Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology

Chemosphere

Volumn 120, Issue , 2015, Pages 764-777

  Groh, Ksenia J ^a,b   Carvalho, Raquel N ^c   Chipman, James K ^d   Denslow, Nancy D ^e   Halder, Marlies ^c   Murphy, Cheryl A ^f   Roelofs, Dick ^g   Rolaki, Alexandra ^c   Schirmer, Kristin ^a,b,h   Watanabe, Karen H ⁱ  

^a SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c JOINT RESEARCH CENTRE   (Italy)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e UNIVERSITY OF FLORIDA   (United States)

^f MICHIGAN STATE UNIVERSITY   (United States)

^g VU UNIVERSITY AMSTERDAM   (Netherlands)

^h EPFL   (Switzerland)

ⁱ OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Adverse outcome pathway (AOP); Chronic toxicity; Cross species extrapolation; Ecotoxicological risk assessment; Extrapolation from individual to population; Toxicokinetics

Indexed keywords

COMPUTATION THEORY; ECOLOGY; EXTRAPOLATION; TOXICITY; WELL TESTING;

ADVERSE OUTCOMES; CHRONIC TOXICITY; CROSS-SPECIES; ECOTOXICOLOGICAL RISK ASSESSMENT; TOXICOKINETICS;

RISK ASSESSMENT;

ECOTOXICOLOGY; FITNESS; MOLECULAR ANALYSIS; NUMERICAL MODEL; RISK ASSESSMENT; SUBLETHAL EFFECT;

ADVERSE OUTCOME; CHEMICAL STRESS; CHRONIC TOXICITY; ECOTOXICOLOGY; ENVIRONMENTAL EXPOSURE; EVOLUTIONARY ADAPTATION; GENE EXPRESSION; GENE SILENCING; HAZARD ASSESSMENT; HUMAN; NONHUMAN; PRACTICE GUIDELINE; REVIEW; RISK ASSESSMENT; STEROIDOGENESIS; TOXICITY TESTING; TOXICOKINETICS; TRANSCRIPTION INITIATION; ADVERSE EFFECTS; ANIMAL; DRUG EFFECTS; ENVIRONMENT; GENETIC EPIGENESIS; POLLUTANT; PROCEDURES; RESEARCH; SPECIES DIFFERENCE; TRENDS;

POLLUTANT;

ANIMALS; ECOTOXICOLOGY; ENVIRONMENT; ENVIRONMENTAL POLLUTANTS; EPIGENESIS, GENETIC; HUMANS; RESEARCH; RISK ASSESSMENT; SPECIES SPECIFICITY; TOXICITY TESTS, CHRONIC;

EID: 84912116063     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2014.09.068     Document Type: Review

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