Age-dependent responses to hepatic ischemia/reperfusion injury

Shock

Volumn 24, Issue 5, 2005, Pages 421-427

  Okaya, Tomohisa ^a   Blanchard, John ^a   Schuster, Rebecca ^a   Kuboki, Satoshi ^a   Husted, Thomas ^a   Caldwell, Charles C ^a   Zingarelli, Basilia ^b   Wong, Hector ^b   Solomkin, Joseph S ^a   Lentsch, Alex B ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Hepatocytes; HSP70; Inflammation; Liver injury; Neutrophils; NF B

Indexed keywords

ALANINE AMINOTRANSFERASE; CHEMOKINE; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 2; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR;

AGE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL PROTECTION; CONTROLLED STUDY; HISTOPATHOLOGY; INFLAMMATION; KUPFFER CELL; LEUKOCYTE ACTIVATION; LIVER INJURY; LIVER ISCHEMIA; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REPERFUSION INJURY; TISSUE INJURY;

AGE FACTORS; AGING; ANIMALS; BLOTTING, WESTERN; CYTOKINES; HEPATOCYTES; HSP70 HEAT-SHOCK PROTEINS; INFLAMMATION; KUPFFER CELLS; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED C57BL; MONOKINES; NEUTROPHILS; NF-KAPPA B; PEROXIDASE; REPERFUSION INJURY; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 27644599031     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000181282.14050.11     Document Type: Article

References (38)

1. Tadros T, Traber DL, Herndon DN: Hepatic blood flow and oxygen consumption after burn and sepsis. J Trauma 49:101-108, 2000.
2. Pachter HL, Spencer FC, Hofstetter SR, Liang HG, Coppa GF: Significant trends in the treatment of hepatic trauma. Experience with 411 injuries. Ann Surg 215:492-500, 1992.
3. Peitzman AB, Billiar TR, Harbrecht BG, Kelly E, Udekwu AO, Simmons RL: Hemorrhagic shock. Curr Probl Surg 32:925-1002, 1995.
4. Huguet C, Gavelli A, Bona S: Hepatic resection with ischemia of the liver exceeding one hour. J Am Coll Surg 178:454-458, 1994.
5. Jaeschke H, Bautista AP, Spolarics Z, Spitzer JJ: Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia. Free Radical Res Commun 15:277-284, 1991.
6. Jaeschke H, Farhood A: Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am J Physiol 260:G355-G362, 1991.
7. Jaeschke H, Farhood A, Smith CW: Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J 4:3355-3359, 1990.
8. Zwacka RM, Zhang Y, Zhou W, Halldorson J, Engelhardt JF: Ischemia/reperfusion injury in the liver of BALB/C mice activates AP-1 and nuclear factor κB independently of IκB degradation. Hepatology 28:1022-1030, 1998.
9. Pahl HL: Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18:6853-6866, 1999.
10. Karin M, Liu Z, Zandi E: AP-1 function and regulation. Curr Opin Cell Biol 9:240-246, 1997.
11. Lentsch AB, Yoshidome H, Kato A, Warner RL, Cheadle WG, Ward PA, Edwards MJ: Requirement for interleukin-12 in the pathogenesis of warm hepatic ischemia/reperfusion injury in mice. Hepatology 30:1448-1453, 1999.
12. Colletti LM, Remick DG, Burtch GD, Kunkel SL, Strieter RM, Campbell DA Jr: Role of tumor necrosis factor-α in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. J Clin Invest 85:1936-1943, 1990.
13. Jaeschke H, Farhood A, Bautista AP, Spolarics Z, Spitzer JJ, Smith CW: Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver. Hepatology 17:915-923, 1993.
14. Colletti LM, Cortis A, Lukacs N, Kunkel SL, Green M, Strieter RM: Tumor necrosis factor upregulates intercellular adhesion molecule 1, which is important in the neutrophil-dependent lung and liver injury associated with hepatic ischemia and reperfusion in the rat. Shock 10:182-191, 1998.
15. Colletti LM, Kunkel SL, Walz A, Burdick MD, Kunkel RG, Wilke CA, Stricter RM: Chemokine expression during hepatic ischemia/reperfusion-induced lung injury in the rat. The role of epithelial neutrophil activating protein. J Clin Invest 95:134-141, 1995.
16. Lentsch AB, Yoshidome H, Cheadle WG, Miller FN, Edwards MJ: Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and KC. Hepatology 27:1172-1177, 1998.
17. Jaeschke H, Smith CW: Mechanisms of neutrophil-induced parenchymal cell injury. J Leukocyte Biol 61:647-653, 1997.
18. Turnbull IR, Wlzorek JJ, Osborne D, Hotchkiss RS, Coopersmith CM, Buchman TG: Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock 19:310-313, 2003.
19. Altman PL, Katz DD: Inbred and Genetically Defined Strains of Laboratory Animals: Part 1. Bethesda, MD: Federation of American Societies of Experimental Biology, 1979, p 47.
20. Zurcher C, van Zwieten MJ, Solleveld HA, Holladner CF: Aging Research. In Foster HL, Fox DJ, Small JD, Fox JG (ed): The Mouse in Biomedical Research, Volume IV. New York: Academic Press, 2001, pp 11-33.
21. Anderson RN: Some trends and comparisons of United States life table data 1900-1991. In U.S. Decennial Life Tables for 1989-1991, Volume 1. Hyattsville: National Center for Health Statistics, 1999, pp 5.
22. Calkins CM, Bensard DD, Moore EE, McIntyre RC, Silliman CC, Biffl W, Harken AH, Partrick DA, Offner PJ: The injured child is resistant to multiple organ failure: a different inflammatory response? J Trauma 53:1058-1063, 2002.
23. Schierwagen C, Bylund-Fellenius AC, Lundberg C: Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity. J Pharmacol Methods 23:179-186, 1990.
24. Kato A, Edwards MJ, Lentsch AB: Gene deletion of NF-κB p50 does not alter the hepatic inflammatory response to ischemia/reperfusion. J Hepatol 37:48-55, 2002.
25. Wheeler DS, Dunsmore KE, Wong HR: Intracellular delivery of HSP70 using HIV-1 Tat protein transduction domain. Biochem Biophys Res Commun 301:54-59, 2003.
26. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW, Brenner DA: NFκB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 101:802-811, 1998.
27. Boeri D, Dondero F, Storace D, Maiello M, Pasqualini M, Pellicci R: Heatshock protein 70 favours human liver recovery from ischaemia-reperfusion. Eur J Clin Invest 33:500-504, 2003.
28. Gutsmann-Conrad A, Pahlavani MA, Heydari AR, Richardson A: Expression of heat shock protein 70 decreases with age in hepatocytes and splenocytes from female rats. Mech Ageing Dev 107:255-270, 1999.
29. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, Calderwood SK: Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 277:15028-15034, 2002.
30. Kimura F, Itoh H, Ambiru S, Shimizu H, Togawa A, Yoshidome H, Ohtsuka M, Shimamura F, Kato A, Nukui Y, Miyazaki M: Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection. Am J Surg 187:777-784, 2004.
31. Barsness KA, Bensard DD, Partrick DA, Calkins CM, Hendrickson RJ, McIntyre RC Jr: Endotoxin induces an exaggerated interleukin-10 response in peritoneal macrophages of children compared with adults. J Pediatr Surg 39:912-915, 2004.
32. Brichard B, Varis I, Latinne D, Deneys V, de Bruyere M, Leveugle P, Cornu G: Intracellular cytokine profile of cord and adult blood monocytes. Bone Marrow Transplant 27:1081-1086, 2001.
33. Lentsch AB, Kato A, Yoshidome H, McMasters KM, Edwards MJ: Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology 32:169-173, 2000.
34. Hagen TM, Yowe DL, Bartholomew JC, Wehr CM, Do KL, Park JY, Ames BN: Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. J Biol Chem 94:3064-3069, 1997.
35. Kiang JG, Tsokos GC: Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther 80:183-201, 1998.
36. Hosoi N, Itoh H, Koyama K, Tashima Y: Overexpression of the heat shock protein 70 confers protection against oxidative injury in HEPG2 cells. Transplant Proc 34:2647-2649, 2002.
37. Zhai Y, Shen XD, O'Connell R, Gao F, Lassman C, Busuttil RW, Cheng G, Kupiec-Weglinski JW: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol 173:7115-7119, 2004.
38. Angele MK, Schwacha MG, Ayala A, Chaudry IH: Effect of gender and sex hormones on immune responses following shock. Shock 14:81-90, 2000.