The Molecular Structure of Epoxide Hydrolase B from Mycobacterium tuberculosis and Its Complex with a Urea-Based Inhibitor

Journal of Molecular Biology

Volumn 381, Issue 4, 2008, Pages 897-912

  Biswal, Bichitra K ^a   Morisseau, Christophe ^b   Garen, Grace ^a   Cherney, Maia M ^a   Garen, Craig ^a   Niu, Chunying ^a   Hammock, Bruce D ^b   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

enzyme mechanism; epoxide hydrolase; hydrolase fold; inhibitor design; Mycobacterium tuberculosis

Indexed keywords

ASPARTIC ACID DERIVATIVE; CARBONYL DERIVATIVE; CARBOXYLIC ACID; EPOXIDE; EPOXIDE HYDROLASE; HISTIDINE DERIVATIVE; HOMODIMER; HYDROLASE; ISOLEUCINE; MONOMER; NITROGEN; OXYGEN; PHENOL DERIVATIVE; TYROSINE; UREA;

ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; HYDROGEN BOND; HYDROLYSIS; IC 50; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ALIGNMENT;

MYCOBACTERIUM TUBERCULOSIS;

EID: 48449095141     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.06.030     Document Type: Article

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