7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-κB and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells

International Journal of Molecular Medicine

Volumn 29, Issue 6, 2012, Pages 1146-1152

  Park, Hye Young ^a,b   Kim, Gi Young ^c   Hyun, Jin Won ^d   Hwang, Hye Jin ^e,g   Kim, Nam Deuk ^b   Kim, Byung Woo ^f,g,h   Choi, Yung Hyun ^a,g,h  

^a Dong Eui University   (South Korea)

^b Pusan National University   (South Korea)

^c Laboratory of Immunobiology   (South Korea)

^d Jeju National University   (South Korea)

^e Department of Food and Nutrition   (South Korea)

^f Department of Life Science and Biotechnology   (South Korea)

^g Graduate School   (South Korea)

^h Dong Eui University   (South Korea)

Author keywords

7,8 dihydroxyflavone; Anti inflammation; MAPKs; NF B

Indexed keywords

7,8 DIHYDROXYFLAVONE; COMPLEMENTARY DNA; CYCLOOXYGENASE 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E2; RNA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; DINOPROSTONE; DOWN-REGULATION; ENZYME ACTIVATION; FLAVONES; GENE EXPRESSION REGULATION; I-KAPPA B PROTEINS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEOLYSIS;

EID: 84860498875     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.935     Document Type: Article

References (41)

1. Abramson SB, Attur M, Amin AR and Clancy R: Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis. Curr Rheumatol Rep 3: 535-541, 2001.
2. Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, Carter C, Yu BP and Leeuwenburgh C: Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 8: 18-30, 2009.
3. Murakami A and Ohigashi H: Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals. Int J Cancer 121: 2357-2363, 2007. (Pubitemid 350022403)
4. Mariotto S, Suzuki Y, Persichini T, Colasanti M, Suzuki H and Cantoni O: Cross-talk between NO and arachidonic acid in inflammation. Curr Med Chem 14: 1940-1944, 2007. (Pubitemid 47209105)
5. Phoa N and Epe B: Influence of nitric oxide on the generation and repair of oxidative DNA damage in mammalian cells. Carcinogenesis 23: 469-475, 2002. (Pubitemid 34257627)
6. Ramsay RG, Ciznadija D, Vanevski M and Mantamadiotis T: Transcriptional regulation of cyclo-oxygenase expression: three pillars of control. Int J Immunopathol Pharmacol 16: S59-S67, 2003.
7. Honda S, Migita K, Hirai Y, Ueki Y, Yamasaki S, Urayama S, Kawabe Y, Fukuda T, Kawakami A, Kamachi M, Kita M, Ida H, Aoyagi T and Eguchi K: Induction of COX-2 expression by nitric oxide in rheumatoid synovial cells. Biochem Biophys Res Commun 268: 928-931, 2000. (Pubitemid 30150893)
8. Fairweather D and Cihakova D: Alternatively activated macrophages in infection and autoimmunity. J Autoimmun 33: 222-230, 2009.
9. Dinarello CA: A clinical perspective of IL-1β as the gatekeeper of inflammation. Eur J Immunol 41: 1203-1217, 2011.
10. Atreya I, Atreya R and Neurath MF: NF-kappaB in inflammatory bowel disease. J Intern Med 263, 591-596, 2008.
11. Sebban H and Courtois G: NF-kappaB and inflammation in genetic disease. Biochem Pharmacol 72: 1153-1160, 2006.
12. Park GY and Christman JW: Nuclear factor kappa B is a promising therapeutic target in inflammatory lung disease. Curr Drug Targets 7: 661-668, 2006. (Pubitemid 43827261)
13. Oeckinghaus A and Ghosh S: The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1: a000034, 2009.
14. Kim SH, Smith CJ and Van Eldik LJ: Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production. Neurobiol Aging 25: 431-439, 2004. (Pubitemid 38317340)
15. Kaminska B, Gozdz A, Zawadzka M, Ellert-Miklaszewska A and Lipko M: MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target. Anat Rec (Hoboken) 292: 1902-1913, 2009.
16. Wei J and Feng J: Signaling pathways associated with inflammatory bowel disease. Recent Pat Inflamm Allergy Drug Discov 4: 105-117, 2010.
17. Ramos S: Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol Nutr Food Res 52: 507-526, 2008.
18. Chen J, Chua KW, Chua CC, Yu H, Pei A, Chua BH, Hamdy RC, Xu X and Liu CF: Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity. Neurosci Lett 499: 181-185, 2011.
19. Dixon RA and Steele CL: Flavonoids and isoflavonoids - a gold mine for metabolic engineering. Trends Plant Sci 4: 394-400, 1999.
20. Chen D, Chen MS, Cui QC, Yang H and Dou QP: Structure-proteasome- inhibitory activity relationships of dietary flavonoids in human cancer cells. Front Biosci 12: 1935-1945, 2007. (Pubitemid 46846817)
21. Szejtli J and Szente L: Elimination of bitter, disgusting tastes of drugs and foods by cyclodextrins. Eur J Pharm Biopharm 61: 115-125, 2005. (Pubitemid 41427619)
22. Curin Y and Andriantsitohaina R: Polyphenols as potential therapeutical agents against cardiovascular diseases. Pharmacol Rep 57: S97-S107, 2005.
23. Pan MH and Ho CT: Chemopreventive effects of natural dietary compounds on cancer development. Chem Soc Rev 37: 2558-2274, 2008.
24. Prasad S, Phromnoi K, Yadav VR, Chaturvedi MM and Aggarwal BB: Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer. Planta Med 76: 1044-1063, 2010.
25. Chahar MK, Sharma N, Dobhal MP and Joshi YC: Flavonoids: A versatile source of anticancer drugs. Pharmacogn Rev 5: 1-12, 2011.
26. Guo W, Kong E and Meydani M: Dietary polyphenols, inflammation, and cancer. Nutr Cancer 61: 807-810, 2009.
27. Jang SW, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y, Wilson WD, Xiao G, Blanchi B, Sun YE and Ye K: A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci USA 107: 2687-2692, 2010.
28. Andero R, Heldt SA, Ye K, Liu X, Armario A and Ressler KJ: Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. Am J Psychiatry 168: 163-172, 2011.
29. Kozics K, Valovicova Z and Slamenova D: Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene-induced DNA damage and micronuclei in HepG2 cells. Neoplasma 58: 516-524, 2011.
30. Zhang R, Kang KA, Piao MJ, Ko DO, Wang ZH, Chang WY, You HJ, Lee IK, Kim BJ, Kang SS and Hyun JW: Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity. Biol Pharm Bull 32: 166-171, 2009.
31. Divsalar A, Saboury AA, Ahadi L, Zemanatiyar E and Mansouri-Torshizi H: Investigation of effects of newly synthesized Pt(II) complex against human serum albumin and leukemia cell line of K562. BMB Rep 43: 766-771, 2010.
32. Woo A, Min B and Ryoo S: Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity. Exp Mol Med 42: 524-532, 2010.
33. Lee SH, Kim DW, Back SS, Hwang HS, Park EY, Kang TC, Kwon OS, Park JH, Cho SW, Han KH, et al: Transduced Tat-Annexin protein suppresses inflammation-associated gene expression in lipopolysaccharide (LPS)-stimulated Raw 264.7 cells. BMB Rep 44: 484-489, 2011.
34. Choi JH, Park JG, Jeon HJ, Kim MS, Lee MR, Lee MN, Sonn S, Kim JH, Lee MH, Choi MS, et al: 5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesion. Exp Mol Med 43: 471-478, 2011.
35. Issac TT, Dokainish H and Lakkis NM: Role of inflammation in initiation and perpetuation of atrial fibrillation: a systematic review of the published data. J Am Coll Cardiol 50: 2021-2028, 2007. (Pubitemid 350087568)
36. Strober W and Fuss IJ: Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140: 1756-1767, 2011.
37. Nam NH: Naturally occurring NF-kappaB inhibitors. Mini Rev Med Chem 6: 945-951, 2006.
38. Luqman S and Pezzuto JM: NFkappaB: a promising target for natural products in cancer chemoprevention. Phytother Res 24: 949-963, 2010.
39. Shin EM, Zhou HY, Guo LY, Kim JA, Lee SH, Merfort I, Kang SS, Kim HS, Kim S and Kim YS: Anti-inflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS-stimulated RAW264.7 macrophages. Int Immunopharmacol 8: 1524-1532, 2008.
40. Pyo H, Jou I, Jung S, Hong S and Joe EH: Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia. Neuroreport 9: 871-874, 1998. (Pubitemid 28179292)
41. Guha M and Mackman N: LPS induction of gene expression in human monocytes. Cell Signal 13: 85-94, 2001. (Pubitemid 32222977)