Impaired Cardiac SIRT1 Activity by Carbonyl Stress Contributes to Aging-Related Ischemic Intolerance

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Gu, Chunhu ^a   Xing, Yuan ^b   Jiang, Li ^b   Chen, Mai ^a   Xu, Ming ^b   Yin, Yue ^b   Li, Chen ^b   Yang, Zheng ^b   Yu, Lu ^a   Ma, Heng ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALDA 1; ALDEHYDE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CARBONYL DERIVATIVE; CARDIOVASCULAR AGENT; ENZYME ACTIVATOR; ENZYME INHIBITOR; N (1,3 BENZODIOXOL 5 YLMETHYL) 2,6 DICHLOROBENZAMIDE; SIRTUIN 1; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL HYPOXIA; CELL ISOLATION; CHEMICAL MODIFICATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFECT; HEART CONTRACTION; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART STRESS; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN CARBONYLATION; REOXYGENATION; REPERFUSION INJURY;

ADAPTATION, PHYSIOLOGICAL; AGE FACTORS; AGING; ALDEHYDE DEHYDROGENASE; ALDEHYDES; ANIMALS; ANOXIA; BENZAMIDES; BENZODIOXOLES; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; MALE; MICE; MICE, KNOCKOUT; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; SIRTUIN 1; STRESS, PHYSIOLOGICAL;

EID: 84883779755     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074050     Document Type: Article

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