The antioxidant effect of carnosol in bovine aortic endothelial cells is mainly mediated via estrogen receptor α pathway

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 11, 2012, Pages 1947-1955

  Zhao, Pi Wen ^a,b   Lee, David Yue Wei ^a   Ma, Zhong Ze ^a   Huang, Lian Sha ^a,b   Sun, Li Ping ^b   Li, Ya Dong ^b   Chen, Jia Xu ^b   Niu, Jian Zhao ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Antioxidant effect; Bovine aortic endothelial cell; Carnosol; Estrogen receptor; Phytoestrogen; Reporter gene

Indexed keywords

1,3 BIS(4 HYDROXYPHENYL) 4 METHYL 5 [4 (2 PIPERIDINYLETHOXY)PHENOL] 1H PYRAZOLE; 4 [2 PHENYL 5,7 BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5 A]PYRIMIDINE 3 YL]PHENOL; ANTIESTROGEN; ANTIOXIDANT; CARNOSOL; DICHLOROFLUORESCEIN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; ROSMARINUS OFFICINALIS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; AORTA; APOPTOSIS; ARTICLE; CARDIOVASCULAR FUNCTION; CELL GROWTH; CELL PROLIFERATION; COW; DRUG STRUCTURE; ENDOTHELIUM CELL; GENETIC ANALYSIS; MEDICINAL PLANT; NONHUMAN; OXIDATIVE STRESS; REPORTER GENE; ROSEMARY;

ANIMALS; ANTIOXIDANTS; AORTA; APOPTOSIS; CATTLE; CELL SURVIVAL; CELLS, CULTURED; DITERPENES, ABIETANE; ENDOTHELIAL CELLS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HEK293 CELLS; HUMANS; HYDROGEN PEROXIDE; OXIDANTS; REACTIVE OXYGEN SPECIES;

EID: 84869225024     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00325     Document Type: Article

References (42)

1. Grady D, Gebretsadik T, Kerlikowske K, Ernster V, Petitti D. Hormone replacement therapy and endometrial cancer risk: a meta-analysis. Obstet. Gynecol., 85, 304-313 (1995).
2. Weiss LK, Burkman RT, Cushing-Haugen KL, Voigt LF, Simon MS, Daling JR, Norman SA, Bernstein L, Ursin G, Marchbanks PA, Strom BL, Berlin JA, Weber AL, Doody DR, Wingo PA, McDonald JA, Malone KE, Folger SG, Spirtas R. Hormone replacement therapy regimens and breast cancer risk (1). Obstet. Gynecol., 100, 1148-1158 (2002).
3. Yusuf S, Anand S. Hormone replacement therapy: a time for pause. CMAJ, 167, 357-359 (2002).
4. Deschamps AM, Murphy E. Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats. Am. J. Physiol. Heart Circ. Physiol., 297, H1806-H1813 (2009).
5. Turner JV, Agatonovic-Kustrin S, Glass BD. Molecular aspects of phytoestrogen selective binding at estrogen receptors. J. Pharm. Sci., 96, 1879-1885 (2007).
6. Widyarini S, Spinks N, Husband AJ, Reeve VE. Isoflavonoid compounds from red clover (Trifolium pratense) protect from inflammation and immune suppression induced by UV radiation. Photoehem. Photobiol., 74, 465-470 (2001).
7. Kovacic P, Somanathan R. Multifaceted approach to resveratrol bioactivity: Focus on antioxidant action, cell signaling and safety. Oxid. Med. Cell. Longev., 3, 86-100 (2010).
8. Le Corre L, Fustier P, Chalabi N, Bignon YJ, Bernard-Gallon D. Effects of resveratrol on the expression of a panel of genes interacting with the BRCA1 oncosuppressor in human breast cell lines. Clin. Chim. Acta, 344, 115-121 (2004).
9. Aruoma OI, Spencer JP, Rossi R, Aeschbach R, Khan A, Mahmood N, Munoz A, Murcia A, Butler J, Halliwell B. An evaluation of the antioxidant and antiviral action of extracts of rosemary and Provençal herbs. Food Chem. Toxicol., 34, 449-456 (1996).
10. Ylikomi T, Bocquel MT, Berry M, Gronemeyer H, Chambon P. Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors. EMBO J., 11, 3681-3694 (1992).
11. Johnson JJ, Syed DN, Heren CR, Suh Y, Adhami VM, Mukhtar H. Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5′-AMP-activated protein kinase (AMPK) pathway. Pharm. Res., 25, 2125-2134 (2008).
12. Richheimer SL, Bernart MW, King GA, Kent MC, Bailey DT. Antioxidant activity of lipid-soluble phenolic diterpenses from rosemary. J. Am. Oil Chem. Soc., 73, 507-514 (1996).
13. McGovern PE, Mirzoian A, Hall GR. Ancient Egyptian herbal wines. Proc. Natl. Acad. Sci. U.S.A., 106, 7361-7366 (2009).
14. Sagar SM, Yance D, Wong RK. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer - Part 1. Curr. Oncol., 13, 14-26 (2006).
15. Visanji JM, Thompson DG, Padfield PJ. Induction of G2/M phase cell cycle arrest by carnosol and carnosic acid is associated with alteration of cyclin A and cyclin B1 levels. Cancer Lett., 237, 130-13 6 (2006).
16. Flowers M, Thompson PA. t10c12 conjugated linoleic acid suppresses HER2 protein and enhances apoptosis in SKBr3 breast cancer cells: possible role of COX2. PLoS ONE, 4, e5342 (2009).
17. Singletary K, MacDonald C, Wallig M. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett., 104, 43-48 (1996).
18. Moran AE, Carothers AM, Weyant MJ, Redston M, Bertagnolli MM. Carnosol inhibits beta-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J/Min/+ (Min/+) mouse. Cancer Res., 65, 1097-1104 (2005).
19. Huang SC, Ho CT, Lin-Shiau SY, Lin JK. Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-Jun. Biochem. Pharmacol., 69, 221-232 (2005).
20. Felty Q. Estrogen-induced DNA synthesis in vascular endothelial cells is mediated by ROS signaling. BMC Cardiovasc. Disord., 6, 16 (2006).
21. Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S. Endothelial dysfunction as a target for prevention of cardiovascular disease. Diabetes Care, 32, S314-S321 (2009).
22. Li H, Förstermann U. Resveratrol: a multifunctional compound improving endothelial function. Editorial to: "Resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats," by S. Soylemez et al. Cardiovasc. Drugs Ther., 23, 425-429 (2009).
23. Kim JK, Levin ER. Estrogen signaling in the cardiovascular system. Nucl. Recept. Signal., 4, e013 (2006).
24. Miller VM, Mulvagh SL. Sex steroids and endothelial function: translating basic science to clinical practice. Trends Pharmacol. Sci., 28, 263-270 (2007).
25. Widlansky ME, Gokce N, Keaney JF Jr, Vita JA. The clinical implications of endothelial dysfunction. J. Am. Coll. Cardiol., 42, 1149-1160 (2003).
26. Klinge CM, Blankenship KA, Risinger KE, Bhatnagar S, Noisin EL, Sumanasekera WK, Zhao L, Brey DM, Keynton RS. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptor a and β in endothelial cells. J. Biol. Client., 280, 7460-7468 (2005).
27. Song JY, Kim MJ, Jo HH, Hwang SJ, Chae B, Chung JE, Kwon DJ, Lew YO, Lim YT, Kim JH, Kim JH, Kim MR. Antioxidant effect of estrogen on bovine aortic endothelial cells. J. Steroid Biochem. Mol Biol., 117, 74-80 (2009).
28. Johnson JJ, Syed DN, Suh Y, Heren CR, Saleem M, Siddiqui IA, Mukhtar H. Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention. Cancer Prev. Res. (Phila.), 3, 1112-1123 (2010).
29. O'Lone R, Knorr K, Jaffe IZ, Schaffer ME, Martini PG, Karas RH, Bienkowska J, Mendelsohn ME, Hansen U. Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species. Mol. Endocrinol., 21, 1281-1296 (2007).
30. Smiley DA, Khalil RA. Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels. Curr. Med. Chem., 16, 1863-1887 (2009).
31. Zhang QG, Raz L, Wang R, Han D, De Sevilla L, Yang F, Vadlamudi RK, Brann DW. Estrogen attenuates ischemic oxidative damage via an estrogen receptor α-mediated inhibition of NADPH oxidase activation. J. Neurosci., 29, 13823-13836 (2009).
32. Roger P, Sahla ME, Mäkelä S, Gustafsson JA, Baldet P, Rochefort H. Decreased expression of estrogen receptor β protein in proliferative preinvasive mammary tumors. Cancer Res., 61, 2537-2541 (2001).
33. Förstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat. Clin. Pract. Cardiovasc. Med., 5, 338-349 (2008).
34. Spanier G, Xu H, Xia N, Tobias S, Deng S, Wojnowski L, Forstermann U, Li H. Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J. Physiol. Pharmacol., 60 (Suppl. 4), 111-116 (2009).
35. Muramatsu M, Inoue S. Estrogen receptors: how do they control reproductive and nonreproductive functions? Biochem. Biophys. Res. Commun., 270, 1-10 (2000).
36. Taylor AH, Al-Azzawi F. Immunolocalisation of oestrogen receptor beta in human tissues. J. Mol. Endocrinol., 24, 145-155 (2000).
37. Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson JA. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology, 138, 863-870 (1997).
38. Shao W, Brown M. Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy. Breast Cancer Res., 6, 39-52 (2004).
39. Fowler AM, Solodin N, Preisler-Mashek MT, Zhang P, Lee AV, Alarid ET. Increases in estrogen receptor-alpha concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen. FASEB J., 18, 81-93 (2004).
40. Gutendorf B, Westendorf J. Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology, 166, 79-89 (2001).
41. Chrzan BG, Bradford PG. Phytoestrogen activate estrogen receptor beta 1 and estrogenic responses in human breast and bone cancer cell lines. Mol. Nutr. Food Res., 51, 171-177 (2007).
42. Morito K, Hirose T, Kinjo J, Hirakawa T, Okawa M, Nohara T, Ogawa S, Inoue S, Muramatsu M, Masamune Y. Interaction of phytoestrogens with estrogen receptors α and β. Biol. Pharm. Bull., 24, 351-356 (2001).