-
1
-
-
22844457491
-
DNA methylation and human disease
-
PMID:16136652
-
Robertson KD. DNA methylation and human disease. Nat Rev Genet 2005; 6:597-610; PMID:16136652; http://dx.doi.org/10.1038/nrg1655
-
(2005)
Nat Rev Genet
, vol.6
, pp. 597-610
-
-
Robertson, K.D.1
-
2
-
-
10344260184
-
CpG island methylator phenotype in cancer
-
PMID:15573120
-
Issa J-P. CpG island methylator phenotype in cancer. Nat Rev Cancer 2004; 4:988-93; PMID:15573120
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 988-993
-
-
Issa, J.-P.1
-
3
-
-
4544250024
-
Gene-promoter hypermethylation as a biomarker in lung cancer
-
PMID:15343277
-
Belinsky SA. Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer 2004; 4:707-17; PMID:15343277; http://dx.doi.org/10.1038/nrc1432
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 707-717
-
-
Belinsky, S.A.1
-
4
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
PMID:12042769
-
Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3:415- 28; PMID:12042769
-
(2002)
Nat Rev Genet
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
5
-
-
0023848637
-
Reduced genomic 5-methylcytosine content in human colonic neoplasia
-
PMID:3342396
-
Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M. Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res 1988; 48:1159-61; PMID:3342396
-
(1988)
Cancer Res
, vol.48
, pp. 1159-1161
-
-
Feinberg, A.P.1
Gehrke, C.W.2
Kuo, K.C.3
Ehrlich, M.4
-
6
-
-
0242584454
-
Chromosomal instability and tumors promoted by DNA hypomethylation
-
PMID:12702868
-
Eden A, Gaudet F, Waghmare A, Jaenisch R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003; 300:455; PMID:12702868; http://dx.doi.org/10.1126/science. 1083557
-
(2003)
Science
, vol.300
, pp. 455
-
-
Eden, A.1
Gaudet, F.2
Waghmare, A.3
Jaenisch, R.4
-
7
-
-
0037068353
-
DNA methylation in cancer: Too much, but also too little
-
PMID:12154403
-
Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 2002; 21:5400-13; PMID:12154403; http://dx.doi.org/10.1038/sj. onc.1205651
-
(2002)
Oncogene
, vol.21
, pp. 5400-5413
-
-
Ehrlich, M.1
-
8
-
-
0029127302
-
5- Methyl-2'-deoxycytidine in single-strandedDNA can act in cis to signal de novo DNA methylation
-
PMID:7638194
-
Christman JK, SheikhnejadG,MarascoCJ, Sufrin JR. 5- Methyl-2'-deoxycytidine in single-strandedDNA can act in cis to signal de novo DNA methylation. Proc Natl Acad Sci USA 1995; 92:7347-51; PMID:7638194; http://dx.doi.org/10.1073/pnas.92.16.7347
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 7347-7351
-
-
Christman, J.K.1
Sheikhnejad, G.2
Marasco, C.J.3
Sufrin, J.R.4
-
9
-
-
0030779188
-
Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase
-
PMID:9358180
-
Pradhan S, Talbot D, Sha M, Benner J, Hornstra L, Li E, Jaenisch R, Roberts RJ. Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase. Nucleic Acids Res 1997; 25:4666-73; PMID:9358180; http://dx.doi.org/10.1093/nar/25.22.4666
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 4666-4673
-
-
Pradhan, S.1
Talbot, D.2
Sha, M.3
Benner, J.4
Hornstra, L.5
Li, E.6
Jaenisch, R.7
Roberts, R.J.8
-
10
-
-
31544467813
-
De novo CpG island methylation in human cancer cells
-
PMID:16423997
-
Jair K-W, Bachman KE, Suzuki H, Ting AH, Rhee I, Yen R-WC, Baylin SB, Schuebel KE. De novo CpG island methylation in human cancer cells. Cancer Res 2006; 66:682-92; PMID:16423997; http://dx.doi.org/10.1158/0008-5472.CAN-05-1980
-
(2006)
Cancer Res
, vol.66
, pp. 682-692
-
-
Jair, K.-W.1
Bachman, K.E.2
Suzuki, H.3
Ting, A.H.4
Rhee, I.5
Yen, R.-W.C.6
Baylin, S.B.7
Schuebel, K.E.8
-
11
-
-
0026317881
-
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
-
PMID:2014266
-
el-DeiryWS,Nelkin BD, Celano P, Yen RW, Falco JP, Hamilton SR, Baylin SB. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc Natl Acad Sci USA 1991; 88:3470-4; PMID:2014266; http://dx.doi.org/10.1073/pnas.88.8.3470
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 3470-4344
-
-
El-Deiry, W.S.1
Nelkin, B.D.2
Celano, P.3
Yen, R.W.4
Falco, J.P.5
Hamilton, S.R.6
Baylin, S.B.7
-
12
-
-
0030006213
-
Increased cytosine DNA-methyltransferase activity is targetcell- specific and an early event in lung cancer
-
PMID: 8633014
-
Belinsky SA, Nikula KJ, Baylin SB, Issa JP. Increased cytosine DNA-methyltransferase activity is targetcell- specific and an early event in lung cancer. Proc Natl Acad Sci USA 1996; 93:4045-50; PMID: 8633014; http://dx.doi.org/10.1073/pnas.93.9.4045
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 4045-4050
-
-
Belinsky, S.A.1
Nikula, K.J.2
Baylin, S.B.3
Issa, J.P.4
-
13
-
-
33846111256
-
Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer
-
PMID:17140695
-
Lin R-K, Hsu H-S, Chang J-W, Chen C-Y, Chen JT, Wang Y-C. Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. Lung Cancer 2007; 55:205-13; PMID:17140695; http://dx.doi.org/10.1016/j. lungcan.2006.10.022
-
(2007)
Lung Cancer
, vol.55
, pp. 205-213
-
-
Lin, R.-K.1
Hsu, H.-S.2
Chang, J.-W.3
Chen, C.-Y.4
Chen, J.T.5
Wang, Y.-C.6
-
14
-
-
0037400909
-
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma
-
PMID:12594811
-
Kimura F, Seifert H-H, Florl AR, Santourlidis S, Steinhoff C, Swiatkowski S, Mahotka C, Gerharz CD, Schulz WA. Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma. Int J Cancer 2003; 104:568- 78; PMID:12594811; http://dx.doi.org/10.1002/ ijc.10988
-
(2003)
Int J Cancer
, vol.104
, pp. 568-578
-
-
Kimura, F.1
Seifert, H.-H.2
Florl, A.R.3
Santourlidis, S.4
Steinhoff, C.5
Swiatkowski, S.6
Mahotka, C.7
Gerharz, C.D.8
Schulz, W.A.9
-
15
-
-
0027504621
-
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells
-
PMID:8415627
-
Wu J, Issa JP, Herman J, Bassett DE, Nelkin BD, Baylin SB. Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells. Proc Natl Acad Sci USA 1993; 90:8891-5; PMID:8415627; http://dx.doi.org/ 10.1073/pnas.90.19.8891
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 8891-8895
-
-
Wu, J.1
Issa, J.P.2
Herman, J.3
Bassett, D.E.4
Nelkin, B.D.5
Baylin, S.B.6
-
16
-
-
0033555953
-
Role of DNA 5-methylcytosine transferase in cell transformation by fos
-
PMID:9888853
-
Bakin AV, Curran T. Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science 1999; 283:387-90; PMID:9888853; http://dx.doi.org/10.1126/science.283.5400.387
-
(1999)
Science
, vol.283
, pp. 387-390
-
-
Bakin, A.V.1
Curran, T.2
-
17
-
-
0036120654
-
Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality
-
PMID:11884600
-
Biniszkiewicz D, Gribnau J, Ramsahoye B, Gaudet F, Eggan K, Humpherys D, Mastrangelo M-A, Jun Z, Walter J, Jaenisch R. Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Mol Cell Biol 2002; 22:2124- 35; PMID:11884600; http://dx.doi.org/10.1128/ MCB.22.7.2124-2135.2002
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2124-2135
-
-
Biniszkiewicz, D.1
Gribnau, J.2
Ramsahoye, B.3
Gaudet, F.4
Eggan, K.5
Humpherys, D.6
Mastrangelo, M.-A.7
Jun, Z.8
Walter, J.9
Jaenisch, R.10
-
18
-
-
0026708177
-
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
-
PMID:1606615
-
Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992; 69:915-26; PMID:1606615; http://dx.doi.org/10.1016/0092-8674(92)90611-F
-
(1992)
Cell
, vol.69
, pp. 915-926
-
-
Li, E.1
Bestor, T.H.2
Jaenisch, R.3
-
19
-
-
0242584449
-
Induction of tumors in mice by genomic hypomethylation
-
PMID: 12702876
-
Gaudet F. Induction of tumors in mice by genomic hypomethylation. Science 2003; 300:489-92; PMID: 12702876; http://dx.doi.org/10.1126/science.1083558
-
(2003)
Science
, vol.300
, pp. 489-492
-
-
Gaudet, F.1
-
20
-
-
0038527642
-
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor
-
PMID:11834837
-
Di Croce L, Raker VA, Corsaro M, Fazi F, Fanelli M, Faretta M, Fuks F, Coco Lo F, Kouzarides T, Nervi C, et al. Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science 2002; 295:1079- 82; PMID:11834837; http://dx.doi.org/10.1126/ science.1065173
-
(2002)
Science
, vol.295
, pp. 1079-1082
-
-
Di Croce, L.1
Raker, V.A.2
Corsaro, M.3
Fazi, F.4
Fanelli, M.5
Faretta, M.6
Fuks, F.7
Coco Lo, F.8
Kouzarides, T.9
Nervi, C.10
-
21
-
-
32844459336
-
The Polycomb group protein EZH2 directly controls DNA methylation
-
Viré E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden J-M, et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 2006; 439:871-4; http://dx.doi.org/10.1038/ nature04431
-
(2006)
Nature
, vol.439
, pp. 871-874
-
-
Viré, E.1
Brenner, C.2
Deplus, R.3
Blanchon, L.4
Fraga, M.5
Didelot, C.6
Morey, L.7
Van Eynde, A.8
Bernard, D.9
Vanderwinden, J.-M.10
-
22
-
-
33751209468
-
Direct interaction between DNMT1 and G9a coordinates DNA and histonemethylation during replication
-
PMID:17085482
-
Esteve PO, Chin HG, Smallwood A, Feehery GR, Gangisetty O, Karpf AR, Carey MF, Pradhan S. Direct interaction between DNMT1 and G9a coordinates DNA and histonemethylation during replication. Genes Dev 2006; 20:3089-103; PMID:17085482; http://dx. doi.org/10.1101/gad.1463706
-
(2006)
Genes Dev
, vol.20
, pp. 3089-0103
-
-
Esteve, P.O.1
Chin, H.G.2
Smallwood, A.3
Feehery, G.R.4
Gangisetty, O.5
Karpf, A.R.6
Carey, M.F.7
Pradhan, S.8
-
23
-
-
34249066239
-
Functional cooperation between HP1 and DNMT1 mediates gene silencing
-
PMID:17470536
-
Smallwood A, Esteve PO, Pradhan S, Carey M. Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev 2007; 21:1169- 78; PMID:17470536; http://dx.doi.org/10.1101/ gad.1536807
-
(2007)
Genes Dev
, vol.21
, pp. 1169-1178
-
-
Smallwood, A.1
Esteve, P.O.2
Pradhan, S.3
Carey, M.4
-
24
-
-
0030770835
-
Human DNA-(Cytosine-5) methyltransferase- PCNA complex as a target for p21WAF
-
PMID:9302295
-
Chuang LS. Human DNA-(Cytosine-5) methyltransferase- PCNA complex as a target for p21WAF Science 1997; 277:1996-2000; PMID:9302295; http://dx.doi.org/10.1126/science.277.5334.1996
-
(1997)
Science
, vol.277
, pp. 1996-2000
-
-
Chuang, L.S.1
-
25
-
-
77955311548
-
Disruption of Dnmt1/PCNA/ UHRF1 interactions promotes tumorigenesis from human and mice glial cells
-
PMID:20613874
-
Hervouet E, Lalier L, Debien E, Cheray M, Geairon A, Rogniaux H, Loussouarn D, Martin SA, Vallette FM, Cartron P-F. Disruption of Dnmt1/PCNA/ UHRF1 interactions promotes tumorigenesis from human and mice glial cells. PLoS ONE 2010; 5:e11333; PMID:20613874; http://dx.doi.org/10.1371/journal. pone.0011333
-
(2010)
PLoS ONE
, vol.5
, pp. e11333
-
-
Hervouet, E.1
Lalier, L.2
Debien, E.3
Cheray, M.4
Geairon, A.5
Rogniaux, H.6
Loussouarn, D.7
Martin, S.A.8
Vallette, F.M.9
Cartron, P.-F.10
-
26
-
-
0037083752
-
The retinoblastoma gene product interacts with maintenance human DNA (cytosine- 5) methyltransferase and modulates its activity
-
PMID:11847125
-
Pradhan S, Kim G-D. The retinoblastoma gene product interacts with maintenance human DNA (cytosine- 5) methyltransferase and modulates its activity. EMBO J 2002; 21:779-88; PMID:11847125; http://dx.doi.org/10.1093/emboj/21.4.779
-
(2002)
EMBO J
, vol.21
, pp. 779-788
-
-
Pradhan, S.1
Kim, G.-D.2
-
27
-
-
0026439115
-
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
-
PMID:1423634
-
Leonhardt H, Page AW, Weier HU, Bestor TH. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 1992; 71:865-73; PMID:1423634; http://dx.doi.org/10.1016/0092-8674(92)90561-P
-
(1992)
Cell
, vol.71
, pp. 865-873
-
-
Leonhardt, H.1
Page, A.W.2
Weier, H.U.3
Bestor, T.H.4
-
28
-
-
0034708336
-
Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structure
-
PMID:10715201
-
Margot JB, Aguirre-Arteta AM, Di Giacco BV, Pradhan S, Roberts RJ, Cardoso MC, Leonhardt H. Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structure. J Mol Biol 2000; 297:293-300; PMID:10715201; http://dx.doi.org/10.1006/jmbi.2000.3588
-
(2000)
J Mol Biol
, vol.297
, pp. 293-300
-
-
Margot, J.B.1
Aguirre-Arteta, A.M.2
Di Giacco, B.V.3
Pradhan, S.4
Roberts, R.J.5
Cardoso, M.C.6
Leonhardt, H.7
-
29
-
-
34648833002
-
UHRF1 plays a role in maintaining DNA methylation in mammalian cells
-
PMID:17673620
-
Bostick M, Kim JK, Estéve P-O, Clark A, Pradhan S, Jacobsen SE. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 2007; 317:1760-4; PMID:17673620; http://dx.doi.org/10.1126/science.1147939
-
(2007)
Science
, vol.317
, pp. 1760-1764
-
-
Bostick, M.1
Kim, J.K.2
Estéve, P.-O.3
Clark, A.4
Pradhan, S.5
Jacobsen, S.E.6
-
30
-
-
36849072573
-
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA
-
PMID:17994007
-
Sharif J, Muto M, Takebayashi S-I, Suetake I, Iwamatsu A, Endo TA, Shinga J, Mizutani-Koseki Y, Toyoda T, Okamura K, et al. The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature 2007; 450:908- 12; PMID:17994007; http://dx.doi.org/10.1038/ nature06397
-
(2007)
Nature
, vol.450
, pp. 908-912
-
-
Sharif, J.1
Muto, M.2
Takebayashi, S.-I.3
Suetake, I.4
Iwamatsu, A.5
Endo, T.A.6
Shinga, J.7
Mizutani-Koseki, Y.8
Toyoda, T.9
Okamura, K.10
-
31
-
-
79955370122
-
The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt
-
PMID:21389349
-
Syeda F, Fagan RL, Wean M, Avvakumov GV, Walker JR, Xue S, Dhe-Paganon S, Brenner C. The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt J Biol Chem 2011; 286:15344-51; PMID:21389349; http://dx.doi.org/10.1074/jbc.M110.209882
-
(2011)
J Biol Chem
, vol.286
, pp. 15344-15351
-
-
Syeda, F.1
Fagan, R.L.2
Wean, M.3
Avvakumov, G.V.4
Walker, J.R.5
Xue, S.6
Dhe-Paganon, S.7
Brenner, C.8
-
32
-
-
79959368232
-
Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1)
-
PMID:21518897
-
Takeshita K, Suetake I, Yamashita E, Suga M, Narita H, Nakagawa A, Tajima S. Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc Natl Acad Sci USA 2011; 108:9055-9; PMID:21518897; http://dx.doi.org/10.1073/pnas.1019629108
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 9055-9059
-
-
Takeshita, K.1
Suetake, I.2
Yamashita, E.3
Suga, M.4
Narita, H.5
Nakagawa, A.6
Tajima, S.7
-
33
-
-
84860221291
-
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation
-
PMID:22362737
-
Hashimoto H, Liu Y, Upadhyay AK, Chang Y, Howerton SB, Vertino PM, Zhang X, Cheng X. Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Res 2012; 40:4841-9; PMID:22362737; http://dx.doi.org/10.1093/nar/gks155
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 4841-4849
-
-
Hashimoto, H.1
Liu, Y.2
Upadhyay, A.K.3
Chang, Y.4
Howerton, S.B.5
Vertino, P.M.6
Zhang, X.7
Cheng, X.8
-
34
-
-
84891710987
-
The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated (SRA) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA
-
PMID:24253042
-
Berkyurek AC, Suetake I, Arita K, Takeshita K, Nakagawa A, Shirakawa M, Tajima S. The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated (SRA) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA. J Biol Chem 2014; 289:379-86; PMID:24253042; http://dx.doi.org/10.1074/jbc.M113.523209
-
(2014)
J Biol Chem
, vol.289
, pp. 379-386
-
-
Berkyurek, A.C.1
Suetake, I.2
Arita, K.3
Takeshita, K.4
Nakagawa, A.5
Shirakawa, M.6
Tajima, S.7
-
35
-
-
84894150374
-
The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism
-
PMID: 24368767
-
Bashtrykov P, Jankevicius G, Jurkowska RZ, Ragozin S, Jeltsch A. The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. J Biol Chem 2014; 289:4106-15; PMID: 24368767; http://dx.doi.org/10.1074/jbc.M1528893
-
(2014)
J Biol Chem
, vol.289
, pp. 4106-4115
-
-
Bashtrykov, P.1
Jankevicius, G.2
Jurkowska, R.Z.3
Ragozin, S.4
Jeltsch, A.5
-
36
-
-
84896399864
-
Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain
-
PMID:24532244
-
Bashtrykov P, Rajavelu A, Hackner B, Ragozin S, Carell T, Jeltsch A. Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain. Chembiochem 2014; 15:743-8; PMID:24532244; http://dx.doi.org/10.1002/cbic.201300740
-
(2014)
Chembiochem
, vol.15
, pp. 743-748
-
-
Bashtrykov, P.1
Rajavelu, A.2
Hackner, B.3
Ragozin, S.4
Carell, T.5
Jeltsch, A.6
-
37
-
-
79952053850
-
Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation
-
PMID:21163962
-
Song J, Rechkoblit O, Bestor TH, Patel DJ. Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science 2011; 331:1036-40; PMID:21163962; http://dx.doi.org/10.1126/science.1195380
-
(2011)
Science
, vol.331
, pp. 1036-1040
-
-
Song, J.1
Rechkoblit, O.2
Bestor, T.H.3
Patel, D.J.4
-
38
-
-
79957623760
-
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
-
PMID:21532572
-
Klein CJ, Botuyan M-V, Wu Y, Ward CJ, Nicholson GA, Hammans S, Hojo K, Yamanishi H, Karpf AR, Wallace DC, et al. Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet 2011; 43:595-600; PMID:21532572; http://dx.doi.org/10.1038/ng.830
-
(2011)
Nat Genet
, vol.43
, pp. 595-600
-
-
Klein, C.J.1
Botuyan, M.-V.2
Wu, Y.3
Ward, C.J.4
Nicholson, G.A.5
Hammans, S.6
Hojo, K.7
Yamanishi, H.8
Karpf, A.R.9
Wallace, D.C.10
-
39
-
-
33644507072
-
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a fullmalignant phenotype on human bronchial epithelial cells
-
PMID:16489012
-
Sato M, Vaughan MB, Girard L, Peyton M, Lee W, Shames DS, Ramirez RD, Sunaga N, Gazdar AF, Shay JW, et al. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a fullmalignant phenotype on human bronchial epithelial cells. Cancer Res 2006; 66:2116-28; PMID:16489012; http://dx.doi.org/10.1158/0008-5472.CAN-05-2521
-
(2006)
Cancer Res
, vol.66
, pp. 2116-2128
-
-
Sato, M.1
Vaughan, M.B.2
Girard, L.3
Peyton, M.4
Lee, W.5
Shames, D.S.6
Ramirez, R.D.7
Sunaga, N.8
Gazdar, A.F.9
Shay, J.W.10
-
40
-
-
55349109940
-
Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells
-
PMID:18974146
-
Damiani LA, Yingling CM, Leng S, Romo PE, Nakamura J, Belinsky SA. Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells. Cancer Res 2008; 68:9005-14; PMID:18974146; http://dx.doi.org/10.1158/0008- 5472.CAN-08-1276
-
(2008)
Cancer Res
, vol.68
, pp. 9005-9014
-
-
Damiani, L.A.1
Yingling, C.M.2
Leng, S.3
Romo, P.E.4
Nakamura, J.5
Belinsky, S.A.6
-
41
-
-
0035967107
-
Promoter methylation of DAP-kinase: Association with advanced stage in non-small cell lung cancer
-
PMID:11313923
-
Kim DH, Nelson HH, Wiencke JK, Christiani DC, Wain JC, Mark EJ, Kelsey KT. Promoter methylation of DAP-kinase: Association with advanced stage in non-small cell lung cancer. Oncogene 2001; 20:1765-70; PMID:11313923; http://dx.doi.org/ 10.1038/sj.onc.1204302
-
(2001)
Oncogene
, vol.20
, pp. 1765-1770
-
-
Kim, D.H.1
Nelson, H.H.2
Wiencke, J.K.3
Christiani, D.C.4
Wain, J.C.5
Mark, E.J.6
Kelsey, K.T.7
-
42
-
-
2542547258
-
Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens
-
PMID:15172992
-
Pulling LC, Vuillemenot BR, Hutt JA, Devereux TR, Belinsky SA. Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens. Cancer Res 2004; 64:3844-8; PMID:15172992; http://dx.doi.org/ 10.1158/0008-5472.CAN-03-2119
-
(2004)
Cancer Res
, vol.64
, pp. 3844-3848
-
-
Pulling, L.C.1
Vuillemenot, B.R.2
Hutt, J.A.3
Devereux, T.R.4
Belinsky, S.A.5
-
43
-
-
39449091629
-
Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer
-
PMID:18281478
-
Luxen S, Belinsky SA, Knaus UG. Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer. Cancer Res 2008; 68:1037-45; PMID:18281478; http://dx.doi.org/10.1158/0008- 5472.CAN-07-5782
-
(2008)
Cancer Res
, vol.68
, pp. 1037-1045
-
-
Luxen, S.1
Belinsky, S.A.2
Knaus, U.G.3
-
44
-
-
33746756014
-
Comparative isoschizomer profiling of cytosine methylation: The HELP assay
-
PMID:16809668
-
Khulan B. Comparative isoschizomer profiling of cytosine methylation: The HELP assay. Genome Res 2006; 16:1046-55; PMID:16809668; http://dx.doi.org/10.1101/gr.5273806
-
(2006)
Genome Res
, vol.16
, pp. 1046-1055
-
-
Khulan, B.1
-
45
-
-
42649129709
-
An analytical pipeline for genomic representations used for cytosine methylation studies
-
PMID:18353789
-
Thompson RF, Reimers M, Khulan B, Gissot M, Richmond TA, Chen Q, Zheng X, Kim K, Greally JM. An analytical pipeline for genomic representations used for cytosine methylation studies. Bioinformatics 2008; 24:1161-7; PMID:18353789; http://dx.doi.org/10.1093/bioinformatics/btn096
-
(2008)
Bioinformatics
, vol.24
, pp. 1161-1167
-
-
Thompson, R.F.1
Reimers, M.2
Khulan, B.3
Gissot, M.4
Richmond, T.A.5
Chen, Q.6
Zheng, X.7
Kim, K.8
Greally, J.M.9
-
46
-
-
39149131380
-
High-performance liquid chromatography determination of 5-methyl-2 "-deoxycytidine, 2-" deoxycytidine, and other deoxynucleosides and nucleosides in DNA digests
-
Magaña AA, Wrobel K, Caudillo YA, Zaina S, Lund G, Wrobel K. High-performance liquid chromatography determination of 5-methyl-2"-deoxycytidine, 2-"deoxycytidine, and other deoxynucleosides and nucleosides in DNA digests. Anal Biochem 2008; 374:378-85; http://dx.doi.org/10.1016/j.ab.2011.026
-
(2008)
Anal Biochem
, vol.374
, pp. 378-385
-
-
Magaña, A.A.1
Wrobel, K.2
Caudillo, Y.A.3
Zaina, S.4
Lund, G.5
Wrobel, K.6
-
47
-
-
12144255958
-
Replication-independent chromatin loading of Dnmt1 during G2 and M phases
-
PMID:15550930
-
Easwaran HP, Schermelleh L, Leonhardt H, Cardoso MC. Replication-independent chromatin loading of Dnmt1 during G2 and M phases. EMBO Rep 2004; 5:1181-6; PMID:15550930; http://dx.doi.org/10.1038/ sj.embor.7400295
-
(2004)
EMBO Rep
, vol.5
, pp. 1181-1186
-
-
Easwaran, H.P.1
Schermelleh, L.2
Leonhardt, H.3
Cardoso, M.C.4
-
48
-
-
84877313553
-
Dissection of cell cycledependent dynamics of Dnmt1 by FRAP and diffusion- coupled modeling
-
PMID:23535145
-
Schneider K, Fuchs C, Dobay A, Rottach A, Qin W, Wolf P, Alvarez-Castro JM, Nalaskowski MM, Kremmer E, Schmid V, et al. Dissection of cell cycledependent dynamics of Dnmt1 by FRAP and diffusion- coupled modeling. Nucleic Acids Res 2013; 41:4860-76; PMID:23535145; http://dx.doi.org/ 10.1093/nar/gkt191
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 4860-4876
-
-
Schneider, K.1
Fuchs, C.2
Dobay, A.3
Rottach, A.4
Qin, W.5
Wolf, P.6
Alvarez-Castro, J.M.7
Nalaskowski, M.M.8
Kremmer, E.9
Schmid, V.10
-
49
-
-
79551642322
-
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers
-
PMID:21233348
-
Ting DT, Lipson D, Paul S, Brannigan BW, Akhavanfard S, Coffman EJ, Contino G, Deshpande V, Iafrate AJ, Letovsky S, et al. Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers. Science 2011; 331:593-6; PMID:21233348; http://dx.doi.org/10.1126/ science.1200801
-
(2011)
Science
, vol.331
, pp. 593-596
-
-
Ting, D.T.1
Lipson, D.2
Paul, S.3
Brannigan, B.W.4
Akhavanfard, S.5
Coffman, E.J.6
Contino, G.7
Deshpande, V.8
Iafrate, A.J.9
Letovsky, S.10
-
50
-
-
0034720284
-
CpG methylation is maintained in human cancer cells lacking DNMT
-
PMID:10801130
-
Rhee I, Jair KW, Yen RW, Lengauer C, Herman JG, Kinzler KW, Vogelstein B, Baylin SB, Schuebel KE. CpG methylation is maintained in human cancer cells lacking DNMT Nature 2000; 404:1003-7; PMID:10801130; http://dx.doi.org/10.1038/35010000
-
(2000)
Nature
, vol.404
, pp. 1003-1007
-
-
Rhee, I.1
Jair, K.W.2
Yen, R.W.3
Lengauer, C.4
Herman, J.G.5
Kinzler, K.W.6
Vogelstein, B.7
Baylin, S.B.8
Schuebel, K.E.9
-
51
-
-
4344705509
-
Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern
-
PMID:15220328
-
Espada J. Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern. J Biol Chem 2004; 279:37175-84; PMID:15220328; http://dx.doi.org/10.1074/jbc.M404842200
-
(2004)
J Biol Chem
, vol.279
, pp. 37175-37184
-
-
Espada, J.1
-
52
-
-
62649172171
-
Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain
-
PMID:19173286
-
Fellinger K, Rothbauer U, Felle M, Längst G, Leonhardt H. Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain. J Cell Biochem 2009; 106:521-8; PMID:19173286; http://dx.doi.org/10.1002/jcb.22071
-
(2009)
J Cell Biochem
, vol.106
, pp. 521-528
-
-
Fellinger, K.1
Rothbauer, U.2
Felle, M.3
Längst, G.4
Leonhardt, H.5
-
53
-
-
80052725628
-
The USP7/Dnmt1 complex stimulates the DNA methylation activity of dnmt1 and regulates the stability of UHRF
-
PMID:21745816
-
Felle M, Joppien S, Nemeth A, Diermeier S, Thalhammer V, Dobner T, Kremmer E, Kappler R, Langst G. The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF Nucleic Acids Res 2011; 39:8355-65; PMID:21745816; http://dx.doi.org/ 10.1093/nar/gkr528
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 8355-8365
-
-
Felle, M.1
Joppien, S.2
Nemeth, A.3
Diermeier, S.4
Thalhammer, V.5
Dobner, T.6
Kremmer, E.7
Kappler, R.8
Langst, G.9
-
54
-
-
77955300851
-
HNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing
-
PMID:20592467
-
Lee C-F,OuDS-C, Lee S-B,Chang L-H, Lin R-K, Li YS, Upadhyay AK, Cheng X, Wang Y-C, Hsu H-S, et al. hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing. J Clin Invest 2010; 120:2920-30; PMID:20592467; http://dx.doi.org/10.1172/JCI42275
-
(2010)
J Clin Invest
, vol.120
, pp. 2920-2930
-
-
Lee, C.-F.1
Ou, D.S.-C.2
Lee, S.-B.3
Chang, L.-H.4
Lin, R.-K.5
Li, Y.S.6
Upadhyay, A.K.7
Cheng, X.8
Wang, Y.-C.9
Hsu, H.-S.10
-
55
-
-
77954656715
-
UHRF1 is a novel diagnostic marker of lung cancer
-
PMID:20517312
-
Unoki M, Daigo Y, Koinuma J, Tsuchiya E, Hamamoto R, Nakamura Y. UHRF1 is a novel diagnostic marker of lung cancer. Br J Cancer 2010; 103:217-22; PMID:20517312; http://dx.doi.org/ 10.1038/sj.bjc.6605717
-
(2010)
Br J Cancer
, vol.103
, pp. 217-222
-
-
Unoki, M.1
Daigo, Y.2
Koinuma, J.3
Tsuchiya, E.4
Hamamoto, R.5
Nakamura, Y.6
-
56
-
-
79952034429
-
UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer
-
PMID:21351083
-
Daskalos A, Oleksiewicz U, Filia A, Nikolaidis G, Xinarianos G, Gosney JR, Malliri A, Field JK, Liloglou T. UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer. Cancer 2011; 117:1027-37; PMID:21351083; http://dx.doi.org/10.1002/cncr.25531
-
(2011)
Cancer
, vol.117
, pp. 1027-1037
-
-
Daskalos, A.1
Oleksiewicz, U.2
Filia, A.3
Nikolaidis, G.4
Xinarianos, G.5
Gosney, J.R.6
Malliri, A.7
Field, J.K.8
Liloglou, T.9
-
57
-
-
0029001154
-
Suppression of intestinal neoplasia by DNA hypomethylation
-
PMID:7537636
-
Laird PW, Jackson-Grusby L, Fazeli A, Dickinson SL, Jung WE, Li E, Weinberg RA, Jaenisch R. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 1995; 81:197-205; PMID:7537636; http://dx.doi.org/10.1016/0092-8674(95)90329-1
-
(1995)
Cell
, vol.81
, pp. 197-205
-
-
Laird, P.W.1
Jackson-Grusby, L.2
Fazeli, A.3
Dickinson, S.L.4
Jung, W.E.5
Li, E.6
Weinberg, R.A.7
Jaenisch, R.8
-
58
-
-
2342575723
-
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells
-
PMID:15126351
-
Suzuki M, Sunaga N, Shames DS, Toyooka S, Gazdar AF, Minna JD. RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells. Cancer Res 2004; 64:3137-43; PMID:15126351; http://dx.doi.org/10.1158/0008-5472.CAN-03-3046
-
(2004)
Cancer Res
, vol.64
, pp. 3137-3143
-
-
Suzuki, M.1
Sunaga, N.2
Shames, D.S.3
Toyooka, S.4
Gazdar, A.F.5
Minna, J.D.6
-
59
-
-
0031025621
-
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide
-
PMID:9012845
-
Ramchandani S, MacLeod AR, Pinard M, Hofe von E, Szyf M. Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide. Proc Natl Acad Sci USA 1997; 94:684-9; PMID:9012845; http://dx.doi.org/10.1073/pnas.94.2.684
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 684-689
-
-
Ramchandani, S.1
Macleod, A.R.2
Pinard, M.3
Von, H.E.4
Szyf, M.5
-
60
-
-
31544458225
-
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer
-
PMID:16397253
-
McCabe MT, Low JA, Daignault S, Imperiale MJ, Wojno KJ, Day ML. Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer. Cancer Res 2006; 66:385- 92; PMID:16397253; http://dx.doi.org/10.1158/ 0008-5472.CAN-05-2020
-
(2006)
Cancer Res
, vol.66
, pp. 385-392
-
-
McCabe, M.T.1
Low, J.A.2
Daignault, S.3
Imperiale, M.J.4
Wojno, K.J.5
Day, M.L.6
-
61
-
-
66249127951
-
A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation
-
PMID:19417133
-
Datta J, Ghoshal K, Denny WA, Gamage SA, Brooke DG, Phiasivongsa P, Redkar S, Jacob ST. A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer Res 2009; 69:4277-85; PMID:19417133; http://dx.doi.org/10.1158/0008-5472.CAN-08-3669
-
(2009)
Cancer Res
, vol.69
, pp. 4277-4285
-
-
Datta, J.1
Ghoshal, K.2
Denny, W.A.3
Gamage, S.A.4
Brooke, D.G.5
Phiasivongsa, P.6
Redkar, S.7
Jacob, S.T.8
-
62
-
-
0347622294
-
Targeting DNA methylation in cancer
-
PMID:12726777
-
Szyf M. Targeting DNA methylation in cancer. Ageing Res Rev 2003; 2:299-328; PMID:12726777; http://dx.doi.org/10.1016/S1568-1637(03)00012-6
-
(2003)
Ageing Res Rev
, vol.2
, pp. 299-328
-
-
Szyf, M.1
-
63
-
-
33744507681
-
Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells
-
PMID:16497664
-
Loriot A. Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells. J Biol Chem 2006; 281:10118-26; PMID:16497664; http://dx.doi.org/10.1074/jbc.M510469200
-
(2006)
J Biol Chem
, vol.281
, pp. 10118-10126
-
-
Loriot, A.1
-
64
-
-
67649794774
-
DNMT1 silencing affects locus specific DNA methylation and increases prostate cancer derived PC3 cell invasiveness
-
PMID:19539327
-
Yaqinuddin A, Qureshi SA, Qazi R, Farooq S, Abbas F. DNMT1 silencing affects locus specific DNA methylation and increases prostate cancer derived PC3 cell invasiveness. J Urol 2009; 182:756-61; PMID:19539327; http://dx.doi.org/10.1016/j.juro.2009.03.082
-
(2009)
J Urol
, vol.182
, pp. 756-761
-
-
Yaqinuddin, A.1
Qureshi, S.A.2
Qazi, R.3
Farooq, S.4
Abbas, F.5
-
65
-
-
77956645469
-
Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer
-
PMID:20584988
-
Morey Kinney SR, Moser MT, Pascual M, Greally JM, Foster BA, Karpf AR. Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer. Mol Cell Biol 2010; 30:4159-74; PMID:20584988;
-
(2010)
Mol Cell Biol
, vol.30
, pp. 4159-4174
-
-
Morey Kinney, S.R.1
Moser, M.T.2
Pascual, M.3
Greally, J.M.4
Foster, B.A.5
Karpf, A.R.6
|