeted to mitochondria. Science, 308: 1909-1911
56. Barja G, Cadenas S, Rojas C, Lopez-Torres M, Perez-Campo R (1994). A decrease of free radical production near critical targets as a cause of maximum longevity in animals. Comparative biochemistry and physiology. Biochemistry and molecular biology, 108: 501-512
57. Barja G (1998). Mitochondrial free radical production and aging in mammals and birds. Annals of the New York Academy of Sciences, 854: 224-238
58. Andziak B, O'Connor TP, Qi W, DeWaal EM, Pierce A, Chaudhuri AR, et al. (2006). High oxidative damage levels in the longest-living rodent, the naked mole-rat. Aging cell, 5: 463-471
59. Sanz A, Stefanatos RK (2008). The mitochondrial free radical theory of aging: a critical view. Current aging science, 1: 10-21
60. Perez VI, Van Remmen H, Bokov A, Epstein CJ, Vijg J, Richardson A (2009). The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging cell, 8: 73-75
61. Pun PB, Gruber J, Tang SY, Schaffer S, Ong RL, Fong S, et al. (2010). Ageing in nematodes: do antioxidants extend lifespan in Caenorhabditis elegans? Biogerontology, 11: 17-30
62. Lucas DT, Szweda LI (1999). Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America, 96: 6689-6693
63. Lesnefsky EJ, Gudz TI, Migita CT, Ikeda-Saito M, Hassan MO, Turkaly PJ, et al. (2001). Ischemic injury to mitochondrial electron transport in the aging heart: damage to the iron-sulfur protein subunit of electron transport complex III. Archives of biochemistry and biophysics, 385: 117-128
64. Mourmoura E, Leguen M, Dubouchaud H, Couturier K, Vitiello D, Lafond JL, et al. (2011). Middle age aggravates myocardial ischemia through surprising upholding of complex II activity, oxidative stress, and reduced coronary perfusion. Age, 33: 321-336
65. Miyamae M, Camacho SA, Weiner MW, Figueredo VM (1996). Attenuation of postischemic reperfusion injury is related to prevention of [Ca2+]m overload in rat hearts. The American journal of physiology, 271: H2145-2153
66. Duicu OM, Mirica SN, Gheorgheosu DE, Privistirescu AI, Fira-Mladinescu O, Muntean DM (2013). Ageing-induced decrease in cardiac mitochondrial function in healthy rats. Canadian journal of physiology and pharmacology, 91: 593-600
67. Raju R, Jian B, Hubbard W, Chaudry I (2011). The Mitoscriptome in Aging and Disease. Aging and disease, 2: 174-180
68. Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, et al. (2008). An integrated genomic analysis of human glioblastoma multiforme. Science, 321: 1807-1812
69. Jian B, Yang S, Chaudry IH, Raju R (2012). Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1. Molecular medicine, 18: 209-214
70. Zhang T, Kraus WL (2010). SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochimica et biophysica acta, 1804: 1666-1675
71. Li L, Pan R, Li R, Niemann B, Aurich AC, Chen Y, et al. (2011). Mitochondrial biogenesis and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation by physical activity: intact adipocytokine signaling is required. Diabetes, 60: 157-167
72. Jian B, Yang S, Chen D, Chaudry I, Raju R (2011). Influence of aging and hemorrhage injury on Sirt1 expression: possible role of myc-Sirt1 regulation in mitochondrial function. Biochim Biophys Acta, 1812: 1446-1451
73. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, et al. (2013). Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, 155: 1624-1638
74. Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW (2010). Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Molecular cell, 38: 864-878
75. Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA, et al. (2005). Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Molecular and cellular biology, 25: 6225-6234
76. Ahuja P, Zhao P, Angelis E, Ruan H, Korge P, Olson A, et al. (2010). Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice. The Journal of clinical investigation, 120: 1494-1505
77. Yuan J, Minter-Dykhouse K, Lou Z (2009). A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. The Journal of cell biology, 185: 203-211
78. Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, et al. (2007). HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer cell, 11: 407-420
79. Gu C, Xing Y, Jiang L, Chen M, Xu M, Yin Y, et al. (2013). Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance. PLoS One, 8: e74050
80. Tsuruoka S, Hiwatashi A, Usui J, Yamagata K (2012). The mitochondrial SIRT1-PGC-1alpha axis in podocyte injury. Kidney international, 82: 735-736
81. Mitchell SJ, Martin-Montalvo A, Mercken EM, Palacios HH, Ward TM, Abulwerdi G, et al. (2014). The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet. Cell reports, in press.