Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Wu, Chun Hu ^a   Hung, Tai Ho ^b   Chen, Chien Cheng ^c   Ke, Chia Hua ^a,c   Lee, Chun Yen ^c   Wang, Pei Yi ^c   Chen, Szu Fu ^a,c  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c CHENG HSIN GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 7,8 DIHYDROXYFLAVONE; ALANINE AMINOTRANSFERASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CREATININE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITROGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SERINE; THREONINE; TROPOMYOSIN RELATED KINASE B; UNCLASSIFIED DRUG; UREA; WATER; 6,7-DIHYDROXYFLAVONE; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; FLAVONE DERIVATIVE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BEAM WALKING TEST; BRAIN CELL; BRAIN DAMAGE; BRAIN DISEASE; BRAIN EDEMA; BRAIN TISSUE; BRAIN TISSUE LOSS; BRAIN WATER CONTENT; CELL SURVIVAL; CELL VIABILITY; COGNITION; CONTROLLED CORTICAL IMPACT INJURY; CONTROLLED STUDY; DNA CLEAVAGE; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXPERIMENTAL TRAUMATIC BRAIN INJURY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; METABOLISM; MOUSE; NEUROPROTECTION; NONHUMAN; POSTOPERATIVE CARE; PROTEIN EXPRESSION; ROTAROD TEST; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY; TREATMENT DURATION; UREA NITROGEN BLOOD LEVEL; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN INJURIES; CELL DEATH; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; INTRAPERITONEAL DRUG ADMINISTRATION; NERVE CELL; PATHOLOGY;

ANIMALS; APOPTOSIS; BRAIN EDEMA; BRAIN INJURIES; CELL DEATH; DISEASE MODELS, ANIMAL; FLAVONES; GENE EXPRESSION REGULATION; INJECTIONS, INTRAPERITONEAL; MAP KINASE SIGNALING SYSTEM; MICE; NEURONS; NEUROPROTECTIVE AGENTS; RECEPTOR, TRKB;

EID: 84913586296     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113397     Document Type: Article

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