STOP accelerating lung aging for the treatment of COPD

Experimental Gerontology

Volumn 59, Issue , 2014, Pages 21-27

  Ito, Kazuhiro ^a   Mercado, Nicolas ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Aging; Autophagy; COPD; Corticosteroid; Emphysema; Inflammation; Lung; Melatonin; Metformin; Oxidative stress; Sirtuin

Indexed keywords

ACETYLCYSTEINE; CIGARETTE SMOKE; CORTICOSTEROID; EPIGALLOCATECHIN GALLATE; HISTONE DEACETYLASE 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; KU ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; MELATONIN; METFORMIN; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLACEBO; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; RESVERATROL; SIRTUIN 1; SIRTUIN 6; SULFORAPHANE; THEOPHYLLINE; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR NRF2; SIRTUIN;

AGING; ARTICLE; ASTHMA; AUTOPHAGY; BREATHING MUSCLE; CALORIC RESTRICTION; CELL AGING; CHRONIC INFLAMMATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; COUGHING; CYTOKINE PRODUCTION; DIABETES MELLITUS; DNA DAMAGE; DRUG MEGADOSE; EXERCISE TOLERANCE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GRAFT REJECTION; HUMAN; IMMUNOMODULATION; LIFE EXTENSION; LUNG; LUNG AGING; LUNG ALVEOLUS MACROPHAGE; LUNG EMPHYSEMA; MUSCLE STRENGTH; NONHUMAN; OVARY POLYCYSTIC DISEASE; OXIDATIVE STRESS; PATHOGENESIS; POLLUTANT; PREMATURE AGING; PROTEIN METABOLISM; SMOKING CESSATION; TELOMERE SHORTENING; DISEASE COURSE; IMMUNOLOGY; INFLAMMATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

AGING; DISEASE PROGRESSION; HUMANS; INFLAMMATION; LUNG; METFORMIN; OXIDATIVE STRESS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SIRTUINS;

EID: 84912089476     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.03.014     Document Type: Article

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