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Angewandte Chemie - International Edition

Volumn 53, Issue 26, 2014, Pages 6641-6644

A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-β-blocker precursors

(5) Kong, Xu Dong a Ma, Qian b Zhou, Jiahai c Zeng, Bu Bing b Xu, Jian He a

a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)

b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)

c SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (China)

Author keywords

enantioselectivity; enzyme catalysis; kinetic resolution; protein engineering; structure activity relationships

Indexed keywords

BIOCHEMICAL ENGINEERING; CELL IMMOBILIZATION; ENANTIOSELECTIVITY; ENZYMES; GENETIC ENGINEERING;

ACTIVE SITE; ENZYME CATALYSIS; EPOXIDE HYDROLASES; HOT SPOT; IMPROVED ACTIVITIES; KINETIC RESOLUTION; PROTEIN ENGINEERING; STRUCTURE ACTIVITY RELATIONSHIPS;

SUBSTRATES;

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; EPOXIDE HYDROLASE;

BACILLUS MEGATERIUM; BIOCATALYSIS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; PROTEIN ENGINEERING; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADRENERGIC BETA-ANTAGONISTS; BACILLUS MEGATERIUM; BIOCATALYSIS; CATALYTIC DOMAIN; EPOXIDE HYDROLASES; PROTEIN ENGINEERING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84903268880 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201402653 Document Type: Article

Times cited : (50)

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