PEG length and chemical linkage controls polyacridine peptide DNA polyplex pharmacokinetics, biodistribution, metabolic stability and in vivo gene expression

Journal of Controlled Release

Volumn 170, Issue 3, 2013, Pages 325-333

  Khargharia, Sanjib ^a   Kizzire, Koby ^a   Ericson, Mark D ^a   Baumhover, Nicholas J ^a   Rice, Kevin G ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Gene delivery; Hydrodynamic dosing; Polyethylene glycol

Indexed keywords

CHEMICAL STABILITY; EFFICIENCY; FLUID DYNAMICS; GENE TRANSFER; GENES; HYDRODYNAMICS; LOCATION; MAMMALS; METABOLISM; PEPTIDES; PHARMACOKINETICS; PHYSIOLOGY; POLYETHYLENE GLYCOLS; POLYETHYLENES;

BIODISTRIBUTIONS; GENE DELIVERY; LOCATION INFLUENCES; LUCIFERASE EXPRESSION; METABOLIC STABILITY; NON-VIRAL GENE DELIVERY; PEPTIDE STRUCTURES; TRANSFER EFFICIENCY;

GENE EXPRESSION;

ACETAMIDE; LUCIFERASE; MACROGOL; MALEIMIDE; PENICILLAMINE; PEPTIDE; POLYACRIDINE PEPTIDE; THIOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; GENE EXPRESSION; HALF LIFE TIME; HYDRODYNAMICS; IN VIVO GENE TRANSFER; IN VIVO STUDY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE;

GENE DELIVERY; HYDRODYNAMIC DOSING; POLYETHYLENE GLYCOL;

ACRIDINES; ANIMALS; DNA; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; LUCIFERASES; MALE; MICE; MICE, INBRED ICR; PEPTIDES; POLYETHYLENE GLYCOLS; POLYMERS; TISSUE DISTRIBUTION;

EID: 84885096275     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.05.024     Document Type: Article

References (42)

1. M. Ogris, S. Brunner, S. Schuller, R. Kircheis, E. Wagner, PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery, Gene Ther. 6 (4) (1999) 595-605. (Pubitemid 29192668)
2. M.L. Read, A. Logan, L.W. Seymour, In: J.C. Hall, J.C. Dunlap, T. Friedmann, V. van Heyningen (Eds.), Advances in Genetics, Vol. 53, Academic Press, 2005, pp. 19-46.
3. P.R. Dash, M.L. Read, L.B. Barrett, M.A. Wolfert, L.W. Seymour, Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery, Gene Ther. 6 (1999) 643-650. (Pubitemid 29192673)
4. D. Oupicky, C. Konak, P.R. Dash, L.W. Seymour, K. Ulbrich, Effect of albumin and polyanion onthe structure of DNA complexes with polycation containing hydrophilic nonionic block, Bioconjug. Chem. 10 (5) (1999) 764-772. (Pubitemid 29456362)
5. M.C. Woodle, D.D. Lasic, Sterically stabilized liposomes, Biochim. Biophys. Acta 1113 (2) (1992) 171-199.
6. K. Kawabata, Y. Takakura, M. Hashida, The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake, Pharm. Res. 12 (6) (1995) 825-830.
7. V.C. Mosqueira, P. Legrand, J.L. Morgat, M. Vert, E. Mysiakine,R. Gref, J.P. Devissaguet, G. Barratt, Biodistribution of long-circulating PEG-grafted nanocapsules in mice: effects of PEG chain length and density, Pharm. Res. 18 (10) (2001) 1411-1419. (Pubitemid 32977246)
8. T.J. Daou, L. Li, P. Reiss, V. Josserand, I. Texier, Effect of poly(ethylene glycol) length on the in vivo behavior of coated quantum dots, Langmuir 25 (5) (2009) 3040-3044.
9. A.C. Faure, S. Dufort, V. Josserand, P. Perriat, J.L. Coll, S. Roux, O. Tillement, Control of the in vivo biodistribution of hybrid nanoparticles with different poly(ethylene glycol) coatings, Small (Weinheim an der Bergstrasse, Germany) 5 (22) (2009) 2565-2575.
10. H.S. Choi, B.I. Ipe, P. Misra, J.H. Lee, M.G. Bawendi, J.V. Frangioni, Tissue-and organ-selective biodistribution of NIR fluorescent quantum dots, Nano Lett. 9 (6) (2009) 2354-2359.
11. T. Maldiney, C. Richard, J. Seguin, N. Wattier, M. Bessodes, D. Scherman, Effect of core diameter, surface coating, and PEG chain length on the biodistribution of persistent luminescence nanoparticles in mice, ACS Nano 5 (2) (2011) 854-862.
12. T. Merdan, K. Kunath, H. Petersen, U. Bakowsky, K.H. Voigt, J. Kopecek, T. Kissel, PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice, Bioconjug. Chem. 16 (4) (2005) 785-792. (Pubitemid 41026164)
13. S. Mao, M. Neu, O. Germershaus, O. Merkel, J. Sitterberg, U. Bakowsky, T. Kissel, Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/ SiRNA polyplexes, Bioconjug. Chem. 17 (5) (2006) 1209-1218. (Pubitemid 44455329)
14. R.S. Burke, S.H. Pun, Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver, Bioconjug. Chem. 19 (3) (2008) 693-704. (Pubitemid 351431402)
15. X. Jaing, H. Dai, K. Leong, S. Goh, M. HQ, Y. YY, Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions, J. Gene Med. 8 (2006) 477-487.
16. R.E. Fitzsimmons, H. Uludag, Specific effects of PEGylation on gene delivery efficacy of polyethylenimine: interplay between PEG substitution and N/P ratio, Acta Biomater. 8 (11) (2012) 3941-3955.
17. S.H. Pun, M.E. Davis, Development of a nonviral gene delivery vehicle for systemic application, Bioconjug. Chem. 13 (3) (2002) 630-639. (Pubitemid 34527526)
18. W.T. Collard, Y. Yang, K.Y. Kwok, Y. Park, K.G. Rice, Biodistribution, metabolism, and in vivo gene expression of low molecular weight glycopeptide polyethylene glycol peptide DNA co-condensates, J. Pharm. Sci. 89 (4) (2000) 499-512.
19. D. Oupicky, M. Ogris, K.A. Howard, P.R. Dash, L. Ulbrich, L.W. Seymour, Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation, Mol. Ther. 5 (2002) 463-472. (Pubitemid 34308672)
20. Y. Yang, Y. Park, S. Man, Y. Liu, K.G. Rice, Cross-linked low molecular weight glycopeptide-mediated gene delivery: relationship between DNA metabolic stability and the level of transient gene expression in vivo, J. Pharm. Sci. 90 (12) (2001) 2010-2022. (Pubitemid 33144447)
21. Q.H. Zhou, D.L. Miller, R.C. Carlisle, L.W. Seymour, D. Oupicky, Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation, J. Control Release 106 (3) (2005) 416-427. (Pubitemid 41187450)
22. C.A. Fernandez, N.J. Baumhover, J.T. Duskey, S. Khargharia, K. Kizzire, M.D. Ericson, K.G. Rice, Metabolically stabilized long-circulating PEGylated polyacridine peptide polyplexes mediate hydrodynamically stimulated gene expression in liver, Gene Ther. 18 (2011) 23-37.
23. K. Kizzire, S. Khargharia, K.G. Rice, High-affinity PEGylated polyacridine peptide polyplexes mediate potent in vivo gene expression, Gene Ther. 20 (2013) 407-416.
24. N.J. Baumhover, K. Anderson, C.A. Fernandez, K.G. Rice, Synthesis and in vitro testing of new potent polyacridine-melittin gene delivery peptides, Bioconjug. Chem. 21 (2010) 74-86.
25. K. Anderson, C.A. Fernandez, K.G. Rice, N-glycan targeted gene delivery to the dendritic cell SIGN receptor, Bioconjug. Chem. 21 (2010) 1479-1485.
26. M.S. Wadhwa, W.T. Collard, R.C. Adami, D.L. McKenzie, K.G. Rice, Peptide-mediated gene delivery: influence of peptide structure on gene expression, Bioconjug. Chem. 8 (1) (1997) 81-88. (Pubitemid 27064227)
27. J. Terebesi, K.Y. Kwok, K.G. Rice, Iodinated plasmid DNA as a tool for studying gene delivery, Anal. Biochem. 263 (1998) 120-123. (Pubitemid 28445437)
28. J.H. Ehrenreich, J.J. Bergeron, P. Siekevitz, G.E. Palade, Golgi fractions prepared from rat liver homogenates. I. Isolation procedure and morphological characterization, J. Cell Biol. 59 (1) (1973) 45-72.
29. F. Liu, Y. Song, D. Liu, Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA, Gene Ther. 6 (7) (1999) 1258-1266. (Pubitemid 29359019)
30. R.I. Mahato, K. Anwer, F. Tagliaferri, C. Meaney, P. Leonard, M.S. Wadhwa, M. Logan, M. French, A. Rolland, Biodistribution and gene expression of lipid/plasmid complexes after systemic administration, Hum. Gene Ther. 9(14) (1998) 2083-2099. (Pubitemid 28463926)
31. R.K. Scheule, J.A. St George, R.G. Bagley, J. Marshall, J.M. Kaplan, G.Y. Akita, K.X. Wang, E.R. Lee, D.J. Harris, C. Jiang, N.S. Yew, A.E. Smith, S.H. Cheng, Basis of pulmonary toxicity associated with cationic lipid-mediated gene transfer to the mammalian lung, Hum. Gene Ther. 8 (6) (1997) 689-707. (Pubitemid 27202056)
32. S. Li, M.A. Rizzo, S. Bhattacharya, L. Huang, Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery, Gene Ther. 5 (7) (1998) 930-937. (Pubitemid 28371910)
33. G. Zhang, V. Budker, J.A. Wolff, High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA, Hum. Gene Ther. 10 (10) (1999) 1735-1737. (Pubitemid 29328217)
34. V.P. Torchilin, Liposomes as targetable drug carriers, CRC Crit. Rev. Therap. Drug Carrier Sys. 2 (1) (1985) 65-115. (Pubitemid 16099051)
35. M. Kursa, G.F. Walker, V. Roessler, M. Ogris, W. Roedl, R. Kircheis, E. Wagner, Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer, Bioconjug. Chem. 14 (1) (2003) 222-231. (Pubitemid 36169036)
36. G.F. Walker, C. Fella, J. Pelisek, J. Fahrmeir, S. Boeckle, M. Ogris, E. Wagner, Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer invitro and invivo, Mol. Ther. 11 (3) (2005) 418-425. (Pubitemid 40277318)
37. C. Fella, G.F. Walker, M. Ogris, E. Wagner, Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding, Eur. J. Pharm. Sci. 34 (4-5) (2008) 309-320.
38. O.H. Drummer, L. Routley, N. Christophidis, Reversibility of disulfide formation. Comparison of chemical and enzyme-mediated reduction of penicillamine and captopril disulfides, Biochem. Pharmacol. 36 (8) (1987) 1197-1201. (Pubitemid 17083172)
39. G. Zhang, X. Gao, Y.K. Song, R. Vollmer, D.B. S., J.Z. Gaskowski, D.A. Dean, D. Liu, Hydroporation as the mechanism of hydrodynamic delivery, Gene Ther. 11 (2004) 675-682. (Pubitemid 38519275)
40. M. Lecocq, F. Andrianaivo, M.T. Warnier, S. Wattiaux-De Coninck, R. Wattiaux, M. Jadot, Uptake by mouse liver and intracellular fate of plasmid DNA after a rapid tail vein injection of a small or a large volume, J. Gene Med. 5 (2) (2003) 142-156. (Pubitemid 40309691)
41. A. Crespo, A. Peydro, F. Dasi, M. Benet, J.J. Calvete, F. Revert, S.F. Alino, Hydrodynamic liver gene transfer mechanism involves transient sinusoidal blood stasis and massive hepatocyte endocytic vesicles, Gene Ther. 12 (11) (2005) 927-935. (Pubitemid 40852211)
42. V.G. Budker, V.M. Subbotin, T. Budker, M.G. Sebestyen, G. Zhang, J.A. Wolff, Mechanism of plasmid delivery by hydrodynamic tail vein injection. II. Morphological studies, J. Gene Med. 8 (7) (2006) 874-888. (Pubitemid 44097142)