Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 44, 2014, Pages 15717-15722

  Kong, Xu Dong ^a,b   Yuan, Shuguang ^b   Li, Lin ^c   Chen, She ^c   Xu, Jian He ^a   Zhou, Jiahai ^b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^c NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ALPHA NAPHTHYL GLYCIDYL ETHER; EPOXIDE HYDROLASE; ETHER DERIVATIVE; INDUSTRIAL ENZYME; PROPRANOLOL; UNCLASSIFIED DRUG; ALPRENOLOL; BACTERIAL PROTEIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; EPOXIDE; GLYCIDYL 1-NAPHTHYL ETHER; NAPHTHOL DERIVATIVE;

ARTICLE; BACILLUS MEGATERIUM; CALCULATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ENGINEERING; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MUTANT; NONHUMAN; PRECURSOR; WILD TYPE; X RAY CRYSTALLOGRAPHY; AMINO ACID SUBSTITUTION; CHEMISTRY; ENZYMOLOGY; GENETICS; MISSENSE MUTATION; SYNTHESIS;

BACILLUS MEGATERIUM;

ADRENERGIC BETA-ANTAGONISTS; ALPRENOLOL; AMINO ACID SUBSTITUTION; BACILLUS MEGATERIUM; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; EPOXIDE HYDROLASES; EPOXY COMPOUNDS; MUTATION, MISSENSE; NAPHTHOLS; PROPRANOLOL;

EID: 84914695544     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1404915111     Document Type: Article

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