Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin

Acta Neuropathologica

Volumn 128, Issue 2, 2014, Pages 215-229

  Bsibsi, Malika ^a   Peferoen, Laura A N ^b   Holtman, Inge R ^c   Nacken, Peter J ^a   Gerritsen, Wouter H ^b   Witte, Maarten E ^b   Van Horssen, Jack ^b   Eggen, Bart J L ^c   Van Der Valk, Paul ^b   Amor, Sandra ^b,d   Van Noort, Johannes M ^a  

^a Delta Crystallon BV   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Demyelination; HSPB5; IFN ; Macrophages; Microglia; Multiple sclerosis

Indexed keywords

ALPHA B CRYSTALLIN; ALPHA CRYSTALLIN; CHAPERONE; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN; UNCLASSIFIED DRUG; CRYAB PROTEIN, HUMAN; CXCL10 PROTEIN, HUMAN; CXCL11 CHEMOKINE; CXCL11 PROTEIN, HUMAN; CXCL9 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; IFNG PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; IL1B PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; UBD PROTEIN, HUMAN;

ADULT; ARTICLE; BRAIN TISSUE; CADAVER; CONTROLLED STUDY; CYTOKINE RESPONSE; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MICROGLIA; MULTIPLE SCLEROSIS; OLIGODENDROGLIA; PRIORITY JOURNAL; T LYMPHOCYTE; BRAIN; CELL CULTURE; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ALPHA-CRYSTALLIN B CHAIN; BRAIN; CELLS, CULTURED; CHEMOKINE CXCL10; CHEMOKINE CXCL11; CHEMOKINE CXCL9; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-1BETA; INTERLEUKIN-6; MACROPHAGES; MICROGLIA; MULTIPLE SCLEROSIS; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITINS;

EID: 84912048872     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1317-8     Document Type: Article

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