A comparison of transcriptomic and metabonomic technologies for identifying biomarkers predictive of two-year rodent cancer bioassays

Toxicological Sciences

Volumn 96, Issue 1, 2007, Pages 40-46

  Thomas, Russell S ^a   O'Connell, Thomas M ^b   Pluta, Linda ^a   Wolfinger, Russell D ^c   Yang, Longlong ^a   Page, Todd J ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c SAS INSTITUTE INC   (United States)

Author keywords

Biomarkers; Genomics; Metabonomics; Rodent cancer bioassays

Indexed keywords

BENZOFURAN DERIVATIVE; CARCINOGEN; QUINTOZENE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DISEASE MARKER; FEMALE; GENE EXPRESSION PROFILING; GENOTOXICITY; INTERMETHOD COMPARISON; LIVER CANCER; LUNG CANCER; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PROTON NUCLEAR MAGNETIC RESONANCE; RODENT; STATISTICAL ANALYSIS; TRANSCRIPTOMICS;

ANIMALS; BIOLOGICAL ASSAY; BIOLOGICAL MARKERS; CARCINOGENICITY TESTS; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; CLUSTER ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; GENOMICS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LUNG; LUNG NEOPLASMS; MICE; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDICTIVE VALUE OF TESTS; PROTEIN ARRAY ANALYSIS; RANDOM ALLOCATION; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; RNA, NEOPLASM; TIME FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA; RODENTIA;

EID: 33847329758     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl171     Document Type: Article

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