Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles

Biomaterials

Volumn 34, Issue 3, 2013, Pages 831-840

  Van Noort, Johannes M ^a   Bsibsi, Malika ^a   Nacken, Peter J ^a   Gerritsen, Wouter H ^b   Amor, Sandra ^b,c   Holtman, Inge R ^d   Boddeke, Erik ^d   van Ark, Ingrid ^e   Leusink Muis, Thea ^e   Folkerts, Gert ^e   Hennink, Wim E ^e   Amidi, Maryam ^e  

^a Delta Crystallon BV   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e UTRECHT UNIVERSITY   (Netherlands)

Author keywords

COPD; Heat shock proteins; Immunomodulation; Macrophage; PLGA microparticles; Toll like receptors

Indexed keywords

COPD; HEAT-SHOCK PROTEIN; IMMUNOMODULATION; PLGA MICROPARTICLES; TOLL-LIKE RECEPTORS;

ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; BIOLOGICAL MATERIALS; BIOLOGICAL ORGANS; CHEMICAL ACTIVATION; LOADING; MACROPHAGES; MAMMALS; PATHOLOGY;

COPOLYMERS;

ANTIINFLAMMATORY AGENT; CD14 ANTIGEN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN ALPHA B CRYSTALLIN; POLYGLACTIN; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PHAGOCYTOSIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOREGULATION; INFLAMMATION; LYMPHOCYTIC INFILTRATION; MACROPHAGE ACTIVATION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR BINDING; SMOKING;

ALPHA-CRYSTALLIN B CHAIN; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD14; CELL LINE; DRUG CARRIERS; HEAT-SHOCK PROTEINS, SMALL; HUMANS; LACTIC ACID; LUNG; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; PNEUMONIA; POLYGLYCOLIC ACID; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 2;

MUS;

EID: 84868458674     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.10.028     Document Type: Article

References (47)

1. Gordon S., Taylor P.R. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005, 5:953-964.
2. Martinez F.O., Gordon S., Locati M., Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol 2006, 177:7303-7311.
3. Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008, 8:958-969.
4. Fleming B.D., Mosser D.M. Regulatory macrophages: setting the threshold for therapy. Eur J Immunol 2011, 41:2498-2502.
5. Masilamoni J.G., Jesudason E.P., Baben B., Jebaraj C.E., Dhandayuthapani S., Jayakumar R. Molecular chaperone alpha-crystallin prevents detrimental effects of neuroinflammation. Biochim Biophys Acta 2006, 1762:284-293.
6. Ousman S.S., Tomooka B.H., van Noort J.M., Wawrousek E.F., O'Connor K.C., Hafler D.A., et al. Protective and therapeutic role for αB-crystallin in autoimmune demyelination. Nature 2007, 448:474-479.
7. Pangratz-Fuehrer S., Kaur K., Ousman S.S., Steinman L., Liao Y.J. Functional rescue of experimental ischemic optic neuropathy with αB-crystallin. Eye 2011, 25:809-817.
8. Velotta J.B., Kimura N., Chang S.H., Chung J., Itoh S., Rothbard J., et al. αB-Crystallin improves murine cardiac function and attenuates apoptosis in human endothelial cells exposed to ischemia-reperfusion. Ann Thorac Surg 2011, 91:1907-1913.
9. Arac A., Brownell S.E., Rothbard J.B., Chen C., Ko R.M., Pereira M.P., et al. Systemic augmentation of αB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation. Proc Natl Acad Sci U S A 2011, 108:13287-13292.
10. Van Noort J.M., Bsibsi M., Gerritsen W.H., van der Valk P., Bajramovic J.J., Steinman L., et al. Alpha B-crystallin is a target for adaptive immune responses and a trigger of innate responses in preactive multiple sclerosis lesions. J Neuropathol Exp Neurol 2010, 69:694-703.
11. Mundargi R.C., Babu V.R., Rangaswamy V., Patel P., Aminabhavi T.M. Nano/micro technologies for delivering macromolecular therapeutics using poly(D, L-lactide-co-glycolide) and its derivatives. J Control Release 2008, 125:193-209.
12. R Development Core Team R: a language and environment for statistical computing 2011, R Foundation for Statistical Computing, Vienna, Austria.
13. Smyth G.K. Limma: linear models for microarray data. Bioinformatics and computational biology solutions using R and bioconductor 2005, 397-420. Springer, New York. R. Gentleman, V. Carey, S. Dudoit, R. Irizarry, W. Huber (Eds.).
14. Ritchie M.E., Siolver J., Oshlack A., Holmes M., Diyagama D., Holloway A., et al. A comparison of background correction methods for two-colour microarrays. Bioinformatics 2007, 23:2700-2707.
15. Ritchie M.E., Diyagama D., Neilson J., van Laar R., Dobrovic A., Holloway A., et al. Empirical array quality weights in the analysis of microarray data. BMC Bioinform 2006, 7:261.
16. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc Ser B (Methodol) 1995, 57:289-300.
17. Henderson B., Calderwood S.K., Coates A.R., Cohen I., van Eden W., Lehner T., et al. Caught with their PAMPs down? the extracellular signaling actions of molecular chaperones are not due to microbial contaminants. Cell Stress Chaperones 2010, 15:123-141.
18. Calderwood S.K., Mambula S.S., Gray P.J., Theriault J.R. Extracellular heat shock proteins in cell signaling. FEBS Lett 2007, 581:3689-3694.
19. Braun N., Zacharias M., Peschek J., Kastenmüller A., Zou J., Hanzlik M., et al. Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach. Proc Natl Acad Sci U S A 2011, 108:20491-20496.
20. Van Noort J.M., van Sechel A.C., Bajramovic J.J., el Ouagmiri M., Polman C.H., Lassmann H., et al. The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis. Nature 1995, 375:798-801.
21. Van Noort J.M., Bajramovic J.J., Plomp A.C., van Stipdonk M.J.B. Mistaken self: a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis. J Neuroimmunol 2000, 105:46-57.
22. Van Noort J.M., Verbeek R., Meilof J.F., Polman C.H., Amor S. Autoantibodies against alpha B-crystallin, a candidate autoantigen in multiple sclerosis, are part of a normal human immune repertoire. Mult Scler 2006, 12:287-293.
23. Van Sechel A.C., Bajramovic J.J., van Stipdonk M.J., Persoon-Deen C., Geutskens S.B., van Noort J.M. Epstein-Barr virus-induced expression and HLA-DR-restricted presentation by human B cells of alpha B-crystallin, a candidate autoantigen in multiple sclerosis. J Immunol 1999, 162:129-135.
24. Van Stipdonk M.J.B., Willems A.A., Verbeek R., Boog C.J.P., van Noort J.M. T- and B-cell non-responsiveness to self-alpha B-crystallin in SJL mice prevents the induction of experimental allergic encephalomyelitis. Cell Immunol 2000, 204:128-134.
25. Van Stipdonk M.J.B., Willems A.A., van Sechel A.C., van Noort J.M., Boog C.J.P. Tolerance controls encephalitogenicity of alpha B-crystallin in the Lewis rat. J Neuroimmunol 2000, 103:103-111.
26. Geiser M. Update on macrophage clearance of inhaled micro- and nanoparticles. J Aerosol Med Pulm Drug Deliv 2010, 23:207-217.
27. Zaja-Milatovic S., Richmond A. CXC chemokines and their receptors: a case for significant biological role in cutaneous wound healing. Histol Histopathol 2008, 23:1399-1407.
28. Sarmiento J., Shumate C., Suetomi K., Ravindran A., Villegas L., Rajarathnam K., et al. Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists. Plos One 2011, 6(12):e27967.
29. Comerford I., Bunting M., Fenix K., Haylock-Jacobs S., Litchfield W., Harata-Lee Y., et al. An immune paradox: how can the same chemokine axis regulate both immune tolerance and activation?. Bioassays 2010, 32:1067-1076.
30. Serhan C.N., Chiang N., Van Dyke T.E. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 2008, 8:349-361.
31. Kalinski P., Hilkens C.M., Snijders A., Snijdeweint F.G., Kapsenberg M.L. IL-12 deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in mature human naïve T cells. J Immunol 1997, 159:28-35.
32. Obermajer N., Muthuswamy R., Lesnock J., Edwards R.P., Kalinski P. Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells towards stable myeloid-derived suppressor cells. Blood 2011, 118:5498-5505.
33. Walczak H. TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation and cancer. Immunol Rev 2011, 244:9-28.
34. McCoy M.K., Tansey M.G. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflamm 2008, 5:45.
35. Sabat R., Grütz G., Warszawska K., Kirsch E., Wolk, Geginat J. Biology of IL-10. Cytokine Growth Factor Rev 2010, 21:331-344.
36. Verstrepen L., Carpentier I., Verhelst K., Beyaert R. ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling. Biochem Pharmacol 2009, 78:105-114.
37. Arlt A., Schäfer H. Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis. Eur J Cell Biol 2011, 90:545-552.
38. Deban L., Russo R.C., Sironi M., Moalli F., Scanziani M., Zambelli V., et al. Regulation of leukocyte recruitment by the long pentraxin PTX3. Nat Immunol 2010, 11:328-334.
39. Milner C.M., Higman V.A., Day A.J. TSG-6: a pluripotent inflammatory mediator. Biochem Soc Trans 2006, 34:446-450.
40. Fife B.T., Bluestone J.A. Control of peripheral tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol Rev 2008, 224:166-182.
41. Huang L., Baban B., Johnson B.A., Mellor A.L. Dendritic cells, indoleamine 2,3 dioxygenase and acquired immune privilege. Int Rev Immunol 2010, 29:133-155.
42. Schraufstatter I.U., Zhao M., Khaldoyanidi S.K., Discipio R.G. The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum. Immunology 2012, 135:287-298.
43. Stevenson C.S., Birrell M. Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance. Pharmacol Ther 2011, 130:93-105.
44. Kim T.H., Park T.G. Critical effect of freezing/freeze-drying on sustained release of FITC-dextran encapsulated within PLGA microspheres. Int J Pharm 2004, 271:207-214.
45. Koller B., Bals R., Roos D., Korting H.C., Griese M., Hartl D. Innate immune receptors on neutrophils and their role in chronic lung disease. Eur J Clin Invest 2009, 39:535-547.
46. Barnes P.J. New molecular targets for the treatment of neutrophilic diseases. J Allergy Clin Immunol 2007, 119:1055-1062.
47. Braber S., Thio M., Blokhuis B.R., Henricks P.A., Koelink P.J., Groot Kormelink T., et al. An association between neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012, 185:817-824.