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Volumn 313, Issue 2-3, 2013, Pages 73-82

Tools and perspectives for assessing chemical mixtures and multiple stressors

Author keywords

Chemical mixtures; Cumulative risk assessment; Dynamic energy budget; Natural stressors; NoMiracle; Toxicity

Indexed keywords

AQUATIC ENVIRONMENT; ARTICLE; BUDGET; CLIMATE CHANGE; COMPUTER SYSTEM; DATA BASE; DRUG MIXTURE; ECOTOXICOLOGY; ENVIRONMENTAL FACTOR; HUMAN; MICROCLIMATE; NOMIRACLE; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; TOXICOKINETICS; ANIMAL; BIOASSAY; BIOLOGICAL MODEL; CHEMICAL MIXTURES; CHEMISTRY; CUMULATIVE RISK ASSESSMENT; DYNAMIC ENERGY BUDGET; ENVIRONMENTAL EXPOSURE; EUROPE; GOVERNMENT REGULATION; LEGAL ASPECT; METHODOLOGY; NATURAL STRESSORS; POLLUTANT; PREDICTIVE VALUE; REVIEW; TOXICITY; TOXICITY TESTING; UNITED STATES; ANALYSIS; LEGISLATION AND JURISPRUDENCE; PROCEDURES;

EID: 84886746045     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.11.009     Document Type: Article
Times cited : (62)

References (106)
  • 1
    • 0026443886 scopus 로고
    • Regulation of the cytochrome P450 enzyme system in fish
    • Andersson T., Förlin L. Regulation of the cytochrome P450 enzyme system in fish. Aquat. Toxicol. 1992, 24:1-19.
    • (1992) Aquat. Toxicol. , vol.24 , pp. 1-19
    • Andersson, T.1    Förlin, L.2
  • 2
    • 0033635575 scopus 로고    scopus 로고
    • Predictability of the toxicity of multiple chemical mixtures to Vibrio fischeri: mixtures composed of similarly acting chemicals
    • Altenburger R., Backhaus T., Boedeker W., Faust M., Scholze M., Grimme L.H. Predictability of the toxicity of multiple chemical mixtures to Vibrio fischeri: mixtures composed of similarly acting chemicals. Environ. Toxicol. Chem. 2000, 19:2341-2347.
    • (2000) Environ. Toxicol. Chem. , vol.19 , pp. 2341-2347
    • Altenburger, R.1    Backhaus, T.2    Boedeker, W.3    Faust, M.4    Scholze, M.5    Grimme, L.H.6
  • 3
    • 0011865905 scopus 로고    scopus 로고
    • ATSDR (Agency for Toxic Substances and Disease Registry), US Department of Health and Human Services, Atlanta
    • ATSDR (Agency for Toxic Substances and Disease Registry) Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures 2004, US Department of Health and Human Services, Atlanta.
    • (2004) Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures
  • 4
    • 59149096526 scopus 로고    scopus 로고
    • A model to analyze effects of complex mixtures on survival
    • Baas J., Jager T., Kooijman S. A model to analyze effects of complex mixtures on survival. Ecotoxicol. Environ. Saf. 2009, 72:669-676.
    • (2009) Ecotoxicol. Environ. Saf. , vol.72 , pp. 669-676
    • Baas, J.1    Jager, T.2    Kooijman, S.3
  • 5
    • 77955053852 scopus 로고    scopus 로고
    • A review of DEB theory in assessing toxic effects of mixtures
    • Baas J., Jager T., Kooijman S. A review of DEB theory in assessing toxic effects of mixtures. Sci. Total Environ. 2010, 408:3740-3745.
    • (2010) Sci. Total Environ. , vol.408 , pp. 3740-3745
    • Baas, J.1    Jager, T.2    Kooijman, S.3
  • 6
    • 77955057258 scopus 로고    scopus 로고
    • Understanding toxicity as processes in time
    • Baas J., Jager T., Kooijman S. Understanding toxicity as processes in time. Sci. Total Environ. 2010, 408:3735-3739.
    • (2010) Sci. Total Environ. , vol.408 , pp. 3735-3739
    • Baas, J.1    Jager, T.2    Kooijman, S.3
  • 7
    • 74249094241 scopus 로고    scopus 로고
    • Model-based experimental design for assessing effects of mixtures of chemicals
    • Baas J., Stefanowicz A.M., Klimek B., Laskowski R., Kooijman S. Model-based experimental design for assessing effects of mixtures of chemicals. Environ. Pollut. 2010, 158:115-120.
    • (2010) Environ. Pollut. , vol.158 , pp. 115-120
    • Baas, J.1    Stefanowicz, A.M.2    Klimek, B.3    Laskowski, R.4    Kooijman, S.5
  • 10
    • 0033636825 scopus 로고    scopus 로고
    • Predictability of the toxicity of a multiple mixture of dissimilarly acting chemicals to Vibrio fischeri
    • Backhaus T., Altenburger R., Boedeker W., Faust M., Scholze M., Grimme L.H. Predictability of the toxicity of a multiple mixture of dissimilarly acting chemicals to Vibrio fischeri. Environ. Toxicol. Chem. 2000, 19:2348-2356.
    • (2000) Environ. Toxicol. Chem. , vol.19 , pp. 2348-2356
    • Backhaus, T.1    Altenburger, R.2    Boedeker, W.3    Faust, M.4    Scholze, M.5    Grimme, L.H.6
  • 11
    • 67650483694 scopus 로고    scopus 로고
    • Changes in membrane phospholipids as a mechanistic explanation for decreased freeze tolerance in earthworms exposed to sublethal copper concentrations
    • Bindesbøl A.M., Bayley M., Damgaard C., Hedlund K., Holmstrup M. Changes in membrane phospholipids as a mechanistic explanation for decreased freeze tolerance in earthworms exposed to sublethal copper concentrations. Environ. Sci. Technol. 2009, 43:5495-5500.
    • (2009) Environ. Sci. Technol. , vol.43 , pp. 5495-5500
    • Bindesbøl, A.M.1    Bayley, M.2    Damgaard, C.3    Hedlund, K.4    Holmstrup, M.5
  • 12
    • 18844461226 scopus 로고    scopus 로고
    • Stress synergy between environmentally realistic levels of copper and frost in the earthworm Dendrobaena octaedra
    • Bindesbøl A.M., Holmstrup M., Damgaard C., Bayley M. Stress synergy between environmentally realistic levels of copper and frost in the earthworm Dendrobaena octaedra. Environ. Toxicol. Chem. 2005, 24:1462-1467.
    • (2005) Environ. Toxicol. Chem. , vol.24 , pp. 1462-1467
    • Bindesbøl, A.M.1    Holmstrup, M.2    Damgaard, C.3    Bayley, M.4
  • 14
    • 1842587397 scopus 로고    scopus 로고
    • Environmental causes of human congenital malformations: the pediatrician's role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factors
    • Brent R.L. Environmental causes of human congenital malformations: the pediatrician's role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factors. Pediatrics 2004, 113:957-968.
    • (2004) Pediatrics , vol.113 , pp. 957-968
    • Brent, R.L.1
  • 15
    • 34249035531 scopus 로고    scopus 로고
    • If cumulative risk assessment is the answer, what is the question?
    • Callahan M., Sexton K. If cumulative risk assessment is the answer, what is the question?. Environ. Health Perspect. 2007, 115:799-806.
    • (2007) Environ. Health Perspect. , vol.115 , pp. 799-806
    • Callahan, M.1    Sexton, K.2
  • 16
    • 46949088342 scopus 로고    scopus 로고
    • A review of independent action compared to concentration addition as reference models for mixtures of compounds with different molecular target sites
    • Cedergreen N., Christensen A.M., Kamper A., Kudsk P., Mathiassen S.K., Streibig J.C., Sorensen H. A review of independent action compared to concentration addition as reference models for mixtures of compounds with different molecular target sites. Environ. Toxicol. Chem. 2008, 27:1621-1632.
    • (2008) Environ. Toxicol. Chem. , vol.27 , pp. 1621-1632
    • Cedergreen, N.1    Christensen, A.M.2    Kamper, A.3    Kudsk, P.4    Mathiassen, S.K.5    Streibig, J.C.6    Sorensen, H.7
  • 17
    • 33748117147 scopus 로고    scopus 로고
    • Fertility, family planning, and reproductive health of U.S. women: data from the 2002 National Survey of Family Growth. National Center for Health Statistics
    • Chandra A., Martinez G.M., Mosher W.D., Abma J.C., Jones J. Fertility, family planning, and reproductive health of U.S. women: data from the 2002 National Survey of Family Growth. National Center for Health Statistics. Vital Health Stat. 2005, 23:175.
    • (2005) Vital Health Stat. , vol.23 , pp. 175
    • Chandra, A.1    Martinez, G.M.2    Mosher, W.D.3    Abma, J.C.4    Jones, J.5
  • 18
    • 0023866380 scopus 로고
    • The joint acute toxicity to Daphnia magna of industrial organic-chemicals at low concentrations
    • Deneer J.W., Sinnige T.L., Seinen W., Hermens J.L.M. The joint acute toxicity to Daphnia magna of industrial organic-chemicals at low concentrations. Aquat. Toxicol. 1988, 12:33-38.
    • (1988) Aquat. Toxicol. , vol.12 , pp. 33-38
    • Deneer, J.W.1    Sinnige, T.L.2    Seinen, W.3    Hermens, J.L.M.4
  • 19
    • 0023824242 scopus 로고
    • Growth of Daphnia magna exposed to mixtures of chemicals with diverse modes of action
    • Deneer J.W., Seinen W., Hermens J.L.M. Growth of Daphnia magna exposed to mixtures of chemicals with diverse modes of action. Ecotoxicol. Environ. Saf. 1988, 15:72-77.
    • (1988) Ecotoxicol. Environ. Saf. , vol.15 , pp. 72-77
    • Deneer, J.W.1    Seinen, W.2    Hermens, J.L.M.3
  • 22
    • 77955054540 scopus 로고    scopus 로고
    • Transcriptomic and proteomic effects of a neonicotinoid insecticide mixture in the marine mussel (Mytilus galloprovincialis, Lam.)
    • Dondero F., Negri A., Boatti L., Marsano F., Mignone F., Viarengo A. Transcriptomic and proteomic effects of a neonicotinoid insecticide mixture in the marine mussel (Mytilus galloprovincialis, Lam.). Sci. Total Environ. 2010, 408:3775-3786.
    • (2010) Sci. Total Environ. , vol.408 , pp. 3775-3786
    • Dondero, F.1    Negri, A.2    Boatti, L.3    Marsano, F.4    Mignone, F.5    Viarengo, A.6
  • 23
    • 34547894707 scopus 로고    scopus 로고
    • Human variability in hepatic and renal elimination: implications for risk assessment
    • Dorne J.L.C.M. Human variability in hepatic and renal elimination: implications for risk assessment. J. Appl. Toxicol. 2007, 27:411-420.
    • (2007) J. Appl. Toxicol. , vol.27 , pp. 411-420
    • Dorne, J.L.C.M.1
  • 24
    • 76749136222 scopus 로고    scopus 로고
    • Metabolism, variability and risk assessment
    • Dorne J.L.C.M. Metabolism, variability and risk assessment. Toxicology 2010, 268:156-164.
    • (2010) Toxicology , vol.268 , pp. 156-164
    • Dorne, J.L.C.M.1
  • 25
    • 0037970516 scopus 로고    scopus 로고
    • Mixture toxicity of s-triazines to Lemna minor under conditions of simultaneous and sequential exposure
    • Drost W., Backhaus T., Vassilakaki M., Grimme L.H. Mixture toxicity of s-triazines to Lemna minor under conditions of simultaneous and sequential exposure. Fresen. Environ. Bull. 2003, 12:601-607.
    • (2003) Fresen. Environ. Bull. , vol.12 , pp. 601-607
    • Drost, W.1    Backhaus, T.2    Vassilakaki, M.3    Grimme, L.H.4
  • 26
    • 84888290451 scopus 로고    scopus 로고
    • European Scientific Committees. Toxicity and Assessment of Chemical Mixtures - (Preliminary Opinion Approved for Public Consultation. Scientific Committee on Consumer Safety (SCCS), Scientific Committee on Health and Environmental Risks (SCHER), Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR)), DG Health & Consumers, Directorate D: Health Systems and Products, Unit D5 - Risk Assessment, Brussels (accessed 07.01.12).
    • European Scientific Committees, 2011. Toxicity and Assessment of Chemical Mixtures - (Preliminary Opinion Approved for Public Consultation. Scientific Committee on Consumer Safety (SCCS), Scientific Committee on Health and Environmental Risks (SCHER), Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR)), DG Health & Consumers, Directorate D: Health Systems and Products, Unit D5 - Risk Assessment, Brussels (accessed 07.01.12). http://ec.europa.eu/health/scientific_committees/consultations/public_consultations/scher_consultation_06_en.htm.
    • (2011)
  • 31
    • 54149096703 scopus 로고    scopus 로고
    • The measurement and modelling of mixture toxicity of imidacloprid and thiacloprid on the soil dwelling nematode Caenorhabditis elegans and the earthworm Eisenia fetida
    • Gomezeyles J., Svendsen C., Lister L.J., Spurgeon D.J. The measurement and modelling of mixture toxicity of imidacloprid and thiacloprid on the soil dwelling nematode Caenorhabditis elegans and the earthworm Eisenia fetida. Ecotoxicol. Environ. Saf. 2009, 72:71-79.
    • (2009) Ecotoxicol. Environ. Saf. , vol.72 , pp. 71-79
    • Gomezeyles, J.1    Svendsen, C.2    Lister, L.J.3    Spurgeon, D.J.4
  • 32
    • 0037404099 scopus 로고    scopus 로고
    • Role of environmental stress in the physiological response to chemical toxicants
    • Gordon C.J. Role of environmental stress in the physiological response to chemical toxicants. Environ. Res. 2001, 92:1-7.
    • (2001) Environ. Res. , vol.92 , pp. 1-7
    • Gordon, C.J.1
  • 34
    • 0000963803 scopus 로고
    • Quantitative structure activity relationships in aquatic toxicity studies of chemicals and complex-mixtures of chemicals
    • Hermens J., Konemann H., Leeuwangh P., Musch A. Quantitative structure activity relationships in aquatic toxicity studies of chemicals and complex-mixtures of chemicals. Environ. Toxicol. Chem. 1985, 4:273-279.
    • (1985) Environ. Toxicol. Chem. , vol.4 , pp. 273-279
    • Hermens, J.1    Konemann, H.2    Leeuwangh, P.3    Musch, A.4
  • 35
    • 0034967666 scopus 로고    scopus 로고
    • A review of the effects of multiple stressors on aquatic organisms and analysis of uncertainty factors for use in risk assessment
    • Heugens E.H.W., Hendriks A.J., Dekker T., Van Straalen N.M., Admiraal W. A review of the effects of multiple stressors on aquatic organisms and analysis of uncertainty factors for use in risk assessment. Crit. Rev. Toxicol. 2001, 31:247-284.
    • (2001) Crit. Rev. Toxicol. , vol.31 , pp. 247-284
    • Heugens, E.H.W.1    Hendriks, A.J.2    Dekker, T.3    Van Straalen, N.M.4    Admiraal, W.5
  • 37
    • 0034997246 scopus 로고    scopus 로고
    • Stress synergy between drought and a common environmental contaminant: studies with the collembolan Folsomia candida
    • Højer R., Bayley M., Damgaard C.F., Holmstrup M. Stress synergy between drought and a common environmental contaminant: studies with the collembolan Folsomia candida. Global Change Biol. 2001, 7:485-494.
    • (2001) Global Change Biol. , vol.7 , pp. 485-494
    • Højer, R.1    Bayley, M.2    Damgaard, C.F.3    Holmstrup, M.4
  • 38
    • 0030755123 scopus 로고    scopus 로고
    • Drought tolerance in Folsomia candida (Collembola) after exposure to sublethal concentrations of three soil-polluting chemicals
    • Holmstrup M. Drought tolerance in Folsomia candida (Collembola) after exposure to sublethal concentrations of three soil-polluting chemicals. Pedobiologia 1997, 41:354-361.
    • (1997) Pedobiologia , vol.41 , pp. 354-361
    • Holmstrup, M.1
  • 40
    • 77951738344 scopus 로고    scopus 로고
    • Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists
    • Howard G.J., Schlezinger J.J., Hahn M.E., Webster T.F. Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists. Environ. Health Perspect. 2010, 118:666-672.
    • (2010) Environ. Health Perspect. , vol.118 , pp. 666-672
    • Howard, G.J.1    Schlezinger, J.J.2    Hahn, M.E.3    Webster, T.F.4
  • 41
    • 22244457376 scopus 로고    scopus 로고
    • Performing spatially and temporally explicit ecological exposure assessments involving multiple stressors
    • Hope B.K. Performing spatially and temporally explicit ecological exposure assessments involving multiple stressors. Hum. Ecol. Risk Assess. 2005, 11:539-565.
    • (2005) Hum. Ecol. Risk Assess. , vol.11 , pp. 539-565
    • Hope, B.K.1
  • 42
    • 84888289096 scopus 로고    scopus 로고
    • Oehoe jaagt in centrum: populatie stadsduiven daalt
    • (in Dutch)
    • Houben J. Oehoe jaagt in centrum: populatie stadsduiven daalt. Dagblad De Limburger 2011, (in Dutch).
    • (2011) Dagblad De Limburger
    • Houben, J.1
  • 43
    • 76849091864 scopus 로고    scopus 로고
    • A biology-based approach for mixture toxicity of multiple endpoints over the life cycle
    • Jager T., Vandenbrouck T., Baas J., De Coen W.M., Kooijman S.A.L.M. A biology-based approach for mixture toxicity of multiple endpoints over the life cycle. Ecotoxicology 2010, 19:351-361.
    • (2010) Ecotoxicology , vol.19 , pp. 351-361
    • Jager, T.1    Vandenbrouck, T.2    Baas, J.3    De Coen, W.M.4    Kooijman, S.A.L.M.5
  • 44
    • 84888287908 scopus 로고    scopus 로고
    • ILSI (International Life Sciences Institute). Cumulative and Aggregate Risk Evaluation System (CARES) V3.0. Downloaded from (accessed 24.07.08).
    • ILSI (International Life Sciences Institute), 2008. Cumulative and Aggregate Risk Evaluation System (CARES) V3.0. Downloaded from (accessed 24.07.08). http://cares.ilsi.org/.
    • (2008)
  • 47
    • 0025186679 scopus 로고
    • Sequence of exposure to noise and toluene can determine loss of auditory sensitivity in the rat
    • Johnson A.C., Nylén P., Borg E., Höglund G. Sequence of exposure to noise and toluene can determine loss of auditory sensitivity in the rat. Acta Otolaryngol. 1990, 109:34-40.
    • (1990) Acta Otolaryngol. , vol.109 , pp. 34-40
    • Johnson, A.C.1    Nylén, P.2    Borg, E.3    Höglund, G.4
  • 48
    • 26844577945 scopus 로고    scopus 로고
    • Significance testing of synergistic/antagonistic, dose level-dependent, or dose ratiodependent effects in mixture dose-response analysis
    • Jonker M.J., Svendsen C., Bedaux J.J.M., Bongers M., Kammenga J.E. Significance testing of synergistic/antagonistic, dose level-dependent, or dose ratiodependent effects in mixture dose-response analysis. Environ. Toxicol. Chem. 2005, 24:2701-2713.
    • (2005) Environ. Toxicol. Chem. , vol.24 , pp. 2701-2713
    • Jonker, M.J.1    Svendsen, C.2    Bedaux, J.J.M.3    Bongers, M.4    Kammenga, J.E.5
  • 49
    • 0025768728 scopus 로고
    • The effects of density-fluctuations on the partitioning of foreign molecules into lipid bilayers - application to anesthetics and insecticides
    • Jørgensen K., Ipsen J.H., Mouritsen O.G., Bennett D., Zuckermann M.J. The effects of density-fluctuations on the partitioning of foreign molecules into lipid bilayers - application to anesthetics and insecticides. Biochim. Biophys. Acta 1991, 1067:241-253.
    • (1991) Biochim. Biophys. Acta , vol.1067 , pp. 241-253
    • Jørgensen, K.1    Ipsen, J.H.2    Mouritsen, O.G.3    Bennett, D.4    Zuckermann, M.J.5
  • 50
    • 0023301899 scopus 로고
    • Co-carcinogenic effect of asbestos and benzo(a)pyrene
    • Kimizuka G., Ohwada H., Hayashi Y. Co-carcinogenic effect of asbestos and benzo(a)pyrene. Acta Pathol. Jpn. 1987, 37:465-474.
    • (1987) Acta Pathol. Jpn. , vol.37 , pp. 465-474
    • Kimizuka, G.1    Ohwada, H.2    Hayashi, Y.3
  • 51
    • 84888287228 scopus 로고
    • Combined effects of asbestos and smoking on hamster lung
    • Captus University Publications, Ontario, Canada, G.W. Gibbs, J. Dunnigan, M. Kido, T. Higashi (Eds.)
    • Kimizuka G., Hayashi Y. Combined effects of asbestos and smoking on hamster lung. Health Risks from Exposure to Mineral Fibres: An International Perspective 1993, 254-263. Captus University Publications, Ontario, Canada. G.W. Gibbs, J. Dunnigan, M. Kido, T. Higashi (Eds.).
    • (1993) Health Risks from Exposure to Mineral Fibres: An International Perspective , pp. 254-263
    • Kimizuka, G.1    Hayashi, Y.2
  • 53
    • 33846384048 scopus 로고    scopus 로고
    • Industrial barrens: extreme habitats created by non-ferrous metallurgy
    • Kozlov M., Zvereva E. Industrial barrens: extreme habitats created by non-ferrous metallurgy. Rev. Environ. Sci. Biotechnol. 2007, 6:231-259.
    • (2007) Rev. Environ. Sci. Biotechnol. , vol.6 , pp. 231-259
    • Kozlov, M.1    Zvereva, E.2
  • 54
    • 78650866271 scopus 로고    scopus 로고
    • State of the Art on Mixture Toxicity
    • Report. Available at: (accessed 06.01.12).
    • Kortenkamp, A., Backhaus, T., Faust, M., 2009. State of the Art on Mixture Toxicity. Report. Available at: (accessed 06.01.12). http://ec.europa.eu/environment/chemicals/pdf/report_Mixture%20toxicity.pdf.
    • (2009)
    • Kortenkamp, A.1    Backhaus, T.2    Faust, M.3
  • 56
    • 67349141400 scopus 로고    scopus 로고
    • Respiratory health, effects of ambient air pollution and its modification by air humidity in Drobeta-Turnu Severin, Romania
    • Leitte A.M., Petrescu C., Franck U., Richter M., Suciu O., Ionovici R., Herbarth O., Schlink U. Respiratory health, effects of ambient air pollution and its modification by air humidity in Drobeta-Turnu Severin, Romania. Sci. Total Environ. 2009, 407:4004-4011.
    • (2009) Sci. Total Environ. , vol.407 , pp. 4004-4011
    • Leitte, A.M.1    Petrescu, C.2    Franck, U.3    Richter, M.4    Suciu, O.5    Ionovici, R.6    Herbarth, O.7    Schlink, U.8
  • 57
    • 77955056489 scopus 로고    scopus 로고
    • Cumulative stressors - risk assessment of mixtures of chemicals and combinations of chemicals and natural stressors
    • Cumulative stressors - risk assessment of mixtures of chemicals and combinations of chemicals and natural stressors. Sci. Total Environ. 2010, 408:3719-3963.
    • (2010) Sci. Total Environ. , vol.408 , pp. 3719-3963
  • 58
    • 77955057791 scopus 로고    scopus 로고
    • Eco-SpaCE: an object-oriented, spatially explicit model to assess the risk of multiple environmental stressors on terrestrial vertebrate populations
    • Loos M., Ragas A.M.J., Plasmeijer R., Schipper A.M., Hendriks A.J. Eco-SpaCE: an object-oriented, spatially explicit model to assess the risk of multiple environmental stressors on terrestrial vertebrate populations. Sci. Total Environ. 2010, 408:3908-3917.
    • (2010) Sci. Total Environ. , vol.408 , pp. 3908-3917
    • Loos, M.1    Ragas, A.M.J.2    Plasmeijer, R.3    Schipper, A.M.4    Hendriks, A.J.5
  • 59
    • 72549107062 scopus 로고    scopus 로고
    • Receptor-oriented approaches in wildlife and human exposure modelling: a comparative study
    • Loos M., Schipper A.M., Schlink U., Strebel K., Ragas A.M.J. Receptor-oriented approaches in wildlife and human exposure modelling: a comparative study. Environ. Modell. Softw. 2010, 25:369-382.
    • (2010) Environ. Modell. Softw. , vol.25 , pp. 369-382
    • Loos, M.1    Schipper, A.M.2    Schlink, U.3    Strebel, K.4    Ragas, A.M.J.5
  • 61
    • 65449174392 scopus 로고    scopus 로고
    • Measurement and modelling the combined toxicity of binary mixtures in the nematode Caenorhabditis elegans - a test of independent action
    • Martin H.L., Svendsen C., Spurgeon D.J., Lister L.J., Gomezeyles J. Measurement and modelling the combined toxicity of binary mixtures in the nematode Caenorhabditis elegans - a test of independent action. Environ. Toxicol. Chem. 2009, 28:97-104.
    • (2009) Environ. Toxicol. Chem. , vol.28 , pp. 97-104
    • Martin, H.L.1    Svendsen, C.2    Spurgeon, D.J.3    Lister, L.J.4    Gomezeyles, J.5
  • 64
    • 84888305666 scopus 로고    scopus 로고
    • MSFD. Directive 2008/56/EC of the European Parliament and of the Council of 17 June 2008 establishing a framework for community action in the field of marine environmental policy. (Marine Strategy Framework Directive).
    • MSFD, 2008. Directive 2008/56/EC of the European Parliament and of the Council of 17 June 2008 establishing a framework for community action in the field of marine environmental policy. (Marine Strategy Framework Directive).
    • (2008)
  • 65
    • 33745887182 scopus 로고    scopus 로고
    • Assessing risks to wildlife populations from multiple stressors: overview of the problem and research needs
    • (article no. 23)
    • Munns W.R. Assessing risks to wildlife populations from multiple stressors: overview of the problem and research needs. Ecol. Soc. 2006, 11(1). (article no. 23) http://www.ecologyandsociety.org/vol11/iss21/art23/.
    • (2006) Ecol. Soc. , vol.11 , Issue.1
    • Munns, W.R.1
  • 67
    • 34249039582 scopus 로고    scopus 로고
    • The interaction of the brominated flame retardant: tetrabromobisphenol A with phospholipid membranes
    • Ogunbayo O.A., Jensen K.T., Michelangeli F. The interaction of the brominated flame retardant: tetrabromobisphenol A with phospholipid membranes. Biochim. Biophys. Acta 2007, 1768:1559-1566.
    • (2007) Biochim. Biophys. Acta , vol.1768 , pp. 1559-1566
    • Ogunbayo, O.A.1    Jensen, K.T.2    Michelangeli, F.3
  • 68
    • 46549085521 scopus 로고    scopus 로고
    • A high-throughput screening method based on stably transformed human cells was used to determine the immunotoxic effects of fluoranthene and other PAHs
    • Oostingh G.J., Schmittner M., Ehart A.K., Tischler U., Duschl A. A high-throughput screening method based on stably transformed human cells was used to determine the immunotoxic effects of fluoranthene and other PAHs. Toxicol. In Vitro 2008, 22:1301-1310.
    • (2008) Toxicol. In Vitro , vol.22 , pp. 1301-1310
    • Oostingh, G.J.1    Schmittner, M.2    Ehart, A.K.3    Tischler, U.4    Duschl, A.5
  • 69
    • 70350020915 scopus 로고    scopus 로고
    • The cytotoxic effects of the organophosphates chlorpyrifos and diazinon differ from their immunomodulating effects
    • Oostingh G.J., Wichmann G., Schmittner M., Lehmann I., Duschl A. The cytotoxic effects of the organophosphates chlorpyrifos and diazinon differ from their immunomodulating effects. J. Immunotoxicol. 2009, 6:136-145.
    • (2009) J. Immunotoxicol. , vol.6 , pp. 136-145
    • Oostingh, G.J.1    Wichmann, G.2    Schmittner, M.3    Lehmann, I.4    Duschl, A.5
  • 70
    • 84888288926 scopus 로고    scopus 로고
    • PCCRARM (Presidential/Congressional Commission on Risk Assessment and Risk Management). Framework for Environmental Health Risk Management. Washington, DC, USA.
    • PCCRARM (Presidential/Congressional Commission on Risk Assessment and Risk Management), 1997. Framework for Environmental Health Risk Management. Washington, DC, USA.
    • (1997)
  • 71
    • 70350491293 scopus 로고    scopus 로고
    • Characterizing the noncancer toxicity of mixtures using concepts from the TTC and quantitative models of uncertainty in mixture toxicity
    • Price P.S., Hollnagel H.M., Zabik J.M. Characterizing the noncancer toxicity of mixtures using concepts from the TTC and quantitative models of uncertainty in mixture toxicity. Risk Anal. 2009, 29:1534-1548.
    • (2009) Risk Anal. , vol.29 , pp. 1534-1548
    • Price, P.S.1    Hollnagel, H.M.2    Zabik, J.M.3
  • 72
    • 85052707726 scopus 로고    scopus 로고
    • Human and ecological risk assessment of chemical mixtures
    • SETAC, CRC Press, New York, C.A.M. Van Gestel, M.J. Jonker, J.E. Kammenga, R. Laskowski, C. Svendsen (Eds.)
    • Ragas A.M.J., Teuschler L.K., Posthuma L., Cowan C. Human and ecological risk assessment of chemical mixtures. Mixture Toxicity - Linking Approaches from Ecological and Human Toxicology 2011, 157-215. SETAC, CRC Press, New York. C.A.M. Van Gestel, M.J. Jonker, J.E. Kammenga, R. Laskowski, C. Svendsen (Eds.).
    • (2011) Mixture Toxicity - Linking Approaches from Ecological and Human Toxicology , pp. 157-215
    • Ragas, A.M.J.1    Teuschler, L.K.2    Posthuma, L.3    Cowan, C.4
  • 74
    • 78650623080 scopus 로고    scopus 로고
    • Implications of the exposome for exposure science
    • Rappaport S.M. Implications of the exposome for exposure science. J. Expo. Anal. Environ. Epidemiol. 2011, 21:5-9.
    • (2011) J. Expo. Anal. Environ. Epidemiol. , vol.21 , pp. 5-9
    • Rappaport, S.M.1
  • 75
    • 77955055064 scopus 로고    scopus 로고
    • The interaction of chemical mixtures and their implications on water quality guidelines
    • Hons Thesis, University of Technology, Sydney, NSW, Australia
    • Ross, H.L.B., 1996. The interaction of chemical mixtures and their implications on water quality guidelines. Hons Thesis, University of Technology, Sydney, NSW, Australia. p. 167.
    • (1996) , pp. 167
    • Ross, H.L.B.1
  • 79
    • 0036754782 scopus 로고    scopus 로고
    • Application of the biotic ligand model to predicting zinc toxicity to rainbow trout, fathead minnow, and Daphnia magna
    • Santore R.C., Mathew R., Paquin P.R., Ditoro D. Application of the biotic ligand model to predicting zinc toxicity to rainbow trout, fathead minnow, and Daphnia magna. Comp. Biochem. Physiol. C: Toxicol. Pharmacol. 2002, 133:271-285.
    • (2002) Comp. Biochem. Physiol. C: Toxicol. Pharmacol. , vol.133 , pp. 271-285
    • Santore, R.C.1    Mathew, R.2    Paquin, P.R.3    Ditoro, D.4
  • 81
    • 79958796332 scopus 로고    scopus 로고
    • Truncated Lévy flights and agenda-based mobility are useful for the assessment of personal human exposure
    • Schlink U., Ragas A.M.J. Truncated Lévy flights and agenda-based mobility are useful for the assessment of personal human exposure. Environ. Pollut. 2011, 159:2061-2070.
    • (2011) Environ. Pollut. , vol.159 , pp. 2061-2070
    • Schlink, U.1    Ragas, A.M.J.2
  • 82
    • 33748457291 scopus 로고    scopus 로고
    • Does lipophilicity of toxic compounds determine effects on drought tolerance of the soil collembolan Folsomia candida?
    • Skovlund G., Damgaard C., Bayley M., Holmstrup M. Does lipophilicity of toxic compounds determine effects on drought tolerance of the soil collembolan Folsomia candida?. Environ. Pollut. 2006, 144:808-815.
    • (2006) Environ. Pollut. , vol.144 , pp. 808-815
    • Skovlund, G.1    Damgaard, C.2    Bayley, M.3    Holmstrup, M.4
  • 86
    • 28444459553 scopus 로고    scopus 로고
    • Effect of temperature on toxicity of a natural pyrethrin pesticide to green anole lizards (Anolis carolinensis)
    • Talent L.G. Effect of temperature on toxicity of a natural pyrethrin pesticide to green anole lizards (Anolis carolinensis). Environ. Toxicol. Chem. 2005, 24:3113-3116.
    • (2005) Environ. Toxicol. Chem. , vol.24 , pp. 3113-3116
    • Talent, L.G.1
  • 88
    • 65649128767 scopus 로고    scopus 로고
    • Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure
    • Thomas R., Gohlke J.M., Stopper G.F., Parham F.M., Portier C.J. Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure. Genome Biol. 2009, 10:R44. 10.1186/gb-2009-10-4-r44.
    • (2009) Genome Biol. , vol.10
    • Thomas, R.1    Gohlke, J.M.2    Stopper, G.F.3    Parham, F.M.4    Portier, C.J.5
  • 90
    • 6344233898 scopus 로고    scopus 로고
    • The National Children's Study: a critical national investment
    • Trasande L., Landrigan P.J. The National Children's Study: a critical national investment. Environ. Health Perspect. 2004, 112:A789-A790.
    • (2004) Environ. Health Perspect. , vol.112
    • Trasande, L.1    Landrigan, P.J.2
  • 91
    • 84888305582 scopus 로고    scopus 로고
    • US EPA (U.S. Environmental Protection Agency). Supplementary guidance for conducting health risk assessment of chemical mixtures. EPA/630/R-00/002. ORD/NCEA. Cincinnati, Ohio.
    • US EPA (U.S. Environmental Protection Agency), 2000. Supplementary guidance for conducting health risk assessment of chemical mixtures. EPA/630/R-00/002. ORD/NCEA. Cincinnati, Ohio.
    • (2000)
  • 92
    • 10944269639 scopus 로고    scopus 로고
    • US EPA (U.S.Environmental Protection Agency), United States Environmental Protection Agency, Risk Assessment Forum, Washington, DC, USA
    • US EPA (U.S.Environmental Protection Agency) Framework for Cumulative Risk Assessment 2003, United States Environmental Protection Agency, Risk Assessment Forum, Washington, DC, USA.
    • (2003) Framework for Cumulative Risk Assessment
  • 95
    • 84888301342 scopus 로고    scopus 로고
    • Concepts, methods and data sources for cumulative health risk assessment of multiple chemicals, exposures and effects: a resource document (EPA/600/R-06/014F)
    • US EPA (U.S.Environmental Protection Agency), US Environmental Protection Agency, Cincinnati, Ohio
    • US EPA (U.S.Environmental Protection Agency) Concepts, methods and data sources for cumulative health risk assessment of multiple chemicals, exposures and effects: a resource document (EPA/600/R-06/014F). National Center for Environmental Assessment, Office of Research and Development 2007, US Environmental Protection Agency, Cincinnati, Ohio.
    • (2007) National Center for Environmental Assessment, Office of Research and Development
  • 96
    • 63249117704 scopus 로고    scopus 로고
    • Effect of sequential isoproturon pulse exposure on Scenedesmus vacuolatus
    • Vallotton N., Eggen R.I.L., Chèvre N. Effect of sequential isoproturon pulse exposure on Scenedesmus vacuolatus. Arch. Environ. Contam. Toxicol. 2009, 56:442-449.
    • (2009) Arch. Environ. Contam. Toxicol. , vol.56 , pp. 442-449
    • Vallotton, N.1    Eggen, R.I.L.2    Chèvre, N.3
  • 97
    • 84888295018 scopus 로고    scopus 로고
    • SETAC, CRC Press, Boca Raton, C.A.M. Van Gestel, M.J. Jonker, J.E. Kammenga, R. Laskowski, C. Svendsen (Eds.)
    • Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology 2010, 280. SETAC, CRC Press, Boca Raton. C.A.M. Van Gestel, M.J. Jonker, J.E. Kammenga, R. Laskowski, C. Svendsen (Eds.).
    • (2010) Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology , pp. 280
  • 98
    • 0030022688 scopus 로고    scopus 로고
    • Membrane burdens of chlorinated benzenes lower the main phase transition temperature in dipalmitoyl-phosphatidylcholine vesicles: implications for toxicity by narcotic chemicals
    • Van Wezel A.P., Cornelissen G., Van Miltenburg J.K., Opperhuizen A. Membrane burdens of chlorinated benzenes lower the main phase transition temperature in dipalmitoyl-phosphatidylcholine vesicles: implications for toxicity by narcotic chemicals. Environ. Toxicol. Chem. 1996, 15:203-212.
    • (1996) Environ. Toxicol. Chem. , vol.15 , pp. 203-212
    • Van Wezel, A.P.1    Cornelissen, G.2    Van Miltenburg, J.K.3    Opperhuizen, A.4
  • 99
    • 60949099991 scopus 로고    scopus 로고
    • Nickel and binary metal mixture responses in Daphnia magna: Molecular fingerprints and (sub)organismal effects
    • Vandenbrouck T., Soetaert A., Van der Ven K., Blust R., De Coen W. Nickel and binary metal mixture responses in Daphnia magna: Molecular fingerprints and (sub)organismal effects. Aquat. Toxicol. 2009, 92:18-29.
    • (2009) Aquat. Toxicol. , vol.92 , pp. 18-29
    • Vandenbrouck, T.1    Soetaert, A.2    Van der Ven, K.3    Blust, R.4    De Coen, W.5
  • 100
    • 0029054080 scopus 로고
    • The number of components in a mixture determines whether synergistic and antagonistic or additive toxicity predominate: the funnel hypothesis
    • Warne M.S., Hawker D.W. The number of components in a mixture determines whether synergistic and antagonistic or additive toxicity predominate: the funnel hypothesis. Ecotoxicol. Environ. Saf. 1995, 31:23-28.
    • (1995) Ecotoxicol. Environ. Saf. , vol.31 , pp. 23-28
    • Warne, M.S.1    Hawker, D.W.2
  • 101
    • 10844278764 scopus 로고    scopus 로고
    • A review of the ecotoxicity of mixtures, approaches to, and recommendations for, their management
    • National Environment Protection Council Service Corporation, Adelaide, SA, A. Langley, M. Gilbey, B. Kennedy (Eds.)
    • Warne M.S.J. A review of the ecotoxicity of mixtures, approaches to, and recommendations for, their management. Proceedings of the Fifth National Workshop on the Assessment of Site Contamination 2003, National Environment Protection Council Service Corporation, Adelaide, SA. A. Langley, M. Gilbey, B. Kennedy (Eds.).
    • (2003) Proceedings of the Fifth National Workshop on the Assessment of Site Contamination
    • Warne, M.S.J.1
  • 102
    • 0001869714 scopus 로고
    • Interactive effects of ambient copper and anoxic, temperature and salinity stress on survival and hemolymph and muscle tissue osmotic effectors in Mytilus edulis
    • Weber R.E., De Zwaan A., Bang A. Interactive effects of ambient copper and anoxic, temperature and salinity stress on survival and hemolymph and muscle tissue osmotic effectors in Mytilus edulis. J. Exp. Mar. Biol. Ecol. 1992, 159:135-156.
    • (1992) J. Exp. Mar. Biol. Ecol. , vol.159 , pp. 135-156
    • Weber, R.E.1    De Zwaan, A.2    Bang, A.3
  • 103
    • 0345074401 scopus 로고    scopus 로고
    • Cambridge University Press, Cambridge
    • Wharton D.A. Life at the Limits 2002, Cambridge University Press, Cambridge, p. 307.
    • (2002) Life at the Limits , pp. 307
    • Wharton, D.A.1
  • 104
    • 84888293431 scopus 로고    scopus 로고
    • WHO (World Health Organization), International Programme on Chemical Safety (IPCS), Inter-Organization Programme for the Sound Management of Chemicals (IOMC), Geneva
    • WHO (World Health Organization) Assessment of Combined Exposures to Multiple Chemicals: Report of a WHO/IPCS International Workshop 2009, International Programme on Chemical Safety (IPCS), Inter-Organization Programme for the Sound Management of Chemicals (IOMC), Geneva.
    • (2009) Assessment of Combined Exposures to Multiple Chemicals: Report of a WHO/IPCS International Workshop
  • 105
    • 33645318739 scopus 로고    scopus 로고
    • A probabilistic arsenic exposure assessment for children who contact Chromated Copper Arsenate (CCA)-treated playsets and decks, part 1: model methodology, variability results, and model evaluation
    • Zartarian V.G., Xue J., Ozkaynak H.A., Dang W., Glen G., Smith L., Stallings C. A probabilistic arsenic exposure assessment for children who contact Chromated Copper Arsenate (CCA)-treated playsets and decks, part 1: model methodology, variability results, and model evaluation. Risk Anal. 2006, 26:515-531.
    • (2006) Risk Anal. , vol.26 , pp. 515-531
    • Zartarian, V.G.1    Xue, J.2    Ozkaynak, H.A.3    Dang, W.4    Glen, G.5    Smith, L.6    Stallings, C.7
  • 106
    • 84888288002 scopus 로고    scopus 로고
    • Stochastic Human Exposure and Dose Simulation Model for Multimedia, Multipathway Chemicals
    • SHEDS-Multimedia Model version 3. Technical Manual, United States Environmental Protection Agency, Presented to the USEPA Office of Pesticide Program's FIFRA Scientific Advisory Panel, August 14-15, 2007. Available at
    • Zartarian, V.G., Glen, G., Smith, L., Xue, J., 2007. Stochastic Human Exposure and Dose Simulation Model for Multimedia, Multipathway Chemicals. SHEDS-Multimedia Model version 3. Technical Manual, United States Environmental Protection Agency, Presented to the USEPA Office of Pesticide Program's FIFRA Scientific Advisory Panel, August 14-15, 2007. Available at:. http://www.epa.gov/scipoly/sap/meetings/2007/august/sheds_techmanual_06_14.pdf.
    • (2007)
    • Zartarian, V.G.1    Glen, G.2    Smith, L.3    Xue, J.4


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