Incorporation of 2-C-methyl-D-erythritol, a putative isoprenoid precursor in the mevalonate-independent pathway, into ubiquinone and menaquinone of Escherichia coli

Tetrahedron Letters

Volumn 38, Issue 35, 1997, Pages 6181-6184

  Duvold, Tore ^a   Calí, Patrizia ^a   Bravo, Jean Michel ^a   Rohmer, Michel ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHRITOL; GLYCERALDEHYDE 3 PHOSPHATE; ISOPRENOID; MENAQUINONE; MEVALONIC ACID; PYRUVIC ACID; UBIQUINONE;

ARTICLE; BIOSYNTHESIS; CHEMICAL MODIFICATION; ESCHERICHIA COLI; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY;

ESCHERICHIA COLI;

EID: 0030855436     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01392-0     Document Type: Article

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25. 4]-2-C-methyl-D-erythritol: m/z = 728.3 (M of ubiquinol, 100%), 729.3 (M+1, 54%), 730.3 (M+2, 15%), 732.3 (M+4, 11%), 734.3 (M+8, 3%). Unlabelled compound: m/z = 728.3 (M of ubiquinol, 100%), 729.3 (M+1, 54%), 730.3 (M+2, 15%). Calculated incorporation rate was 10% based on the increased relative intensities of M+4 and M+8 of ubiquinol from the labelled ubiquinone by comparison with the spectrum of the non-labelled compound.
26. 2]-2-C-methyl-D-erythritol: m/z = 715.7 (M, 100%), 716.6 (M+1, 60%), 717.6 (M+2, 28%). Unlabelled compound m/z = 715.7 (M, 100%), 716.6 (M+1, 57%), 717.6 (M+2, 19%).