The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo

Cell Death and Differentiation

Volumn 19, Issue 7, 2012, Pages 1117-1126

  Hyde, B B ^a   Liesa, M ^a   Elorza, A A ^a   Qiu, W ^a   Haigh, S E ^a   Richey, L ^b   Mikkola, H K ^c   Schlaeger, T M ^d   Shirihai, O S ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

ABCB10; erythropoiesis; hemoglobin; mitochondria; oxidative stress

Indexed keywords

ABC TRANSPORTER; ABCB10 PROTEIN; CD71 ANTIGEN; MANGANESE SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; EMBRYO; ERYTHROID CELL; ERYTHROPOIESIS; EX VIVO STUDY; GENE DELETION; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION;

ANIMALS; APOPTOSIS; ATP-BINDING CASSETTE TRANSPORTERS; ERYTHROPOIESIS; GATA TRANSCRIPTION FACTORS; HEMOGLOBINS; METALLOPORPHYRINS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OXIDATIVE STRESS; PROTEIN CARBONYLATION; SUPEROXIDES;

MUS;

EID: 84862123582     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2011.195     Document Type: Article

References (24)

1. Krishnamurthy P, Xie T, Schuetz JD. The role of transporters in cellular heme and porphyrin homeostasis. Pharmacol Ther 2007; 114: 345-358.
2. May BK, Dogra SC, Sadlon TJ, Bhasker CR, Cox TC, Bottomley SS. Molecular regulation of heme biosynthesis in higher vertebrates. Prog Nucleic Acid Res Mol Biol 1995; 51: 1-51.
3. Ponka P. Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells. Blood 1997; 89: 1-25.
4. Bottomley SS. Congenital sideroblastic anemias. Curr Hematol Rep 2006; 5: 41-49.
5. Nilsson R, Schultz IJ, Pierce EL, Soltis KA, Naranuntarat A, Ward DM et al. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab 2009; 10: 119-130.
6. Shirihai OS, Gregory T, Yu C, Orkin SH, Weiss MJ. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J 2000; 19: 2492-2502.
7. Graf SA, Haigh SE, Corson ED, Shirihai OS. Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). J Biol Chem 2004; 279: 42954-42963.
8. Fraser ST, Isern J, Baron MH. Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression. Blood 2007; 109: 343-352.
9. Kina T, Ikuta K, Takayama E, Wada K, Majumdar AS, Weissman IL et al. The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br J Haematol 2000; 109: 280-287.
10. Chen W, Paradkar PN, Li L, Pierce EL, Langer NB, Takahashi-Makise N et al. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci USA 2009; 106: 16263-16268.
11. Lill R, Kispal G. Mitochondrial ABC transporters. Res Microbiol 2001; 152: 331-340.
12. Chloupkova M, LeBard LS, Koeller DM. MDL1 is a high copy suppressor of ATM1: evidence for a role in resistance to oxidative stress. J Mol Biol 2003; 331: 155-165.
13. Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA et al. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation 2011; 124: 806-813.
14. Young L, Leonhard K, Tatsuta T, Trowsdale J, Langer T. Role of the ABC transporter Mdl1 in peptide export from mitochondria. Science 2001; 291: 2135-2138.
15. Zhang J, Socolovsky M, Gross AW, Lodish HF. Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood 2003; 102: 3938-3946.
16. Martin FM, Bydlon G, Friedman JS. SOD2-deficiency sideroblastic anemia and red blood cell oxidative stress. Antioxid Redox Signal 2006; 8: 1217-1225.
17. Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS. UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem 2008; 283: 30461-30470.
18. Pevny L, Lin CS, D'Agati V, Simon MC, Orkin SH, Costantini F. Development of hematopoietic cells lacking transcription factor GATA-1. Development 1995; 121: 163-172.
19. Weiss MJ, Orkin SH. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci USA 1995; 92: 9623-9627.
20. Gregory T, Yu C, Ma A, Orkin SH, Blobel GA, Weiss MJ. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. Blood 1999; 94: 87-96.
21. Motoyama N, Wang F, Roth KA, Sawa H, Nakayama K, Nakayama K et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 1995; 267: 1506-1510.
22. Rooke HM, Orkin SH. Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo. Blood 2006; 107: 3527-3530.
23. Chen W, Dailey HA, Paw BH. Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. Blood 2010; 116: 628-630.
24. Liesa M, Borda-d'Agua B, Medina-Gomez G, Lelliott CJ, Paz JC, Rojo M et al. Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS One 2008; 3: e3613.