Alteration of the flexible loop in 1-deoxy- d -xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin

Biochemistry

Volumn 53, Issue 21, 2014, Pages 3423-3431

  Kholodar, Svetlana A ^a   Tombline, Gregory ^a   Liu, Juan ^a   Tan, Zhesen ^a   Allen, C Leigh ^b   Gulick, Andrew M ^b   Murkin, Andrew S ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOCHEMISTRY; HYDROGEN BONDS; ISOTOPES; PROTEINS;

2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE PATHWAYS; DEUTERIUM KINETIC ISOTOPE EFFECT; ENTHALPY DIFFERENCES; HYDROGEN BOND INTERACTION; ISOPRENOID BIOSYNTHESIS; ISOTHERMAL TITRATION CALORIMETRY; MYCOBACTERIUM TUBERCULOSIS; X RAY CRYSTAL STRUCTURES;

ENTHALPY;

1 DEOXY XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; ALANINE; DEUTERIUM; FOSMIDOMYCIN; GLYCINE; ISOMERASE; PHENYLALANINE; PHOSPHONIC ACID DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CRYSTAL STRUCTURE; ENTHALPY; ENTROPY; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; KINETICS; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS;

ALDOSE-KETOSE ISOMERASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; FOSFOMYCIN; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS; XYLULOSE;

EID: 84901923883     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi5004074     Document Type: Article

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