Diblock glycopolymers promote colloidal stability of polyplexes and effective pDNA and siRNA delivery under physiological salt and serum conditions

Biomacromolecules

Volumn 12, Issue 8, 2011, Pages 3015-3022

  Smith, Adam E ^a   Sizovs, Antons ^a   Grandinetti, Giovanna ^a   Xue, Lian ^a   Reineke, Theresa M ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR UPTAKE; COLLOIDAL STABILITY; DIBLOCK COPOLYMER; DIBLOCKS; GENE KNOCK DOWN; GLIOBLASTOMAS; GLUCOPYRANOSE; GLYCOPOLYMERS; HELA CELL; IN-VITRO; LIPOFECTAMINE; METHACRYLAMIDES; PHYSIOLOGICAL SALT; POLYPLEXES; REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER POLYMERIZATION; SIRNA DELIVERY; TIME-PERIODS; TRANSFECTION EFFICIENCY;

BLOCK COPOLYMERS; COPOLYMERIZATION; GENES; LIPOSOMES;

BODY FLUIDS;

2 DEOXY 2 METHACRYLAMIDO GLUCOPYRANOSE; DIBLOCK GLYCOPOLYMER; N (2 AMINOETHYL) METHACRYLAMIDE; PLASMID DNA; POLYMER; SMALL INTERFERING RNA; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; COLLOID; CONTROLLED STUDY; CYTOTOXICITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGHT SCATTERING; NONVIRAL GENE DELIVERY SYSTEM; POLYMERIZATION; PRIORITY JOURNAL; REVERSIBLE ADDITION FRAGMENTATION CHAIN TRANSFER POLYMERIZATION; SERUM; SYNTHESIS;

BLOOD; COLLOIDS; DNA; HELA CELLS; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; PLASMIDS; POLYMERS; RNA, SMALL INTERFERING; SALTS;

EID: 80051538989     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm200643c     Document Type: Article

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