Multiple sclerosis: A protective or a pathogenic role for heat shock protein 60 in the central nervous system?

Laboratory Investigation

Volumn 75, Issue 1, 1996, Pages 109-123

  Raine, Cedric S ^a   Wu, Elizabeth ^a   Ivanyi, Juraj ^b   Katz, David ^c   Brosnan, Celia F ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN;

ARTICLE; AUTOPSY; CENTRAL NERVOUS SYSTEM; DEMYELINATION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MULTIPLE SCLEROSIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; ASTROCYTES; BRAIN; BRAIN CHEMISTRY; CENTRAL NERVOUS SYSTEM DISEASES; CHAPERONIN 60; CHRONIC DISEASE; FEMALE; HUMANS; MALE; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; MULTIPLE SCLEROSIS; OLIGODENDROGLIA; ORGANELLES; UP-REGULATION;

EID: 0030016525     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Allegretta M, Nicklas JA, Sriram S, and Albertini RJ (1990). T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 247:718-721.
2. Aquino DA, Klipfel AA, Brosnan CF, and Norton WT (1993). The 70kDa heat shock cognate protein is a major constituent of the central nervous system and is upregulated only at the mRNA level in acute experimental autoimmune encephalomyelitis. J Neurochem 61:1340-1348.
3. Birnbaum G, Kotinilek L, and Albrecht L (1993). Spinal fluid lymphocytes from a subgroup of multiple sclerosis patients respond to mycobacterial antigens. Ann Neurol 34:18-24.
4. Birnbaum G, Kotinilek L, Schleivert P, Clark HB, Trotter J, and Braun E (1994). Immunologic cross-reactivity between a mycobacterial heat shock protein and the myelin protein 2′ 3′ cyclic nucleotide 3′ phosphodiesterase (abstract). Neurology 44(Suppl 2):82.
5. Born W, Happ MP, and Dallas A (1990). Recognition of heat shock proteins and γδ T cell function. Immunol Today 11:40-43.
6. Cannella B and Raine CS (1995). The adhesion molecule/cytokine profile of multiple sclerosis lesions. Ann Neurol 37:424-435.
7. Capello E, Voskhul R, McFarland HF, and Raine CS (1995). A novel candidate antigen, X2 MBP, in multiple sclerosis (MS) lesions (abstract). J Neuropath Exp Neurol 54:464A.
8. Cohen IR (1991). Autoimmunity to chaperonins in the pathogenesis of authoritis and diabetes. Annu Rev Immunol 9:567-589.
9. Cross AH, Touhy VK, and Raine CS (1993). Development of reactivity to new myelin antigens during chronic relapsing autoimmune demyelination. Cell Immunol 146:261-269.
10. D'Souza SD, Antel JP, and Freedman MS (1994). Cytokine induction of heat shock protein expression in human oligodendrocytes: An interleukin-1-mediated mechanism. J Neuroimmunol 50:17-24.
11. Evans DJ, Norton P, and Ivanyi J (1990). Distribution in tissue sections of the human groEL stress-protein homologue. APMIS 98:437-441.
12. Fallis RJ, Raine CS, and McFarlin DE (1989). Chronic relapsing experimental allergic encephalomyelitis in SJL mice following the adoptive transfer of an epitope-specific T-cell line. J Neuroimmunol 22:93-106.
13. Freedman MS, Buu NN, Fuijs TCG, Williams K, and Antel JP (1992). Differential expression of heat shock proteins by human glial cells. J Neuroimmunol 41:231-238.
14. Fritz RB and Zhao ML (1994). Encephalitogencity of myelin basic protein exon-2 peptide in mice. J Neuroimmunol 51: 1-6.
15. Gao YL, Brosnan CF, and Raine CS (1995). Experimental autoimmune encephalomyelitis: Qualitative and semi-quantitative differences in heat shock protein 60 expression in the central nervous system. J Immunol 154:3548-3556.
16. Gao YL, Raine CS, and Brosnan CF (1994). Humoral response to hsp-65 in multiple sclerosis and other neurological conditions. Neurology 44:941-946.
17. Hofman FM, Hinton DR, Johnson K, and Merrill JE (1989). Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med 170:607-612.
18. Holoshitz J (1990). Potential role of γδ T cells in autoimmune diseases. Res Immunol 141:651-657.
19. Ivanyi L and Ivanyi J (1990). Elevated antibody levels to mycobacterial 65-kDa stress protein in patients with superficial candidiasis. J Infect Dis 162:519-522.
20. Ivanyi J, Sharp K, Jackett P, and Bothamley G (1988). Immunologic study of the defined constituents of mycobacteria. Springer Sem Immunopathol 10:279-299.
21. Ivanyi J, Sinha S, Aston R, Cussell D, Keen M, and Sengupta U (1983). Definition of species-specific and antigenic determinants of Mycobacterium leprae using monoclonal antibodies. Clin Exp Immunol 52:528-536.
22. Jäättelä M, Saksela K, and Saksela E (1989). Heat shock protects WEHI-164 target cells from the cytolysis by tumor necrosis factor α. Eur J Immunol, 19:1413-1417.
23. Jäättela M and Wissing D (1993). Heat shock proteins protect cells from monocyte cytoxicity: Possible mechanisms of self-protection. J Exp Med 177:231-236.
24. Janeway CA, Jones B, and Hayday A (1988). Specificity and function of T cells bearing γδ receptors. Immunol Today 9:73-76.
25. Jones DB, Coulson AFW, and Duff GW (1993). Sequence homologies between hsp60 and autoantigens. Immunol Today 14:115-118.
26. Katz D, Taubenberger JK, Canella B, McFarlin DE, Raine CS, and McFarland HF (1993). Correlation between MRI findings and lesion development in chronic active multiple sclerosis. Ann Neurol 34:661-669.
27. Kaufmann SH (1994). Heat shock proteins and autoimmunity: A critical appraisal. Int Arch All Immunol 130:317-322.
28. Kaur I, Voss SD, Gupta RS, Schell K, Fisch P, and Sondel PM (1993). Human peripheral gamma-delta T cells recognize hsp60 molecules on Daudi Burkitt's lymphoma cells. J Immunol 150:2046-2055.
29. Lee SC, Moore GRW, Golenskwy G, and Raine CS (1990). A role for astroglia in active demyelination suggested by class II MHC expression and ultrastructural study. J Neuropathol Exp Neurol 49:122-136.
30. Martin JE, Swash M, Mather K, and Leigh PN (1993). Expression of the human groEL stress-protein homologue in the brain and spinal cord. J Neurol Sci 118:202-206.
31. Miller SD and WJ Karpus (1994). The immunopathogenesis and regulation of T cell-mediated demyelinating diseases. Immunol Today 15:356-360.
32. O'Brien RL, Happ MP, Dallas A, Palmer E, Kubo R, and Born W (1989). Stimulation of a major subset of lymphocytes expressing T cell receptor 78 by an antigen from Mycobacterium tuberculosis. Cell 57:667-674.
33. Prabhakar S, Kurien E, Gupta RS, Zielinski S, and Freedman MS (1994). Heat shock protein immunoreactivity in CSF: Correlation with oligoclonal banding and demyelinating disease. Neurology 44:1644-1668.
34. Prineas J (1985). The neuropathology of multiple sclerosis. In: Koetsier JC, editor. Handbook of clinical neurology. Vol 3(47). Demyelinating diseases. Amsterdam: Elsevier, 213-257.
35. Prineas JW, Kwon EE, Goldenberg PZ, Cho ES, and Sharer LR (1990). Interaction of astrocytes and newly formed oligodendrocytes in resolving multiple sclerosis lesions. Lab Invest 63:624-636.
36. Prineas JW, Kwon EE, Goldenberg PZ, Ilyas AA, Quarles RH, Benjamins JA, and Sprinkle TJ (1989). Multiple sclerosis: Oligodendrocyte proliferation and differentiation in fresh lesions. Lab Invest 61:489-503.
37. Raine CS (1984). Biology of disease: The analysis of autoimmune demyelination - Its impact upon multiple sclerosis. Lab Invest 50:608-635.
38. Raine CS (1990). Demyelinating diseases. In: Davis RL and Robertson DM, editors. Textbook of neuropathology, 2nd ed. Baltimore: Williams and Wilkins, 535-620 Raine CS (1994). The Dale E. McFarlin Memorial Lecture: The immunology of the multiple sclerosis lesion. Ann Neurol 36:561-572.
39. Raine CS (1990). Demyelinating diseases. In: Davis RL and Robertson DM, editors. Textbook of neuropathology, 2nd ed. Baltimore: Williams and Wilkins, 535-620 Raine CS (1994). The Dale E. McFarlin Memorial Lecture: The immunology of the multiple sclerosis lesion. Ann Neurol 36:561-572.
40. Raine CS and Scheinberg LC (1988). On the immunopathology of plaque development and repair in multiple sclerosis. J Neuroimmunol 20:189-201.
41. Raine CS, Scheinberg LC, and Waltz JM (1981). Multiple sclerosis: Oligodendrocyte survival and proliferation in an active, established lesion. Lab Invest 45:534-546.
42. Raine CS, Wu E, and Brosnan CF (1994). The immunologic response of the oligodendrocyte in the active multiple sclerosis lesion. In: Salvati S, editor. A multidisciplinary approach to myelin diseases. New York: Plenum Press, 143-151.
43. Ransohoff RM, Touhy V, and Lehman P (1994). The immunology of multiple sclerosis: New intricacies and insights. Curr Opin Neurol 7:242-249.
44. Salvetti M, Buttinelli C, Ristori G, Carbonari M, Cherchi M, Fiorello M, Grasso MG, Toma L, and Pozzilli C (1992). T lymphocyte reactivity to the recombinant mycobacterial 65-and 70-kDa heat shock proteins in multiple sclerosis. J Autoimmun 5:691-702.
45. Satoh J, Nomaguchi H, and Tabira T (1992a). Constitutive expression of 65-kDa heat shock protein (Hsp65)-like immunoreactivity in cultured mouse oligodendrocytes. Brain Res 595:281-290.
46. Satoh J, Yamamura T, Kunishita T, and Tabira T (1992b). Heterogeneous induction of a 72 kDa heat shock protein (HSP72) in cultured mouse oligodendrocytes and astrocytes. Brain Res 573:37-43.
47. Segal BM, Raine CS, McFarlin DE, Voskhul RR, and McFarland HF (1994). Experimental allergic encephalomyelitis induced by the peptide encoded by exon 2 of the MBP gene, a peptide implicated in remyelination. J Neuroimmunol 51:7-19.
48. + oligodendrocytes in multiple sclerosis. Proc Natl Acad Svi USA 88:6452-6456.
49. Selmaj K, Brosnan CF, and Raine CS (1992). Expression of heat shock protein-65 by oligodendrocytes in vivo and in vitro: Implications for multiple sclerosis. Neurology 42:795-800.
50. Selmaj K, Farooq M, Norton WT, Raine CS, and Brosnan CF (1990). Proliferation of astrocytes in vitro in response to cytokines: A primary role of tumor necrosis factor. J Immunol 144:129-135.
51. Selmaj K and Raine CS (1988). Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol 23:339-346.
52. Selmaj K, Raine CS, Cannella B, and Brosnan CF (1991b). Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 87:949-954.
53. Stinissen P, Vandevyer C, Medaer R, Vandegaer L, Nies J, Tuyls L, Hafler DA, Raus J, and Zhany J (1995). Increased frequency of γδ T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis: Reactivity, cytotoxicity, and T cell receptor V gene rearrangements. J Immunol 154:4883-4894.
54. Van Noort JM, van Sechel AC, Bajramoric JJ, el Ouagmiri M, Polman CH, Lassmann H, and Ravid R (1995). The small heat shock protein alpha-B crystallin as a candidate autoantigen in multiple sclerosis. Nature 375:798-801.
55. Voskuhl RR, McFarlin DE, Rhame L, Deibler G, Stone R, Maloni H, and McFarland HF (1993). A novel candidate autoantigen in a multiplex family with multiple sclerosis: Prevalence of T-lymphocytes specific for an MBP epitope unique to myelination. J Neuroimmunol 46:137-144.
56. Wu E and Raine CS (1992). Multiple sclerosis: Interactions between oligodendrocytes and hypertrophic astrocytes and their occurrence in other, non-demyelinating conditions. Lab Invest 67:88-99.
57. Wücherpfennig K, Newcombe J, Li H, Keddy C, Cuzner ML, and Hafler DA (1992). γδ T cell receptor repertoire in acute multiple sclerosis lesions. Proc Natl Acad Sci USA 89:4588-4592.
58. Young D, Roman E, Moreno C, O'Brien R, and Born W (1993). Molecular chaperones and the immune response (review). Phil Trans R Soc B 339:363-367.
59. Young RA (1990). Stress proteins and immunology. Annu Rev Immunol 8:401-420.