메뉴 건너뛰기




Volumn 19, Issue 11, 2014, Pages 18733-18746

Identification of natural compound carnosol as a novel TRPA1 receptor agonist

Author keywords

Anti nociceptive; Calcium mobilization; Canosol; TRPA1

Indexed keywords

A 967079; ABIETANE DERIVATIVE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CALCIUM CHANNEL; CARNOSOL; NERVE PROTEIN; OXIME; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, HUMAN;

EID: 84912095289     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules191118733     Document Type: Article
Times cited : (17)

References (52)
  • 1
    • 0033548702 scopus 로고    scopus 로고
    • An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts
    • Jaquemar, D.; Schenker, T.; Trueb, B. An Ankyrin-like Protein with Transmembrane Domains is Specifically Lost after Oncogenic Transformation of Human Fibroblasts. J. Biol. Chem. 1999, 274, 7325-7333.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7325-7333
    • Jaquemar, D.1    Schenker, T.2    Trueb, B.3
  • 2
  • 3
    • 84866031550 scopus 로고    scopus 로고
    • Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura
    • Huang, D.; Li, S.; Dhaka, A.; Story, G.M.; Cao, Y.-Q. Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura. Mol. Pain 2012, 8, 1-19
    • (2012) Mol. Pain , vol.8 , pp. 1-19
    • Huang, D.1    Li, S.2    Dhaka, A.3    Story, G.M.4    Cao, Y.-Q.5
  • 5
    • 84875968496 scopus 로고    scopus 로고
    • Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia and urinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis
    • Meotti, F.C.; Forner, S.; Lima-Garcia, J.F.; Viana, A.F.; Calixto, J.B. Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia and urinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis. Chem. Biol. Interact. 2013, 203, 440-447
    • (2013) Chem. Biol. Interact. , vol.203 , pp. 440-447
    • Meotti, F.C.1    Forner, S.2    Lima-Garcia, J.F.3    Viana, A.F.4    Calixto, J.B.5
  • 6
    • 77949486271 scopus 로고    scopus 로고
    • Transient receptor potential A1 and cannabinoid receptor activity in human normal and hyperplastic prostate: Relation to nerves and interstitial cells
    • Gratzke, C.; Weinhold, P.; Reich, O.; Seitz, M.; Schlenker, B.; Stief, C.G.; Andersson, K.E.; Hedlund, P. Transient receptor potential A1 and cannabinoid receptor activity in human normal and hyperplastic prostate: Relation to nerves and interstitial cells. Eur. Urol. 2010, 57, 902-910
    • (2010) Eur. Urol. , vol.57 , pp. 902-910
    • Gratzke, C.1    Weinhold, P.2    Reich, O.3    Seitz, M.4    Schlenker, B.5    Stief, C.G.6    Andersson, K.E.7    Hedlund, P.8
  • 9
    • 79953678388 scopus 로고    scopus 로고
    • A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor alpha-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis
    • Fernandes, E.S.; Russell, F.A.; Spina, D.; McDougall, J.J.; Graepel, R.; Gentry, C.; Staniland, A.A.; Mountford, D.M.; Keeble, J.E.; Malcangio, M.; et al. A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor alpha-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis. Arthritis Rheum. 2011, 63, 819-829
    • (2011) Arthritis Rheum. , vol.63 , pp. 819-829
    • Fernandes, E.S.1    Russell, F.A.2    Spina, D.3    McDougall, J.J.4    Graepel, R.5    Gentry, C.6    Staniland, A.A.7    Mountford, D.M.8    Keeble, J.E.9    Malcangio, M.10
  • 10
    • 84867872657 scopus 로고    scopus 로고
    • The transient receptor potential channel TRPA1: From gene to pathophysiology
    • Nilius, B.; Appendino, G.; Owsianik, G. The transient receptor potential channel TRPA1: From gene to pathophysiology. Pflug. Arch. Eur. J. Physiol. 2012, 464, 425-458
    • (2012) Pflug. Arch. Eur. J. Physiol. , vol.464 , pp. 425-458
    • Nilius, B.1    Appendino, G.2    Owsianik, G.3
  • 12
    • 84902343834 scopus 로고    scopus 로고
    • TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis
    • DeBerry, J.J.; Schwartz, E.S.; Davis, B.M. TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis. Pain 2014, 155, 1280-1287
    • (2014) Pain , vol.155 , pp. 1280-1287
    • Deberry, J.J.1    Schwartz, E.S.2    Davis, B.M.3
  • 14
    • 84900799033 scopus 로고    scopus 로고
    • Transient receptor potential (TRP) channels in the airway: Role in airway disease
    • Grace, M.S.; Baxter, M.; Dubuis, E.; Birrell, M.A.; Belvisi, M.G. Transient receptor potential (TRP) channels in the airway: Role in airway disease. Br. J. Pharmacol. 2014, 171, 2593-2607
    • (2014) Br. J. Pharmacol. , vol.171 , pp. 2593-2607
    • Grace, M.S.1    Baxter, M.2    Dubuis, E.3    Birrell, M.A.4    Belvisi, M.G.5
  • 15
    • 76349099584 scopus 로고    scopus 로고
    • The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation
    • Da Costa, D.S.; Meotti, F.C.; Andrade, E.L.; Leal, P.C.; Motta, E.M.; Calixto, J.B. The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation. Pain 2010, 148, 431-437
    • (2010) Pain , vol.148 , pp. 431-437
    • Da Costa, D.S.1    Meotti, F.C.2    Andrade, E.L.3    Leal, P.C.4    Motta, E.M.5    Calixto, J.B.6
  • 16
    • 84890749065 scopus 로고    scopus 로고
    • Transient receptor potential (TRP) channels: A clinical perspective.
    • Kaneko, Y.; Szallasi, A. Transient receptor potential (TRP) channels: A clinical perspective. Br. J. Pharmacol. 2014, 171, 2474-2507
    • (2014) Br. J. Pharmacol. , vol.171 , pp. 2474-2507
    • Kaneko, Y.1    Szallasi, A.2
  • 17
    • 84893739125 scopus 로고    scopus 로고
    • Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain
    • Kojima, R.; Nozawa, K.; Doihara, H.; Keto, Y.; Kaku, H.; Yokoyama, T.; Itou, H. Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur. J. Pharmacol. 2014, 723, 288-293
    • (2014) Eur. J. Pharmacol. , vol.723 , pp. 288-293
    • Kojima, R.1    Nozawa, K.2    Doihara, H.3    Keto, Y.4    Kaku, H.5    Yokoyama, T.6    Itou, H.7
  • 19
    • 84862150176 scopus 로고    scopus 로고
    • Ingestion of cinnamaldehyde, a TRPA1 agonist, reduces visceral fats in mice fed a high-fat and high-sucrose diet
    • Amura, Y.T.; Wasaki, Y.I.; Arukawa, M.N.; Atanabe, T.W. Ingestion of cinnamaldehyde, a TRPA1 agonist, reduces visceral fats in mice fed a high-fat and high-sucrose diet. J. Nutr. Sci. Vitaminol. 2012, 58, 9-13
    • (2012) J. Nutr. Sci. Vitaminol. , vol.58 , pp. 9-13
    • Amura, Y.T.1    Wasaki, Y.I.2    Arukawa, M.N.3    Atanabe, T.W.4
  • 21
    • 52549112698 scopus 로고    scopus 로고
    • Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators
    • Karashima, Y.; Prenen, J.; Meseguer, V.; Owsianik, G.; Voets, T.; Nilius, B. Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflug. Arch. Eur. J. Physiol. 2008, 457, 77-89
    • (2008) Pflug. Arch. Eur. J. Physiol. , vol.457 , pp. 77-89
    • Karashima, Y.1    Prenen, J.2    Meseguer, V.3    Owsianik, G.4    Voets, T.5    Nilius, B.6
  • 22
    • 84902458125 scopus 로고    scopus 로고
    • Effect of intraperitoneal administered ginseng total saponins on hyperalgesia induced by repeated intramuscular injection of acidic saline in rats
    • Kim, W.J.; Kang, H.; Kim, J.E.; Choi, G.J.; Shin, H.Y.; Baek, C.W.; Jung, Y.H.; Woo, Y.C.; Kim, S.H.; Lee, J.H. Effect of intraperitoneal administered ginseng total saponins on hyperalgesia induced by repeated intramuscular injection of acidic saline in rats. J. Med. Food 2014, 17, 657-662
    • (2014) J. Med. Food , vol.17 , pp. 657-662
    • Kim, W.J.1    Kang, H.2    Kim, J.E.3    Choi, G.J.4    Shin, H.Y.5    Baek, C.W.6    Jung, Y.H.7    Woo, Y.C.8    Kim, S.H.9    Lee, J.H.10
  • 24
    • 77956286062 scopus 로고    scopus 로고
    • The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica thunb and anemarrhena asphodeloides BUNGE in vivo
    • Kang, M.; Jung, I.; Hur, J.; Kim, S.H.; Lee, J.H.; Kang, J.Y.; Jung, K.C.; Kim, K.S.; Yoo, M.C.; Park, D.S.; et al. The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo. J. Ethnopharmacol. 2010, 131, 485-496
    • (2010) J. Ethnopharmacol. , vol.131 , pp. 485-496
    • Kang, M.1    Jung, I.2    Hur, J.3    Kim, S.H.4    Lee, J.H.5    Kang, J.Y.6    Jung, K.C.7    Kim, K.S.8    Yoo, M.C.9    Park, D.S.10
  • 25
    • 70349916369 scopus 로고    scopus 로고
    • Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones
    • Wrigley, P.J.; Jeong, H.J.; Vaughan, C.W. Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones. Br. J. Pharmacol. 2009, 157, 371-380
    • (2009) Br. J. Pharmacol. , vol.157 , pp. 371-380
    • Wrigley, P.J.1    Jeong, H.J.2    Vaughan, C.W.3
  • 26
    • 79954576919 scopus 로고    scopus 로고
    • Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
    • Chen, J.; Joshi, S.K.; DiDomenico, S.; Perner, R.J.; Mikusa, J.P.; Gauvin, D.M.; Segreti, J.A.; Han, P.; Zhang, X.F.; Niforatos, W.; et al. Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 2011, 152, 1165-1172
    • (2011) Pain , vol.152 , pp. 1165-1172
    • Chen, J.1    Joshi, S.K.2    Didomenico, S.3    Perner, R.J.4    Mikusa, J.P.5    Gauvin, D.M.6    Segreti, J.A.7    Han, P.8    Zhang, X.F.9    Niforatos, W.10
  • 27
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang, J.H. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J. Biomol. Screen. 1999, 4, 67-73
    • (1999) J. Biomol. Screen. , vol.4 , pp. 67-73
    • Zhang, J.H.1
  • 28
    • 84977916244 scopus 로고    scopus 로고
    • Carnosol: A phenolic diterpene with cancer chemopreventive potential
    • Chun, K.S.; Kundu, J.; Chae, I.G.; Kundu, J.K. Carnosol: A phenolic diterpene with cancer chemopreventive potential. J. Cancer Prev. 2014, 19, 103-110
    • (2014) J. Cancer Prev. , vol.19 , pp. 103-110
    • Chun, K.S.1    Kundu, J.2    Chae, I.G.3    Kundu, J.K.4
  • 30
    • 84884288091 scopus 로고    scopus 로고
    • Antibacterial allelopathic and antioxidant activities of essential oil of Salvia officinalis L growing wild in the Atlas Mountains of Morocco
    • Bouajaj, S.; Benyamna, A.; Bouamama, H.; Romane, A.; Falconieri, D.; Piras, A.; Marongiu, B. Antibacterial, allelopathic and antioxidant activities of essential oil of Salvia officinalis L. growing wild in the Atlas Mountains of Morocco. Nat. Prod. Res. 2013, 27, 1673-1676
    • (2013) Nat. Prod. Res. , vol.27 , pp. 1673-1676
    • Bouajaj, S.1    Benyamna, A.2    Bouamama, H.3    Romane, A.4    Falconieri, D.5    Piras, A.6    Marongiu, B.7
  • 31
    • 45049087994 scopus 로고    scopus 로고
    • Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes
    • Poeckel, D.; Greiner, C.; Verhoff, M.; Rau, O.; Tausch, L.; Hornig, C.; Steinhilber, D.; Schubert-Zsilavecz, M.; Werz, O. Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. Biochem. Pharmacol. 2008, 76, 91-97
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 91-97
    • Poeckel, D.1    Greiner, C.2    Verhoff, M.3    Rau, O.4    Tausch, L.5    Hornig, C.6    Steinhilber, D.7    Schubert-Zsilavecz, M.8    Werz, O.9
  • 33
    • 80053268400 scopus 로고    scopus 로고
    • Effect of Salvia officinalis Hydroalcoholic Extract on Vincristine-induced Neuropathy in Mice
    • Abad, A.N.A.; Nour, M.H.K.; Tavakkoli, F. Effect of Salvia officinalis Hydroalcoholic Extract on Vincristine-induced Neuropathy in Mice. Chin. J. Nat. Med. 2011, 9, 354-358
    • (2011) Chin. J. Nat. Med. , vol.9 , pp. 354-358
    • Abad, A.N.A.1    Nour, M.H.K.2    Tavakkoli, F.3
  • 34
    • 77957022255 scopus 로고    scopus 로고
    • The antinociceptive and anti-inflammatory effects of Salvia officinalis leaf aqueous and butanol extracts
    • Qnais, E.Y.; Abu-Dieyeh, M.; Abdulla, F.A.; Abdalla, S.S. The antinociceptive and anti-inflammatory effects of Salvia officinalis leaf aqueous and butanol extracts. Pharm. Biol. 2010, 48, 1149-1156
    • (2010) Pharm. Biol. , vol.48 , pp. 1149-1156
    • Qnais, E.Y.1    Abu-Dieyeh, M.2    Abdulla, F.A.3    Abdalla, S.S.4
  • 39
    • 84869225024 scopus 로고    scopus 로고
    • The antioxidant effect of carnosol in bovine aortic endothelial cells is mainly mediated via estrogen receptor α pathway
    • Zhao, P.W.; Lee, D.Y.; Ma, Z.Z.; Huang, L.S.; Sun, L.P.; Li, Y.D.; Chen, J.X.; Niu, J.Z. The antioxidant effect of carnosol in bovine aortic endothelial cells is mainly mediated via estrogen receptor α pathway. Biol. Pharm. Bull. 2012, 35, 1947-1955
    • (2012) Biol. Pharm. Bull. , vol.35 , pp. 1947-1955
    • Zhao, P.W.1    Lee, D.Y.2    Ma, Z.Z.3    Huang, L.S.4    Sun, L.P.5    Li, Y.D.6    Chen, J.X.7    Niu, J.Z.8
  • 40
    • 84872674746 scopus 로고    scopus 로고
    • Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary
    • Lopez-Jimenez, A.; Garcia-Caballero, M.; Medina, M.A.; Quesada, A.R. Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary. Eur. J. Nutr. 2013, 52, 85-95
    • (2013) Eur. J. Nutr. , vol.52 , pp. 85-95
    • Lopez-Jimenez, A.1    Garcia-Caballero, M.2    Medina, M.A.3    Quesada, A.R.4
  • 41
    • 33750801884 scopus 로고    scopus 로고
    • Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization
    • Lee, J.J.; Jin, Y.R.; Lim, Y.; Hong, J.T.; Kim, T.J.; Chung, J.H.; Yun, Y.P. Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. Vasc. Pharmacol. 2006, 45, 148-153
    • (2006) Vasc. Pharmacol. , vol.45 , pp. 148-153
    • Lee, J.J.1    Jin, Y.R.2    Lim, Y.3    Hong, J.T.4    Kim, T.J.5    Chung, J.H.6    Yun, Y.P.7
  • 43
    • 80053246998 scopus 로고    scopus 로고
    • Curcumin ((EE)-1,7-bis(4- hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1
    • Leamy, A.W.; Shukla, P.; McAlexander, M.A.; Carr, M.J.; Ghatta, S. Curcumin ((E,E)-1,7-bis(4- hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1. Neurosci. Lett. 2011, 503, 157-162
    • (2011) Neurosci. Lett. , vol.503 , pp. 157-162
    • Leamy, A.W.1    Shukla, P.2    McAlexander, M.A.3    Carr, M.J.4    Ghatta, S.5
  • 44
    • 84856409044 scopus 로고    scopus 로고
    • TRPA1 antagonists as potential analgesic drugs
    • Andrade, E.L.; Meotti, F.C.; Calixto, J.B. TRPA1 antagonists as potential analgesic drugs. Pharmacol. Ther. 2012, 133, 189-204
    • (2012) Pharmacol. Ther. , vol.133 , pp. 189-204
    • Andrade, E.L.1    Meotti, F.C.2    Calixto, J.B.3
  • 45
    • 55749087512 scopus 로고    scopus 로고
    • Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels
    • Xiao, B.; Dubin, A.E.; Bursulaya, B.; Viswanath, V.; Jegla, T.J.; Patapoutian, A. Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J. Neurosci. Off. J. Soc. Neurosci. 2008, 28, 9640-9651
    • (2008) J. Neurosci. Off. J. Soc. Neurosci. , vol.28 , pp. 9640-9651
    • Xiao, B.1    Dubin, A.E.2    Bursulaya, B.3    Viswanath, V.4    Jegla, T.J.5    Patapoutian, A.6
  • 50
    • 84892892044 scopus 로고    scopus 로고
    • Activation of transient receptor potential ankyrin 1 by eugenol
    • Chung, G.; Im, S.T.; Kim, Y.H.; Jung, S.J.; Rhyu, M.R.; Oh, S.B. Activation of transient receptor potential ankyrin 1 by eugenol. Neuroscience 2014, 261, 153-160
    • (2014) Neuroscience , vol.261 , pp. 153-160
    • Chung, G.1    Im, S.T.2    Kim, Y.H.3    Jung, S.J.4    Rhyu, M.R.5    Oh, S.B.6
  • 51
    • 84875752137 scopus 로고    scopus 로고
    • [6]-gingerol: A novel AT1 antagonist for the treatment of cardiovascular disease
    • Liu, Q.; Liu, J.; Guo, H.; Sun, S.; Wang, S.; Zhang, Y.; Li, S.; Qiao, Y. [6]-gingerol: A novel AT1 antagonist for the treatment of cardiovascular disease. Planta Med. 2013, 79, 322-326
    • (2013) Planta Med. , vol.79 , pp. 322-326
    • Liu, Q.1    Liu, J.2    Guo, H.3    Sun, S.4    Wang, S.5    Zhang, Y.6    Li, S.7    Qiao, Y.8
  • 52
    • 84884329017 scopus 로고    scopus 로고
    • Pinacidil a Katp channel opener, identified as a novel agonist for TRPA1
    • Ma, L.H.; Deng, Y.; Zhang, B.; Bai, Y.Q.; Cao, J.; Li, S.Y.; Liu, J.F. Pinacidil, a Katp channel opener, identified as a novel agonist for TRPA1. Chin. Sci. Bull. 2012, 57, 1810-1817.
    • (2012) Chin. Sci. Bull. , vol.57 , pp. 1810-1817
    • Ma, L.H.1    Deng, Y.2    Zhang, B.3    Bai, Y.Q.4    Cao, J.5    Li, S.Y.6    Liu, J.F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.