Mechanism and inhibition of 1-deoxy-d-xylulose-5-phosphate reductoisomerase

Bioorganic Chemistry

Volumn 57, Issue , 2014, Pages 171-185

  Murkin, Andrew S ^a   Manning, Kathryn A ^a   Kholodar, Svetlana A ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

1 Deoxy D xylulose 5 phosphate (DXP); DXR; Enzyme mechanism; Fosmidomycin; Kinetic mechanism; Malaria; Reductoisomerase; Tuberculosis

Indexed keywords

1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; COBALT; DINUCLEOTIDE; FOSMIDOMYCIN; ISOPRENOID; MAGNESIUM; MANGANESE; MEVALONIC ACID; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; FOSFOMYCIN; ISOMERASE;

ACUTODESMUS OBLIQUUS; ALDOL REACTION; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARABIDOPSIS THALIANA; ARTICLE; BACILLUS SUBTILIS; BIOSYNTHESIS; CARBON SKELETON REARRANGEMENT; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CATHARANTHUS ROSEUS; CHEMICAL REACTION; COLEUS; COLEUS FORSKOHLII; CONFORMATIONAL TRANSITION; CORYNEBACTERIUM; CORYNEBACTERIUM AMMONIAGENES; CRYSTAL STRUCTURE; ELECTROPHILICITY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; EQUILIBRIUM CONSTANT; ESCHERICHIA COLI; FRANCISELLA TULARENSIS; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HYDROGEN BOND; ISOMERIZATION; ISOTHERMAL TITRATION CALORIMETRY; KINETICS; METHYLOBACTERIUM; METHYLOBACTERIUM FUJISAWAENSE; MOLECULAR DYNAMICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLASMODIUM FALCIPARUM (HB3); PROTON NUCLEAR MAGNETIC RESONANCE; RETRO ALDOL REACTION; SEQUENCE ALIGNMENT; STEREOCHEMISTRY; STREPTOMYCES; STREPTOMYCES AERIOUVIFER; STREPTOMYCES COELICOLOR; STREPTOMYCES LAVENDUALAE; SYNECHOCOCCUS; SYNECHOCOCCUS LEOPOLIENSIS; THERMODYNAMICS; THERMOTOGA MARITIMA; TOXOPLASMA GONDII; X RAY CRYSTALLOGRAPHY; ZYMOMONAS MOBILIS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BACTERIAL INFECTIONS; BACTERIUM; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIOLOGY; MOLECULARLY TARGETED THERAPY;

ALDOSE-KETOSE ISOMERASES; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; DRUG DISCOVERY; ENZYME INHIBITORS; FOSFOMYCIN; HUMANS; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY;

EID: 84913552431     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2014.06.001     Document Type: Article

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