Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κb signaling after experimental traumatic brain injury

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Chen, Chien Cheng ^a,b   Hung, Tai Ho ^c   Wang, Yen Ho ^d   Lin, Chii Wann ^b   Wang, Pei Yi ^a   Lee, Chun Yen ^a   Chen, Szu Fu ^a,e  

^a CHENG HSIN GENERAL HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^e NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; TOLL LIKE RECEPTOR 4; WOGONIN; CXCL2 CHEMOKINE; FLAVANONE DERIVATIVE; HERBACEOUS AGENT; PTGS2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CONTUSION; BRAIN EDEMA; BRAIN WATER; CELL ACTIVATION; CELL INFILTRATION; CONTROLLED STUDY; DNA BINDING; DRUG BRAIN LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG PENETRATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FUNCTIONAL ASSESSMENT; HISTOLOGY; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RISK REDUCTION; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY; TREATMENT DURATION; TREATMENT RESPONSE; WATER CONTENT; ANIMAL; APOPTOSIS; BRAIN INJURY; C57BL MOUSE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETICS; MALE; METABOLISM; NICK END LABELING; PATHOPHYSIOLOGY; PERMEABILITY; PHYTOTHERAPY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS;

ANIMALS; APOPTOSIS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; BRAIN EDEMA; BRAIN INJURIES; CHEMOKINE CXCL2; CYCLOOXYGENASE 2; DRUGS, CHINESE HERBAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVANONES; GENE EXPRESSION; IN SITU NICK-END LABELING; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PERMEABILITY; PHYTOTHERAPY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84855829747     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030294     Document Type: Article

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