Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models

Acta Neuropathologica

Volumn 128, Issue 2, 2014, Pages 247-266

  Schuh, Cornelia ^a   Wimmer, Isabella ^a   Hametner, Simon ^a   Haider, Lukas ^a   Van Dam, Anne Marie ^b   Liblau, Roland S ^c   Smith, Ken J ^d   Probert, Lesley ^e   Binder, Christoph J ^a   Bauer, Jan ^a   Bradl, Monika ^a   Mahad, Don ^f   Lassmann, Hans ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e HELLENIC PASTEUR INSTITUTE   (Greece)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Experimental autoimmune encephalomyelitis (EAE); Inducible nitric oxide synthase (iNOS); Iron; Multiple sclerosis; NADPH oxidase; Oxidative injury

Indexed keywords

AMYLOID PRECURSOR PROTEIN; FORMALDEHYDE; INDUCIBLE NITRIC OXIDE SYNTHASE; IRON; MYELIN; P22PHOX PROTEIN; PARAFFIN; PHOSPHOLIPID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; CD4 ANTIGEN; CD8 ANTIGEN; CUPRIZONE; LIPOPOLYSACCHARIDE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); PEPTIDE FRAGMENT;

ACTIVE IMMUNIZATION; ADULT; AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AXONAL INJURY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL GRANULE; CONTROLLED STUDY; CORONAVIRUS INFECTION; DEMYELINATION; DENSITOMETRY; DISEASE COURSE; DISEASE MODEL; ENCEPHALITIS; ENCEPHALOMYELITIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATION; INNATE IMMUNITY; IRON METABOLISM; MACROPHAGE ACTIVATION; MICROARRAY ANALYSIS; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; OLIGODENDROGLIA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESPIRATORY BURST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE INJURY; TRANSIENT EXPRESSION; WHITE MATTER LESION; YOUNG ADULT; AGING; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; GENE EXPRESSION; IMMUNOLOGY; LEWIS RAT; MACROPHAGE; METABOLISM; PATHOLOGY; PHYSIOLOGY; T LYMPHOCYTE; TRANSPLANTATION;

AGING; ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; CORONAVIRUS INFECTIONS; CUPRIZONE; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION; IRON; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE, INBRED C57BL; MICROGLIA; MULTIPLE SCLEROSIS; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; RATS; RATS, INBRED LEW; RESPIRATORY BURST; T-LYMPHOCYTES;

EID: 84906934485     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1263-5     Document Type: Article

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