Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 2, 2012, Pages 330-340

  Park, Juyeon ^a   Zhang, Jimmy ^a   Qiu, Jianhua ^a   Zhu, Xiaoxia ^a,b   Degterev, Alexei ^c   Lo, Eng H ^a   Whalen, Michael J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b FUDAN UNIVERSITY   (China)

^c TUFTS UNIVERSITY   (United States)

Author keywords

Akt; cognition; mammalian target of rapamycin; mice; protein kinase B; traumatic brain injury

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN PHOSPHO AKT 473; PROTEIN S6; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; COGNITIVE DEFECT; DRUG EFFECT; ENZYME INHIBITION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; MALE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN; BRAIN INJURIES; DRUG SYNERGISM; ENZYME INHIBITORS; MALE; MEMORY; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84856472838     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.131     Document Type: Article

References (40)

1. Bermpohl D, You Z, Korsmeyer SJ, Moskowitz MA, Whalen MJ (2006) Traumatic brain injury in mice deficient in Bid: effects on histopathology and functional outcome. J Cereb Blood Flow Metab 26:625-33
2. Carloni S, Girelli S, Scopa C, Buonocore G, Longini M, Balduini W (2010) Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxiaischemia. Autophagy 6:366-77
3. Chandarlapaty S, Sawai A, Scaltriti M, Rodrik-Outmezguine V, Grbovic-Huezo O, Serra V, Majumder PK, Baselga J, Rosen N (2011) AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell 19:58-71
4. Chen S, Atkins CM, Liu CL, Alonso OF, Dietrich WD, Hu BR (2007) Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. J Cereb Blood Flow Metab 27:939-49 (Pubitemid 46659022)
5. D'Ercole AJ, Ye P, Calikoglu AS, Gutierrez-Ospina G (1996) The role of the insulin-like growth factors in the central nervous system. Mol Neurobiol 13:227-55 (Pubitemid 126715878)
6. Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC (2005) Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell 19:159-70 (Pubitemid 41019664)
7. Endo H, Nito C, Kamada H, Nishi T, Chan PH (2006) Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats. J Cereb Blood Flow Metab 26:1479-89 (Pubitemid 44809077)
8. Erlich S, Alexandrovich A, Shohami E, Pinkas-Kramarski R (2007) Rapamycin is a neuroprotective treatment for traumatic brain injury. Neurobiol Dis 26:86-93 (Pubitemid 46436489)
9. Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA (2006) A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 9:341-9 (Pubitemid 43668732)
10. Frame S, Cohen P (2001) GSK3 takes centre stage more than 20 years after its discovery. Biochem J 359:1-16 (Pubitemid 32939202)
11. Franke TF, Cantley LC (1997) Apoptosis. A Bad kinase makes good. Nature 390:116-7 (Pubitemid 27507959)
12. Guan KL, Figueroa C, Brtva TR, Zhu T, Taylor J, Barber TD, Vojtek AB (2000) Negative regulation of the serine/threonine kinase B-Raf by Akt. J Biol Chem 275:27354-9
13. Hailer NP (2008) Immunosuppression after traumatic or ischemic CNS damage: it is neuroprotective and illuminates the role of microglial cells. Prog Neurobiol 84:211-33
14. Hollander MC, Blumenthal GM, Dennis PA (2011) PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer 11:289-301
15. Hooper C, Killick R, Lovestone S (2008) The GSK3 hypothesis of Alzheimer's disease. J Neurochem 104:1433-9 (Pubitemid 351316776)
16. Hu LY, Sun ZG, Wen YM, Cheng GZ, Wang SL, Zhao HB, Zhang XR (2010) ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes improvement of locomotor function after spinal cord injury in rats. Neuroscience 169:1046-62
17. Jenkins LW, Peters GW, Dixon CE, Zhang X, Clark RS, Skinner JC, Marion DW, Adelson PD, Kochanek PM (2002) Conventional and functional proteomics using large format two-dimensional gel electrophoresis 24 hours after controlled cortical impact in postnatal day 17 rats. J Neurotrauma 19:715-40 (Pubitemid 34761335)
18. Jo J, Whitcomb DJ, Olsen KM, Kerrigan TL, Lo SC, Bru-Mercier G, Dickinson B, Scullion S, Sheng M, Collingridge G, Cho K (2011) Abeta(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta. Nat Neurosci 14:545-7
19. Khuman J, Meehan III WP, Zhu X, Qiu J, Hoffmann U, Zhang J, Giovannone E, Lo EH, Whalen MJ (2010) Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice. J Cereb Blood Flow Metab 31:778-89
20. Komandirov MA, Knyazeva EA, Fedorenko YP, Rudkovskii MV, Stetsurin DA, Uzdensky AB (2011) On the role of phosphatidylinositol 3-kinase, protein kinase b/akt, and glycogen synthase kinase-3beta in photodynamic injury of crayfish neurons and glial cells. J Mol Neurosci (in press)
21. Lewen A, Sugawara T, Gasche Y, Fujimura M, Chan PH (2001) Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury. Neurobiol Dis 8:380-90 (Pubitemid 32566130)
22. Li J, Lang J, Zheng Z, McCullough LD (2008) Akt 1 gene deletion and stroke. J Neurol Sci 269:105-12
23. Maddika S, Ande SR,Wiechec E, Hansen LL,Wesselborg S, Los M (2008) Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis. J Cell Sci 121:979-88 (Pubitemid 351639417)
24. Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M (2002) Regulation of Raf-Akt cross-talk. J Biol Chem 277:31099-106 (Pubitemid 34970815)
25. Namikawa K, Honma M, Abe K, Takeda M, Mansur K, Obata T, Miwa A, Okado H, Kiyama H (2000) Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration. J Neurosci 20:2875-86 (Pubitemid 30220313)
26. Neary JT (2005) Protein kinase signaling cascades in CNS trauma. IUBMB Life 57:711-8 (Pubitemid 41770186)
27. Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Unterman T, Hay N (2008) Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 14:458-70
28. Noshita N, Lewen A, Sugawara T, Chan PH (2001) Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 21:1442-50 (Pubitemid 33120944)
29. Noshita N, Lewen A, Sugawara T, Chan PH (2002) Akt phosphorylation and neuronal survival after traumatic brain injury in mice. Neurobiol Dis 9:294-304 (Pubitemid 34442078)
30. Pignataro G, Esposito E, Cuomo O, Sirabella R, Boscia F, Guida N, Di Renzo G, Annunziato L (2010) The NCX3 isoform of the Na +Ca2+ exchanger contributes to neuroprotection elicited by ischemic postconditioning. J Cereb Blood Flow Metab 31:362-70
31. Qi S, Mizuno M, Yonezawa K, Nawa H, Takei N (2010) Activation of mammalian target of rapamycin signaling in spatial learning. Neurosci Res 68:88-93
32. Ropelle ER, Fernandes MF, Flores MB, Ueno M, Rocco S, Marin R, Cintra DE, Velloso LA, Franchini KG, Saad MJ, Carvalheira JB (2008) Central exercise action increases the AMPK and mTOR response to leptin. PLoS One 3:e3856
33. Rubovitch V, Edut S, Sarfstein R, Werner H, Pick CG (2010) The intricate involvement of the insulin-like growth factor receptor signaling in mild traumatic brain injury in mice. Neurobiol Dis 38:299-303
34. Song YS, Narasimhan P, Kim GS, Jung JE, Park EH, Chan PH (2008) The role of Akt signaling in oxidative stress mediates NF-kappaB activation in mild transient focal cerebral ischemia. J Cereb Blood Flow Metab 28:1917-26
35. Whalen MJ, Dalkara T, You Z, Qiu J, Bermpohl D, Mehta N, Suter B, Bhide PG, Lo EH, Ericsson M, Moskowitz MA (2008) Acute plasmalemma permeability and protracted clearance of injured cells after controlled cortical impact in mice. J Cereb Blood Flow Metab 28:490-505 (Pubitemid 351304258)
36. Wu YT, Tan HL, Huang Q, Ong CN, Shen HM (2009) Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy. Autophagy 5:824-34
37. Wymann MP, Bjorklof K, Calvez R, Finan P, Thomast M, Trifilieff A, Barbier M, Altruda F, Hirsch E, Laffargue M (2003) Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy. Biochem Soc Trans 31:275-80 (Pubitemid 36241444)
38. You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz MA, Whalen MJ (2008) Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab 28:1564-73
39. Zhao H, Shimohata T, Wang JQ, Sun G, Schaal DW, Sapolsky RM, Steinberg GK (2005) Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats. J Neurosci 25:9794-806 (Pubitemid 41510919)
40. Zhu ZF, Wang QG, Han BJ, William CP (2010) Neuroprotective effect and cognitive outcome of chronic lithium on traumatic brain injury in mice. Brain Res Bull 83:272-7