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Volumn 62, Issue 11, 2014, Pages 1816-1830

Mechanisms of white matter damage in multiple sclerosis

Author keywords

Astrocytes; Demyelination; Microglia; Multiple sclerosis; Oligodendrocytes

Indexed keywords

IRON; MYELIN PROTEIN;

EID: 84912567915     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22597     Document Type: Review
Times cited : (149)

References (163)
  • 2
    • 33947547648 scopus 로고    scopus 로고
    • Extensive cortical remyelination in patients with chronic multiple sclerosis
    • Albert M, Antel J, Brück W, Stadelmann C. 2007. Extensive cortical remyelination in patients with chronic multiple sclerosis. Brain Pathol 17:129-138.
    • (2007) Brain Pathol , vol.17 , pp. 129-138
    • Albert, M.1    Antel, J.2    Brück, W.3    Stadelmann, C.4
  • 3
    • 79955042876 scopus 로고    scopus 로고
    • Antigen presentation in EAE: Role of microglia, macrophages and dendritic cells
    • Amolda B, Gonzales B, Castellano B. 2011. Antigen presentation in EAE: Role of microglia, macrophages and dendritic cells Front Biosci 16:1157-1171
    • (2011) Front Biosci , vol.16 , pp. 1157-1171
    • Amolda, B.1    Gonzales, B.2    Castellano, B.3
  • 4
    • 78149481589 scopus 로고    scopus 로고
    • Meningeal T-cells associate with diffuse axonal loss in multiple sclerosis spinal cords
    • Androdias G, Reynolds R, Chanal M, Ritleng C, Confavreux C, Nataf S. 2010. Meningeal T-cells associate with diffuse axonal loss in multiple sclerosis spinal cords. Ann Neurol 68:465-476.
    • (2010) Ann Neurol , vol.68 , pp. 465-476
    • Androdias, G.1    Reynolds, R.2    Chanal, M.3    Ritleng, C.4    Confavreux, C.5    Nataf, S.6
  • 6
    • 0005900248 scopus 로고
    • Recherches sur l'anatomie pathologique de la sclerose en plaque et etude comparative des diverses varietes de la scleroses de la moelle
    • Babinski J. 1885. Recherches sur l'anatomie pathologique de la sclerose en plaque et etude comparative des diverses varietes de la scleroses de la moelle. Arch Physiol (Paris) 5-6:186-207.
    • (1885) Arch Physiol (Paris) , vol.5-6 , pp. 186-207
    • Babinski, J.1
  • 8
    • 0030612483 scopus 로고    scopus 로고
    • Expression of alphaB-crystallin in glia cells during lesional development in multiple sclerosis
    • Bajramovic JJ, Lassmann H, VanNoort JM. 1997. Expression of alphaB-crystallin in glia cells during lesional development in multiple sclerosis. J Neuroimmunol 78:143-151.
    • (1997) J Neuroimmunol , vol.78 , pp. 143-151
    • Bajramovic, J.J.1    Lassmann, H.2    VanNoort, J.M.3
  • 9
    • 1642281535 scopus 로고    scopus 로고
    • Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
    • Barnett MH, Prineas JW. 2004. Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion. Ann Neurol 55:458-468.
    • (2004) Ann Neurol , vol.55 , pp. 458-468
    • Barnett, M.H.1    Prineas, J.W.2
  • 10
    • 84883727292 scopus 로고    scopus 로고
    • Myelination: Do astrocytes play a role?
    • Barnett SC, Linington C. 2013. Myelination: Do astrocytes play a role? Neuroscientist 19:442-450.
    • (2013) Neuroscientist , vol.19 , pp. 442-450
    • Barnett, S.C.1    Linington, C.2
  • 11
    • 27244450879 scopus 로고    scopus 로고
    • Elevated protein carbonylation in the brain white matter and grey matter of patients with multiple sclerosis
    • Bizzozero OA, Dejesus G, Callaha K, Pastuszyn A. 2005. Elevated protein carbonylation in the brain white matter and grey matter of patients with multiple sclerosis. J Neurosci Res 81:687-695.
    • (2005) J Neurosci Res , vol.81 , pp. 687-695
    • Bizzozero, O.A.1    Dejesus, G.2    Callaha, K.3    Pastuszyn, A.4
  • 15
    • 77649192930 scopus 로고    scopus 로고
    • Oligodendrocytes: biology and pathology
    • Bradl M, Lassmann H. 2010. Oligodendrocytes: biology and pathology. Acta Neuropathologica 119:37-53.
    • (2010) Acta Neuropathologica , vol.119 , pp. 37-53
    • Bradl, M.1    Lassmann, H.2
  • 18
    • 49049091033 scopus 로고    scopus 로고
    • Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody responses is focused on one dominant conformational epitope region in rodents
    • Breithaupt C, Schäfer B, Pellkofer H, Huber R, Linington C, Jacob U. 2008. Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody responses is focused on one dominant conformational epitope region in rodents. J Immunol 181:1255-1263.
    • (2008) J Immunol , vol.181 , pp. 1255-1263
    • Breithaupt, C.1    Schäfer, B.2    Pellkofer, H.3    Huber, R.4    Linington, C.5    Jacob, U.6
  • 19
    • 14844293538 scopus 로고    scopus 로고
    • The pathology of multiple sclerosis is location dependent: No significant complement activation is detected in purely cortical lesions
    • Brink BP, Veerhuis R, Breij EC, Van der Valk P, Dijkstra CD, Bo L. 2005. The pathology of multiple sclerosis is location dependent: No significant complement activation is detected in purely cortical lesions. J Neuropath Exp Neurol 64:147-155.
    • (2005) J Neuropath Exp Neurol , vol.64 , pp. 147-155
    • Brink, B.P.1    Veerhuis, R.2    Breij, E.C.3    Van der Valk, P.4    Dijkstra, C.D.5    Bo, L.6
  • 20
    • 84873709602 scopus 로고    scopus 로고
    • The astrocyte in multiple sclerosis revisited
    • Brosnan CF, Raine CS. 2013. The astrocyte in multiple sclerosis revisited. Glia 61:453-465.
    • (2013) Glia , vol.61 , pp. 453-465
    • Brosnan, C.F.1    Raine, C.S.2
  • 24
    • 0037122960 scopus 로고    scopus 로고
    • Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
    • Chang A, Tourtelotte WW, Rudick R, Trapp BD. 2002. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N Engl J Med 346:165-173.
    • (2002) N Engl J Med , vol.346 , pp. 165-173
    • Chang, A.1    Tourtelotte, W.W.2    Rudick, R.3    Trapp, B.D.4
  • 28
    • 27644591304 scopus 로고    scopus 로고
    • Axon degeneration mechanisms: commonality and diversity
    • Coleman M. 2005. Axon degeneration mechanisms: commonality and diversity. Nat Rev Neurosci 6:889-898.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 889-898
    • Coleman, M.1
  • 29
    • 84912543982 scopus 로고    scopus 로고
    • Iron and glia
    • Kettenmann H, Ransom BR, editors. Oxford University Press, New York
    • Connor JR. 2013. Iron and glia. In: Kettenmann H, Ransom BR, editors. Neuroglia. Oxford University Press, New York; pp 586-602.
    • (2013) Neuroglia , pp. 586-602
    • Connor, J.R.1
  • 35
    • 0019305016 scopus 로고
    • Multiple sclerosis: A quantitative and qualitative study of immunoglobulin-containing cells in the central nervous system
    • Esiri MM. 1980. Multiple sclerosis: A quantitative and qualitative study of immunoglobulin-containing cells in the central nervous system. Neuropath Appl Neurobiol 6:9-21.
    • (1980) Neuropath Appl Neurobiol , vol.6 , pp. 9-21
    • Esiri, M.M.1
  • 36
    • 0034840729 scopus 로고    scopus 로고
    • Size-selective neuronal changes in the anterior optic pathways suggest a differential susceptibility to injury in multiple sclerosis
    • Evangelou N, Konz D, Esiri MM, Smith S, Palace J, Matthews PM. 2001. Size-selective neuronal changes in the anterior optic pathways suggest a differential susceptibility to injury in multiple sclerosis. Brain 124:1813-1820.
    • (2001) Brain , vol.124 , pp. 1813-1820
    • Evangelou, N.1    Konz, D.2    Esiri, M.M.3    Smith, S.4    Palace, J.5    Matthews, P.M.6
  • 37
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • Ferguson B, Matyszak MK, Esiri MM, Perry VH. 1997. Axonal damage in acute multiple sclerosis lesions. Brain 120:393-399.
    • (1997) Brain , vol.120 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3    Perry, V.H.4
  • 40
    • 23444434940 scopus 로고    scopus 로고
    • + T cells in multiple sclerosis: A new target for therapy?
    • + T cells in multiple sclerosis: A new target for therapy? Brain 128:1747-1763.
    • (2005) Brain , vol.128 , pp. 1747-1763
    • Friese, M.A.1    Fugger, L.2
  • 44
    • 0032950794 scopus 로고    scopus 로고
    • Identification of autoantibodies associated with myelin damage in multiple sclerosis
    • Genain CP, Cannella B, Hauser SL, Raine CS. 1999. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 5:170-175.
    • (1999) Nat Med , vol.5 , pp. 170-175
    • Genain, C.P.1    Cannella, B.2    Hauser, S.L.3    Raine, C.S.4
  • 45
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
    • Gold R, Linington C, Lassmann . 2006. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 129(Part 8):1953-1971.
    • (2006) Brain , vol.129 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann3
  • 47
    • 51349137371 scopus 로고    scopus 로고
    • Elevated myeloperoxidase activity in white matter in multiple sclerosis
    • Gray E, Thomas TL, Betmouni S, Scolding N, Love S. 2008. Elevated myeloperoxidase activity in white matter in multiple sclerosis. Neurosci Lett 442:195-198.
    • (2008) Neurosci Lett , vol.442 , pp. 195-198
    • Gray, E.1    Thomas, T.L.2    Betmouni, S.3    Scolding, N.4    Love, S.5
  • 48
    • 77951218761 scopus 로고    scopus 로고
    • Laquinimod supress antigen presentation in relapsing-remitting multiple sclerosis: In vitro high-throughput gene expression study
    • Gurevich M, Gritzman T, Orbach R, Tuller T, Feldman A, Achiron A. 2010. Laquinimod supress antigen presentation in relapsing-remitting multiple sclerosis: In vitro high-throughput gene expression study. J Neuroimmunol 221:87-94.
    • (2010) J Neuroimmunol , vol.221 , pp. 87-94
    • Gurevich, M.1    Gritzman, T.2    Orbach, R.3    Tuller, T.4    Feldman, A.5    Achiron, A.6
  • 49
    • 0031951041 scopus 로고    scopus 로고
    • Transcription factor NF-kappaB and inhibitor I kappaBalpha are localized in macrophages in active multiple sclerosis lesions
    • Gveric D, Kaltschmidt C, Cuzner ML, Newcombe J. 1998. Transcription factor NF-kappaB and inhibitor I kappaBalpha are localized in macrophages in active multiple sclerosis lesions. J Neuropathol Exp Neurol 57:168-178.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 168-178
    • Gveric, D.1    Kaltschmidt, C.2    Cuzner, M.L.3    Newcombe, J.4
  • 50
    • 33646577436 scopus 로고    scopus 로고
    • Degenerative and spontaneous regenerative processes after spinal cord trauma
    • Hagg T, Oudega M. 2006. Degenerative and spontaneous regenerative processes after spinal cord trauma. J Neurotrauma 23:264-280.
    • (2006) J Neurotrauma , vol.23 , pp. 264-280
    • Hagg, T.1    Oudega, M.2
  • 52
    • 84961042345 scopus 로고
    • The effect of age on the non-haemin iron in the human brain
    • Hallgren B, Sourander P. 1958. The effect of age on the non-haemin iron in the human brain. J Neurochem 3:41-51.
    • (1958) J Neurochem , vol.3 , pp. 41-51
    • Hallgren, B.1    Sourander, P.2
  • 54
    • 0026782507 scopus 로고
    • Occurrence of a multiple sclerosis like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation
    • Harding AE, Sweeney MG, Miller DH, Mumford CJ, Kellar-Wood H, Menard D, McDonald WI, Compston DA. 1992. Occurrence of a multiple sclerosis like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation. Brain 115:979-989.
    • (1992) Brain , vol.115 , pp. 979-989
    • Harding, A.E.1    Sweeney, M.G.2    Miller, D.H.3    Mumford, C.J.4    Kellar-Wood, H.5    Menard, D.6    McDonald, W.I.7    Compston, D.A.8
  • 61
    • 0344422924 scopus 로고
    • Zur Pathogenese der diffusen infiltrativen Enzephalomyelitis in ihren Beziehungen zur diffusen und multiplen Sklerose
    • Jakob A. 1915. Zur Pathogenese der diffusen infiltrativen Enzephalomyelitis in ihren Beziehungen zur diffusen und multiplen Sklerose. Z ges Neurol Psychiat 27:290-320.
    • (1915) Z ges Neurol Psychiat , vol.27 , pp. 290-320
    • Jakob, A.1
  • 65
    • 46849098585 scopus 로고    scopus 로고
    • Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis
    • Kuhlmann T, Miron V, Cui Q, Wegner C, Antel J, Brück W. 2009. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 131:1749-1758.
    • (2009) Brain , vol.131 , pp. 1749-1758
    • Kuhlmann, T.1    Miron, V.2    Cui, Q.3    Wegner, C.4    Antel, J.5    Brück, W.6
  • 66
    • 39749152316 scopus 로고    scopus 로고
    • Diagnosis of inflammatory demyelination in biopsy specimens: A practical approach
    • Kuhlmann T, Lassmann H, Brück W. 2008. Diagnosis of inflammatory demyelination in biopsy specimens: A practical approach. Acta Neuropathol 115:275-287.
    • (2008) Acta Neuropathol , vol.115 , pp. 275-287
    • Kuhlmann, T.1    Lassmann, H.2    Brück, W.3
  • 69
    • 84868535759 scopus 로고    scopus 로고
    • Progressive multiple sclerosis: Pathology and pathogenesis
    • Lassmann H, Van Horssen J, Mahad D. 2012. Progressive multiple sclerosis: Pathology and pathogenesis. Nat Rev Neurol 8:647-656.
    • (2012) Nat Rev Neurol , vol.8 , pp. 647-656
    • Lassmann, H.1    Van Horssen, J.2    Mahad, D.3
  • 70
    • 79959760430 scopus 로고    scopus 로고
    • Review: The architecture of inflammatory demyelinating lesions: Implications for studies on pathogenesis
    • Lassmann H. 2011. Review: The architecture of inflammatory demyelinating lesions: Implications for studies on pathogenesis. Neuropathol Appl Neurobiol 37:698-710.
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 698-710
    • Lassmann, H.1
  • 71
    • 33947509525 scopus 로고    scopus 로고
    • The immunopathology of multiple sclerosis: An overview
    • Lassmann H, Brück W, Lucchinetti C. 2007. The immunopathology of multiple sclerosis: An overview. Brain Pathol 17:210-218.
    • (2007) Brain Pathol , vol.17 , pp. 210-218
    • Lassmann, H.1    Brück, W.2    Lucchinetti, C.3
  • 72
    • 63649109017 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in disorders of myelinating cells
    • Lin W, Popko B. 2009. Endoplasmic reticulum stress in disorders of myelinating cells. Nat Neurosci 12:379-385.
    • (2009) Nat Neurosci , vol.12 , pp. 379-385
    • Lin, W.1    Popko, B.2
  • 73
    • 0023931606 scopus 로고
    • Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein
    • Linington C, Bradl M, Lassmann H, Brunner C, Vass K. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am J Pathol 1988;130:443-454.
    • (1988) Am J Pathol , vol.130 , pp. 443-454
    • Linington, C.1    Bradl, M.2    Lassmann, H.3    Brunner, C.4    Vass, K.5
  • 75
    • 60749126977 scopus 로고    scopus 로고
    • Differential effects of Th1, monocyte/macrophage and Th2 cytokin mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures
    • Lisak RP, Benjamins JA, Bealmear B, Nedelkoska L, Studzinski D, Retland E, Yao B, Land S. 2009. Differential effects of Th1, monocyte/macrophage and Th2 cytokin mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures. J Neuroinflammation 6:4.
    • (2009) J Neuroinflammation , vol.6 , pp. 4
    • Lisak, R.P.1    Benjamins, J.A.2    Bealmear, B.3    Nedelkoska, L.4    Studzinski, D.5    Retland, E.6    Yao, B.7    Land, S.8
  • 77
    • 0034965383 scopus 로고    scopus 로고
    • Expression of indicible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions
    • Liu JSH, Zhao ML, Brosnan CF, Lee SC. 2001. Expression of indicible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am J Pathol 158:2057-2066.
    • (2001) Am J Pathol , vol.158 , pp. 2057-2066
    • Liu, J.S.H.1    Zhao, M.L.2    Brosnan, C.F.3    Lee, S.C.4
  • 78
    • 51349095669 scopus 로고    scopus 로고
    • Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity
    • Lopes KO, Sparks DL, Streit WJ. 2008. Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity. Glia 56:1048-1060.
    • (2008) Glia , vol.56 , pp. 1048-1060
    • Lopes, K.O.1    Sparks, D.L.2    Streit, W.J.3
  • 79
    • 0034662806 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis
    • Lu F, Selak M, O'Connor J, Croul S, Lorenzana C, Butunoi C, Kalman B. 2000. Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis. J Neurol Sci 177:95-103.
    • (2000) J Neurol Sci , vol.177 , pp. 95-103
    • Lu, F.1    Selak, M.2    O'Connor, J.3    Croul, S.4    Lorenzana, C.5    Butunoi, C.6    Kalman, B.7
  • 80
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: Results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    • Lublin FD, Reingold SC. 1996. Defining the clinical course of multiple sclerosis: Results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 46:907-911.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 81
  • 82
    • 0345633543 scopus 로고    scopus 로고
    • A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 117 cases
    • Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. 1999. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 117 cases. Brain 122:2279-2295.
    • (1999) Brain , vol.122 , pp. 2279-2295
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 84
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • Magliozzi R, Howell O, Vora A, Serafini B, Nicholas R, Puopoplo M, Reynolds R, Aloisi F. 2007. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 130:1089-1104.
    • (2007) Brain , vol.130 , pp. 1089-1104
    • Magliozzi, R.1    Howell, O.2    Vora, A.3    Serafini, B.4    Nicholas, R.5    Puopoplo, M.6    Reynolds, R.7    Aloisi, F.8
  • 85
    • 46849122006 scopus 로고    scopus 로고
    • Mitochondrial defects in acute multiple sclerosis lesions
    • Mahad D, Ziabreva I, Lassmann H, Turnbull D. 2008. Mitochondrial defects in acute multiple sclerosis lesions. Brain 131:1722-1735.
    • (2008) Brain , vol.131 , pp. 1722-1735
    • Mahad, D.1    Ziabreva, I.2    Lassmann, H.3    Turnbull, D.4
  • 89
    • 35649018602 scopus 로고    scopus 로고
    • Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?
    • Marik C, Felts P, Bauer J, Lassmann H, Smith KJ. 2007. Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity? Brain 130:2800-2815.
    • (2007) Brain , vol.130 , pp. 2800-2815
    • Marik, C.1    Felts, P.2    Bauer, J.3    Lassmann, H.4    Smith, K.J.5
  • 92
    • 0035198691 scopus 로고    scopus 로고
    • The neurotoxicant, #cuprizone, as a model to study demyelination and remyelination in the central nervous system
    • Matsushima GK, Morell P. 2001. The neurotoxicant, #cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol 11:107-116.
    • (2001) Brain Pathol , vol.11 , pp. 107-116
    • Matsushima, G.K.1    Morell, P.2
  • 94
    • 33747886404 scopus 로고    scopus 로고
    • A new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination
    • Merkler D, Ernsting T, Kerschensteiner M, Brück W, Stadelmann C. 2006. A new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination. Brain 129:1972-1983.
    • (2006) Brain , vol.129 , pp. 1972-1983
    • Merkler, D.1    Ernsting, T.2    Kerschensteiner, M.3    Brück, W.4    Stadelmann, C.5
  • 99
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy MP. 2009. How mitochondria produce reactive oxygen species. Biochem J 417:1-13.
    • (2009) Biochem J , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 100
    • 50849121345 scopus 로고    scopus 로고
    • Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system
    • Na SY, Cao Y, Toben C, Nitschke L, Stadelmann C, Gold R, Schimpl A, Hünig T. 2008. Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system. Brain 131:2353-2365.
    • (2008) Brain , vol.131 , pp. 2353-2365
    • Na, S.Y.1    Cao, Y.2    Toben, C.3    Nitschke, L.4    Stadelmann, C.5    Gold, R.6    Schimpl, A.7    Hünig, T.8
  • 101
    • 84864322740 scopus 로고    scopus 로고
    • Oligodendrocytes enforce immune tolerance of the uninfected brain by purging the peripheral repertoire of autoactive CD8+ T cells
    • Na SY, Hermann A, Snachez-Ruiz M, Storch A, Deckert M, Hünig T. 2012. Oligodendrocytes enforce immune tolerance of the uninfected brain by purging the peripheral repertoire of autoactive CD8+ T cells. Immunity 37:134-146.
    • (2012) Immunity , vol.37 , pp. 134-146
    • Na, S.Y.1    Hermann, A.2    Snachez-Ruiz, M.3    Storch, A.4    Deckert, M.5    Hünig, T.6
  • 102
    • 51349134916 scopus 로고    scopus 로고
    • Astrocytes in multiple sclerosis: A product of their environment
    • Nair A, Frederick TJ, Miller SD. 2008. Astrocytes in multiple sclerosis: A product of their environment. Cell Mol Life Sci 65:2702-2720.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2702-2720
    • Nair, A.1    Frederick, T.J.2    Miller, S.D.3
  • 103
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: An essential link between degeneration and regeneration
    • Neumann H, Kotter MR, Franklin RJ. 2009. Debris clearance by microglia: An essential link between degeneration and regeneration. Brain 132:288-295.
    • (2009) Brain , vol.132 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.3
  • 104
    • 0036602982 scopus 로고    scopus 로고
    • Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
    • Neumann H, Medana I, Bauer J, Lassmann H. 2002. Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci 25:313-319.
    • (2002) Trends Neurosci , vol.25 , pp. 313-319
    • Neumann, H.1    Medana, I.2    Bauer, J.3    Lassmann, H.4
  • 107
    • 84912543981 scopus 로고    scopus 로고
    • Immune functions of microglia
    • Kettenmann H, Ransom BR, editors. Oxford University Press, New York.
    • Owens T. Immune functions of microglia. 2013. In: Kettenmann H, Ransom BR, editors. Neuroglia. Oxford University Press, New York. pp 638-652.
    • (2013) Neuroglia , pp. 638-652
    • Owens, T.1
  • 109
    • 0029792305 scopus 로고    scopus 로고
    • Cerebral white matter is highly vulnerable to ischemia
    • Pantoni L, Garcia JH, Gutierrez JA. 1996. Cerebral white matter is highly vulnerable to ischemia. Stroke 27:1641-1646.
    • (1996) Stroke , vol.27 , pp. 1641-1646
    • Pantoni, L.1    Garcia, J.H.2    Gutierrez, J.A.3
  • 110
    • 77957601341 scopus 로고    scopus 로고
    • Neuromyelitis optica: A demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes
    • Parratt JD, Prineas JW. 2010. Neuromyelitis optica: A demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes. Mult Scler 16:1156-1172.
    • (2010) Mult Scler , vol.16 , pp. 1156-1172
    • Parratt, J.D.1    Prineas, J.W.2
  • 111
    • 34247862406 scopus 로고    scopus 로고
    • Remyelination can be extensive in multiple sclerosis despite a long disease course
    • Patani R, Balaratnam M, Vora A, Reynolds R. 2007. Remyelination can be extensive in multiple sclerosis despite a long disease course. Neuropath Appl Neurobiol 33:277-287.
    • (2007) Neuropath Appl Neurobiol , vol.33 , pp. 277-287
    • Patani, R.1    Balaratnam, M.2    Vora, A.3    Reynolds, R.4
  • 115
    • 0001612484 scopus 로고
    • The neuropathology of multiple sclerosis
    • Koetsier JC, editor. Elsevier: New York
    • Prineas JW 1985. The neuropathology of multiple sclerosis. In: Koetsier JC, editor. Handbook of clinical neurology. Vol 47, Elsevier: New York, pp 337-395.
    • (1985) Handbook of clinical neurology , vol.47 , pp. 337-395
    • Prineas, J.W.1
  • 120
    • 0019860769 scopus 로고
    • Multiple sclerosis: Oligodendrocyte survival and proliferation in an active established lesion
    • Raine CS, Scheinberg L, Waltz JM. 1981. Multiple sclerosis: Oligodendrocyte survival and proliferation in an active established lesion. Lab Invest 45:534-546.
    • (1981) Lab Invest , vol.45 , pp. 534-546
    • Raine, C.S.1    Scheinberg, L.2    Waltz, J.M.3
  • 121
    • 0030016525 scopus 로고    scopus 로고
    • Multiple sclerosis: A protective or a pathogenic role for heat shock protein 60 in the central nervous system?
    • Raine CS, Wi E, Ivani J, Katz D, Brosnan CF. 1996. Multiple sclerosis: A protective or a pathogenic role for heat shock protein 60 in the central nervous system? Lab Invest 75:109-123.
    • (1996) Lab Invest , vol.75 , pp. 109-123
    • Raine, C.S.1    Wi, E.2    Ivani, J.3    Katz, D.4    Brosnan, C.F.5
  • 124
    • 84862684427 scopus 로고    scopus 로고
    • Mitochondrial sirtuins-A new therapeutic target for repair and protection in multiple sclerosis
    • Rice CM, Sun M, Kemp K, Gray E, Wilkins A, Scolding NJ. 2012. Mitochondrial sirtuins-A new therapeutic target for repair and protection in multiple sclerosis. Eur J Neurosci 35:1887-1893.
    • (2012) Eur J Neurosci , vol.35 , pp. 1887-1893
    • Rice, C.M.1    Sun, M.2    Kemp, K.3    Gray, E.4    Wilkins, A.5    Scolding, N.J.6
  • 127
    • 80052923220 scopus 로고    scopus 로고
    • Iron efflux from oligodendrocytes is differentially regulated in gray and white matter
    • Schulz K, Vulpe CD, Harris LZ, David S. 2011. Iron efflux from oligodendrocytes is differentially regulated in gray and white matter. J Neurosci 31:13301-13311.
    • (2011) J Neurosci , vol.31 , pp. 13301-13311
    • Schulz, K.1    Vulpe, C.D.2    Harris, L.Z.3    David, S.4
  • 128
    • 2442708947 scopus 로고    scopus 로고
    • Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
    • Serafini B, Rosicarelli B, Magliozzi R, Stigliano E, Aloisi F. 2004. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol 14:164-174.
    • (2004) Brain Pathol , vol.14 , pp. 164-174
    • Serafini, B.1    Rosicarelli, B.2    Magliozzi, R.3    Stigliano, E.4    Aloisi, F.5
  • 129
    • 77957275551 scopus 로고    scopus 로고
    • Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination
    • Sharma R, Fischer MT, Bauer J, Felts PA, Smith KJ, Misu T, Fujihara K, Bradl M, Lassmann H. 2010. Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination. Acta Neuropathol 120:223-236.
    • (2010) Acta Neuropathol , vol.120 , pp. 223-236
    • Sharma, R.1    Fischer, M.T.2    Bauer, J.3    Felts, P.A.4    Smith, K.J.5    Misu, T.6    Fujihara, K.7    Bradl, M.8    Lassmann, H.9
  • 131
    • 84876670276 scopus 로고    scopus 로고
    • Microglial nodules in early multiple sclerosis white matter are asscociated with degenerating axons
    • Singh S, Metz I, Amor S, Van der Valk P, Stadelmann C, Brück W. 2013. Microglial nodules in early multiple sclerosis white matter are asscociated with degenerating axons. Acta Neuropathol 125:595-608.
    • (2013) Acta Neuropathol , vol.125 , pp. 595-608
    • Singh, S.1    Metz, I.2    Amor, S.3    Van der Valk, P.4    Stadelmann, C.5    Brück, W.6
  • 132
    • 0032950964 scopus 로고    scopus 로고
    • Demyelination: The role of reactive oxygen and nitrogen species
    • Smith KJ, Kapoor PA, Felts PA. 1999. Demyelination: The role of reactive oxygen and nitrogen species. Brain Pathol 9:69-92.
    • (1999) Brain Pathol , vol.9 , pp. 69-92
    • Smith, K.J.1    Kapoor, P.A.2    Felts, P.A.3
  • 134
    • 84912543980 scopus 로고    scopus 로고
    • Astrocyte responses to central nervous system injury
    • Kettenmann H, Ransom BR, editors. Oxford University Press
    • Sofroniew MV. 2013. Astrocyte responses to central nervous system injury. In: Kettenmann H, Ransom BR, editors. Neuroglia. Oxford University Press, pp 653-664.
    • (2013) Neuroglia , pp. 653-664
    • Sofroniew, M.V.1
  • 136
    • 34548863185 scopus 로고    scopus 로고
    • Differential up-regulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders
    • Stahnke T. Stadelmann C, Netzler A, Brück W, Richter-Landsberg C. 2007. Differential up-regulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders. J Mol Neurosci 32:25-37.
    • (2007) J Mol Neurosci , vol.32 , pp. 25-37
    • Stahnke, T.1    Stadelmann, C.2    Netzler, A.3    Brück, W.4    Richter-Landsberg, C.5
  • 138
    • 33845371444 scopus 로고    scopus 로고
    • Cortical demyelination can be modeled in specific rat models of autoimmune encephalomyelitis and is major histocompatibility complex (MHC) haplotype-related
    • Storch MK, Bauer J, Linington C, Olsson T. Weissert R, Lassmann H. 2006. Cortical demyelination can be modeled in specific rat models of autoimmune encephalomyelitis and is major histocompatibility complex (MHC) haplotype-related. J Neuropathol Exp Neurol 65:1137-1142.
    • (2006) J Neuropathol Exp Neurol , vol.65 , pp. 1137-1142
    • Storch, M.K.1    Bauer, J.2    Linington, C.3    Olsson, T.4    Weissert, R.5    Lassmann, H.6
  • 139
    • 84866457079 scopus 로고    scopus 로고
    • Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges
    • Su K, Bourdette D, Forte M. 2012. Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges. Front Physiol 3:285.
    • (2012) Front Physiol , vol.3 , pp. 285
    • Su, K.1    Bourdette, D.2    Forte, M.3
  • 140
    • 0035877190 scopus 로고    scopus 로고
    • Myelin antigen specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice
    • Sun D, Whitaker JN, Huang Z, Liu D, Coleclough C, Wekerle H, Raine CS. 2001. Myelin antigen specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J Immunol 166:7579-7587.
    • (2001) J Immunol , vol.166 , pp. 7579-7587
    • Sun, D.1    Whitaker, J.N.2    Huang, Z.3    Liu, D.4    Coleclough, C.5    Wekerle, H.6    Raine, C.S.7
  • 141
    • 59949106172 scopus 로고    scopus 로고
    • Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis
    • Trapp BD, Stys PK. 2009. Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis. Lancet Neurol 8:280-291.
    • (2009) Lancet Neurol , vol.8 , pp. 280-291
    • Trapp, B.D.1    Stys, P.K.2
  • 144
    • 67049099173 scopus 로고    scopus 로고
    • Preactive lesions in multiple sclerosis
    • Van der Valk P, Amor S. 2009. Preactive lesions in multiple sclerosis. Curr Opin Neurol 22:207-213.
    • (2009) Curr Opin Neurol , vol.22 , pp. 207-213
    • Van der Valk, P.1    Amor, S.2
  • 151
    • 0025104589 scopus 로고
    • Intrathecal application of interferon gamma progressive appearance of MHC antigens within the rat nervous system
    • Vass K, Lassmann H. 1990. Intrathecal application of interferon gamma progressive appearance of MHC antigens within the rat nervous system. Am J Pathol 137:789-800.
    • (1990) Am J Pathol , vol.137 , pp. 789-800
    • Vass, K.1    Lassmann, H.2
  • 154
    • 0037062455 scopus 로고    scopus 로고
    • Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination
    • Von Büdingen HC, Hauser SL, Fuhrmann A, Nabavi CB, Lee JI, Genain CP. 2002. Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination. Proc Natl Acad Sci USA 99:8207-8212.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8207-8212
    • Von Büdingen, H.C.1    Hauser, S.L.2    Fuhrmann, A.3    Nabavi, C.B.4    Lee, J.I.5    Genain, C.P.6
  • 155
    • 83855163999 scopus 로고    scopus 로고
    • Pathogenic implications of iron accumulation in multiple sclerosis
    • Williams R, Buchheit CL, Berman NE, LeVine SM. 2012. Pathogenic implications of iron accumulation in multiple sclerosis. J Neurochem 120:7-25.
    • (2012) J Neurochem , vol.120 , pp. 7-25
    • Williams, R.1    Buchheit, C.L.2    Berman, N.E.3    LeVine, S.M.4
  • 156
    • 34548206670 scopus 로고    scopus 로고
    • Astrocytes-Friends or foes in multiple sclerosis?
    • Williams A, Piaton G, Lubetzki C. 2007a. Astrocytes-Friends or foes in multiple sclerosis? Glia 55:1300-1312.
    • (2007) Glia , vol.55 , pp. 1300-1312
    • Williams, A.1    Piaton, G.2    Lubetzki, C.3
  • 159
    • 0026643531 scopus 로고
    • Multiple sclerosis. Interactions between oligodendrocytes and hypertrophic astrocytes and their occurrence in other, #non demyelinating conditions
    • Wu E, Raine CS. 1992. Multiple sclerosis. Interactions between oligodendrocytes and hypertrophic astrocytes and their occurrence in other, #non demyelinating conditions. Lab Invest 67:88-99.
    • (1992) Lab Invest , vol.67 , pp. 88-99
    • Wu, E.1    Raine, C.S.2
  • 160
    • 0033962548 scopus 로고    scopus 로고
    • Oligodendrocyte survival, #loss and birth in lesions of chronic multiple sclerosis
    • Wolswijk G. 2000. Oligodendrocyte survival, #loss and birth in lesions of chronic multiple sclerosis. Brain 123:105-115.
    • (2000) Brain , vol.123 , pp. 105-115
    • Wolswijk, G.1
  • 162
    • 66949152122 scopus 로고    scopus 로고
    • Molecular changes in white matter adjacent to an active demyelinating lesion in early multiple sclerosis
    • Zeis T, Propst A, Steck AJ, Stadelmann C, Brück W, Schaeren-Wiemers N. 2009. Molecular changes in white matter adjacent to an active demyelinating lesion in early multiple sclerosis. Brain Pathol 19:459-466.
    • (2009) Brain Pathol , vol.19 , pp. 459-466
    • Zeis, T.1    Propst, A.2    Steck, A.J.3    Stadelmann, C.4    Brück, W.5    Schaeren-Wiemers, N.6
  • 163


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