The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo

Journal of Ethnopharmacology

Volumn 131, Issue 2, 2010, Pages 485-496

  Kang, Moonkyu ^a   Jung, Inho ^a   Hur, Jonghyun ^a   Kim, Soon Han ^a   Lee, Jeong Hun ^a   Kang, Ji Yun ^a   Jung, Kyoung Chul ^a   Kim, Kyoung Soo ^b   Yoo, Myung Chul ^b   Park, Dong Suk ^b   Lee, Jae Dong ^c   Cho, Yong Baik ^a  

^a Central Research Institute   (South Korea)

^b Kyung Hee University College of Medicine   (South Korea)

^c Kyung Hee University   (South Korea)

Author keywords

Anemarrhena asphodeloides BUNGE; Anti inflammatory activity; Anti nociceptive activity; Lonicera japonica Thunb; Osteoarthritis; WIN 34B

Indexed keywords

ACETIC ACID; ANEMARRHENA ASPHODELOIDES EXTRACT; CARRAGEENAN; CELECOXIB; CROTON OIL; FORMALDEHYDE; INDOMETACIN; IODOACETIC ACID; LONICERA JAPONICA EXTRACT; MONOSODIUM IODOACETATE; UNCLASSIFIED DRUG; WIN 34 B; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; PLANT EXTRACT; PYRAZOLE DERIVATIVE; SULFONAMIDE;

ANALGESIA; ANEMARRHENA ASPHODELOIDES; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOT PLATE TEST; LABORATORY TEST; LONICERA JAPONICA; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PAIN ASSESSMENT; RAT; TAIL FLICK TEST; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WRITHING TEST; ANEMARRHENA; ANIMAL; ANIMAL BEHAVIOR; CAPILLARY PERMEABILITY; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; EDEMA; FLOWER; HEAT; INSTITUTE FOR CANCER RESEARCH MOUSE; LONICERA; PAIN; PHYTOTHERAPY; PLANT ROOT; SPRAGUE DAWLEY RAT; WISTAR RAT;

ANEMARRHENA ASPHODELOIDES; ANIMALIA; LONICERA JAPONICA; MUS;

ANALGESICS; ANEMARRHENA; ANIMALS; ANTI-INFLAMMATORY AGENTS; BEHAVIOR, ANIMAL; CAPILLARY PERMEABILITY; CARRAGEENAN; CROTON OIL; DISEASE MODELS, ANIMAL; EDEMA; FLOWERS; HOT TEMPERATURE; INDOMETHACIN; IODOACETATES; LONICERA; MICE; MICE, INBRED ICR; OSTEOARTHRITIS; PAIN; PAIN MEASUREMENT; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SULFONAMIDES;

EID: 77956286062     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.07.025     Document Type: Article

References (50)

1. Ameye L.G., Chee W.S. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systemic review of the scientific evidence. Arthritis Research & Therapy 2006, 8:R127.
2. Bhatia H.S., Candelario-Jail E., de Oliveira A.C., Olajide O.A., Martinez-Sanchez G. Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells. Archives of Biochemistry and Biophysics 2008, 477:253-258.
3. Chan C.F., Sun W.Z., Lin J.K., Lin-Shiau S.Y. Activation of transcription factors of nuclear factor kappa b, activation protein-1 and octamer factors in hyperalgesia. European Journal of Pharmacology 2000, 402:61-68.
4. Coderre T.J. Contribution of protein kinase C to central sensitization and persistent pain following tissue injury. Neuroscience Letters 1992, 140:181-184.
5. Cunha F.Q., Teixeira M.M., Ferreira S.H. Pharmacological modulation of secondary mediator systems-cyclic AMP and cyclic GMP-on inflammatory hyperalgesia. British Journal of Pharmacology 1999, 127:671-678.
6. Di Rosa M., Giroud J.P., Willoughby D.A. Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. Journal of Pathology 1971, 104:15-29.
7. dos Santos M.D., Almeida M.C., Lopes N.P., de Souza G.E. Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biological & Pharmaceutical Bulletin 2006, 29:2236-2240.
8. Ferreira S.H., Nakamura M. I - Prostaglandin hyperalgesia, a cAMP/Ca2+ dependent process. Prostaglandins 1979, 18:179-190.
9. Fischer L.G., Santos D., Serafin C., Malheiros A., Delle Monache F., Delle Monache G., Cechinel Filho V., de Souza M.M. Further antinociceptive properties of extracts and phenolic compounds from Plinia glomerata (Myrtaceae) leaves. Biological & Pharmaceutical Bulletin 2008, 31:235-239.
10. Franzotti E.M., Santos C.V., Rodrigues H.M., Mourao R.H., Andrade M.R., Antoniolli A.R. Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L (Malva-branca). Journal of Ethnopharmacology 2000, 72:273-277.
11. Garrido G., Delgado R., Lemus Y., Rodriguez J., Garcia D., Nunez-Selles A.J. Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production on macrophages and microglia by a standard aqueous extract of Mangifera indica L. (VIMANG). Role of mangiferin isolated from the extract. Pharmacological Research 2004, 50:165-172.
12. Garrido G., Gonzalez D., Lemus Y., Garcia D., Lodeiro L., Quintero G., Delporte C., Nunez-Selles A.J., Delgado R. In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG). Pharmacological Research 2004, 50:143-149.
13. Grosser T., Fries S., Fitzgerald G.A. Biological basis for cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. Journal of Clinical Investigation 2006, 116:4-15.
14. Hargreaves K., Dubner R., Brown F., Flores C., Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988, 32:77-88.
15. Hartog A., Hougee S., Faber J., Sanders A., Zuurman C., Smit H.F., van der Kraan P.M., Hoijer M.A., Garssen J. The multicomponent phytopharmaceutical SKI306X inhibits in vitro cartilage degradation and the production of inflammatory mediators. Phytomedicine 2008, 15:313-320.
16. Hippisley-Cox J., Coupland C. Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. British Medical Journal 2005, 330:1366.
17. Hu X., Jin H., Xu W., Zhang W., Liu X., Yan S., Chen M., Li J., Zhang W.D. Anti-inflammatory and analgesic effects of Daphne retusa Hemsl. Journal of Ethnopharmacology 2008, 120:118-122.
18. Jung K., Lee B., Han S.J., Ryu J.H., Kim D.H. Mangiferin ameliorates scopolamine-induced learning deficits in mice. Biological & Pharmaceutical Bulletin 2009, 32:242-246.
19. Kalbhen D.A. Chemical model of osteoarthritis-a pharmacological evaluation. Journal of Rheumatology 1987, 14:130-131.
20. Kang O.H., Choi J.G., Lee J.H., Kwon D.Y. Luteolin isolated from the flowers of Linocera japonica suppresses inflammatory mediator release by blocking NF-κB and MAPKs activation pathways in HMC-1 cells. Molecules 2010, 15:385-398.
21. Kidd B.L. Osteoarthritis and joint pain. Pain 2006, 123:6-9.
22. Kim J.Y., Shin J.S., Ryu J.H., Kim S.Y., Cho Y.W., Choi J.H., Lee K.T. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food and Chemical Toxicology 2009, 47:1610-1617.
23. Kwak W.J., Han C.K., Chang H.W., Kim H.P., Kang S.S., Son K.H. Loniceroside C, an antiinflammatory saponin from Lonicera japonica. Chemical & Pharmaceutical Bulletin (Tokyo) 2003, 51:333-335.
24. Lark M.W., Bayne E.K., Flanagan J., Harper C.F., Hoerrner L.A., Hutchinson N.I., Singer I.I., Donatelli S.A., Weidner J.R., Williams H.R., Mumford R.A., Lohmander L.S. Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. Journal of Clinical Investigation 1997, 100:93-106.
25. Lee J.H., Lee Y.M., Kim P.N., Jeong C.S. Potential analgesic and anti-inflammatory activities of Panax ginseng head butanolic fraction in animals. Food and Chemical Toxicology 2008, 46:3749-3752.
26. Lenzer J. FDA advisers warn: COX 2 inhibitors increase risk of heart attack and stroke. British Medical Journal 2005, 330:440.
27. Lynn B., O'Shea N.R. Inhibition of forskolin-induced sensitisation of frog skin nociceptors by the cyclic AMP-dependent protein kinase A antagonist H-89. Brain Research 1998, 780:360-362.
28. Miles A.A., Miles E.M. Vascular reactions to histamine, histamine-liberator and leukotaxine in the skin of guinea-pigs. Journal of Physiology 1952, 118:228-257.
29. Ojewole J.A Antinociceptive, anti-inflammatory and antidiabetic properties of Hypoxis hemerocallidea Fisch. & C.A. Mey. (Hypoxidaceae) corm ['African Potato'] aqueous extract in mice and rats. Journal of Ethnopharmacology 2006, 103:126-134.
30. Poole A.R. An introduction to the pathophysiology of osteoarthritis. Frontiers in Bioscience 1999, 4:D662-670.
31. Pratico D., Dogne J.M. Selective cyclooxygenase-2 inhibitors development in cardiovascular medicine. Circulation 2005, 112:1073-1079.
32. Qian Z.M., Li H.J., Li P., Ren M.T., Tang D. Simultaneous qualitation and quantification of thirteen bioactive compounds in Flos lonicerae by high-performance liquid chromatography with diode array detector and mass spectrometry. Chemical & Pharmaceutical Bulletin (Tokyo) 2007, 55:1073-1076.
33. Qian Z.M., Wen X.D., Li H.J., Liu Y., Qin S.J., Li P. Analysis of interaction property of bioactive components in Flos Lonicerae Japonicae with protein by microdialysis coupled with HPLC-DAD-MS. Biological & Pharmaceutical Bulletin 2008, 31:126-130.
34. Randall L.O., Selitto J.J. A method for measurement of analgesic activity on inflamed tissue. Archives Internationales de Pharmacodynamie et de Therapie 1957, 111:409-419.
35. Rao T.S., Currie J.L., Shaffer A.F., Isakson P.C. Comparative evaluation of arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation. Inflammation 1993, 17:723-741.
36. Saag K.G. Low-dose corticosteroids theraphy in rheumatoid arthritis: balancing the evidence. American Journal of medicine 1997, 103:315-395.
37. Shan J., Fu J., Zhao Z., Kong X., Huang H., Luo L., Yin Z. Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK/AP-1 activation. International Immunopharmacology 2009, 9:1042-1048.
38. Shimoyama N., Shimoyama M., Davis A.M., Inturrisi C.E., Elliott K.J. Spinal gabapentin is antinociceptive in the rat formalin test. Neuroscience Letters 1997, 222:65-67.
39. Spector W.G., Willoughby D.A. The inflammatory response. Bacteriological Reviews 1963, 27:117-154.
40. Taiwo Y.O., Levine J.D. Contribution of guanine nucleotide regulatory proteins to prostaglandin hyperalgesia in the rat. Brain Research 1989, 492:400-403.
41. Taniguchi K., Shinjo K., Mizutani M., Shimada K., Ishikawa T., Menniti F.S., Nagahisa A. Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist. British Journal of Pharmacology 1997, 122:809-812.
42. Tegeder T., Geisslinger G. Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences. Naunyn-Schmiedeberg's Archives of Pharmacology 2006, 373:1-17.
43. Tomassini L., Cometa F.M., Serafini M., Nicoletti M. Isolation of secoiridoid artifacts from Lonicera japonica. Journal of Natural Products 1995, 58:1756-1758.
44. van der Kraan P.M., Vitters E.L., van de Putte L.B., van den Berg W.B. Development of osteoarthritic lesions in mice by " metabolic" and " mechanical" alterations in the knee joints. American Journal of Pathology 1989, 135:1001-1014.
45. Whittle B.A. The use of changes in capillary permeability in mice to distinguish between Narcotic and Nonnarcotic Alalgesics. British Journal of Pharmacological Chemotherapy 1964, 22:246-253.
46. Williams J.M., Brandt K.D. Immobilization ameliorates chemically-induced articular cartilage damage. Arthritis & Rheumatism 1984, 27:208-216.
47. Wolfe F., Cathey M.A. The assessment and prediction of functional disability in disability in rheumatoid arthritis. Journal of Rheumatology 1991, 18:1298-1306.
48. Zhou H., Wong Y.F., Cai X., Liu Z.Q., Jiang Z.H., Bian Z.H., Xu H.X., Liu L. Suppressive effects of JCICM-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and nociceptive models in rodents. Biological & Pharmaceutical Bulletin 2006, 29:253-260.
49. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110.
50. Zvejniece L., Muceniece R., Krigere L., Dambrova M., Klusa V.Z. The differential influences of melanocortins on nociception in the formalin and tail flick tests. Pharmacology Biochemistry & Behavior 2006, 85:287-291.