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Volumn 130, Issue 11, 2007, Pages 2800-2815

Lesion genesis in a subset of patients with multiple sclerosis: A role for innate immunity?

Author keywords

Fibrin; Innate immunity; Lesion development; Lipopolysaccharide; Microglial activation; Multiple sclerosis

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; FIBRIN; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; NITRIC OXIDE SYNTHASE;

EID: 35649018602     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awm236     Document Type: Article
Times cited : (267)

References (48)
  • 1
    • 0037226838 scopus 로고    scopus 로고
    • Preferential loss of myelin associated glycoprotein reflects hypoxialike white matter damage in stroke and inflammatory brain diseases
    • Aboul-Enein F, Rauschka H, Kornel B, Stadelmann C, Stefferl A, Brück W, et al. Preferential loss of myelin associated glycoprotein reflects hypoxialike white matter damage in stroke and inflammatory brain diseases. J Neuropath Exp Neurol 2003; 62: 25-33.
    • (2003) J Neuropath Exp Neurol , vol.62 , pp. 25-33
    • Aboul-Enein, F.1    Rauschka, H.2    Kornel, B.3    Stadelmann, C.4    Stefferl, A.5    Brück, W.6
  • 2
    • 33947363967 scopus 로고    scopus 로고
    • 377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
    • 377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med 2007; 204: 571-82.
    • (2007) J Exp Med , vol.204 , pp. 571-582
    • Adams, R.A.1    Bauer, J.2    Flick, M.J.3    Sikorski, S.4    Nuriel, T.5    Lassmann, H.6
  • 3
    • 2342570412 scopus 로고    scopus 로고
    • Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis
    • Akassoglou K, Adams RA, Bauer J, Mercado P, Tseveleki V, Lassmann H, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA 2004; 101: 6698-703.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6698-6703
    • Akassoglou, K.1    Adams, R.A.2    Bauer, J.3    Mercado, P.4    Tseveleki, V.5    Lassmann, H.6
  • 4
    • 0024109978 scopus 로고
    • Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen
    • Altieri DC, Bader R, Mannucci PM, Edgington TS. Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen. J Cell Biol 1988; 107: 1893-900.
    • (1988) J Cell Biol , vol.107 , pp. 1893-1900
    • Altieri, D.C.1    Bader, R.2    Mannucci, P.M.3    Edgington, T.S.4
  • 5
    • 0005900248 scopus 로고
    • Recherches sur l0anatomie pathologique de la sclerose en plaque et etude comparative des diverses varietes de la scleroses de la moelle
    • Babinski J. Recherches sur l0anatomie pathologique de la sclerose en plaque et etude comparative des diverses varietes de la scleroses de la moelle. Arch Physiol (Paris) 1885; 5-6: 186-207.
    • (1885) Arch Physiol (Paris)
    • Babinski, J.1
  • 6
    • 1642281535 scopus 로고    scopus 로고
    • Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
    • Barnett MH, Prineas JW. Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann Neurol 2004; 55: 458-68.
    • (2004) Ann Neurol , vol.55 , pp. 458-468
    • Barnett, M.H.1    Prineas, J.W.2
  • 7
    • 0033839757 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor 1 in hypoxia-induced ischemic tolerance in neonatal rat brain
    • Bergeron M, Gidday JM, Yu AY, et al. Role of hypoxia-inducible factor 1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol 2000; 48: 285-96.
    • (2000) Ann Neurol , vol.48 , pp. 285-296
    • Bergeron, M.1    Gidday, J.M.2    Yu, A.Y.3
  • 8
    • 0037131170 scopus 로고    scopus 로고
    • Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance
    • Bernaudin M, Tang Y, Reilly M, et al. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J Biol Chem 2002; 277: 39728-38.
    • (2002) J Biol Chem , vol.277 , pp. 39728-39738
    • Bernaudin, M.1    Tang, Y.2    Reilly, M.3
  • 9
    • 0036198111 scopus 로고    scopus 로고
    • Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in Rasmussen's encephalitis
    • Bien CG, Bauer J, Deckwerth TL, Wiendl H, Deckert M, Wiestler OD, et al. Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis. Ann Neurol 2002; 51: 311-8.
    • (2002) Ann Neurol , vol.51 , pp. 311-318
    • Bien, C.G.1    Bauer, J.2    Deckwerth, T.L.3    Wiendl, H.4    Deckert, M.5    Wiestler, O.D.6
  • 10
    • 0033031925 scopus 로고    scopus 로고
    • Lesion development in Marburg's type of acute multiple sclerosis: From inflammation to demyelination
    • Bitsch A, Wegener C, da Costa C, Bunkowski S, Reimers CD, Prange HW, et al. Lesion development in Marburg's type of acute multiple sclerosis: from inflammation to demyelination. Mult Scler 1999; 5: 138-46.
    • (1999) Mult Scler , vol.5 , pp. 138-146
    • Bitsch, A.1    Wegener, C.2    da Costa, C.3    Bunkowski, S.4    Reimers, C.D.5    Prange, H.W.6
  • 11
    • 0021079164 scopus 로고
    • Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis
    • Booss J, Esiri MM, Tourtellotte WW, Mason DY. Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. J Neurol Sci 1983; 62: 219-32.
    • (1983) J Neurol Sci , vol.62 , pp. 219-232
    • Booss, J.1    Esiri, M.M.2    Tourtellotte, W.W.3    Mason, D.Y.4
  • 12
    • 0037782137 scopus 로고    scopus 로고
    • Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord
    • Buss A, Schwab ME. Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord. Glia 2003; 42: 424-32.
    • (2003) Glia , vol.42 , pp. 424-432
    • Buss, A.1    Schwab, M.E.2
  • 13
    • 0036160052 scopus 로고    scopus 로고
    • Heat shock factor-1 and heat shock proteins: Critical partners in protection against acute cell injury
    • Christians ES, Yan LJ, Benjamin IJ. Heat shock factor-1 and heat shock proteins: critical partners in protection against acute cell injury. Crit Care Med 2002; 30: S43-50.
    • (2002) Crit Care Med , vol.30
    • Christians, E.S.1    Yan, L.J.2    Benjamin, I.J.3
  • 14
    • 84974201150 scopus 로고
    • The histology of disseminated sclerosis
    • Dawson JW. The histology of disseminated sclerosis. Trans R Soc 1916; 50: 517-40.
    • (1916) Trans R Soc , vol.50 , pp. 517-540
    • Dawson, J.W.1
  • 15
    • 0034906715 scopus 로고    scopus 로고
    • Post-mortem MRI-guided sampling of multiple sclerosis brain lesions. Increased yield of active demyelinating and (p)reactive lesions
    • De Groot CJA, Bergers E, Kamphorst W, Ravid R, Polman F, Barkhof F, et al. Post-mortem MRI-guided sampling of multiple sclerosis brain lesions. Increased yield of active demyelinating and (p)reactive lesions. Brain 2001; 124: 1635-45.
    • (2001) Brain , vol.124 , pp. 1635-1645
    • De Groot, C.J.A.1    Bergers, E.2    Kamphorst, W.3    Ravid, R.4    Polman, F.5    Barkhof, F.6
  • 16
    • 0037070630 scopus 로고    scopus 로고
    • The allograft inflammatory factor-1 family of proteins
    • Deininger MH, Meyermann R, Schlüsener HJ. The allograft inflammatory factor-1 family of proteins. FEBS Lett 2002; 514: 115-21.
    • (2002) FEBS Lett , vol.514 , pp. 115-121
    • Deininger, M.H.1    Meyermann, R.2    Schlüsener, H.J.3
  • 17
    • 0021917632 scopus 로고
    • Generation and characterization of mouse monoclonal antibodies to myelin associated glycoprotein (MAG)
    • Dobersen MJ, Hammer JA, Noronha AB, et al. Generation and characterization of mouse monoclonal antibodies to myelin associated glycoprotein (MAG). Neurochem Res 1985; 10: 499-513.
    • (1985) Neurochem Res , vol.10 , pp. 499-513
    • Dobersen, M.J.1    Hammer, J.A.2    Noronha, A.B.3
  • 18
    • 34347347039 scopus 로고    scopus 로고
    • Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin
    • El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett 2007; 31: 36-44.
    • (2007) Immunol Lett , vol.31 , pp. 36-44
    • El Mezayen, R.1    El Gazzar, M.2    Seeds, M.C.3    McCall, C.E.4    Dreskin, S.C.5    Nicolls, M.R.6
  • 19
    • 0023585086 scopus 로고
    • Macrophage populations associated with multiple sclerosis plaques
    • Esiri MM, Reading MC. Macrophage populations associated with multiple sclerosis plaques. Neuropathol Appl Neurobiol 1987; 13: 451-65.
    • (1987) Neuropathol Appl Neurobiol , vol.13 , pp. 451-465
    • Esiri, M.M.1    Reading, M.C.2
  • 20
    • 21944442728 scopus 로고    scopus 로고
    • Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide
    • Felts PA, Woolston AM, Fernando HB, Asquith S, Gregson NA, Mizzi OJ, et al. Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide. Brain 2005; 128: 1649-66.
    • (2005) Brain , vol.128 , pp. 1649-1666
    • Felts, P.A.1    Woolston, A.M.2    Fernando, H.B.3    Asquith, S.4    Gregson, N.A.5    Mizzi, O.J.6
  • 21
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • Ferguson B, Matyszak MK, Esiri MM, Perry VH. Axonal damage in acute multiple sclerosis lesions. Brain 1997; 120: 393-9.
    • (1997) Brain , vol.120 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3    Perry, V.H.4
  • 22
    • 0031839220 scopus 로고    scopus 로고
    • Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis
    • Filippi M, Rocca MA, Martino G, Horsfield MA, Comi G. Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis. Ann Neurol 1998; 43: 809-14.
    • (1998) Ann Neurol , vol.43 , pp. 809-814
    • Filippi, M.1    Rocca, M.A.2    Martino, G.3    Horsfield, M.A.4    Comi, G.5
  • 23
    • 85047691114 scopus 로고    scopus 로고
    • Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo
    • Flick MJ, Du X, Witte DP, Jirouskova DA, Busuttil SJ, Plow EF, et al. Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo. J Clin Invest 2004; 113: 1596-606.
    • (2004) J Clin Invest , vol.113 , pp. 1596-1606
    • Flick, M.J.1    Du, X.2    Witte, D.P.3    Jirouskova, D.A.4    Busuttil, S.J.5    Plow, E.F.6
  • 24
    • 1842367972 scopus 로고    scopus 로고
    • The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis: Identification and characterization of the primary demyelinating lesion
    • Gay FW, Drye GW, Dick GWA, Esiri MM. The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis: identification and characterization of the primary demyelinating lesion. Brain 1997; 120: 1461-83.
    • (1997) Brain , vol.120 , pp. 1461-1483
    • Gay, F.W.1    Drye, G.W.2    Dick, G.W.A.3    Esiri, M.M.4
  • 25
    • 0038157213 scopus 로고    scopus 로고
    • Impaired fibrinolysis in multiple sclerosis: A role for tissue plasminogen activator inhibitors
    • Gveric D, Herrera B, Petzold A, Lawrence DA, Cuzner ML. Impaired fibrinolysis in multiple sclerosis: a role for tissue plasminogen activator inhibitors. Brain 2003; 126: 1590-8.
    • (2003) Brain , vol.126 , pp. 1590-1598
    • Gveric, D.1    Herrera, B.2    Petzold, A.3    Lawrence, D.A.4    Cuzner, M.L.5
  • 26
    • 35648932322 scopus 로고    scopus 로고
    • TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: A critical role of IFN-beta as a decision maker
    • Jung DY, Lee H, Jung BY, Ock J, Lee WH, Suk K. TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol 2005; 164: 154-60.
    • (2005) J Immunol , vol.164 , pp. 154-160
    • Jung, D.Y.1    Lee, H.2    Jung, B.Y.3    Ock, J.4    Lee, W.H.5    Suk, K.6
  • 28
    • 0023931606 scopus 로고
    • Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating antibodies against a myelin oligodendrocyte glycoprotein
    • Linington C, Bradl M, Lassmann H, et al. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating antibodies against a myelin oligodendrocyte glycoprotein. Am J Pathol 1988; 130: 443-54.
    • (1988) Am J Pathol , vol.130 , pp. 443-454
    • Linington, C.1    Bradl, M.2    Lassmann, H.3
  • 29
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000; 47: 707-17.
    • (2000) Ann Neurol , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 31
    • 0000197889 scopus 로고
    • Die sogenannte "akute Multiple Sklerose". Jahrb
    • Marburg O. Die sogenannte "akute Multiple Sklerose". Jahrb Psychiatrie 1906; 27: 211-312.
    • (1906) Psychiatrie , vol.27 , pp. 211-312
    • Marburg, O.1
  • 32
    • 0031891884 scopus 로고    scopus 로고
    • Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis
    • Narayanan PA, Doyle TJ, Lai D, Wolinski JS. Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis. Ann Neurol 1998; 43: 56-71.
    • (1998) Ann Neurol , vol.43 , pp. 56-71
    • Narayanan, P.A.1    Doyle, T.J.2    Lai, D.3    Wolinski, J.S.4
  • 34
    • 0001612484 scopus 로고
    • The neuropathology of multiple sclerosis
    • Koetsier JC, editor, New York: Elsevier;
    • Prineas JW. The neuropathology of multiple sclerosis. In: Koetsier JC, editor. Handbook of clinical neurology, Vol. 47. New York: Elsevier; 1985; p. 337-95.
    • (1985) Handbook of clinical neurology , vol.47 , pp. 337-395
    • Prineas, J.W.1
  • 35
    • 0000138505 scopus 로고
    • Histologisches Detail zur grauen Degeneration von Gehirn und Rückenmark
    • Virchow
    • Rindfleisch E. Histologisches Detail zur grauen Degeneration von Gehirn und Rückenmark. Arch Pathol Anat Physiol Klin Med (Virchow) 1863; 26: 474-83.
    • (1863) Arch Pathol Anat Physiol Klin Med , vol.26 , pp. 474-483
    • Rindfleisch, E.1
  • 36
    • 0034910692 scopus 로고    scopus 로고
    • Bacterial petidoglycan and immune reactivity in the central nervous system in multiple sclerosis
    • Schrijver IA, van Meurs M, Melief M-J, Wim-Ang C, Bujevac D, Ravid R, et al. Bacterial petidoglycan and immune reactivity in the central nervous system in multiple sclerosis. Brain 2001; 124: 1544-54.
    • (2001) Brain , vol.124 , pp. 1544-1554
    • Schrijver, I.A.1    van Meurs, M.2    Melief, M.-J.3    Wim-Ang, C.4    Bujevac, D.5    Ravid, R.6
  • 38
    • 2642555563 scopus 로고    scopus 로고
    • HIF1 and oxygen sensing in the brain
    • Sharp FR, Bernaudin M. HIF1 and oxygen sensing in the brain. Nature Rev Neurosci 2004; 5: 437-48.
    • (2004) Nature Rev Neurosci , vol.5 , pp. 437-448
    • Sharp, F.R.1    Bernaudin, M.2
  • 39
    • 0034985945 scopus 로고    scopus 로고
    • Quantitative contrast-enhanced magnetic resonance imaging to evaluate blood-barin barrier integrity in multiple sclerosis. A preliminary study
    • Silver NC, Tofts PS, Symms MR, Barker GJ, Thompson AJ, Miller DH. Quantitative contrast-enhanced magnetic resonance imaging to evaluate blood-barin barrier integrity in multiple sclerosis. A preliminary study. Mult Scler 2001; 7: 75-82.
    • (2001) Mult Scler , vol.7 , pp. 75-82
    • Silver, N.C.1    Tofts, P.S.2    Symms, M.R.3    Barker, G.J.4    Thompson, A.J.5    Miller, D.H.6
  • 40
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    • Smiley ST, King JA, Hancock WW. Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 2001; 167: 2887-94.
    • (2001) J Immunol , vol.167 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 41
    • 18744394057 scopus 로고    scopus 로고
    • Tissue preconditioning may explain concentric lesions in Balo's type of multiple sclerosis
    • Stadelmann C, Ludwin S, Tabira T, Guseo A, Lucchinetti CF, Leel-Össy L, et al. Tissue preconditioning may explain concentric lesions in Balo's type of multiple sclerosis. Brain 2005; 128: 979-87.
    • (2005) Brain , vol.128 , pp. 979-987
    • Stadelmann, C.1    Ludwin, S.2    Tabira, T.3    Guseo, A.4    Lucchinetti, C.F.5    Leel-Össy, L.6
  • 42
    • 0025095531 scopus 로고
    • HLA-Aand HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy
    • Stam NJ, Vroom TM, Peters PJ, Pastoors EB, Ploegh HL. HLA-Aand HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy. Int Immunol 1990; 2: 113-25.
    • (1990) Int Immunol , vol.2 , pp. 113-125
    • Stam, N.J.1    Vroom, T.M.2    Peters, P.J.3    Pastoors, E.B.4    Ploegh, H.L.5
  • 43
    • 0031688565 scopus 로고    scopus 로고
    • Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology
    • Storch MK, Stefferl A, Brehm U, Weissert R, Wallström E, Kerschensteiner M, et al. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol 1998a; 8: 681-94.
    • (1998) Brain Pathol , vol.8 , pp. 681-694
    • Storch, M.K.1    Stefferl, A.2    Brehm, U.3    Weissert, R.4    Wallström, E.5    Kerschensteiner, M.6
  • 45
    • 0020962424 scopus 로고
    • Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages
    • Traugott U, Reinherz EL, Raine CS. Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages. J Neuroimmunol 1983; 4: 201-21.
    • (1983) J Neuroimmunol , vol.4 , pp. 201-221
    • Traugott, U.1    Reinherz, E.L.2    Raine, C.S.3
  • 46
    • 19944427519 scopus 로고    scopus 로고
    • Proinflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease
    • Visser L, Jan de Heer H, Boven LA, van Riet D, van Meurs M, Melief MJ, et al. Proinflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease. J Immunol 2005; 174: 808-16.
    • (2005) J Immunol , vol.174 , pp. 808-816
    • Visser, L.1    Jan de Heer, H.2    Boven, L.A.3    van Riet, D.4    van Meurs, M.5    Melief, M.J.6
  • 47
    • 33847786702 scopus 로고    scopus 로고
    • Up-regulation of human monocyte CD163 upon activation of cell surface Toll.like receptors
    • Weaver LK, Pioli PA, Wardwell K, Vogel SN, Guyre PM. Up-regulation of human monocyte CD163 upon activation of cell surface Toll.like receptors. J Leukocyte Biol 2007; 81: 663-71.
    • (2007) J Leukocyte Biol , vol.81 , pp. 663-671
    • Weaver, L.K.1    Pioli, P.A.2    Wardwell, K.3    Vogel, S.N.4    Guyre, P.M.5
  • 48
    • 0346097881 scopus 로고    scopus 로고
    • Changes in cerebral perfusion precede plaque formation in multiple sclerosis: A longitudinal perfusion MRI study
    • Wuerfel J, Bellmann-Strobl J, Brunecker P, Aktas O, McFarland H, Villringer A, et al. Changes in cerebral perfusion precede plaque formation in multiple sclerosis: a longitudinal perfusion MRI study. Brain 2004; 127: 111-9.
    • (2004) Brain , vol.127 , pp. 111-119
    • Wuerfel, J.1    Bellmann-Strobl, J.2    Brunecker, P.3    Aktas, O.4    McFarland, H.5    Villringer, A.6


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