The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation

Journal of Biological Chemistry

Volumn 289, Issue 47, 2014, Pages 32926-32936

  Okada, Masahiro ^a,b   Matsuzawa, Atsushi ^a,c   Yoshimura, Akihiko ^b   Ichijo, Hidenori ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM;

INFLAMMASOME; INFLAMMATORY DISEASE; THERAPEUTIC TARGETS;

CHEMICAL ACTIVATION;

ADAPTOR PROTEIN; APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CASPASE RECRUITMENT DOMAIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG; AIM2 PROTEIN, HUMAN; CALCIUM; CARRIER PROTEIN; CYTOSKELETON PROTEIN; DNA BINDING PROTEIN; MAP KINASE KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NLRP3 PROTEIN, HUMAN; PYCARD PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYSOSOME; MALE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; OLIGOMERIZATION; PERITONEUM MACROPHAGE; PERITONITIS; SIGNAL TRANSDUCTION; CHEMISTRY; FLUORESCENCE MICROSCOPY; GENETICS; HEK293 CELL LINE; IMMUNOBLOTTING; METABOLISM; PROTEIN MULTIMERIZATION; RNA INTERFERENCE; TUMOR CELL LINE;

CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CARRIER PROTEINS; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; INFLAMMASOMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYSOSOMES; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, FLUORESCENCE; PROTEIN MULTIMERIZATION; RNA INTERFERENCE;

EID: 84911945382     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.579961     Document Type: Article

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