Expression of the interferon-γ-inducible chemokines IP-10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions

Neuropathology and Applied Neurobiology

Volumn 26, Issue 2, 2000, Pages 133-142

  Simpson, J E ^a   Newcombe, J ^b   Cuzner, M L ^b   Woodroofe, M N ^a  

^a SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Chemokines; CXCR3; IFN ; Inflammation; IP 10; Mig; Multiple sclerosis

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MONOKINE;

ADULT; ARTICLE; ASTROCYTE; AUTOPSY; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; DEMYELINATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MACROPHAGE; MALE; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

EID: 0034055609     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.2000.026002133.x     Document Type: Article

References (52)

1. 1 Arenberg D, Kunkel S, Polverini P et al. Interferon-γ-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases. J Invest Med 1996; 44: 371
2. 2 Baggiolini M. Chemokines and leukocyte trafficking. Nature 1998; 392: 565-8
3. 3 Balashov K, Rottman J. Weiner H, Hancock W. CCR5( + ) and CXCR3( + ) T cells are increased in multiple sclerosis and their ligands MIP-1 alpha and IP-10 are expressed in demyelinating brain lesions. Proc Natl Acad Sci 1999; 96: 6873-8
4. 4 Beneviste EN. Sparacio SM, Norris JG, Grenett HE, Fuller GM. Induction and regulation of interleukin-6 gene expression in rat astrocytes. J Neuroimmunol 1990; 30: 201-12
5. 5 Beneviste EN, Benos DJ. TNF-alpha-and IFN-gamma-mediated signal transduction pathways: Effects on glial cell gene expression and function. FASEB J 1995; 9: 1577-84
6. 6 Brosnan CF, Canella B, Battistini L, Raine CS. Cytokine localisation in multiple sclerosis lesions - correlation with adhesion molecule expression and reactive nitrogen species. Neurology 1995; 45: S16-21
7. 7 Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science 1996; 272: 60-6
8. 8 Campbell JJ. Foxman EF, Butcher EC. Chemoattractant receptor cross talk as a regulatory mechanism in leukocyte adhesion and migration. Eur J Immunol 1997; 27: 2571-8
9. 9 Cavaillon JM. Cytokines and macrophages. Biomed Pharmacother 1994; 48: 445-53
10. 10 Charo IF, Myers A, Herman A, Franci C, Connolly AJ. Coughlin SR. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci USA 1994; 91: 2752-6
11. 11 Cross AK, Woodroofe MN. Chemokines induce migration and changes in actin polymerisation in adult rat microglia and a human foetal cell line in vitro. J Neurosci Res 1999; 55: 17-23
12. 12 Dewald B, MoSeries B, Barella L, Schumacher C, Baggiolini M, Clark LI. IP-10, a gamma-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties. Immunol Lett 1992; 32: 81-4
13. 13 Dunon D, Imhof B. How penetrating cells cause cancer and inflammation. Recherché 1996; 283: 64-8
14. 14 Enk A, Katz S. Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci USA 1992; 89: 1398-405
15. 15 Farber JM. A macrophage mRNA selectively induced by γ-interferon encodes a member of the platelet factor 4 family of cytokines. Proc Natl Acad Sci USA 1990; 87: 5238-42
16. 16 Farber J. HuMig: a new human member of the chemokine family of cytokines. Biochem Biophys Res Comm 1993; 192: 223-8
17. 17 Fontana A, Fierz W, Wekerle H. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature (London) 1984; 307: 273-6
18. 18 Frei K, Bodmer S, Schwerdel C, Fontana A. Astrocytes of the brain synthesize interleukin 3-like factors. J Immunol 1985; 135: 4044-7
19. 19 Freiz W, Endler B, Reske K, Wekerle H, Fontana A. Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune Interferon and its effects on antigen presentation. J Immunol 1985; 134: 3785-93
20. 20 Gao JL, Kuhns DB, Tiffany HL et al. Structure and functional expression of the human macrophage inflammatory protein 1α/RANTES receptor. J Exp Med 1993; 177: 1421-7
21. 21 Godiska R, Chantry D, Dietsch GN, Gray PW. Chemokine expression in murine experimental autoimmune encephalomyelitis. J Neuroimmunol 1995; 58: 167-76
22. 22 Lee H-H, Farber JM. Localisation of the gene for the human MIG cytokine on chromosome 4q21 adjacent to IP10 reveals a chemokine 'mini-cluster'. Cytogenet Cell Genet 1996; 74: 225-31
23. 23 Liao F, Rabin R, Yannelli J, Koniaris L, Vanguri P, Farber J. Human Mig chemokine: Biochemical and functional characterisation. J Exp Med 1995; 182: 1301-14
24. 24 Loetscher M, Gerber B, Loetscher P et al. Chemokine receptor specific for IP10 and Mig: Structure, function and expression in activated T-lymphocytes. J Exp Med 1996; 184: 963-9
25. 25 Loughlin AJ, Honegger P, Woodroofe MN, Comte V, Matthieu JM. Cuzner ML. Myelin basic-protein content of aggregating rat-brain cell-cultures treated with cytokines and/or demyelinating antibody-effects of macrophage enrichment. Neurosci Res 1994; 37: 647-53
26. 26 Luster AD, Unkeless JC. Ravetch JV. γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 1985; 315: 672-6
27. 27 Luster AD, Jhanwar SC, Changanti RSK, Kersey JH. Ravetch JV. Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells. Proc Natl Acad Sci USA 1987; 84: 2868-71
28. 28 Luster A, Leder P. IP-10, a C-X-C chemokine elicits a potent thymus-dependent antitumor response in vivo. J Exp Med 1993; 178: 1057-65
29. 29 McManus C, Berman JW, Brett FM, Staunton H, Farrell M, Brosnan C. MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridisation study. J Neuroimmunol 1998; 86: 20-9
30. 30 Miyagishi R, Kikuchi S, Takayama C, Inoue Y, Tashiro K. Identification of cell types producing RANTES, MIP-1α and MIP-1β in rat experimental autoimmune encephalomyelitis by in situ hybridisation. J Neuroimmunol 1997; 77: 17-26
31. 31 Murphy PM. The molecular biology of leukocyte chemoattractant receptors. Ann Rev Immunol 1994; 12: 593-633
32. 32 Neote K, DiGregario D, Mak JY, Horuk R, Schall TJ. Molecular cloning, functional expression, and signalling characteristics of a C-C chemokine receptor. Cell 1993: 72: 415-25
33. 33 Newcombe J, Cuzner ML. Organisation and research applications of the U.K. Multiple Sclerosis Society Tissue Bank. In How to Run a Brain Bank. J Neural Trans (Suppl. 39). Eds. FF Cruz-Sanchez, E Tolsa, 1993: 155-63
34. 34 Oppenheim JJ, Zachariae COC, Mukaida N, Matsushima K. Properties of the novel proinflamatory supergene 'intercrine' family. Ann Rev Immunol 1991: 9: 617-48
35. 35 Ransohoff RM, Hamilton TA, Tani M et al. Astrocyte expression of mRNA encoding cytokines IP-10 and JE/ MCP-1 in experimental allergic encephalomyelitis. FASEB J 1993; 7: 592-600
36. 36 Renno T, Lin JY, Piccirillo C, Antel J. Owens T. Cytokine production by cells in the cerebrospinal fluid during experimental allergic encephalomyelitis in SJL/J mice. J Neuroimmunol 1994; 49: 1-7
37. + lymphocytes: an explanation for the epidermotropism of cutaneous T-cell lymphoma? Blood 1995; 86: 651-7
38. 38 Schall TJ. Biology of the rantes/sis cytokine family. Cytokine 1991; 3: 165-70
39. 39 Sgadari C, Angiolillo A, Cherney B et al. Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo. Proc Natl Acad Sci USA 1996; 93: 13791-6
40. 40 Simpson JE, Newcombe J, Cuzner ML, Woodroofe MN. Expression of monocyte chemoattractant protein-1 and other β-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. J Neuroimmunol 1998; 84: 238-44
41. 41 Sorensen T, Tani M, Jensen J et al. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest 1999; 103: 807-15
42. 42 Storch M, Lassmann H. Pathology and pathogenesis of demyelinating diseases. Curr Op Neurol 1997; 10: 186-92
43. 43 Taub DD, Lloyd A, Conlon K et al. Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. J Exp Med 1993; 177: 1809-15
44. 44 Taub DD, Oppenheim JJ. Chemokines, inflammation and the immune system. Ther Immunol 1994; 1: 229-36
45. 45 Traugott U, Lebon P. Interferon-gamma and la antigen are present on astrocytes in active chronic multiple sclerosis lesions. J Neurol Sci 1988; 84: 257-64
46. 46 Van Damme J. lnterleukin-8 and related molecules. In The Cytokine Handbook. Ed. A. Thompson. NY: Academic Press, 1994: 185-208
47. 47 Vandervoorn P, Tekstra J, Beelen RHT, Tensen CP, Vandervalk P, DeGroot CJA. Expression of MCP-1 by reactive astrocytes in demyelinating mutliple sclerosis lesions. Am J Pathol 1999; 154: 45-51
48. 48 Vanguri P. Interferon-gamma-inducible genes in primary glial-cells of the central nervous system - comparisons of astrocytes and microglia and Lewis rats and Brown-Norway rats. J Neuroimmunol 1994; 56: 35-43
49. 49 Vanguri P, Farber JM. IFN and virus-inducible expression of an intermediate-early gene, CRG-2/IP-10, and a delayed gene I-A-Alpha, in astrocytes and microglia. J Immunol 1995; 152: 1411-8
50. 50 Wang X, Ellison JA, Siren A-L et al. Prolonged expression of interferon-inducible protein-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in rat. J Neurochem 1998; 71: 1194-204
51. 51 Woodroofe MN, Hayes GM, Cuzner ML. Fc receptor density, MHC antigen expression and superoxide production are increased by interferon-γ treated microglia isolated from adult rat brain. Immunology 1989; 68: 421-6
52. 52 Woodroofe MN, Cuzner ML. Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridisation. Cytokine 1993; 5: 583-8