Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice

Gastroenterology

Volumn 141, Issue 6, 2011, Pages

  Wang, Jinhee ^a   Ahn, Insook ^a   Fischer, Trevan D ^a   Byeon, Jaeil ^a   Dunn, William A ^b   Behrns, Kevin E ^a   Leeuwenburgh, Christiaan ^b   Kim, Jaesung ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Aging; Liver Injury; Mouse Model; MPT

Indexed keywords

AUTOPHAGY RELATED PROTEIN 3; AUTOPHAGY RELATED PROTEIN 4B; BECLIN 1; CALPAIN 2; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL DEATH; CONFOCAL MICROSCOPY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENETIC ANALYSIS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; INTRAVITAL MULTI PHOTON MICROSCOPY; LIVER CELL; LIVER ISCHEMIA; MITOCHONDRIAL PERMEABILITY; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; REPERFUSION INJURY;

EID: 81855221944     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.08.005     Document Type: Article

References (43)

1. M. Selzner, N. Selzner, and W. Jochum Increased ischemic injury in old mouse liver: an ATP-dependent mechanism Liver Transpl 13 2007 382 390 (Pubitemid 46444467)
2. H. Jaeschke, and J.J. Lemasters Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury Gastroenterology 125 2003 1246 1257 (Pubitemid 37193469)
3. H. Schweiger, E. Lutjen-Drecoll, and E. Arnold Ischemia-induced alterations of mitochondrial structure and function in brain, liver, and heart muscle of young and senescent rats Biochem Med Metab Biol 40 1988 162 185 (Pubitemid 18261795)
4. P.A. Clavien, M. Selzner, and H.A. Rudiger A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning Ann Surg 238 2003 843 850
5. T. Yorimitsu, and D.J. Klionsky Autophagy: molecular machinery for self-eating Cell Death Differ 12 Suppl 2 2005 1542 1552 (Pubitemid 41553991)
6. J.-S. Kim, T. Nitta, and D. Mohuczy Impaired autophagy: a mechanism of mitochondrial dysfunction in anoxic rat hepatocytes Hepatology 47 2008 1725 1736 (Pubitemid 351702754)
7. I. Kim, S. Rodriguez-Enriquez, and J.J. Lemasters Selective degradation of mitochondria by mitophagy Arch Biochem Biophys 462 2007 245 253 (Pubitemid 46876640)
8. J.-S. Kim, T. Qian, and J.J. Lemasters Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes Gastroenterology 124 2003 494 503 (Pubitemid 36169265)
9. Y.S. Sou, S. Waguri, and J. Iwata The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice Mol Biol Cell 19 2008 4762 4775
10. T.P. Theruvath, Z. Zhong, and P. Pediaditakis Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition Hepatology 47 2008 236 246
11. N.L. Nadon Exploiting the rodent model for studies on the pharmacology of lifespan extension Aging Cell 5 2006 9 15 (Pubitemid 43348957)
12. N. Mizushima, and D.J. Klionsky Protein turnover via autophagy: implications for metabolism Annu Rev Nutr 27 2007 19 40 (Pubitemid 351373346)
13. N. Mizushima, T. Yoshimori, and B. Levine Methods in mammalian autophagy research Cell 140 2010 313 326
14. S. Kimura, T. Noda, and T. Yoshimori Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3 Autophagy 3 2007 452 460 (Pubitemid 47293726)
15. T. Kirisako, Y. Ichimura, and H. Okada The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway J Cell Biol 151 2000 263 276
16. E.J. Blumenthal, and A.M. Malkinson Age-dependent changes in murine protein kinase and protease enzymes Mech Ageing Dev 46 1988 201 217 (Pubitemid 19028948)
17. S. Yousefi, R. Perozzo, and I. Schmid Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis Nat Cell Biol 8 2006 1124 1132 (Pubitemid 44473608)
18. D.E. Goll, V.F. Thompson, and H. Li The calpain system Physiol Rev 83 2003 731 801 (Pubitemid 36828925)
19. S. Sinha, and B. Levine The autophagy effector Beclin 1: a novel BH3-only protein Oncogene 27 Suppl 1 2008 S137 S148
20. N. Mizushima, A. Yamamoto, and M. Matsui In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker Mol Biol Cell 15 2004 1101 1111 (Pubitemid 38316219)
21. J.S. Kim, L. He, and T. Qian Role of the mitochondrial permeability transition in apoptotic and necrotic death after ischemia/reperfusion injury to hepatocytes Curr Mol Med 3 2003 527 535 (Pubitemid 37173382)
22. Y. Ichimura, T. Kirisako, and T. Takao A ubiquitin-like system mediates protein lipidation Nature 408 2000 488 492
23. L. Radoshevich, L. Murrow, and N. Chen ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death Cell 142 2010 590 600
24. X.H. Liang, L.K. Kleeman, and H.H. Jiang Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein J Virol 72 1998 8586 8596 (Pubitemid 28471796)
25. T. Oltersdorf, S.W. Elmore, and A.R. Shoemaker An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature 435 2005 677 681 (Pubitemid 40825512)
26. M.L. Genova, M.M. Pich, and A. Bernacchia The mitochondrial production of reactive oxygen species in relation to aging and pathology Ann N Y Acad Sci 1011 2004 86 100 (Pubitemid 38608395)
27. N. Fujita, M. Hayashi-Nishino, and H. Fukumoto An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure Mol Biol Cell 19 2008 4651 4659
28. G. Marino, A.F. Fernandez, and S. Cabrera Autophagy is essential for mouse sense of balance J Clin Invest 120 2010 2331 2344
29. R.A. Nixon The calpains in aging and aging-related diseases Ageing Res Rev 2 2003 407 418 (Pubitemid 37159401)
30. R. Scherz-Shouval, E. Shvets, and E. Fass Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 EMBO J 26 2007 1749 1760 (Pubitemid 46624042)
31. J.M. Norman, G.M. Cohen, and E.T. Bampton The in vitro cleavage of the hAtg proteins by cell death proteases Autophagy 6 2010 1042 1056
32. P. Pacher, and G. Hajnoczky Propagation of the apoptotic signal by mitochondrial waves EMBO J 20 2001 4107 4121 (Pubitemid 32751827)
33. A. Donati, G. Cavallini, and C. Paradiso Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes J Gerontol A Biol Sci Med Sci 56 2001 B288 B293
34. R.A. Del, S. Vittorini, and G. Cavallini Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis Exp Gerontol 38 2003 519 527 (Pubitemid 36549038)
35. S.E. Wohlgemuth, D. Julian, and D.E. Akin Autophagy in the heart and liver during normal aging and calorie restriction Rejuvenation Res 10 2007 281 292 (Pubitemid 47378708)
36. D.G. Le Couteur, L.P. Rivory, and S.M. Pond The effects of aging and nutritional state on hypoxia-reoxygenation injury in the perfused rat liver Transplantation 58 1994 531 536 (Pubitemid 24289841)
37. M. Gamerdinger, P. Hajieva, and A.M. Kaya Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3 EMBO J 28 2009 889 901
38. C. Zhang, and A.M. Cuervo Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function Nat Med 14 2008 959 965
39. S. Kaushik, A.C. Massey, and N. Mizushima Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy Mol Biol Cell 19 2008 2179 2192
40. J.-S. Kim, T. Qian, and J.J. Lemasters Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes Gastroenterology 124 2003 494 503 (Pubitemid 36169265)
41. J.-S. Kim, T. Nitta, and D. Mohuczy Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes Hepatology 47 2008 1725 1736 (Pubitemid 351702754)
42. W.X. Ding, H.M. Ni, and W. Gao Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival J Biol Chem 282 2007 4702 4710 (Pubitemid 47101001)
43. J.-S. Kim, S. Ohshima, and P. Pediaditakis Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition Hepatology 39 2004 1533 1543 (Pubitemid 38702654)