메뉴 건너뛰기




Volumn 5, Issue 2, 2010, Pages 109-117

Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease

Author keywords

Alzheimer's disease; Gastric inhibitory polypeptide; Gip; Glp 1; Glucagon like peptide 1; Glucose dependent insulinotropic peptide; Incretins; Neurodegeneration

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUCAGON LIKE PEPTIDE 1; INSULIN DETEMIR; LIRAGLUTIDE; NERVE GROWTH FACTOR; SOMATOMEDIN C; VASCULOTROPIN;

EID: 77953880083     PISSN: 15748898     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488910791213130     Document Type: Article
Times cited : (93)

References (105)
  • 1
  • 2
    • 3543067962 scopus 로고    scopus 로고
    • Neurodegenerative disorders associated with diabetes mellitus
    • Ristow M. Neurodegenerative disorders associated with diabetes mellitus. J Mol Med 2004; 82(8): 510-29.
    • (2004) J Mol Med , vol.82 , Issue.8 , pp. 510-529
    • Ristow, M.1
  • 3
    • 33644585223 scopus 로고    scopus 로고
    • Therapy Insight: Type 2 diabetes mellitus and the risk of late-onset Alzheimers disease
    • Haan MN. Therapy Insight: Type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease. Nat Clin Pract Neurol 2006; 2(3): 159-66.
    • (2006) Nat Clin Pract Neurol , vol.2 , Issue.3 , pp. 159-166
    • Haan, M.N.1
  • 5
    • 0345862282 scopus 로고    scopus 로고
    • Insulin-like growth factor I and Alzheimers disease: Therapeutic prospects?
    • Carro E, Torres-Aleman I. Insulin-like growth factor I and Alzheimer's disease: Therapeutic prospects? Expert Rev Neurother 2004; 4(1): 79-86.
    • (2004) Expert Rev Neurother , vol.4 , Issue.1 , pp. 79-86
    • Carro, E.1    Torres-Aleman, I.2
  • 6
    • 1842785179 scopus 로고    scopus 로고
    • Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
    • Hoyer S. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur J Pharmacol 2004; 490(1-3): 115-25.
    • (2004) Eur J Pharmacol , vol.490 , Issue.1-3 , pp. 115-125
    • Hoyer, S.1
  • 7
    • 1842684434 scopus 로고    scopus 로고
    • Insulin-like growth factor-I, cognition and brain aging
    • van Dam P, Aleman A. Insulin-like growth factor-I, cognition and brain aging. Eur J Pharmacol 2004; 490(1-3): 87-95.
    • (2004) Eur J Pharmacol , vol.490 , Issue.1-3 , pp. 87-95
    • Van Dam, P.1    Aleman, A.2
  • 8
    • 34548249096 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model
    • Cohen AC, Tong M, Wands JR, de la Monte SM. Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model. Alcohol Clin Exp Res 2007; 31(9): 1558-73.
    • (2007) Alcohol Clin Exp Res , vol.31 , Issue.9 , pp. 1558-1573
    • Cohen, A.C.1    Tong, M.2    Wands, J.R.3    de la Monte, S.M.4
  • 9
    • 36448936053 scopus 로고    scopus 로고
    • Common pathological processes in Alzheimer Disease and Type 2 Diabetes review
    • Li L, Hölscher C. Common pathological processes in Alzheimer Disease and Type 2 Diabetes: A review. Brain Res Rev 2007; 56(2): 384-402.
    • (2007) Brain Res Rev , vol.56 , Issue.2 , pp. 384-402
    • Li, L.1    Hölscher, C.2
  • 10
    • 1842633868 scopus 로고    scopus 로고
    • The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimers disease
    • Carro E, Torres AI. The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease. Eur J Pharmacol 2004; 490(1-3): 127-33.
    • (2004) Eur J Pharmacol , vol.490 , Issue.1-3 , pp. 127-133
    • Carro, E.1    Torres, A.I.2
  • 11
    • 34347377319 scopus 로고    scopus 로고
    • Alzheimer-like changes in rat models of spontaneous diabetes
    • Li ZG, Zhang W, Sima AA. Alzheimer-like changes in rat models of spontaneous diabetes. Diabetes 2007; 56(7): 1817-24.
    • (2007) Diabetes , vol.56 , Issue.7 , pp. 1817-1824
    • Li, Z.G.1    Zhang, W.2    Sima, A.A.3
  • 12
    • 15244351255 scopus 로고    scopus 로고
    • Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimers disease-is this type 3 diabetes?
    • Steen E, Terry BM, Rivera E, Cannon JL, Neely TR, Tavares R, et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes? J Alzheimer's Dis 2005; 7(1): 63-80.
    • (2005) J Alzheimers Dis , vol.7 , Issue.1 , pp. 63-80
    • Steen, E.1    Terry, B.M.2    Rivera, E.3    Cannon, J.L.4    Neely, T.R.5    Tavares, R.6
  • 14
    • 1842785174 scopus 로고    scopus 로고
    • Hippocampal synaptic plasticity and glutamate receptor regulation: Influences of diabetes mellitus
    • Trudeau F, Gagnon S, Massicotte G. Hippocampal synaptic plasticity and glutamate receptor regulation: influences of diabetes mellitus. Eur J Pharmacol 2004; 490(1-3): 177-86.
    • (2004) Eur J Pharmacol , vol.490 , Issue.1-3 , pp. 177-186
    • Trudeau, F.1    Gagnon, S.2    Massicotte, G.3
  • 16
    • 6344250713 scopus 로고    scopus 로고
    • Insulin and the CNS: Effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans
    • Stockhorst U, de Fries D, Steingrueber HJ, Scherbaum WA. Insulin and the CNS: Effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol Behav 2004; 83(1): 47-54.
    • (2004) Physiol Behav , vol.83 , Issue.1 , pp. 47-54
    • Stockhorst, U.1    De Fries, D.2    Steingrueber, H.J.3    Scherbaum, W.A.4
  • 17
    • 0034333018 scopus 로고    scopus 로고
    • Cognition and synaptic plasticity in diabetes mellitus
    • Gispen WH, Biessels GJ. Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci 2000; 23(11): 542-9.
    • (2000) Trends Neurosci , vol.23 , Issue.11 , pp. 542-549
    • Gispen, W.H.1    Biessels, G.J.2
  • 18
    • 1842684436 scopus 로고    scopus 로고
    • Glucose, insulin and the brain: Modulation of cognition and synaptic plasticity in health and disease: A preface
    • Biessels GJ, Bravenboer B, Gispen WH. Glucose, insulin and the brain: Modulation of cognition and synaptic plasticity in health and disease: A preface. Eur J Pharmacol 2004; 490: 1-4.
    • (2004) Eur J Pharmacol , vol.490 , pp. 1-4
    • Biessels, G.J.1    Bravenboer, B.2    Gispen, W.H.3
  • 19
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol 2009; 5: 262-9.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 20
    • 3042792777 scopus 로고    scopus 로고
    • Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid
    • Green BD, Gault VA, Flatt PR, Harriott P, Greer B, O'Harte FP. Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid. Arch Biochem Biophys 2004; 428(2): 136-43.
    • (2004) Arch Biochem Biophys , vol.428 , Issue.2 , pp. 136-143
    • Green, B.D.1    Gault, V.A.2    Flatt, P.R.3    Harriott, P.4    Greer, B.5    O Harte, F.P.6
  • 21
    • 33745937115 scopus 로고    scopus 로고
    • Novel GLP-1 analogue (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta cell function after 3 weeks daily administration in obese diabetic (ob/ob) mice
    • Green BD, Lavery KS, Irwin N, O'Harte FP, Harriott P, Greer B, et al. Novel GLP-1 analogue (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta cell function after 3 weeks daily administration in obese diabetic (ob/ob) mice. J Pharmacol Exp Ther 2006; 318: 914-21.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 914-921
    • Green, B.D.1    Lavery, K.S.2    Irwin, N.3    O Harte, F.P.4    Harriott, P.5    Greer, B.6
  • 22
    • 77953895020 scopus 로고    scopus 로고
    • Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture
    • [E-Pub ahead of print]
    • Toso C, McCall M, Emamaullee J, Merani S, Davis J, Edgar R, et al. Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture. Transpl Int 2009; [E-Pub ahead of print]
    • (2009) Transpl Int
    • Toso, C.1    McCall, M.2    Emamaullee, J.3    Merani, S.4    Davis, J.5    Edgar, R.6
  • 23
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse JB, Lewin A, Schwartz S, Raskin P, et al. Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD). Diabetes Care 2009; 32(7): 1224-30.
    • (2009) Diabetes Care , vol.32 , Issue.7 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3    Lewin, A.4    Schwartz, S.5    Raskin, P.6
  • 24
    • 60549097258 scopus 로고    scopus 로고
    • Targeting Incretins in Type 2 Diabetes: Role of GLP-1 Receptor Agonists and DPP-4 Inhibitors
    • Pratley RE, Gilbert M. Targeting Incretins in Type 2 Diabetes: Role of GLP-1 Receptor Agonists and DPP-4 Inhibitors. Rev Diabet Stud 2008; 5(2): 73-94.
    • (2008) Rev Diabet Stud , vol.5 , Issue.2 , pp. 73-94
    • Pratley, R.E.1    Gilbert, M.2
  • 25
    • 15044354562 scopus 로고    scopus 로고
    • Glucagon-related peptide 1 (GLP-1): Hormone and neurotransmitter
    • Larsen PJ, Holst JJ. Glucagon-related peptide 1 (GLP-1): Hormone and neurotransmitter. Regul Pept 2005; 128(2): 97-107.
    • (2005) Regul Pept , vol.128 , Issue.2 , pp. 97-107
    • Larsen, P.J.1    Holst, J.J.2
  • 26
    • 6344241190 scopus 로고    scopus 로고
    • Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents
    • Green BD, Gault VA, O'Harte FP, Flatt PR. Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents. Curr Pharm Des 2004; 10(29): 3651-62.
    • (2004) Curr Pharm Des , vol.10 , Issue.29 , pp. 3651-3662
    • Green, B.D.1    Gault, V.A.2    O Harte, F.P.3    Flatt, P.R.4
  • 27
    • 23844434969 scopus 로고    scopus 로고
    • A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide
    • Green BD, Gault VA, O'Harte FP, Flatt PR. A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Diabetes Obes Metab 2005; 7(5): 595-604.
    • (2005) Diabetes Obes Metab , vol.7 , Issue.5 , pp. 595-604
    • Green, B.D.1    Gault, V.A.2    O Harte, F.P.3    Flatt, P.R.4
  • 28
    • 39749143348 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus
    • Vilsboll T, Brock B, Perrild H, Levin K, Lervang HH, Kolendorf K, et al. Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus. Diabet Med 2008; 25(2): 152-6.
    • (2008) Diabet Med , vol.25 , Issue.2 , pp. 152-156
    • Vilsboll, T.1    Brock, B.2    Perrild, H.3    Levin, K.4    Lervang, H.H.5    Kolendorf, K.6
  • 29
    • 33846548176 scopus 로고    scopus 로고
    • Nonpeptidic glucagon-like peptide 1 receptor agonists: A magic bullet for diabetes?
    • USA
    • Murphy KG, Bloom SR. Nonpeptidic glucagon-like peptide 1 receptor agonists: A magic bullet for diabetes? Proc Natl Acad Sci USA 2007; 104(3): 689-90.
    • (2007) Proc Natl Acad Sci , vol.104 , Issue.3 , pp. 689-690
    • Murphy, K.G.1    Bloom, S.R.2
  • 30
    • 57649232757 scopus 로고    scopus 로고
    • Molecular, pharmacological and clinical aspects of liraglutide, a once-daily human GLP-1 analogue
    • Russell-Jones D. Molecular, pharmacological and clinical aspects of liraglutide, a once-daily human GLP-1 analogue. Mol Cell Endocrinol 2009; 297(1-2): 137-40.
    • (2009) Mol Cell Endocrinol , vol.297 , Issue.1-2 , pp. 137-140
    • Russell-Jones, D.1
  • 31
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA. The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006; 368(9548): 1696-705.
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 32
    • 67849124134 scopus 로고    scopus 로고
    • The effect of exenatide re-exposure on safety and efficacy
    • Faludi P, Brodows R, Burger J, Ivanyi T, Braun DK. The effect of exenatide re-exposure on safety and efficacy. Peptides 2009; 30(9): 1771-4.
    • (2009) Peptides , vol.30 , Issue.9 , pp. 1771-1774
    • Faludi, P.1    Brodows, R.2    Burger, J.3    Ivanyi, T.4    Braun, D.K.5
  • 33
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial
    • Russell-Jones D, Vaag A, Schmitz O, Sethi BK, Lalic N, Antic S, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial. Diabetologia 2009; 52(10): 2046-55.
    • (2009) Diabetologia , vol.52 , Issue.10 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3    Sethi, B.K.4    Lalic, N.5    Antic, S.6
  • 34
    • 77649187436 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimers disease
    • McClean PL, Gault VA, Harriott P, Holscher C. Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease. Eur J Pharmacol 2010; 630:158-62.
    • (2010) Eur J Pharmacol , vol.630 , pp. 158-162
    • McClean, P.L.1    Gault, V.A.2    Harriott, P.3    Holscher, C.4
  • 35
    • 37849026464 scopus 로고    scopus 로고
    • Structure-activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: Importance of fatty acid length, polarity, and bulkiness
    • Madsen K, Knudsen LB, Agersoe H, Nielsen PF, Thogersen H, Wilken M, et al. Structure-activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: importance of fatty acid length, polarity, and bulkiness. J Med Chem 2007; 50(24): 6126-32.
    • (2007) J Med Chem , vol.50 , Issue.24 , pp. 6126-6132
    • Madsen, K.1    Knudsen, L.B.2    Agersoe, H.3    Nielsen, P.F.4    Thogersen, H.5    Wilken, M.6
  • 36
    • 0041592594 scopus 로고    scopus 로고
    • Glucose-dependent insulino-tropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes
    • Gault VA, Flatt PR, O'Harte FP. Glucose-dependent insulino-tropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes. Biochem Biophys Res Commun 2003; 308: 207-13.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 207-213
    • Gault, V.A.1    Flatt, P.R.2    O Harte, F.P.3
  • 37
    • 34249941340 scopus 로고    scopus 로고
    • Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice
    • Irwin N, McClean PL, O'Harte FP, Gault VA, Harriott P, Flatt PR. Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia 2007; 50: 1532-40.
    • (2007) Diabetologia , vol.50 , pp. 1532-1540
    • Irwin, N.1    McClean, P.L.2    O Harte, F.P.3    Gault, V.A.4    Harriott, P.5    Flatt, P.R.6
  • 38
    • 0036373430 scopus 로고    scopus 로고
    • Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients
    • Vilsboll T, Krarup T, Madsbad S, Holst JJ. Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients. Diabetologia 2002; 45:1111-9.
    • (2002) Diabetologia , vol.45 , pp. 1111-1119
    • Vilsboll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.J.4
  • 39
    • 23644434110 scopus 로고    scopus 로고
    • Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-diabetes
    • Gault V, Irwin N, Green B, McCluskey J, Greer B, Bailey C, et al. Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-diabetes. Diabetes 2005; 54(8): 2436-46.
    • (2005) Diabetes , vol.54 , Issue.8 , pp. 2436-2446
    • Gault, V.1    Irwin, N.2    Green, B.3    McCluskey, J.4    Greer, B.5    Bailey, C.6
  • 40
    • 34247564632 scopus 로고    scopus 로고
    • Characterisation and biological activity of Glu3 amino acid substituted GIP receptor antagonists
    • Gault VA, Hunter K, Irwin N, Green BD, Greer B, Harriott P, et al. Characterisation and biological activity of Glu3 amino acid substituted GIP receptor antagonists. Arch Biochem Biophys 2007; 461(2): 263-74.
    • (2007) Arch Biochem Biophys , vol.461 , Issue.2 , pp. 263-274
    • Gault, V.A.1    Hunter, K.2    Irwin, N.3    Green, B.D.4    Greer, B.5    Harriott, P.6
  • 41
    • 42249106405 scopus 로고    scopus 로고
    • Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by Beta-amyloid
    • Gault VA, Holscher C. Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by Beta-amyloid. J Neurophysiol 2008; 99: 1590-95.
    • (2008) J Neurophysiol , vol.99 , pp. 1590-1595
    • Gault, V.A.1    Holscher, C.2
  • 42
    • 20044362580 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation
    • Nyberg J, Anderson MF, Meister B, Alborn AM, Strom AK, Brederlau A, et al. Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation. J Neurosci 2005; 25(7): 1816-25.
    • (2005) J Neurosci , vol.25 , Issue.7 , pp. 1816-1825
    • Nyberg, J.1    Anderson, M.F.2    Meister, B.3    Alborn, A.M.4    Strom, A.K.5    Brederlau, A.6
  • 43
    • 69549128161 scopus 로고    scopus 로고
    • Receptors for the insulin-like peptide GLP-1 are expressed on neurons in the CNS
    • Hamilton A, Holscher C. Receptors for the insulin-like peptide GLP-1 are expressed on neurons in the CNS. Neuroreport 2009; 20(13): 1161-6.
    • (2009) Neuroreport , vol.20 , Issue.13 , pp. 1161-1166
    • Hamilton, A.1    Holscher, C.2
  • 44
    • 34547444040 scopus 로고    scopus 로고
    • Immunohisto-chemical distribution of glucose-dependent insulinotropic polypeptide in the adult rat brain
    • Nyberg J, Jacobsson C, Anderson MF, Eriksson PS. Immunohisto-chemical distribution of glucose-dependent insulinotropic polypeptide in the adult rat brain. J Neurosci Res 2007; 85: 2099-19.
    • (2007) J Neurosci Res , vol.85 , pp. 2099-2119
    • Nyberg, J.1    Jacobsson, C.2    Anderson, M.F.3    Eriksson, P.S.4
  • 46
    • 0028867442 scopus 로고
    • Distribution of GLP-1 binding sites in the rat brain: Evidence that exendin-4 is a ligand of brain GLP-1 binding sites
    • Goke R, Larsen PJ, Mikkelsen JD, Sheikh SP. Distribution of GLP-1 binding sites in the rat brain: Evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci 1995; 7(11): 2294-300.
    • (1995) Eur J Neurosci , vol.7 , Issue.11 , pp. 2294-2300
    • Goke, R.1    Larsen, P.J.2    Mikkelsen, J.D.3    Sheikh, S.P.4
  • 47
    • 22144491473 scopus 로고    scopus 로고
    • Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimers disease
    • Perry T, Greig NH. Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer's disease. Curr Alzheimer Res 2005; 2(3): 377-85.
    • (2005) Curr Alzheimer Res , vol.2 , Issue.3 , pp. 377-385
    • Perry, T.1    Greig, N.H.2
  • 48
    • 2542567240 scopus 로고    scopus 로고
    • Alzheimers disease:Intraneuronal alterations precede insoluble amyloid-beta formation
    • Braak H, Del Tredici K. Alzheimer's disease:Intraneuronal alterations precede insoluble amyloid-beta formation. Neurobiol Aging 2004; 25(6): 713-8; discussion 743-16.
    • (2004) Neurobiol Aging , vol.25 , pp. 713-718
    • Braak, H.1    Tredici Del, K.2
  • 49
    • 0036182251 scopus 로고    scopus 로고
    • A novel neurotrophic property of glucagon-like peptide 1: A promoter of nerve growth factor-mediated differentiation in PC12 cells
    • Perry T, Lahiri DK, Chen D, Zhou J, Shaw KT, Egan JM, et al. A novel neurotrophic property of glucagon-like peptide 1: A promoter of nerve growth factor-mediated differentiation in PC12 cells. J Pharmacol Exp Ther 2002; 300: 958-66.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 958-966
    • Perry, T.1    Lahiri, D.K.2    Chen, D.3    Zhou, J.4    Shaw, K.T.5    Egan, J.M.6
  • 50
    • 0038248960 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron
    • Perry T, Lahiri DK, Sambamurti K, Chen D, Mattson MP, Egan JM, et al. Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res 2003; 72(5): 603-12.
    • (2003) J Neurosci Res , vol.72 , Issue.5 , pp. 603-612
    • Perry, T.1    Lahiri, D.K.2    Sambamurti, K.3    Chen, D.4    Mattson, M.P.5    Egan, J.M.6
  • 51
    • 33846501672 scopus 로고    scopus 로고
    • Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy
    • Perry T, Holloway HW, Weerasuriya A, Mouton PR, Duffy K, Mattison JA, et al. Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. Exp Neurol 2007; 203(2): 293-301.
    • (2007) Exp Neurol , vol.203 , Issue.2 , pp. 293-301
    • Perry, T.1    Holloway, H.W.2    Weerasuriya, A.3    Mouton, P.R.4    Duffy, K.5    Mattison, J.A.6
  • 52
    • 0141461415 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
    • During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, et al. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 2003; 9: 1173-9.
    • (2003) Nat Med , vol.9 , pp. 1173-1179
    • During, M.J.1    Cao, L.2    Zuzga, D.S.3    Francis, J.S.4    Fitzsimons, H.L.5    Jiao, X.6
  • 53
    • 69549138878 scopus 로고    scopus 로고
    • Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimers disease
    • Abbas T, Faivre E, Hölscher C. Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease. Behav Brain Res 2009; 205(1): 265-71.
    • (2009) Behav Brain Res , vol.205 , Issue.1 , pp. 265-271
    • Abbas, T.1    Faivre, E.2    Hölscher, C.3
  • 54
    • 0345305844 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons
    • Gilman CP, Perry T, Furukawa K, Grieg NH, Egan JM, Mattson MP. Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons. J Neurochem 2003; 87(5): 1137-44.
    • (2003) J Neurochem , vol.87 , Issue.5 , pp. 1137-1144
    • Gilman, C.P.1    Perry, T.2    Furukawa, K.3    Grieg, N.H.4    Egan, J.M.5    Mattson, M.P.6
  • 55
    • 77954953382 scopus 로고    scopus 로고
    • New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimers disease?
    • New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimers disease? Neurobiol Aging 2008; DOI: 10.1016/ j.neurobiolaging.2008.08.023
    • Holscher C, Li L. New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer's disease? Neurobiol Aging 2008; DOI: 10.1016/ j.neurobiolaging.2008.08.023.
    • (2008) Neurobiol Aging 2008; DOI: 10.1016/ J.neurobiolaging
    • Holscher, C.1    Li, L.2
  • 56
    • 33847793387 scopus 로고    scopus 로고
    • Is Glucagon-like peptide-1, an agent treating diabetes, a new hope for Alzheimers disease?
    • Li L. Is Glucagon-like peptide-1, an agent treating diabetes, a new hope for Alzheimer's disease? Neurosci Bull 2007; 23(1): 58-65.
    • (2007) Neurosci Bull , vol.23 , Issue.1 , pp. 58-65
    • Li, L.1
  • 57
    • 33747188115 scopus 로고    scopus 로고
    • Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide
    • Irwin N, Clarke GC, Green BD, Greer B, Harriott P, Gault VA, et al. Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide. Biochem Pharmacol 2006; 72(6): 719-28.
    • (2006) Biochem Pharmacol , vol.72 , Issue.6 , pp. 719-728
    • Irwin, N.1    Clarke, G.C.2    Green, B.D.3    Greer, B.4    Harriott, P.5    Gault, V.A.6
  • 58
    • 77953878817 scopus 로고    scopus 로고
    • Novel incretin analogues promote stem cell proliferation in the brains of diabetic mice. In 39th Society for Neurosci Annual Meeting
    • Hamilton A, Patterson S, Gault V, Holscher C. Novel incretin analogues promote stem cell proliferation in the brains of diabetic mice. In 39th Society for Neurosci Annual Meeting, Chicago, USA, (2009), pp. 529.9.
    • (2009) Chicago, USA , vol.9 , pp. 529
    • Hamilton, A.1    Patterson, S.2    Gault, V.3    Holscher, C.4
  • 59
    • 33645882245 scopus 로고    scopus 로고
    • Neurodegeneration and neurogenesis: Focus on Alzheimers disease
    • Greenberg DA, Jin K. Neurodegeneration and neurogenesis: Focus on Alzheimer's disease. Curr Alzheimer Res 2006; 3(1): 25-8.
    • (2006) Curr Alzheimer Res , vol.3 , Issue.1 , pp. 25-28
    • Greenberg, D.A.1    Jin, K.2
  • 60
    • 33746543038 scopus 로고    scopus 로고
    • Nerve growth factor, neural stem cells and Alzheimers disease
    • Heese K, Low JW, Inoue N. Nerve growth factor, neural stem cells and Alzheimer's disease. Neurosignals 2006; 15(1): 1-12.
    • (2006) Neurosignals , vol.15 , Issue.1 , pp. 1-12
    • Heese, K.1    Low, J.W.2    Inoue, N.3
  • 61
    • 0026793903 scopus 로고
    • Selective release of glutamine and glutamic acid produced by perfusion of GLP-1 (7-36) amide in the basal ganglia of the conscious rat
    • Mora F, Exposito I, Sanz B, Blazquez E. Selective release of glutamine and glutamic acid produced by perfusion of GLP-1 (7-36) amide in the basal ganglia of the conscious rat. Brain Res Bull 1992; 29(3-4): 359-61.
    • (1992) Brain Res Bull , vol.29 , Issue.3-4 , pp. 359-361
    • Mora, F.1    Exposito, I.2    Sanz, B.3    Blazquez, E.4
  • 62
    • 0033519562 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 modu-lates neuronal activity in the rats hippocampus
    • Oka JI, Goto N, Kameyama T. Glucagon-like peptide-1 modu-lates neuronal activity in the rat's hippocampus. Neuroreport 1999; 10(8): 1643-6.
    • (1999) Neuroreport , vol.10 , Issue.8 , pp. 1643-1646
    • Oka, J.I.1    Goto, N.2    Kameyama, T.3
  • 63
    • 0035128734 scopus 로고    scopus 로고
    • Blockade of long-term potentiation by beta-Amyloid peptides in the CA1 region of the rat hippocampus in vivo
    • Freir DB, Holscher C, Herron CE. Blockade of long-term potentiation by beta-Amyloid peptides in the CA1 region of the rat hippocampus in vivo. J Neurophysiol 2001; 85(2): 708-13.
    • (2001) J Neurophysiol , vol.85 , Issue.2 , pp. 708-713
    • Freir, D.B.1    Holscher, C.2    Herron, C.E.3
  • 64
    • 33947262557 scopus 로고    scopus 로고
    • Soluble beta-amyloid [25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning
    • Hölscher C, Gengler S, Gault V, Harriott P, Mallot H. Soluble beta-amyloid [25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning. Eur J Pharmacol 2007; 561(1-3): 85-90.
    • (2007) Eur J Pharmacol , vol.561 , Issue.1-3 , pp. 85-90
    • Hölscher, C.1    Gengler, S.2    Gault, V.3    Harriott, P.4    Mallot, H.5
  • 65
    • 0026570528 scopus 로고
    • Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson M, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel R. Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992; 12: 376-89.
    • (1992) J Neurosci , vol.12 , pp. 376-389
    • Mattson, M.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.6
  • 66
    • 0037470822 scopus 로고    scopus 로고
    • Inhibition of L-type voltage dependent calcium channels causes impairment of long-term potentiation in the hippocampal CA1 region in vivo
    • Freir DB, Herron CE. Inhibition of L-type voltage dependent calcium channels causes impairment of long-term potentiation in the hippocampal CA1 region in vivo. Brain Res 2003; 967(1-2): 27-36.
    • (2003) Brain Res , vol.967 , Issue.1-2 , pp. 27-36
    • Freir, D.B.1    Herron, C.E.2
  • 67
    • 0030942145 scopus 로고    scopus 로고
    • Beta-amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus
    • Cullen WK, Wu JQ, Anwyl R, Rowan MJ. Beta-amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus. Neuroreport 1996; 8: 87-92.
    • (1996) Neuroreport , vol.8 , pp. 87-92
    • Cullen, W.K.1    Wu, J.Q.2    Anwyl, R.3    Rowan, M.J.4
  • 68
    • 18744438248 scopus 로고    scopus 로고
    • Alzheimers beta-amyloid peptides compete for insulin binding to the insulin receptor
    • Xie L, Helmerhorst E, Taddei K, Plewright B, Van BW, Martins R. Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor. J Neurosci 2002; 22(10): RC221.
    • (2002) J Neurosci , vol.22 , Issue.10
    • Xie, L.1    Helmerhorst, E.2    Taddei, K.3    Plewright, B.4    Van, B.W.5    Martins, R.6
  • 70
  • 71
    • 34249024370 scopus 로고    scopus 로고
    • Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25-35) are dependent on stimulation-protocol and genetic background
    • Gengler S, Gault V, Harriott P, Hölscher C. Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25-35) are dependent on stimulation-protocol and genetic background. Exp Brain Res 2007; 179(4): 621-30.
    • (2007) Exp Brain Res , vol.179 , Issue.4 , pp. 621-630
    • Gengler, S.1    Gault, V.2    Harriott, P.3    Hölscher, C.4
  • 72
    • 44149122563 scopus 로고    scopus 로고
    • GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
    • Gault V, Holscher C. GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid. Eur J Pharmacol 2008; 587(1-3): 112-7.
    • (2008) Eur J Pharmacol , vol.587 , Issue.1-3 , pp. 112-117
    • Gault, V.1    Holscher, C.2
  • 73
    • 0042838303 scopus 로고    scopus 로고
    • Alzheimers disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    • Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, et al. Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci USA 2003; 100(18): 10417-22.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.18 , pp. 10417-10422
    • Gong, Y.1    Chang, L.2    Viola, K.L.3    Lacor, P.N.4    Lambert, M.P.5    Finch, C.E.6
  • 74
    • 0034730477 scopus 로고    scopus 로고
    • Endogenous GLP-1 is involved in beta-amyloid protein-induced memory impairment and hippocampal neuronal death in rats
    • Oka J, Suzuki E, Kondo Y. Endogenous GLP-1 is involved in beta-amyloid protein-induced memory impairment and hippocampal neuronal death in rats. Brain Res 2000; 878(1-2): 194-8.
    • (2000) Brain Res , vol.878 , Issue.1-2 , pp. 194-198
    • Oka, J.1    Suzuki, E.2    Kondo, Y.3
  • 75
    • 33748988258 scopus 로고    scopus 로고
    • Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
    • Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, et al. Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep 2006; 7(9): 940-6.
    • (2006) EMBO Rep , vol.7 , Issue.9 , pp. 940-946
    • Radde, R.1    Bolmont, T.2    Kaeser, S.A.3    Coomaraswamy, J.4    Lindau, D.5    Stoltze, L.6
  • 76
    • 77957173186 scopus 로고    scopus 로고
    • Val(8)GLP-1 rescues synaptic plasticity and reduces dense core amyloid plaque load in an APP/PS1 mouse model of Alzheimers disease
    • Gengler S, McClean P, McCurtin R, Gault V, Holscher C. Val(8)GLP-1 rescues synaptic plasticity and reduces dense core amyloid plaque load in an APP/PS1 mouse model of Alzheimer's disease. Neurobiol Aging 2010 (in press).
    • (2010) Neurobiol Aging
    • Gengler, S.1    McClean, P.2    McCurtin, R.3    Gault, V.4    Holscher, C.5
  • 77
    • 77953904957 scopus 로고    scopus 로고
    • Liraglutide, a novel GLP-1 analogue, prevents the impairment of learning and LTP in an APP/PS-1 mouse model of Alzheimers disease
    • Hawaii, USA
    • McClean P, Pathasarthy V, Gault V, Holscher C. Liraglutide, a novel GLP-1 analogue, prevents the impairment of learning and LTP in an APP/PS-1 mouse model of Alzheimer's disease. In ICAD Annual Conference, abstr. 103 Hawaii, USA, (2010).
    • (2010) In ICAD Annual Conference, Abstr , pp. 103
    • McClean, P.1    Pathasarthy, V.2    Gault, V.3    Holscher, C.4
  • 78
    • 6944255523 scopus 로고    scopus 로고
    • Delivery of therapeutic agents to the central nervous system: The problems and the possibilities
    • Begley DJ. Delivery of therapeutic agents to the central nervous system: The problems and the possibilities. Pharmacol Ther 2004; 104(1): 29-45.
    • (2004) Pharmacol Ther , vol.104 , Issue.1 , pp. 29-45
    • Begley, D.J.1
  • 79
    • 0036198285 scopus 로고    scopus 로고
    • Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
    • Kastin AJ, Akerstrom V, Pan W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J Mol Neurosci 2002; 18(1-2): 7-14.
    • (2002) J Mol Neurosci , vol.18 , Issue.1-2 , pp. 7-14
    • Kastin, A.J.1    Akerstrom, V.2    Pan, W.3
  • 80
    • 0037349072 scopus 로고    scopus 로고
    • Entry of exendin-4 into brain is rapid but may be limited at high doses
    • Kastin AJ, Akerstrom V. Entry of exendin-4 into brain is rapid but may be limited at high doses. Int J Obes Relat Metab Disord 2003; 27(3): 313-8.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , Issue.3 , pp. 313-318
    • Kastin, A.J.1    Akerstrom, V.2
  • 82
    • 1842734659 scopus 로고    scopus 로고
    • The source of cerebral insulin
    • Banks WA. The source of cerebral insulin. Eur J Pharmacol 2004; 490(1-3): 5-12.
    • (2004) Eur J Pharmacol , vol.490 , Issue.1-3 , pp. 5-12
    • Banks, W.A.1
  • 83
    • 70349847831 scopus 로고    scopus 로고
    • Central nervous insulin resistance: A promising target in the treatment of metabolic and cognitive disorders?
    • Hallschmid M, Schultes B. Central nervous insulin resistance: A promising target in the treatment of metabolic and cognitive disorders? Diabetologia 2009; 52(11): 2264-9.
    • (2009) Diabetologia , vol.52 , Issue.11 , pp. 2264-2269
    • Hallschmid, M.1    Schultes, B.2
  • 85
    • 62049083420 scopus 로고    scopus 로고
    • Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimers disease
    • Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med 2009; 15: 331-7.
    • (2009) Nat Med , vol.15 , pp. 331-337
    • Nagahara, A.H.1    Merrill, D.A.2    Coppola, G.3    Tsukada, S.4    Schroeder, B.E.5    Shaked, G.M.6
  • 87
    • 35448995279 scopus 로고    scopus 로고
    • Neurotrophic factors-a tool for therapeutic strategies in neurological, neuropsychiatric and neuroimmuno-logical diseases?
    • Schulte-Herbruggen O, Braun A, Rochlitzer S, Jockers-Scherubl MC, Hellweg R. Neurotrophic factors--a tool for therapeutic strategies in neurological, neuropsychiatric and neuroimmuno-logical diseases? Curr Med Chem 2007; 14(22): 2318-29.
    • (2007) Curr Med Chem , vol.14 , Issue.22 , pp. 2318-2329
    • Schulte-Herbruggen, O.1    Braun, A.2    Rochlitzer, S.3    Jockers-Scherubl, M.C.4    Hellweg, R.5
  • 88
    • 68849083063 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in neurodegenerative diseases
    • Zuccato C, Cattaneo E. Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 2009; 5: 311-22.
    • (2009) Nat Rev Neurol , vol.5 , pp. 311-322
    • Zuccato, C.1    Cattaneo, E.2
  • 89
    • 0028292343 scopus 로고
    • Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimers disease from hippocampal explants
    • Clarris HJ, Nurcombe V, Small DH, Beyreuther K, Masters CL. Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants. J Neurosci Res 1994; 38(3): 248-58.
    • (1994) J Neurosci Res , vol.38 , Issue.3 , pp. 248-258
    • Clarris, H.J.1    Nurcombe, V.2    Small, D.H.3    Beyreuther, K.4    Masters, C.L.5
  • 90
    • 0030848990 scopus 로고    scopus 로고
    • Cellular delivery of NGF does not alter the expression of beta-amyloid immunoreactivity in young or aged nonhuman primates
    • Kordower JH, Mufson EJ, Fox N, Martel L, Emerich DF. Cellular delivery of NGF does not alter the expression of beta-amyloid immunoreactivity in young or aged nonhuman primates. Exp Neurol 1997; 145(2): 586-91.
    • (1997) Exp Neurol , vol.145 , Issue.2 , pp. 586-591
    • Kordower, J.H.1    Mufson, E.J.2    Fox, N.3    Martel, L.4    Emerich, D.F.5
  • 92
    • 20444453676 scopus 로고    scopus 로고
    • Hope for AD with NGF gene-therapy trial
    • Bradbury J. Hope for AD with NGF gene-therapy trial. Lancet Neurol 2005; 4(6): 335.
    • (2005) Lancet Neurol , vol.4 , Issue.6 , pp. 335
    • Bradbury, J.1
  • 93
    • 27244455282 scopus 로고    scopus 로고
    • Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis
    • Nagano I, Shiote M, Murakami T, Kamada H, Hamakawa Y, Matsubara E, et al. Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis. Neruol Res 2005; 27(7): 768-72.
    • (2005) Neruol Res , vol.27 , Issue.7 , pp. 768-772
    • Nagano, I.1    Shiote, M.2    Murakami, T.3    Kamada, H.4    Hamakawa, Y.5    Matsubara, E.6
  • 94
    • 14244251413 scopus 로고    scopus 로고
    • Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus
    • Shi L, Linville MC, Tucker EW, Sonntag WE, Brunso-Bechtold JK. Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus. Cereb Cortex 2005; 15: 571-7.
    • (2005) Cereb Cortex , vol.15 , pp. 571-577
    • Shi, L.1    Linville, M.C.2    Tucker, E.W.3    Sonntag, W.E.4    Brunso-Bechtold, J.K.5
  • 95
  • 96
    • 34447274187 scopus 로고    scopus 로고
    • Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model
    • Lee HJ, Kim KS, Park IH, Kim SU. Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model. PLoS One 2007; 2: e156.
    • (2007) PLoS One , vol.2 , pp. 156
    • Lee, H.J.1    Kim, K.S.2    Park, I.H.3    Kim, S.U.4
  • 97
    • 70350167840 scopus 로고    scopus 로고
    • Intrathecal transplantation of human neural stem cells over- expressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice
    • Hwang DH, Lee HJ, Park IH, Seok JI, Kim BG, Joo IS, et al. Intrathecal transplantation of human neural stem cells over- expressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice. Gene Ther 2009; 16(10): 1234-44.
    • (2009) Gene Ther , vol.16 , Issue.10 , pp. 1234-1244
    • Hwang, D.H.1    Lee, H.J.2    Park, I.H.3    Seok, J.I.4    Kim, B.G.5    Joo, I.S.6
  • 100
    • 59049096074 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated gene delivery approaches for the treatment of CNS disorders
    • Terzi D, Zachariou V. Adeno-associated virus-mediated gene delivery approaches for the treatment of CNS disorders. Biotechnol J 2008; 3(12): 1555-63.
    • (2008) Biotechnol J , vol.3 , Issue.12 , pp. 1555-1563
    • Terzi, D.1    Zachariou, V.2
  • 101
    • 65949122960 scopus 로고    scopus 로고
    • Gregory-Evans CY. Ex vivo gene therapy using intravitreal injection of GDNF-secreting mouse embryonic stem cells in a rat model of retinal degeneration
    • Gregory-Evans K, Chang F, Hodges MD, Gregory-Evans CY. Ex vivo gene therapy using intravitreal injection of GDNF-secreting mouse embryonic stem cells in a rat model of retinal degeneration. Mol Vis 2009; 15: 962-73.
    • (2009) Mol Vis , vol.15 , pp. 962-973
    • Gregory-Evans, K.1    Chang, F.2    Hodges, M.D.3
  • 103
    • 77953903669 scopus 로고    scopus 로고
    • Use of GLP-1 analogues for the treatment of disorders associated with dysfunctional synaptic transmission
    • Flatt, P.R., Holscher, C., Gault, V.A. Use of GLP-1 analogues for the treatment of disorders associated with dysfunctional synaptic transmission. WO2009030499A1 (2009).
    • (2009) WO2009030499A1
    • Flatt, P.R.1    Holscher, C.2    Gault, V.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.