Pinacidil, a Katp channel opener, identified as a novel agonist for TRPA1

Chinese Science Bulletin

Volumn 57, Issue 15, 2012, Pages 1810-1817

  Ma, LiangHui ^a,b   Deng, Ying ^d   Zhang, Bi ^d   Bai, YanQiu ^a,b   Cao, Jing ^c   Li, ShiYou ^a   Liu, JianFeng ^d  

^a Chinese Academy of Sciences   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

covalent modification; pinacidil; TRPA1

Indexed keywords

EID: 84884329017     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-012-5035-0     Document Type: Article

References (38)

1. Patapoutian A, Peier A M, Story G M, et al. ThermoTRP channels and beyond: Mechanisms of temperature sensation. Nat Rev Neurosci, 2003, 4: 529-539.
2. Alexander S P, Mathie A, Peters J A. Guide to receptors and channels. 2nd ed. Br J Pharmacol, 2006, 147(Suppl 3): S1-168.
3. Kwan K Y, Allchorne A J, Vollrath M A, et al. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron, 2006, 50: 277-289.
4. Vannier B, Zhu X, Brown D, et al. The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry. J Biol Chem, 1998, 273: 8675-8679.
5. Montell C. Thermosensation: Hot findings make TRPNs very cool. Curr Biol, 2003, 13: R476-478.
6. Nilius B, Owsianik G, Voets T, et al. Transient receptor potential cation channels in disease. Physiol Rev, 2007, 87: 165-217.
7. Ramsey I S, Delling M, Clapham D E. An introduction to TRP channels. Annu Rev Physiol, 2006, 68: 619-647.
8. Jaquemar D, Schenker T, Trueb B. An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. J Biol Chem, 1999, 274: 7325-7333.
9. Story G M, Peier A M, Reeve A J, et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell, 2003, 112: 819-829.
10. Nagata K, Duggan A, Kumar G, et al. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci, 2005, 25: 4052-4061.
11. Stokes A, Wakano C, Koblan-Huberson M, et al. TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. Cell Signal, 2006, 18: 1584-1594.
12. Nozawa K, Kawabata-Shoda E, Doihara H, et al. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci USA, 2009, 106: 3408-3413.
13. Bandell M, Story G M, Hwang S W, et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron, 2004, 41: 849-857.
14. Baraldi P G, Preti D, Materazzi S, et al. Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem, 2010, 53: 5085-5107.
15. Bautista D M, Movahed P, Hinman A, et al. Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci USA, 2005, 102: 12248-12252.
16. Bautista D M, Jordt S E, Nikai T, et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell, 2006, 124: 1269-1282.
17. Terada Y, Narukawa M, Watanabe T. Specific hydroxy fatty acids in royal jelly activate TRPA1. J Agric Food Chem, 2011, 59: 2627-2635.
18. Gijsen H J, Berthelot D, Zaja M, et al. Analogues of morphanthridine and the tear gas dibenz[b, f][1, 4]oxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel. J Med Chem, 2010, 53: 7011-7020.
19. Andre E, Gatti R, Trevisani M, et al. Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents. Br J Pharmacol, 2009, 158: 1621-1628.
20. Nilius B. From TRPs to SOCs, CCEs, and CRACs: Consensus and controversies. Cell Calcium, 2003, 33: 293-298.
21. Rankow R M. Question: What is the best method to deal with bony ankylosis of the temporomandibular joint? Ann Plast Surg, 1978, 1: 627.
22. Lin Y F, Raab-Graham K, Jan Y N, et al. NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection. Proc Natl Acad Sci USA, 2004, 101: 7799-7804.
23. Sun X, Cao K, Yang G, et al. Selective expression of Kir6. 1 protein in different vascular and non-vascular tissues. Biochem Pharmacol, 2004, 67: 147-156.
24. Prost A, Derand R, Gros L, et al. Inhibition of ATP-sensitive K+ channels by substituted benzo[c]quinolizinium CFTR activators. Biochem Pharmacol, 2003, 66: 425-430.
25. Gojkovic-Bukarica L C, Beleslin-Cokic B B, Novakovic A N, et al. The effects of potassium channel opener P1075 on the human saphenous vein and human internal mammary artery. J Cardiovasc Pharmacol, 2011 (in press).
26. Hinman A, Chuang H H, Bautista D M, et al. TRP channel activation by reversible covalent modification. Proc Natl Acad Sci USA, 2006, 103: 19564-19568.
27. Jordt S E, Bautista D M, Chuang H H, et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature, 2004, 427: 260-265.
28. Eid S R, Crown E D, Moore E L, et al. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain, 2008, 4: 48.
29. Taylor-Clark T E, Undem B J, Macglashan D W, et al. Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1). Mol Pharmacol, 2008, 73: 274-281.
30. Maher M, Ao H, Banke T, et al. Activation of TRPA1 by farnesyl thiosalicylic acid. Mol Pharmacol, 2008, 73: 1225-1234.
31. Doerner J F, Gisselmann G, Hatt H, et al. Transient receptor potential channel A1 is directly gated by calcium ions. J Biol Chem, 2007, 282: 13180-13189.
32. 2+. Nat Neurosci, 2007, 10: 277-279.
33. 2+ reveals different functional channel states. Neuroscience, 2008, 154: 1467-1476.
34. Macpherson L J, Dubin A E, Evans M J, et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature, 2007, 445: 541-545.
35. Sterndorff B, Johansen P. The antihypertensive effect of pinacidil versus prazosin in mild to moderate hypertensive patients seen in general practice. Acta Med Scand, 1988, 224: 329-336.
36. Friedel H A, Brogden R N. Pinacidil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the treatment of hypertension. Drugs, 1990, 39: 929-967.
37. Obata K, Katsura H, Mizushima T, et al. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest, 2005, 115: 2393-2401.
38. Caterina M J, Leffler A, Malmberg A B, et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science, 2000, 288: 306-313.