Inhibition of 1-deoxy-d-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4721-4734

  Deng, Lisheng ^a   Diao, Jiasheng ^a   Chen, Pinhong ^a   Pujari, Venugopal ^b   Yao, Yuan ^a   Cheng, Gang ^a   Crick, Dean C ^b   Prasad, B V Venkataram ^a,b   Song, Yongcheng ^a  

^a Department of Ecosystem Science and Sustainability   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(4 BROMOPYRIDIN 2 YL)METHYLPHOSPHONIC ACID DISODIUM SALT; (4PHENYLPYRIDIN 2 YL)METHYLPHOSPHONIC ACID DISODIUM SALT; (5 BENZYLOXYPYRIDIN 2 YL)METHYLPHOSPHONIC ACID DISODIUM SALT; (5 BROMOPYRIDIN 2 YL)METHYLPHOSPHONIC ACID DISODIUM SALT; (5 HYDROXYLPYRIDIN 2 YL)METHYLPHOSPHONIC ACID DISODIUM SALT; (5 PHENYLPYRIDIN 2 YL)ACETIC ACID; (6 BROMOPYRIDIN 2 YL)METHYLPHOSPHONIC ACID DISODIUM SALT; (6 PHENYLPYRIDIN 2 YL)METHYLPHOSPHONIC ACID DISODIUM SALT; 1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; 2 (2 HYDROXYPHENYL)ETHYLPHOSPHONIC ACID DISODIUM SALT; 2 (PYRIDIN 2 ONE 6 YL)ETHYLPHOSPHONIC ACID DISODIUM SALT; 2 (PYRIDIN 2 YL)ETHYLPHOSPHONIC ACID DISODIUM SALT; 2 PHENYLETHYLPHOSPHONIC ACID DISODIUM SALT; 3 (PYRIDIN 2 YL)ETHYLPHOSPHONIC ACID DISODIUM SALT; 4 (4 FLUOROPHENYL)PYRIDIN 2 YLMETHYLPHOSPHONIC ACID DISODIUM SALT; 5 (1 HYDROXY PYRIDIN 2 ONE)METHYLPHOSPHONIC ACID DISODIUM SALT; 5 (3 METHOXYPHENYL)PYRIDIN 2 YLMETHYLPHOSPHONIC ACID DISODIUM SALT; 5 (4 CHLOROPHENYL)PYRIDIN 2 YLMETHYLPHOSPHONIC ACID DISODIUM SALT; 5 (4 FLUOROPHENYL)PYRIDIN 2 YLMETHYLPHOSPHONIC ACID DISODIUM SALT; 5 (4 METHYLPHENYL)PYRIDIN 2 YLMETHYLPHOSPHONIC ACID DISODIUM SALT; 5 (NAPHTHALEN 2 YL)PYRIDIN 2 YLMETHYLPHOSPHONIC DISODIUM SALT; BENZYLPHOSPHONIC ACID DISODIUM SALT; ISOMERASE; N HYDROXY PYRIDINE 2 CARBOXAMIDE; PHENYLPHOSPHONIC ACID DISODIUM SALT; PHOSPHONIC ACID DERIVATIVE; PYRAZIN 2 YLMETHYLPHOSPHONIC ACID DISODIUM SALT; PYRIDIN 2 YLPHOSPHONIC ACID DISODIUM SALT; PYRIMIDIN 4 YLMETHYLPHOSPHONIC ACID DISODIUM SALT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CRYSTALLOGRAPHY; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; HYDROPHOBICITY; LIPOPHILICITY; MICROBIAL DIVERSITY; MOLECULAR INTERACTION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION;

ALDOSE-KETOSE ISOMERASES; ANTI-BACTERIAL AGENTS; ANTITUBERCULAR AGENTS; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PHOSPHONIC ACIDS; PROTEIN BINDING; PROTEIN CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960155208     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200363d     Document Type: Article

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