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Volumn 91, Issue 8, 2013, Pages 593-600

Ageing-induced decrease in cardiac mitochondrial function in healthy rats

Author keywords

Ageing; Calcium retention capacity; Oxidative phosphorylation; Reactive oxygen species

Indexed keywords

CALCIUM; CALCIUM ION; CITRATE SYNTHASE; HYDROGEN PEROXIDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; REACTIVE OXYGEN METABOLITE; TETRAPHENYLPHOSPHONIUM;

EID: 84880749482     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2012-0422     Document Type: Article
Times cited : (34)

References (48)
  • 2
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • PMID:9562038
    • Beckman, K.B., and Ames, B.N. 1998. The free radical theory of aging matures. Physiol. Rev. 78: 547-581. PMID:9562038.
    • (1998) Physiol. Rev , vol.78 , pp. 547-581
    • Beckman, K.B.1    Ames, B.N.2
  • 3
    • 77953733762 scopus 로고    scopus 로고
    • Mitochondrial energy metabolism and ageing
    • doi:10.1016/j.bbabio.2010.01.004. PMID:20064485
    • Bratic, I., and Trifunovic, A. 2010. Mitochondrial energy metabolism and ageing. Biochim. Biophys. Acta, 1797: 961-967. doi:10.1016/j.bbabio.2010.01.004. PMID:20064485.
    • (2010) Biochim. Biophys. Acta , vol.1797 , pp. 961-967
    • Bratic, I.1    Trifunovic, A.2
  • 4
    • 0028324422 scopus 로고
    • Age related changes of mitochondrial energy metabolism in rat liver and heart
    • doi:10.1016/S0167-4943(05) 80045-7. PMID:18649840
    • Capozza, G., Guerierri, F., Vendemiale, G., Altomare, E., and Papa, S. 1994. Age related changes of mitochondrial energy metabolism in rat liver and heart. Arch. Gerontol. Geriatr. 19(Suppl. I): 31-38. doi:10.1016/S0167-4943(05) 80045-7. PMID:18649840.
    • (1994) Arch. Gerontol. Geriatr , vol.19 , Issue.SUPPL. I , pp. 31-38
    • Capozza, G.1    Guerierri, F.2    Vendemiale, G.3    Altomare, E.4    Papa, S.5
  • 5
    • 0019137665 scopus 로고
    • Effect of age on the function of mitochondria isolated from brain and heart tissue
    • doi:10.1016/ 0531-5565(80)90003-0. PMID:7202569
    • Chiu, Y.J., and Richardson, A. 1980. Effect of age on the function of mitochondria isolated from brain and heart tissue. Exp. Gerontol. 15: 511-517. doi:10.1016/ 0531-5565(80)90003-0. PMID:7202569.
    • (1980) Exp. Gerontol , vol.15 , pp. 511-517
    • Chiu, Y.J.1    Richardson, A.2
  • 6
    • 0010393136 scopus 로고
    • Edited by D.B. Roodyn. Academic Press, New York, N.Y
    • De Duve, C. 1967. In Enzyme cytology. Edited by D.B. Roodyn. Academic Press, New York, N.Y.
    • (1967) In Enzyme Cytology
    • de Duve, C.1
  • 7
    • 0031081410 scopus 로고    scopus 로고
    • A proposed refinement of the mitochondrial free radical theory of aging
    • doi:10.1002/bies.950190211. PMID: 9046246
    • de Grey, A.D. 1997. A proposed refinement of the mitochondrial free radical theory of aging. Bioessays, 19: 161-166. doi:10.1002/bies.950190211. PMID: 9046246.
    • (1997) Bioessays , vol.19 , pp. 161-166
    • de Grey, A.D.1
  • 8
    • 16344374718 scopus 로고    scopus 로고
    • Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition
    • doi:10.1016/j.cardiores.2005.02.009. PMID:15820191
    • Di Lisa, F., and Bernardi, P. 2005. Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition. Cardiovasc. Res. 66: 222-232. doi:10.1016/j.cardiores.2005.02.009. PMID:15820191.
    • (2005) Cardiovasc. Res , vol.66 , pp. 222-232
    • Di, L.F.1    Bernardi, P.2
  • 9
    • 33646060099 scopus 로고    scopus 로고
    • Mitochondria and ischemia-reperfusion injury of the heart: Fixing a hole
    • doi:10.1016/ j.cardiores.2006.01.016. PMID:16497286
    • Di Lisa, F., and Bernardi, P. 2006. Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole. Cardiovasc Res. 70(2): 191-199. doi:10.1016/ j.cardiores.2006.01.016. PMID:16497286.
    • (2006) Cardiovasc Res , vol.70 , Issue.2 , pp. 191-199
    • Di, L.F.1    Bernardi, P.2
  • 11
    • 0033572337 scopus 로고    scopus 로고
    • Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria
    • doi:10.1006/abbi.1999. 1508. PMID:10600182
    • Fannin, S.W., Lesnefsky, E.J., Slabe, T.J., Hassan, M.O., and Hoppel, C.L. 1999. Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria. Arch. Biochem. Biophys. 372: 399-407. doi:10.1006/abbi.1999. 1508. PMID:10600182.
    • (1999) Arch. Biochem. Biophys , vol.372 , pp. 399-407
    • Fannin, S.W.1    Lesnefsky, E.J.2    Slabe, T.J.3    Hassan, M.O.4    Hoppel, C.L.5
  • 12
    • 84862829641 scopus 로고    scopus 로고
    • Opposite and tissue-specific effects of coenzyme Q2 on mPTP opening and ROS production between heart and liver mitochondria: Role of complex I
    • doi:10.1016/j.yjmcc.2012.02.005. PMID: 22387164
    • Gharib, A., De Paulis, D., Li, B., Augeul, L., Couture-Lepetit, E., Gomez, L., et al. 2012. Opposite and tissue-specific effects of coenzyme Q2 on mPTP opening and ROS production between heart and liver mitochondria: Role of complex I. J. Mol. Cell. Cardiol. 52: 1091-1095. doi:10.1016/j.yjmcc.2012.02.005. PMID: 22387164.
    • (2012) J. Mol. Cell. Cardiol , vol.52 , pp. 1091-1095
    • Gharib, A.1    de Paulis, D.2    Li, B.3    Augeul, L.4    Couture-Lepetit, E.5    Gomez, L.6
  • 13
    • 84889491515 scopus 로고    scopus 로고
    • Polarographic oxygen sensors, the oxygraph and highresolution respirometry to assess mitochondrial function
    • Edited by J.A. Dykens, and Y. Will. John Wiley
    • Gnaiger, E. 2008. Polarographic oxygen sensors, the oxygraph and highresolution respirometry to assess mitochondrial function. In Mitochondrial dysfunction in drug-induced toxicity. Edited by J.A. Dykens, and Y. Will. John Wiley. pp. 327-352.
    • (2008) Mitochondrial Dysfunction In Drug-induced Toxicity , pp. 327-352
    • Gnaiger, E.1
  • 14
    • 68949148655 scopus 로고    scopus 로고
    • Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology
    • doi:10.1016/j.biocel.2009.03.013. PMID:19467914
    • Gnaiger, E. 2009. Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int. J. Biochem. Cell Biol. 41: 1837-1845. doi:10.1016/j.biocel.2009.03.013. PMID:19467914.
    • (2009) Int. J. Biochem. Cell Biol , vol.41 , pp. 1837-1845
    • Gnaiger, E.1
  • 15
    • 0029564901 scopus 로고
    • Control of mitochondrial and cellular respiration by oxygen
    • doi:10.1007/BF02111656. PMID:8746845
    • Gnaiger, E., Steinlechner-Maran, R., Mendez, G., Eberl, T., and Margreiter, R. 1995. Control of mitochondrial and cellular respiration by oxygen. J. Bioenerg. Biomembr. 27: 583-596. doi:10.1007/BF02111656. PMID:8746845.
    • (1995) J. Bioenerg. Biomembr , vol.27 , pp. 583-596
    • Gnaiger, E.1    Steinlechner-Maran, R.2    Mendez, G.3    Eberl, T.4    Margreiter, R.5
  • 16
    • 34548448546 scopus 로고    scopus 로고
    • Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice
    • doi:10.1152/ ajpheart.01378.2006. PMID:17557911
    • Gomez, L., Thibault, H., Gharib, A., Dumont, J.M., Vuagniaux, G., Scalfaro, P., et al. 2007. Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice. Am. J. Physiol. Heart Circ. Physiol. 293: H1654-1661. doi:10.1152/ ajpheart.01378.2006. PMID:17557911.
    • (2007) Am. J. Physiol. Heart Circ. Physiol , vol.293
    • Gomez, L.1    Thibault, H.2    Gharib, A.3    Dumont, J.M.4    Vuagniaux, G.5    Scalfaro, P.6
  • 17
    • 29744466425 scopus 로고
    • Determination of serum proteins by means of the biuret reaction
    • PMID: 18110453
    • Gornal, A.G., Bardavill, G.J., and David, M.M. 1949. Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 177: 751-766. PMID: 18110453.
    • (1949) J. Biol. Chem , vol.177 , pp. 751-766
    • Gornal, A.G.1    Bardavill, G.J.2    David, M.M.3
  • 18
    • 0015319592 scopus 로고
    • The biologic clock: The mitochondria
    • PMID:5016631
    • Harman, D. 1972. The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20(4): 145-147. PMID:5016631.
    • (1972) J. Am. Geriatr. Soc , vol.20 , Issue.4 , pp. 145-147
    • Harman, D.1
  • 19
    • 56149094682 scopus 로고    scopus 로고
    • Helium-induced preconditioning in young and old rat heart. impact of mitochondrial Ca2+-sensitive potassium channel activation
    • doi:10.1097/ALN.0b013e3181895aa0. PMID: 18946295
    • Heinen, A., Huhn, R., Smeele, K.M.A., Zuurbier, C.J., Schlack, W., Preckel, B., et al. 2008. Helium-induced preconditioning in young and old rat heart. impact of mitochondrial Ca2+-sensitive potassium channel activation. Anesthesiology, 109: 830-836. doi:10.1097/ALN.0b013e3181895aa0. PMID: 18946295.
    • (2008) Anesthesiology , vol.109 , pp. 830-836
    • Heinen, A.1    Huhn, R.2    Smeele, K.M.A.3    Zuurbier, C.J.4    Schlack, W.5    Preckel, B.6
  • 20
    • 0003633755 scopus 로고    scopus 로고
    • ILAR (Institute of Laboratory Animal Resources), NIH Publication No. 85-23 (revised 1996). National Academy Press, Washington, D.C. Available from
    • ILAR (Institute of Laboratory Animal Resources). 1996. Guide for the Care and Use of Laboratory Animals. NIH Publication No. 85-23 (revised 1996). National Academy Press, Washington, D.C. Available from www.nap.edu/openbook.php?record_id=5140.
    • (1996) Guide For the Care and Use of Laboratory Animals
  • 21
    • 0024215562 scopus 로고
    • Age-related changes in repiration coupled with phosphorylation
    • doi:10.1016/0047-6374(88)90130-3. PMID:2852282
    • Kim, J.H., Shrago, E., and Elson, C.E. 1988. Age-related changes in repiration coupled with phosphorylation. II. Cardiac mitochondria. Mech. Ageing Dev. 46: 279-290. doi:10.1016/0047-6374(88)90130-3. PMID:2852282.
    • (1988) II. Cardiac Mitochondria. Mech. Ageing Dev , vol.46 , pp. 279-290
    • Kim, J.H.1    Shrago, E.2    Elson, C.E.3
  • 22
    • 84864560789 scopus 로고    scopus 로고
    • Longevity and mitochondrial membrane potential
    • doi:10.1134/S0006297912070127. PMID:22817543
    • Knorre, D.A., and Severin, F.F. 2012. Longevity and mitochondrial membrane potential. Biochemistry (Mosc.), 77(7): 793-794. doi:10.1134/S0006297912070127. PMID:22817543.
    • (2012) Biochemistry (Mosc.) , vol.77 , Issue.7 , pp. 793-794
    • Knorre, D.A.1    Severin, F.F.2
  • 23
    • 44949185670 scopus 로고    scopus 로고
    • Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells
    • doi:10.1038/nprot.2008.61. PMID:18536644
    • Kuznetsov, A.V., Veksler, V., Gellerich, F.N., Saks, V., Margreiter, R., and Kunz, W.S. 2008. Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells. Nat. Protoc. 3(6): 965-976. doi:10.1038/nprot.2008.61. PMID:18536644.
    • (2008) Nat. Protoc , vol.3 , Issue.6 , pp. 965-976
    • Kuznetsov, A.V.1    Veksler, V.2    Gellerich, F.N.3    Saks, V.4    Margreiter, R.5    Kunz, W.S.6
  • 24
    • 33646348697 scopus 로고    scopus 로고
    • Evaluation of mitochondrial membrane potential using a computerized device with a tetraphenylphosphonium-selective electrode
    • doi:10.1016/j.ab.2006.03.032. PMID:16643832
    • Labajova, A., Vojtiskova, A., Krivakova, P., Kofranek, J., Drahota, Z., and Houstek, J. 2006. Evaluation of mitochondrial membrane potential using a computerized device with a tetraphenylphosphonium-selective electrode. Anal. Biochem. 353: 37-42. doi:10.1016/j.ab.2006.03.032. PMID:16643832.
    • (2006) Anal. Biochem , vol.353 , pp. 37-42
    • Labajova, A.1    Vojtiskova, A.2    Krivakova, P.3    Kofranek, J.4    Drahota, Z.5    Houstek, J.6
  • 25
    • 77958032255 scopus 로고    scopus 로고
    • Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype
    • doi:10. 1093/gerona/glq141. PMID:20801909
    • Lemieux, H., Vazquez, E.J., Fujioka, H., and Hoppel, C.L. 2010. Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype. J. Gerontol. A Biol. Sci. Med. Sci. 65A(11): 1157-1164. doi:10. 1093/gerona/glq141. PMID:20801909.
    • (2010) J. Gerontol. a Biol. Sci. Med. Sci , vol.65 A , Issue.11 , pp. 1157-1164
    • Lemieux, H.1    Vazquez, E.J.2    Fujioka, H.3    Hoppel, C.L.4
  • 26
    • 79954509823 scopus 로고    scopus 로고
    • Age-associated differences in the inhibition of mitochondrial permeability transition pore opening by cyclosporine A
    • doi: 10.1111/j.1399-6576.2011.02421.x. PMID:21827445
    • Liu, L., Zhu, J., Brink, P.R., Glass, P.S., and Rebecchi, M.J. 2011. Age-associated differences in the inhibition of mitochondrial permeability transition pore opening by cyclosporine A. Acta Anaesthesiol. Scand. 255(5): 623-630. doi: 10.1111/j.1399-6576.2011.02421.x. PMID:21827445.
    • (2011) Acta Anaesthesiol. Scand , vol.255 , Issue.5 , pp. 623-630
    • Liu, L.1    Zhu, J.2    Brink, P.R.3    Glass, P.S.4    Rebecchi, M.J.5
  • 27
    • 1842440378 scopus 로고    scopus 로고
    • Is defective electron transport at the hub of aging?
    • doi:10.1111/j.1474-9728.2003.00078.x. PMID: 14965352
    • Maklashina, E., and Akrell, B.A. 2004. Is defective electron transport at the hub of aging? Aging Cell, 3: 21-27. doi:10.1111/j.1474-9728.2003.00078.x. PMID: 14965352.
    • (2004) Aging Cell , vol.3 , pp. 21-27
    • Maklashina, E.1    Akrell, B.A.2
  • 28
    • 85047677188 scopus 로고
    • Mitochondrial metabolism and substrate competition in the aging Fischer rat heart
    • McMillin, J.B., Taffet, G.E., Taegtmeyer, H., Hudson, E.K., and Tate, C.A. 1993. Mitochondrial metabolism and substrate competition in the aging Fischer rat heart. Cardiovasc. Res. 27(12): 2222-2228.
    • (1993) Cardiovasc. Res , vol.27 , Issue.12 , pp. 2222-2228
    • McMillin, J.B.1    Taffet, G.E.2    Taegtmeyer, H.3    Hudson, E.K.4    Tate, C.A.5
  • 29
    • 0038367809 scopus 로고    scopus 로고
    • Aging defect at Q(o) site of complex III augments oxyradical production in rat heart interfibrillar mitochondria
    • doi:10.1016/S0003-9861(03) 00166-8. PMID:12745255
    • Moghaddas, S., Hoppel, C.L., and Lesnefsky, E.L. 2003. Aging defect at Q(o) site of complex III augments oxyradical production in rat heart interfibrillar mitochondria. Arch. Biochem. Biophys. 414: 59-66. doi:10.1016/S0003-9861(03) 00166-8. PMID:12745255.
    • (2003) Arch. Biochem. Biophys , vol.414 , pp. 59-66
    • Moghaddas, S.1    Hoppel, C.L.2    Lesnefsky, E.L.3
  • 30
    • 7444267355 scopus 로고    scopus 로고
    • Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart
    • doi:10.1016/j.bbrc.2004.10.011. PMID:15522199
    • Moreau, R., Heath, S.H., Doneanu, C.E., Harris, R.A., and Hagen, T.M. 2004. Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart. Biochem. Biophys. Res. Commun. 325: 48-58. doi:10.1016/j.bbrc.2004.10.011. PMID:15522199.
    • (2004) Biochem. Biophys. Res. Commun , vol.325 , pp. 48-58
    • Moreau, R.1    Heath, S.H.2    Doneanu, C.E.3    Harris, R.A.4    Hagen, T.M.5
  • 31
    • 33847059997 scopus 로고    scopus 로고
    • The mitochondrial energy transduction system and the aging process
    • doi:10.1152/ajpcell.00213.2006. PMID:17020935
    • Navarro, A., and Boveris, A. 2007. The mitochondrial energy transduction system and the aging process. Am. J. Physiol. Cell Physiol. 292: C670-C686. doi:10.1152/ajpcell.00213.2006. PMID:17020935.
    • (2007) Am. J. Physiol. Cell Physiol , vol.292
    • Navarro, A.1    Boveris, A.2
  • 32
    • 57449084690 scopus 로고    scopus 로고
    • Mitochondrial complex I dysfunction in rat heart with aging: Critical role of reactive oxygen species and cardiolipin
    • doi:10.1016/j.freeradbiomed.2008.09.031. PMID:18973802
    • Petrosillo, G., Matera, M., Moro, N., Rugierro, F.M., and Paradies, G. 2009. Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin. Free Radic. Biol. Med. 46: 88-94. doi:10.1016/j.freeradbiomed.2008.09.031. PMID:18973802.
    • (2009) Free Radic. Biol. Med , vol.46 , pp. 88-94
    • Petrosillo, G.1    Matera, M.2    Moro, N.3    Rugierro, F.M.4    Paradies, G.5
  • 33
    • 77950670564 scopus 로고    scopus 로고
    • Increased susceptibility to Ca(2+)-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: Effect of melatonin
    • doi:10.1111/j.1600-079X.2010.00758.x. PMID: 20345745
    • Petrosillo, G., Moro, N., Paradies, V., Ruggiero, F.M., and Paradies, G. 2010. Increased susceptibility to Ca(2+)-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: effect of melatonin. J. Pineal Res. 48: 340-346. doi:10.1111/j.1600-079X.2010.00758.x. PMID: 20345745.
    • (2010) J. Pineal Res , vol.48 , pp. 340-346
    • Petrosillo, G.1    Moro, N.2    Paradies, V.3    Ruggiero, F.M.4    Paradies, G.5
  • 34
    • 0036081753 scopus 로고    scopus 로고
    • Cytochrome c release from mitochondria in the aging heart: A possible mechanism for apoptosis with age
    • doi:10.1152/ajpregu.00296.2001. PMID:11792651
    • Phaneuf, S., and Leeuwenburgh, C. 2002. Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282: R423-R430. doi:10.1152/ajpregu.00296.2001. PMID:11792651.
    • (2002) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.282
    • Phaneuf, S.1    Leeuwenburgh, C.2
  • 35
    • 78249257768 scopus 로고    scopus 로고
    • Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized fibers
    • doi:10.1111/j.1474-9726.2010.00628.x. PMID:20849523
    • Picard, M., Ritchie, D., Wright, K.J., Romestaing, C., Thomas, M.M., Rowan, L., et al. 2010. Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized fibers. Aging Cell, 9(6): 1032-1046. doi:10.1111/j.1474-9726.2010.00628.x. PMID:20849523.
    • (2010) Aging Cell , vol.9 , Issue.6 , pp. 1032-1046
    • Picard, M.1    Ritchie, D.2    Wright, K.J.3    Romestaing, C.4    Thomas, M.M.5    Rowan, L.6
  • 36
    • 84880729382 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in aging and longevity: A causal or protective role?
    • doi:10.1089/ars.2012.4950. PMID:23025472
    • Pulliam, D.A., Bhattacharya, A., and van Remmen, H. 2012. Mitochondrial dysfunction in aging and longevity: a causal or protective role? Antiox. Redox Signal. doi:10.1089/ars.2012.4950. PMID:23025472.
    • (2012) Antiox. Redox Signal
    • Pulliam, D.A.1    Bhattacharya, A.2    van Remmen, H.3
  • 37
    • 84880732588 scopus 로고    scopus 로고
    • Determination of membrane potential with TPP+ and an ion selective electrode system
    • Renner-Sattler, K., Fasching, M., and Gnaiger, E. 2010. Determination of membrane potential with TPP+ and an ion selective electrode system. Mitochondrial Physiology Network, 14.05: 1-15.
    • (2010) Mitochondrial Physiology Network , vol.14 , Issue.5 , pp. 1-15
    • Renner-Sattler, K.1    Fasching, M.2    Gnaiger, E.3
  • 38
    • 0021207554 scopus 로고
    • Membrane potential and surface potential in mitochondria: Uptake and binding of lipophilic cations
    • doi:10.1007/BF01868977. PMID:6492133
    • Rottenberg, H. 1984. Membrane potential and surface potential in mitochondria: uptake and binding of lipophilic cations. J. Membr. Biol. 81: 127-138. doi:10.1007/BF01868977. PMID:6492133.
    • (1984) J. Membr. Biol , vol.81 , pp. 127-138
    • Rottenberg, H.1
  • 39
    • 75149165994 scopus 로고    scopus 로고
    • Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?
    • doi:10.1016/j.freeradbiomed.2009.12.015. PMID:20036736
    • Salmon, A.B., Richardson, A., and Perez, V.I. 2010. Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? Free Radic. Biol. Med. 48: 642-655. doi:10.1016/j.freeradbiomed.2009.12.015. PMID:20036736.
    • (2010) Free Radic. Biol. Med , vol.48 , pp. 642-655
    • Salmon, A.B.1    Richardson, A.2    Perez, V.I.3
  • 40
    • 33344476096 scopus 로고    scopus 로고
    • Mitochondrial membrane damage during aging process in rat heart: Potential efficacy of L-carnitine and DL alpha lipoic acid
    • doi:10.1016/j.mad.2005.12.004. PMID:16430943
    • Savitha, S., and Panneerselvam, C. 2006. Mitochondrial membrane damage during aging process in rat heart: potential efficacy of L-carnitine and DL alpha lipoic acid. Mech. Ageing Dev. 127: 349-355. doi:10.1016/j.mad.2005.12.004. PMID:16430943.
    • (2006) Mech. Ageing Dev , vol.127 , pp. 349-355
    • Savitha, S.1    Panneerselvam, C.2
  • 41
    • 33846787157 scopus 로고    scopus 로고
    • Bionenergetics in aging: Mitochondrial proton leak in aging liver, kidney and heart
    • doi:10.1179/ 135100007X162112. PMID:17263918
    • Serviddio, G., Bellanti, F., Romano, A.D., Tamborra, R., Rollo, T., Altomare, E., and Vendemiale, G. 2007. Bionenergetics in aging: mitochondrial proton leak in aging liver, kidney and heart. Redox Rep. 12: 91-95. doi:10.1179/ 135100007X162112. PMID:17263918.
    • (2007) Redox Rep , vol.12 , pp. 91-95
    • Serviddio, G.1    Bellanti, F.2    Romano, A.D.3    Tamborra, R.4    Rollo, T.5    Altomare, E.6    Vendemiale, G.7
  • 42
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • doi:10.1126/science.273.5271.59. PMID:8658196
    • Sohal, R.S., and Weindruch, R. 1996. Oxidative stress, caloric restriction, and aging. Science, 273: 59-63. doi:10.1126/science.273.5271.59. PMID:8658196.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 43
    • 0027182560 scopus 로고
    • Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages
    • PMID: 8220242
    • Sugiyama, S., Takasawa, M., Hayakawa, M., and Ozawa, T. 1993. Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages. Biochem. Mol. Biol. Int. 30: 937-944. PMID: 8220242.
    • (1993) Biochem. Mol. Biol. Int , vol.30 , pp. 937-944
    • Sugiyama, S.1    Takasawa, M.2    Hayakawa, M.3    Ozawa, T.4
  • 44
    • 0038637258 scopus 로고    scopus 로고
    • Mitochondrial ageing
    • PMID:12835950
    • Szibor, M., and Holtz, J. 2003. Mitochondrial ageing. Basic Res. Cardiol. 98: 210-218. PMID:12835950.
    • (2003) Basic Res. Cardiol , vol.98 , pp. 210-218
    • Szibor, M.1    Holtz, J.2
  • 45
    • 0027309116 scopus 로고
    • Age-associated damage in mitochondrial function in rat heart
    • doi:10.1016/0531-5565(93)90034-B. PMID:8344397
    • Takasawa, M., Hayakawa, M., Sugiyama, S., Hattori, K., Ito, T., and Ozawa, T. 1993. Age-associated damage in mitochondrial function in rat heart. Exp. Gerontol. 28: 269-280. doi:10.1016/0531-5565(93)90034-B. PMID:8344397.
    • (1993) Exp. Gerontol , vol.28 , pp. 269-280
    • Takasawa, M.1    Hayakawa, M.2    Sugiyama, S.3    Hattori, K.4    Ito, T.5    Ozawa, T.6
  • 46
    • 79959280235 scopus 로고    scopus 로고
    • Effects of aging on activities of mitochondrial electron transport chain complexes and oxidative damage in rat heart
    • PMID:21114360
    • Tatarkova, Z., Kuka, S., Račay, P., Lehotsky, J., Dobrota, D., Mištuna, D., and Kaplan, P. 2011. Effects of aging on activities of mitochondrial electron transport chain complexes and oxidative damage in rat heart. Physiol. Res. 60: 281-289. PMID:21114360.
    • (2011) Physiol. Res , vol.60 , pp. 281-289
    • Tatarkova, Z.1    Kuka, S.2    Račay, P.3    Lehotsky, J.4    Dobrota, D.5    Mištuna, D.6    Kaplan, P.7
  • 47
    • 84880714283 scopus 로고    scopus 로고
    • Modulation of respiratory function of mitochondria isolated during the postischaemic reperfusion as cardioprotective strategy
    • Trancota, S., Mirica, N., Duicu, O., Sturza, A., Ordodi, V., Fira-Mladinescu, O., and Muntean, D. 2010. Modulation of respiratory function of mitochondria isolated during the postischaemic reperfusion as cardioprotective strategy. Timisoara Med. J. 2(Suppl.): 25-29.
    • (2010) Timisoara Med. J , vol.2 , Issue.SUPPL. , pp. 25-29
    • Trancota, S.1    Mirica, N.2    Duicu, O.3    Sturza, A.4    Ordodi, V.5    Fira-Mladinescu, O.6    Muntean, D.7
  • 48
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine
    • doi:10.1146/annurev.genet.39.110304.095751. PMID:16285865
    • Wallace, D.C. 2005. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39: 359-407. doi:10.1146/annurev.genet.39.110304.095751. PMID:16285865.
    • (2005) Annu. Rev. Genet , vol.39 , pp. 359-407
    • Wallace, D.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.