-
1
-
-
84872109456
-
The global prevalence of dementia: A systematic review and metaanalysis
-
Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: A systematic review and metaanalysis. Alzheimers Dement 2013; 9: 63,75.
-
(2013)
Alzheimers Dement
, vol.9
, Issue.63
, pp. 75
-
-
Prince, M.1
Bryce, R.2
Albanese, E.3
Wimo, A.4
Ribeiro, W.5
Ferri, C.P.6
-
2
-
-
82955247909
-
IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030
-
Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011; 94: 311-21.
-
(2011)
Diabetes Res Clin Pract
, vol.94
, pp. 311-321
-
-
Whiting, D.R.1
Guariguata, L.2
Weil, C.3
Shaw, J.4
-
3
-
-
68149131622
-
Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: The action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial
-
Cukierman-Yaffe T, Gerstein HC, Williamson JD, Lazar RM, Lovato L, Miller ME, et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial. Diabetes Care 2009; 32: 221-6.
-
(2009)
Diabetes Care
, vol.32
, pp. 221-226
-
-
Cukierman-Yaffe, T.1
Gerstein, H.C.2
Williamson, J.D.3
Lazar, R.M.4
Lovato, L.5
Miller, M.E.6
-
4
-
-
84866062805
-
Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia
-
Yaffe K, Falvey C, Hamilton N, Schwartz AV, Simonsick EM, Satterfield S, et al. Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia. Arch Neurol 2012; 69: 1170-5.
-
(2012)
Arch Neurol
, vol.69
, pp. 1170-1175
-
-
Yaffe, K.1
Falvey, C.2
Hamilton, N.3
Schwartz, A.V.4
Simonsick, E.M.5
Satterfield, S.6
-
5
-
-
34247110809
-
Relation of diabetes to mild cognitive impairment
-
Luchsinger JA, Reitz C, Patel B, Tang MX, Manly JJ, Mayeux R. Relation of diabetes to mild cognitive impairment. Arch Neurol 2007; 64: 570-5.
-
(2007)
Arch Neurol
, vol.64
, pp. 570-575
-
-
Luchsinger, J.A.1
Reitz, C.2
Patel, B.3
Tang, M.X.4
Manly, J.J.5
Mayeux, R.6
-
6
-
-
29044449855
-
Risk of dementia in diabetes mellitus: A systematic review
-
Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 2006; 5: 64-74.
-
(2006)
Lancet Neurol
, vol.5
, pp. 64-74
-
-
Biessels, G.J.1
Staekenborg, S.2
Brunner, E.3
Brayne, C.4
Scheltens, P.5
-
7
-
-
82255179765
-
Advanced glycation end product level, diabetes, and accelerated cognitive aging
-
Yaffe K, Lindquist K, Schwartz AV, Vitartas C, Vittinghoff E, Satterfield S, et al. Advanced glycation end product level, diabetes, and accelerated cognitive aging. Neurology 2011; 77: 1351-6.
-
(2011)
Neurology
, vol.77
, pp. 1351-1356
-
-
Yaffe, K.1
Lindquist, K.2
Schwartz, A.V.3
Vitartas, C.4
Vittinghoff, E.5
Satterfield, S.6
-
8
-
-
77957940731
-
Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study
-
Ahtiluoto S, Polvikoski T, Peltonen M, Solomon A, Tuomilehto J, Winblad B, et al. Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study. Neurology 2010; 75: 1195-202.
-
(2010)
Neurology
, vol.75
, pp. 1195-1202
-
-
Ahtiluoto, S.1
Polvikoski, T.2
Peltonen, M.3
Solomon, A.4
Tuomilehto, J.5
Winblad, B.6
-
10
-
-
34147173277
-
Insulin resistance and Alzheimer’s disease pathogenesis: Potential mechanisms and implications for treatment
-
Craft S. Insulin resistance and Alzheimer’s disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res 2007; 4: 147-52.
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 147-152
-
-
Craft, S.1
-
11
-
-
1242316296
-
Insulin and neurodegenerative disease: Shared and specific mechanisms
-
Craft S, Watson GS. Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol 2004; 3: 169-78.
-
(2004)
Lancet Neurol
, vol.3
, pp. 169-178
-
-
Craft, S.1
Watson, G.S.2
-
12
-
-
84878222639
-
Effects of type 2 diabetes on 12-year cognitive change: Results from the Maastricht Aging Study
-
Spauwen PJ, Köhler S, Verhey FR, Stehouwer CD, Van Boxtel MP. Effects of type 2 diabetes on 12-year cognitive change: results from the Maastricht Aging Study. Diabetes Care 2013; 36: 1554-61.
-
(2013)
Diabetes Care
, vol.36
, pp. 1554-1561
-
-
Spauwen, P.J.1
Köhler, S.2
Verhey, F.R.3
Stehouwer, C.D.4
Van Boxtel, M.P.5
-
13
-
-
72449143567
-
A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus
-
Van den Berg E, Reijmer YD, De Bresser J, Kessels RP, Kappelle LJ, Biessels GJ, et al. A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus. Diabetologia 2010; 53: 58-65.
-
(2010)
Diabetologia
, vol.53
, pp. 58-65
-
-
Van Den Berg, E.1
Reijmer, Y.D.2
De Bresser, J.3
Kessels, R.P.4
Kappelle, L.J.5
Biessels, G.J.6
-
14
-
-
84885216130
-
Association of depression with accelerated cognitive decline among patients with type 2 diabetes in the ACCORD-MIND trial
-
Sullivan MD, Katon WJ, Lovato LC, Miller ME, Murray AM, Horowitz KR, et al. Association of depression with accelerated cognitive decline among patients with type 2 diabetes in the ACCORD-MIND trial. JAMA Psychiatry 2013; 70: 1041-7.
-
(2013)
JAMA Psychiatry
, vol.70
, pp. 1041-1047
-
-
Sullivan, M.D.1
Katon, W.J.2
Lovato, L.C.3
Miller, M.E.4
Murray, A.M.5
Horowitz, K.R.6
-
16
-
-
78649521177
-
Utrecht Diabetic Encephalopathy Study Group. Cerebral cortical thickness in patients with type 2 diabetes
-
Brundel M, Van den Heuvel M, De Bresser J, Kappelle LJ, Biessels GJ, Utrecht Diabetic Encephalopathy Study Group. Cerebral cortical thickness in patients with type 2 diabetes. J Neurol Sci 2010; 299: 126-30.
-
(2010)
J Neurol Sci
, vol.299
, pp. 126-130
-
-
Brundel, M.1
Van Den Heuvel, M.2
De Bresser, J.3
Kappelle, L.J.4
Biessels, G.J.5
-
17
-
-
84916630515
-
Cerebral white matter integrity and resting-state functional connectivity in middle-aged patients with type 2 diabetes
-
Nov 7. [Epub ahead of print]
-
Hoogenboom WS, Marder TJ, Flores VL, Huisman S, Eaton HP, Schneiderman JS, et al. Cerebral white matter integrity and resting-state functional connectivity in middle-aged patients with type 2 diabetes. Diabetes 2013; Nov 7. [Epub ahead of print].
-
(2013)
Diabetes
-
-
Hoogenboom, W.S.1
Marder, T.J.2
Flores, V.L.3
Huisman, S.4
Eaton, H.P.5
Schneiderman, J.S.6
-
18
-
-
77956083626
-
Progression of cerebral atrophy and white matter hyperintensities in patients with type 2 diabetes
-
De Bresser J, Tiehuis AM, Van den Berg E, Reijmer YD, Jongen C, Kappelle LJ, et al. Progression of cerebral atrophy and white matter hyperintensities in patients with type 2 diabetes. Diabetes Care 2010; 33: 1309-14.
-
(2010)
Diabetes Care
, vol.33
, pp. 1309-1314
-
-
De Bresser, J.1
Tiehuis, A.M.2
Van Den Berg, E.3
Reijmer, Y.D.4
Jongen, C.5
Kappelle, L.J.6
-
19
-
-
78651274000
-
Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early T2DM
-
Baker LD, Cross DJ, Minoshima S, Belongia D, Watson GS, Craft S. Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early T2DM. Arch Neurol 2011; 68: 51-7.
-
(2011)
Arch Neurol
, vol.68
, pp. 51-57
-
-
Baker, L.D.1
Cross, D.J.2
Minoshima, S.3
Belongia, D.4
Watson, G.S.5
Craft, S.6
-
20
-
-
33745317068
-
Brain magnetic resonance imaging correlates of impaired cognition in patients with T2DM
-
Manschot SM, Brands AM, Van der Grond J, Kessels RP, Algra A, Kappelle LJ, et al. Brain magnetic resonance imaging correlates of impaired cognition in patients with T2DM. Diabetes 2006; 55: 1106-13.
-
(2006)
Diabetes
, vol.55
, pp. 1106-1113
-
-
Manschot, S.M.1
Brands, A.M.2
Van Der Grond, J.3
Kessels, R.P.4
Algra, A.5
Kappelle, L.J.6
-
21
-
-
77957266306
-
Progression of brain atrophy and cognitive decline in diabetes mellitus: A 3-year follow-up
-
Van Elderen SG, De Roos A, De Craen AJ, Westendorp RG, Blauw GJ, Jukema JW, et al. Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up. Neurology 2010; 75: 997-1002.
-
(2010)
Neurology
, vol.75
, pp. 997-1002
-
-
Van Elderen, S.G.1
De Roos, A.2
De Craen, A.J.3
Westendorp, R.G.4
Blauw, G.J.5
Jukema, J.W.6
-
22
-
-
84901929243
-
Structural and functional brain changes in middle-aged type 2 diabetic patients: A cross-sectional study
-
Jan 21. [Epub ahead of print]
-
García-Casares N, Berthier ML, Jorge RE, González-Alegre P, Cardo AG, Rioja J, et al. Structural and functional brain changes in middle-aged type 2 diabetic patients: a cross-sectional study. J Alzheimers Dis 2014; Jan 21. [Epub ahead of print]
-
(2014)
J Alzheimers Dis
-
-
García-Casares, N.1
Berthier, M.L.2
Jorge, R.E.3
González-Alegre, P.4
Cardo, A.G.5
Rioja, J.6
-
23
-
-
77956364857
-
Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama study
-
Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi K, Matsui Y, et al. Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study. Neurology 2010; 75: 764-70.
-
(2010)
Neurology
, vol.75
, pp. 764-770
-
-
Matsuzaki, T.1
Sasaki, K.2
Tanizaki, Y.3
Hata, J.4
Fujimi, K.5
Matsui, Y.6
-
24
-
-
84859718265
-
Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
-
Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, et al. Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 2012; 122: 1316-38.
-
(2012)
J Clin Invest
, vol.122
, pp. 1316-1338
-
-
Talbot, K.1
Wang, H.Y.2
Kazi, H.3
Han, L.Y.4
Bakshi, K.P.5
Stucky, A.6
-
25
-
-
33645960672
-
Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer’s disease
-
Lester-Coll N, Rivera EJ, Soscia SJ, Doiron K, Wands JR, De la Monte SM. Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer’s disease. J Alzheimers Dis 2006; 9: 13-33.
-
(2006)
J Alzheimers Dis
, vol.9
, pp. 13-33
-
-
Lester-Coll, N.1
Rivera, E.J.2
Soscia, S.J.3
Doiron, K.4
Wands, J.R.5
De La Monte, S.M.6
-
26
-
-
84856496197
-
Brain insulin resistance and deficiency as therapeutic targets in Alzheimer’s disease
-
De la Monte SM. Brain insulin resistance and deficiency as therapeutic targets in Alzheimer’s disease. Curr Alzheimer Res 2012; 9: 35-66.
-
(2012)
Curr Alzheimer Res
, vol.9
, pp. 35-66
-
-
De La Monte, S.M.1
-
27
-
-
34347377319
-
Alzheimer-like changes in rat models of spontaneous diabetes
-
Li ZG, Zhang W, Sima AA. Alzheimer-like changes in rat models of spontaneous diabetes. Diabetes 2007; 56: 1817-24.
-
(2007)
Diabetes
, vol.56
, pp. 1817-1824
-
-
Li, Z.G.1
Zhang, W.2
Sima, A.A.3
-
28
-
-
84872431424
-
Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes
-
Yang Y, Ma D, Wang Y, Jiang T, Hu S, Zhang M, et al. Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes. J Alzheimers Dis 2013; 33: 329-38
-
(2013)
J Alzheimers Dis
, vol.33
, pp. 329-338
-
-
Yang, Y.1
Ma, D.2
Wang, Y.3
Jiang, T.4
Hu, S.5
Zhang, M.6
-
29
-
-
40349091597
-
Intranasal insulin improves cognition and modulates beta-amyloid in early AD
-
Reger MA, Watson GS, Green PS, Wilkinson CW, Baker LD, Cholerton B, et al. Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology 2008; 70: 440-8.
-
(2008)
Neurology
, vol.70
, pp. 440-448
-
-
Reger, M.A.1
Watson, G.S.2
Green, P.S.3
Wilkinson, C.W.4
Baker, L.D.5
Cholerton, B.6
-
30
-
-
47849123972
-
Intranasal insulin administration dosedependently modulates verbal memory and plasma amyloidbeta in memory-impaired older adults
-
Reger MA, Watson GS, Green PS, Baker LD, Cholerton B, Fishel MA, et al. Intranasal insulin administration dosedependently modulates verbal memory and plasma amyloidbeta in memory-impaired older adults. J Alzheimers Dis 2008; 13: 323-31.
-
(2008)
J Alzheimers Dis
, vol.13
, pp. 323-331
-
-
Reger, M.A.1
Watson, G.S.2
Green, P.S.3
Baker, L.D.4
Cholerton, B.5
Fishel, M.A.6
-
31
-
-
84855613853
-
Intranasal insulin therapy for Alzheimer disease and amnesic mild cognitive imp irment: A pilot clinical trial
-
Craft S, Baker LD, Montine TJ, Minoshima S, Watson GS, Claxton A, et al. Intranasal insulin therapy for Alzheimer disease and amnesic mild cognitive imp irment: a pilot clinical trial. Arch Neurol 2012; 69: 29-38.
-
(2012)
Arch Neurol
, vol.69
, pp. 29-38
-
-
Craft, S.1
Baker, L.D.2
Montine, T.J.3
Minoshima, S.4
Watson, G.S.5
Claxton, A.6
-
32
-
-
84944484435
-
The mechanism of pancreatic secretion
-
Bayliss WM, Starling EH. The mechanism of pancreatic secretion. J Physiol 1902; 28: 325-53.
-
(1902)
J Physiol
, vol.28
, pp. 325-353
-
-
Bayliss, W.M.1
Starling, E.H.2
-
33
-
-
0022461548
-
Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
-
Nauck MA, Homberger E, Siegel EG, Allen RC, Eaton RP, Ebert R, et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 1986; 63: 492-8.
-
(1986)
J Clin Endocrinol Metab
, vol.63
, pp. 492-498
-
-
Nauck, M.A.1
Homberger, E.2
Siegel, E.G.3
Allen, R.C.4
Eaton, R.P.5
Ebert, R.6
-
34
-
-
0141446228
-
Enhancing incretin action for the treatment of type 2 diabetes
-
Drucker DJ. Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care 2003; 26: 2929-40.
-
(2003)
Diabetes Care
, vol.26
, pp. 2929-2940
-
-
Drucker, D.J.1
-
35
-
-
34250635159
-
GLP-1 receptor expression in human tumors and human normal tissues: Potential for in vivo targeting
-
Körner M, Stöckli M, Waser B, Reubi JC. GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting. J Nucl Med 2007; 48: 736-43.
-
(2007)
J Nucl Med
, vol.48
, pp. 736-743
-
-
Körner, M.1
Stöckli, M.2
Waser, B.3
Reubi, J.C.4
-
36
-
-
67651173077
-
Incretin-based therapies for type 2 diabetes mellitus
-
Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol 2009; 5: 262-9.
-
(2009)
Nat Rev Endocrinol
, vol.5
, pp. 262-269
-
-
Lovshin, J.A.1
Drucker, D.J.2
-
37
-
-
84873306844
-
Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
-
Duarte AI, Candeias E, Correia SC, Santos RX, Carvalho C, Cardoso S, et al. Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration. Biochim Biophys Acta 2013; 1832: 527-41.
-
(2013)
Biochim Biophys Acta
, vol.1832
, pp. 527-541
-
-
Duarte, A.I.1
Candeias, E.2
Correia, S.C.3
Santos, R.X.4
Carvalho, C.5
Cardoso, S.6
-
38
-
-
35748957503
-
The physiology of glucagon-like peptide 1
-
Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007; 87: 1409-39.
-
(2007)
Physiol Rev
, vol.87
, pp. 1409-1439
-
-
Holst, J.J.1
-
39
-
-
0022617246
-
Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
-
Nauck M, Stöckmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 1986; 29: 46-52.
-
(1986)
Diabetologia
, vol.29
, pp. 46-52
-
-
Nauck, M.1
Stöckmann, F.2
Ebert, R.3
Creutzfeldt, W.4
-
40
-
-
22144491473
-
Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer’s disease
-
Perry T, Greig NH. Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer’s disease. Curr Alzheimer Res 2005; 2: 377-85.
-
(2005)
Curr Alzheimer Res
, vol.2
, pp. 377-385
-
-
Perry, T.1
Greig, N.H.2
-
41
-
-
69549128161
-
Receptors for the incretin glucagonlike peptide-1 are expressed on neurons in the central nervous system
-
Hamilton A, Holscher C. Receptors for the incretin glucagonlike peptide-1 are expressed on neurons in the central nervous system. Neuroreport 2009; 20: 1161-6.
-
(2009)
Neuroreport
, vol.20
, pp. 1161-1166
-
-
Hamilton, A.1
Holscher, C.2
-
42
-
-
0141461415
-
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
-
During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, et al. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 2003; 9: 1173-9.
-
(2003)
Nat Med
, vol.9
, pp. 1173-1179
-
-
During, M.J.1
Cao, L.2
Zuzga, D.S.3
Francis, J.S.4
Fitzsimons, H.L.5
Jiao, X.6
-
43
-
-
0033545166
-
Distribution of prepro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
-
Merchenthaler I, Lane M, Shughrue P. Distribution of prepro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J Comp Neurol 1999; 403: 261-80.
-
(1999)
J Comp Neurol
, vol.403
, pp. 261-280
-
-
Merchenthaler, I.1
Lane, M.2
Shughrue, P.3
-
44
-
-
0037349072
-
Entry of exendin-4 into brain is rapid but may be limited at high doses
-
Kastin AJ, Akerstrom V. Entry of exendin-4 into brain is rapid but may be limited at high doses. Int J Obes Relat Metab Disord 2003; 27: 313-8.
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, pp. 313-318
-
-
Kastin, A.J.1
Akerstrom, V.2
-
45
-
-
84858713174
-
Drugs developed to treat diabetes, liraglutida and lixisenatide, cross the blood brain barrier and enhance neurogenesis
-
Hunter K, Holscher C. Drugs developed to treat diabetes, liraglutida and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci 2012; 13: 33.
-
(2012)
BMC Neurosci
, vol.13
, pp. 33
-
-
Hunter, K.1
Holscher, C.2
-
46
-
-
0036323652
-
Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo
-
Lee CS, Sund NJ, Vatamaniuk MZ, Matschinsky FM, Stoffers DA, Kaestner KH. Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo. Diabetes 2002; 51: 2546-51.
-
(2002)
Diabetes
, vol.51
, pp. 2546-2551
-
-
Lee, C.S.1
Sund, N.J.2
Vatamaniuk, M.Z.3
Matschinsky, F.M.4
Stoffers, D.A.5
Kaestner, K.H.6
-
47
-
-
0034032317
-
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
-
Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 2000; 49: 741-8.
-
(2000)
Diabetes
, vol.49
, pp. 741-748
-
-
Stoffers, D.A.1
Kieffer, T.J.2
Hussain, M.A.3
Drucker, D.J.4
Bonner-Weir, S.5
Habener, J.F.6
-
48
-
-
0032768616
-
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
-
Buteau J, Roduit R, Susini S, Prentki M. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 1999; 42: 856-64.
-
(1999)
Diabetologia
, vol.42
, pp. 856-864
-
-
Buteau, J.1
Roduit, R.2
Susini, S.3
Prentki, M.4
-
49
-
-
3042792777
-
Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid
-
Green BD, Gault VA, Flatt PR, Harriott P, Greer B, O’Harte FP. Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid. Arch Biochem Biophys 2004; 428: 136-43.
-
(2004)
Arch Biochem Biophys
, vol.428
, pp. 136-143
-
-
Green, B.D.1
Gault, V.A.2
Flatt, P.R.3
Harriott, P.4
Greer, B.5
O’harte, F.P.6
-
50
-
-
0037371744
-
Pharmacological agents that directly modulate insulin secretion
-
Doyle ME, Egan JM. Pharmacological agents that directly modulate insulin secretion. Pharmacol Rev 2003; 55: 105-31.
-
(2003)
Pharmacol Rev
, vol.55
, pp. 105-131
-
-
Doyle, M.E.1
Egan, J.M.2
-
51
-
-
0033153535
-
Calcium-and activity-dependent synaptic plasticity
-
Zucker RS. Calcium-and activity-dependent synaptic plasticity. Curr Opin Neurobiol 1999; 9: 305-13.
-
(1999)
Curr Opin Neurobiol
, vol.9
, pp. 305-313
-
-
Zucker, R.S.1
-
52
-
-
0025882999
-
Activation of a large-conductance Ca2+-dependent K+ channel by stimulation of glutamate phosphoinositide-coupled receptors in cultured cerebellar granule cells
-
Fagni L, Bossu JL, Bockaert J. Activation of a large-conductance Ca2+-dependent K+ channel by stimulation of glutamate phosphoinositide-coupled receptors in cultured cerebellar granule cells. Eur J Neurosci 1991; 3: 778-89.
-
(1991)
Eur J Neurosci
, vol.3
, pp. 778-789
-
-
Fagni, L.1
Bossu, J.L.2
Bockaert, J.3
-
53
-
-
77953880083
-
Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer’s disease
-
Holscher C. Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer’s disease. Recent Pat CNS Drug Discov 2010; 5: 109-17.
-
(2010)
Recent Pat CNS Drug Discov
, vol.5
, pp. 109-117
-
-
Holscher, C.1
-
54
-
-
77954953382
-
New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer’s disease?
-
Holscher C, Li L. New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer’s disease? Neurobiol Aging 2010; 31: 1495-502.
-
(2010)
Neurobiol Aging
, vol.31
, pp. 1495-1502
-
-
Holscher, C.1
Li, L.2
-
55
-
-
77950352189
-
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer’s disease
-
Li Y, Duffy KB, Ottinger MA, Ray B, Bailey JA, Holloway HW, et al. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer’s disease. J Alzheimers Dis 2010; 19: 1205-19.
-
(2010)
J Alzheimers Dis
, vol.19
, pp. 1205-1219
-
-
Li, Y.1
Duffy, K.B.2
Ottinger, M.A.3
Ray, B.4
Bailey, J.A.5
Holloway, H.W.6
-
56
-
-
84879366324
-
Exenatida promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals
-
Bomba M, Ciavardelli D, Silvestri E, Canzoniero LM, Lattanzio R, Chiappini P, et al. Exenatida promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals. Cell Death Dis 2013; 4: e612.
-
(2013)
Cell Death Dis
, vol.4
-
-
Bomba, M.1
Ciavardelli, D.2
Silvestri, E.3
Canzoniero, L.M.4
Lattanzio, R.5
Chiappini, P.6
-
57
-
-
79955629694
-
Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect
-
Newington JT, Pitts A, Chien A, Arseneault R, Schubert D, Cumming RC. Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect. PLoS One 2011; 6: e19191.
-
(2011)
PLoS One
, vol.6
-
-
Newington, J.T.1
Pitts, A.2
Chien, A.3
Arseneault, R.4
Schubert, D.5
Cumming, R.C.6
-
58
-
-
84868260725
-
Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production
-
Newington JT, Rappon T, Albers S, Wong DY, Rylett RJ, Cumming RC. Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production. J Biol Chem 2012; 287: 37245-58.
-
(2012)
J Biol Chem
, vol.287
, pp. 37245-37258
-
-
Newington, J.T.1
Rappon, T.2
Albers, S.3
Wong, D.Y.4
Rylett, R.J.5
Cumming, R.C.6
-
59
-
-
78649745810
-
The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test
-
Isacson R, Nielsen E, Dannaeus K, Bertilsson G, Patrone C, Zachrisson O, et al. The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test. Eur J Pharmacol 2011; 650: 249-55.
-
(2011)
Eur J Pharmacol
, vol.650
, pp. 249-255
-
-
Isacson, R.1
Nielsen, E.2
Dannaeus, K.3
Bertilsson, G.4
Patrone, C.5
Zachrisson, O.6
-
60
-
-
84859726053
-
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease-associated Aβ oligomers
-
Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease-associated Aβ oligomers. J Clin Invest 2012; 122: 1339-53.
-
(2012)
J Clin Invest
, vol.122
, pp. 1339-1353
-
-
Bomfim, T.R.1
Forny-Germano, L.2
Sathler, L.B.3
Brito-Moreira, J.4
Houzel, J.C.5
Decker, H.6
-
61
-
-
84864201829
-
Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an intrahippocampal lipopolysaccharide injection
-
Huang HJ, Chen YH, Liang KC, Jheng YS, Jhao JJ, Su MT, et al. Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an intrahippocampal lipopolysaccharide injection. PLoS One 2012; 7: e39656.
-
(2012)
PLoS One
, vol.7
-
-
Huang, H.J.1
Chen, Y.H.2
Liang, K.C.3
Jheng, Y.S.4
Jhao, J.J.5
Su, M.T.6
-
62
-
-
84867577041
-
Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer’s disease by exendin-4
-
Chen S, Liu AR, An FM, Yao WB, Gao XD. Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer’s disease by exendin-4. Age (Dordr) 2012; 34: 1211-24.
-
(2012)
Age (Dordr)
, vol.34
, pp. 1211-1224
-
-
Chen, S.1
Liu, A.R.2
An, F.M.3
Yao, W.B.4
Gao, X.D.5
-
63
-
-
77955470617
-
Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet
-
Gault VA, Porter WD, Flatt PR, Hölscher C. Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. Int J Obes (Lond) 2010; 34: 1341-4.
-
(2010)
Int J Obes (Lond)
, vol.34
, pp. 1341-1344
-
-
Gault, V.A.1
Porter, W.D.2
Flatt, P.R.3
Hölscher, C.4
-
64
-
-
84868458245
-
Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice
-
Tweedie D, Rachmany L, Rubovitch V, Lehrmann E, Zhang Y, Becker KG, et al. Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice. Exp Neurol 2013; 239: 170-82.
-
(2013)
Exp Neurol
, vol.239
, pp. 170-182
-
-
Tweedie, D.1
Rachmany, L.2
Rubovitch, V.3
Lehrmann, E.4
Zhang, Y.5
Becker, K.G.6
-
65
-
-
79960881826
-
Diabetes as a risk factor for Alzheimer’s disease: Insulin signalling impairment in the brain as an alternative model of Alzheimer’s disease
-
Holscher C. Diabetes as a risk factor for Alzheimer’s disease: insulin signalling impairment in the brain as an alternative model of Alzheimer’s disease. Biochem Soc Trans 2011; 39: 891-7.
-
(2011)
Biochem Soc Trans
, vol.39
, pp. 891-897
-
-
Holscher, C.1
-
66
-
-
84886592674
-
Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer’s disease
-
McClean PL, Holscher C. Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer’s disease. Neuropharmacology 2014; 76 (Pt A): 57-67.
-
(2014)
Neuropharmacology
, vol.76
, pp. 57-67
-
-
McClean, P.L.1
Holscher, C.2
-
67
-
-
84874722479
-
The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signaling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer’s disease
-
Long-Smith CM, Manning S, McClean PL, Coakley MF, O’Halloran DJ, Holscher C, et al. The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signaling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer’s disease. Neuromolecular Med 2013; 15: 102-14.
-
(2013)
Neuromolecular Med
, vol.15
, pp. 102-114
-
-
Long-Smith, C.M.1
Manning, S.2
McClean, P.L.3
Coakley, M.F.4
O’halloran, D.J.5
Holscher, C.6
-
68
-
-
77956134398
-
Four weeks administration of liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance
-
Porter DW, Kerr BD, Flatt PR, Holscher C, Gault VA. Four weeks administration of liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance. Diabetes Obes Metab 2010; 12: 891-9.
-
(2010)
Diabetes Obes Metab
, vol.12
, pp. 891-899
-
-
Porter, D.W.1
Kerr, B.D.2
Flatt, P.R.3
Holscher, C.4
Gault, V.A.5
-
69
-
-
84890808796
-
Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes
-
Yang Y, Zhang J, Ma D, Zhang M, Hu S, Shao S, et al. Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes. J Alzheimers Dis 2013; 37: 637-48.
-
(2013)
J Alzheimers Dis
, vol.37
, pp. 637-648
-
-
Yang, Y.1
Zhang, J.2
Ma, D.3
Zhang, M.4
Hu, S.5
Shao, S.6
-
70
-
-
77649187436
-
Glucagonlike peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer’s disease
-
McClean PL, Gault VA, Harriott P, Hölscher C. Glucagonlike peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer’s disease. Eur J Pharmacol 2010; 630: 158-62.
-
(2010)
Eur J Pharmacol
, vol.630
, pp. 158-162
-
-
McClean, P.L.1
Gault, V.A.2
Harriott, P.3
Hölscher, C.4
-
71
-
-
77957126457
-
Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats
-
Wang XH, Li L, Hölscher C, Pan YF, Chen XR, Qi JS. Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats. Neuroscience 2010; 170: 1239-48.
-
(2010)
Neuroscience
, vol.170
, pp. 1239-1248
-
-
Wang, X.H.1
Li, L.2
Hölscher, C.3
Pan, Y.F.4
Chen, X.R.5
Qi, J.S.6
-
72
-
-
82755176046
-
Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
-
Gengler S, McClean PL, McCurtin R, Gault VA, Holscher C. Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol Aging 2012; 33: 265-76.
-
(2012)
Neurobiol Aging
, vol.33
, pp. 265-276
-
-
Gengler, S.1
McClean, P.L.2
McCurtin, R.3
Gault, V.A.4
Holscher, C.5
-
73
-
-
84866972198
-
Glucagonlike peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer’s disease model mice
-
Ma T, Du X, Pick JE, Sui G, Brownlee M, Klann E. Glucagonlike peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer’s disease model mice. J Neurosci 2012; 32: 13701-8.
-
(2012)
J Neurosci
, vol.32
, pp. 13701-13708
-
-
Ma, T.1
Du, X.2
Pick, J.E.3
Sui, G.4
Brownlee, M.5
Klann, E.6
-
74
-
-
84873266979
-
Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer’s disease –protocol for a controlled, randomized double-blinded trial
-
Egefjord L, Gejl M, Moller A, Braendgaard H, Gottrup H, Antropova O, et al. Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer’s disease –protocol for a controlled, randomized double-blinded trial. Dan Med J 2012; 59: A4519.
-
(2012)
Dan Med J
, vol.59
-
-
Egefjord, L.1
Gejl, M.2
Moller, A.3
Braendgaard, H.4
Gottrup, H.5
Antropova, O.6
|