Cortical reorganization after spinal cord injury: Always for good?

Neuroscience

Volumn 283, Issue , 2014, Pages 78-94

  Moxon, K A ^a   Oliviero, A ^b   Aguilar, J ^b   Foffani, G ^b  

^a DREXEL UNIVERSITY   (United States)

^b HOSPITAL NACIONAL DE PARAPLÉJICOS   (Spain)

Author keywords

Brain plasticity; Brain derived neurotrophic factor; Exercise; Pain; Serotonin; Spinal transection

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHONDROITIN ABC LYASE; PROTEOCHONDROITIN SULFATE; SEROTONIN AGONIST;

AGE; COMBINATION CHEMOTHERAPY; CORTICAL REMAPPING; CORTICAL REORGANIZATION; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; KINESIOTHERAPY; MOTOR ACTIVITY; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NERVE REGENERATION; NERVE SPROUTING; NERVOUS SYSTEM PARAMETERS; NONHUMAN; REVIEW; SENSORIMOTOR FUNCTION; SEROTONINERGIC SYSTEM; SPECIES DIFFERENCE; SPINAL CORD INJURY; TIME; TISSUE REPAIR; TRANSCRANIAL MAGNETIC STIMULATION; UPREGULATION;

EID: 84911891998     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.06.056     Document Type: Review

References (248)

1. Aguilar J.R., Castro-Alamancos M.A. Spatiotemporal gating of sensory inputs in thalamus during quiescent and activated states. J Neurosci 2005, 25:10990-11002.
2. Aguilar J., Humanes-Valera D., Alonso-Calvino E., Yague J.G., Moxon K.A., Oliviero A., Foffani G. Spinal cord injury immediately changes the state of the brain. J Neurosci 2010, 30:7528-7537.
3. Angeli C.A., Edgerton V.R., Gerasimenko Y.P., Harkema S.J. Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans. Brain 2014, 137:1394-1409.
4. Antri M., Orsal D., Barthe J.Y. Locomotor recovery in the chronic spinal rat: effects of long-term treatment with a 5-HT2 agonist. Eur J Neurosci 2002, 16:467-476.
5. Antri M., Mouffle C., Orsal D., Barthe J.Y. 5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat. Eur J Neurosci 2003, 18:1963-1972.
6. Antri M., Barthe J.Y., Mouffle C., Orsal D. Long-lasting recovery of locomotor function in chronic spinal rat following chronic combined pharmacological stimulation of serotonergic receptors with 8-OHDPAT and quipazine. Neurosci Lett 2005, 384:162-167.
7. Aston-Jones G., Bloom F.E. Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J Neurosci 1981, 1:887-900.
8. Aston-Jones G., Bloom F.E. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci 1981, 1:876-886.
9. Azmitia E.C., Rubinstein V.J., Strafaci J.A., Rios J.C., Whitaker-Azmitia P.M. 5-HT1A agonist and dexamethasone reversal of para-chloroamphetamine induced loss of MAP-2 and synaptophysin immunoreactivity in adult rat brain. Brain Res 1995, 677:181-192.
10. Bachmann L.C., Matis A., Lindau N.T., Felder P., Gullo M., Schwab M.E. Deep brain stimulation of the midbrain locomotor region improves paretic hindlimb function after spinal cord injury in rats. Sci Transl Med 2013, 5:208ra146.
11. Barbeau H. Locomotor training in neurorehabilitation: emerging rehabilitation concepts. Neurorehabil Neural Repair 2003, 17:3-11.
12. Barnes S.J., Finnerty G.T. Sensory experience and cortical rewiring. Neuroscientist 2010, 16:186-198.
13. Barritt A.W., Davies M., Marchand F., Hartley R., Grist J., Yip P., McMahon S.B., Bradbury E.J. Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J Neurosci 2006, 26:10856-10867.
14. Bassant M.H., Ennouri K., Lamour Y. Effects of iontophoretically applied monoamines on somatosensory cortical neurons of unanesthetized rats. Neuroscience 1990, 39:431-439.
15. Basura G.J., Zhou S.Y., Walker P.D., Goshgarian H.G. Distribution of serotonin 2A and 2C receptor mRNA expression in the cervical ventral horn and phrenic motoneurons following spinal cord hemisection. Exp Neurol 2001, 169:255-263.
16. Belci M., Catley M., Husain M., Frankel H.L., Davey N.J. Magnetic brain stimulation can improve clinical outcome in incomplete spinal cord injured patients. Spinal cord 2004, 42:417-419.
17. Bennett-Clarke C.A., Leslie M.J., Lane R.D., Rhoades R.W. Effect of serotonin depletion on vibrissa-related patterns of thalamic afferents in the rat's somatosensory cortex. J Neurosci 1994, 14:7594-7607.
18. Bennett-Clarke C.A., Lane R.D., Rhoades R.W. Fenfluramine depletes serotonin from the developing cortex and alters thalamocortical organization. Brain Res 1995, 702:255-260.
19. Bohn M.C. Motoneurons crave glial cell line-derived neurotrophic factor. Exp Neurol 2004, 190:263-275.
20. Boord P., Siddall P.J., Tran Y., Herbert D., Middleton J., Craig A. Electroencephalographic slowing and reduced reactivity in neuropathic pain following spinal cord injury. Spinal cord 2008, 46:118-123.
21. Bowes C., Massey J.M., Burish M., Cerkevich C.M., Kaas J.H. Chondroitinase ABC promotes selective reactivation of somatosensory cortex in squirrel monkeys after a cervical dorsal column lesion. Proc Natl Acad Sci U S A 2012, 109:2595-2600.
22. Bregman B.S., Goldberger M.E. Infant lesion effect: III. Anatomical correlates of sparing and recovery of function after spinal cord damage in newborn and adult cats. Brain Res 1983, 285:137-154.
23. Bregman B.S., Goldberger M.E. Infant lesion effect: II. Sparing and recovery of function after spinal cord damage in newborn and adult cats. Brain Res 1983, 285:119-135.
24. Bregman B.S., Goldberger M.E. Infant lesion effect: I. Development of motor behavior following neonatal spinal cord damage in cats. Brain Res 1983, 285:103-117.
25. Bruehlmeier M., Dietz V., Leenders K.L., Roelcke U., Missimer J., Curt A. How does the human brain deal with a spinal cord injury?. Eur J Neurosci 1998, 10:3918-3922.
26. Cafferty W.B., Bradbury E.J., Lidierth M., Jones M., Duffy P.J., Pezet S., McMahon S.B. Chondroitinase ABC-mediated plasticity of spinal sensory function. J Neurosci 2008, 28:11998-12009.
27. Calford M.B., Tweedale R. Immediate and chronic changes in responses of somatosensory cortex in adult flying-fox after digit amputation. Nature 1988, 332:446-448.
28. Carter L.M., Starkey M.L., Akrimi S.F., Davies M., McMahon S.B., Bradbury E.J. The yellow fluorescent protein (YFP-H) mouse reveals neuroprotection as a novel mechanism underlying chondroitinase ABC-mediated repair after spinal cord injury. J Neurosci 2008, 28:14107-14120.
29. Casanova C., McKinley P.A., Molotchnikoff S. Responsiveness of reorganized primary somatosensory, (SI) cortex after local inactivation of normal SI cortex in chronic spinal cats. Somatosens Mot Res 1991, 8:65-76.
30. Cha M., Ji Y., Masri R. Motor cortex stimulation activates the incertothalamic pathway in an animal model of spinal cord injury. J Pain 2013, 14:260-269.
31. Chau C.W., McKinley P.A. Chronological observations of primary somatosensory cortical maps in kittens following low thoracic (T12) spinal cord transection at 2 weeks of age. Somatosens Mot Res 1991, 8:355-376.
32. Chen L.M., Qi H.X., Kaas J.H. Dynamic reorganization of digit representations in somatosensory cortex of nonhuman primates after spinal cord injury. J Neurosci 2012, 32:14649-14663.
33. Clineschmidt B.V., Pierce J.E., Lovenberg W. Tryptophan hydroxylase and serotonin in spinal cord and brain stem before and after chronic transection. J Neurochem 1971, 18:1593-1596.
34. Conner J.M., Chiba A.A., Tuszynski M.H. The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury. Neuron 2005, 46:173-179.
35. Corbetta M., Burton H., Sinclair R.J., Conturo T.E., Akbudak E., McDonald J.W. Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recovery. Proc Natl Acad Sci U S A 2002, 99:17066-17071.
36. Courtine G., Gerasimenko Y., van den Brand R., Yew A., Musienko P., Zhong H., Song B., Ao Y., Ichiyama R.M., Lavrov I., Roy R.R., Sofroniew M.V., Edgerton V.R. Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nat Neurosci 2009, 12:1333-1342.
37. Cramer S.C., Lastra L., Lacourse M.G., Cohen M.J. Brain motor system function after chronic, complete spinal cord injury. Brain 2005, 128:2941-2950.
38. Curt A., Alkadhi H., Crelier G.R., Boendermaker S.H., Hepp-Reymond M.C., Kollias S.S. Changes of non-affected upper limb cortical representation in paraplegic patients as assessed by fMRI. Brain 2002, 125:2567-2578.
39. Curt A., Bruehlmeier M., Leenders K.L., Roelcke U., Dietz V. Differential effect of spinal cord injury and functional impairment on human brain activation. J Neurotrauma 2002, 19:43-51.
40. Darian-Smith C. Primary afferent terminal sprouting after a cervical dorsal rootlet section in the macaque monkey. J Comp Neurol 2004, 470:134-150.
41. Darian-Smith C., Brown S. Functional changes at periphery and cortex following dorsal root lesions in adult monkeys. Nat Neurosci 2000, 3:476-481.
42. Darian-Smith C., Ciferri M. Cuneate nucleus reorganization following cervical dorsal rhizotomy in the macaque monkey: its role in the recovery of manual dexterity. J Comp Neurol 2006, 498:552-565.
43. Darian-Smith C., Lilak A., Alarcon C. Corticospinal sprouting occurs selectively following dorsal rhizotomy in the macaque monkey. J Comp Neurol 2013, 521:2359-2372.
44. David F., Schmiedt J.T., Taylor H.L., Orban G., Di Giovanni G., Uebele V.N., Renger J.J., Lambert R.C., Leresche N., Crunelli V. Essential thalamic contribution to slow waves of natural sleep. J Neurosci 2013, 33:19599-19610.
45. Davies S.J., Goucher D.R., Doller C., Silver J. Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci 1999, 19:5810-5822.
46. de Groat W.C., Yoshimura N. Plasticity in reflex pathways to the lower urinary tract following spinal cord injury. Exp Neurol 2012, 235:123-132.
47. De Mello M.T., Esteves A.M., Tufik S. Comparison between dopaminergic agents and physical exercise as treatment for periodic limb movements in patients with spinal cord injury. Spinal cord 2004, 42:218-221.
48. Densmore V.S., Kalous A., Keast J.R., Osborne P.B. Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. Pain 2010, 151:184-193.
49. Dietz V., Harkema S.J. Locomotor activity in spinal cord-injured persons. J Appl Physiol 2004, 96:1954-1960.
50. Ding Q., Ying Z., Gomez-Pinilla F. Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing. Neuroscience 2011, 192:773-780.
51. Dobkin B., Apple D., Barbeau H., Basso M., Behrman A., Deforge D., Ditunno J., Dudley G., Elashoff R., Fugate L., Harkema S., Saulino M., Scott M. Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI. Neurology 2006, 66:484-493.
52. Ebadi M., Bashir R.M., Heidrick M.L., Hamada F.M., Refaey H.E., Hamed A., Helal G., Baxi M.D., Cerutis D.R., Lassi N.K. Neurotrophins and their receptors in nerve injury and repair. Neurochem Int 1997, 30:347-374.
53. Eccles J.C. Presynaptic inhibition in the spinal cord. Prog Brain Res 1964, 12:65-91.
54. Edgerton V.R., Tillakaratne N.J., Bigbee A.J., de Leon R.D., Roy R.R. Plasticity of the spinal neural circuitry after injury. Annu Rev Neurosci 2004, 27:145-167.
55. Elbert T., Pantev C., Wienbruch C., Rockstroh B., Taub E. Increased cortical representation of the fingers of the left hand in string players. Science 1995, 270:305-307.
56. Endo T., Spenger C., Tominaga T., Brene S., Olson L. Cortical sensory map rearrangement after spinal cord injury: fMRI responses linked to Nogo signalling. Brain 2007, 130:2951-2961.
57. Endo T., Spenger C., Hao J., Tominaga T., Wiesenfeld-Hallin Z., Olson L., Xu X.J. Functional MRI of the brain detects neuropathic pain in experimental spinal cord injury. Pain 2008, 138:292-300.
58. Endo T., Tominaga T., Olson L. Cortical changes following spinal cord injury with emphasis on the Nogo signaling system. Neuroscientist 2009, 15:291-299.
59. Engineer N.D., Riley J.R., Seale J.D., Vrana W.A., Shetake J.A., Sudanagunta S.P., Borland M.S., Kilgard M.P. Reversing pathological neural activity using targeted plasticity. Nature 2011, 470:101-104.
60. Erzurumlu R.S., Kind P.C. Neural activity: sculptor of 'barrels' in the neocortex. Trends Neurosci 2001, 24:589-595.
61. Feldman D.E., Brecht M. Map plasticity in somatosensory cortex. Science 2005, 310:810-815.
62. Flor H., Elbert T., Knecht S., Wienbruch C., Pantev C., Birbaumer N., Larbig W., Taub E. Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature 1995, 375:482-484.
63. Florence S.L., Taub H.B., Kaas J.H. Large-scale sprouting of cortical connections after peripheral injury in adult macaque monkeys. Science 1998, 282:1117-1121.
64. Florence S.L., Boydston L.A., Hackett T.A., Lachoff H.T., Strata F., Niblock M.M. Sensory enrichment after peripheral nerve injury restores cortical, not thalamic, receptive field organization. Eur J Neurosci 2001, 13:1755-1766.
65. Foffani G., Humanes-Valera D., Calderon-Munoz F., Oliviero A., Aguilar J. Spinal cord injury immediately decreases anesthetic requirements in rats. Spinal cord 2011, 49:822-826.
66. Foote S.L., Aston-Jones G., Bloom F.E. Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal. Proc Natl Acad Sci U S A 1980, 77:3033-3037.
67. Fox K., Armstrong-James M. The role of the anterior intralaminar nuclei and N-methyl d-aspartate receptors in the generation of spontaneous bursts in rat neocortical neurones. Exp Brain Res 1986, 63:505-518.
68. Fouad K., Pedersen V., Schwab M.E., Brösamle C. Cervical sprouting of corticospinal fibers after thoracic spinal cord injury accompanies shifts in evoked motor responses. Curr Biol 2001, 11:1766-1770.
69. Fregni F., Boggio P.S., Lima M.C., Ferreira M.J., Wagner T., Rigonatti S.P., Castro A.W., Souza D.R., Riberto M., Freedman S.D., Nitsche M.A., Pascual-Leone A. A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury. Pain 2006, 122:197-209.
70. Freund P., Weiskopf N., Ward N.S., Hutton C., Gall A., Ciccarelli O., Craggs M., Friston K., Thompson A.J. Disability, atrophy and cortical reorganization following spinal cord injury. Brain 2011, 134:1610-1622.
71. Freund P., Wheeler-Kingshott C.A., Nagy Z., Gorgoraptis N., Weiskopf N., Friston K., Thompson A.J., Hutton C. Axonal integrity predicts cortical reorganisation following cervical injury. J Neurol Neurosurg Psychiatry 2012, 83:629-637.
72. Fricker A.D., Rios C., Devi L.A., Gomes I. Serotonin receptor activation leads to neurite outgrowth and neuronal survival. Brain Res Mol Brain Res 2005, 138:228-235.
73. Friel K.M., Heddings A.A., Nudo R.J. Effects of postlesion experience on behavioral recovery and neurophysiologic reorganization after cortical injury in primates. Neurorehabil Neural Repair 2000, 14:187-198.
74. Ganzer P.D., Moxon K.A., Knudsen E.B., Shumsky J.S. Serotonergic pharmacotherapy promotes cortical reorganization after spinal cord injury. Exp Neurol 2013, 241:84-94.
75. Garcia C., Chen M.J., Garza A.A., Cotman C.W., Russo-Neustadt A. The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Neuroscience 2003, 119:721-732.
76. Garraway S.M., Hochman S. Modulatory actions of serotonin, norepinephrine, dopamine, and acetylcholine in spinal cord deep dorsal horn neurons. J Neurophysiol 2001, 86:2183-2194.
77. Ghosh A., Sydekum E., Haiss F., Peduzzi S., Zorner B., Schneider R., Baltes C., Rudin M., Weber B., Schwab M.E. Functional and anatomical reorganization of the sensory-motor cortex after incomplete spinal cord injury in adult rats. J Neurosci 2009, 29:12210-12219.
78. Ghosh A., Haiss F., Sydekum E., Schneider R., Gullo M., Wyss M.T., Mueggler T., Baltes C., Rudin M., Weber B., Schwab M.E. Rewiring of hindlimb corticospinal neurons after spinal cord injury. Nat Neurosci 2010, 13:97-104.
79. Ghosh A., Peduzzi S., Snyder M., Schneider R., Starkey M., Schwab M.E. Heterogeneous spine loss in layer 5 cortical neurons after spinal cord injury. Cereb Cortex 2012, 22:1309-1317.
80. Giszter S.F., Kargo W.J., Davies M., Shibayama M. Fetal transplants rescue axial muscle representations in M1 cortex of neonatally transected rats that develop weight support. J Neurophysiol 1998, 80:3021-3030.
81. Giszter S.F., Davies M.R., Graziani V. Motor strategies used by rats spinalized at birth to maintain stance in response to imposed perturbations. J Neurophysiol 2007, 97:2663-2675.
82. Giszter S., Davies M.R., Ramakrishnan A., Udoekwere U.I., Kargo W.J. Trunk sensorimotor cortex is essential for autonomous weight-supported locomotion in adult rats spinalized as P1/P2 neonates. J Neurophysiol 2008, 100:839-851.
83. Gomez-Pinilla F., Ying Z., Roy R.R., Molteni R., Edgerton V.R. Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J Neurophysiol 2002, 88:2187-2195.
84. Gomez-Pinilla F., Ying Z., Zhuang Y. Brain and spinal cord interaction: protective effects of exercise prior to spinal cord injury. PLoS One 2012, 7:e32298.
85. Graziano A., Foffani G., Knudsen E.B., Shumsky J., Moxon K.A. Passive exercise of the hind limbs after complete thoracic transection of the spinal cord promotes cortical reorganization. PLoS One 2013, 8:e54350.
86. Green J.B., Sora E., Bialy Y., Ricamato A., Thatcher R.W. Cortical sensorimotor reorganization after spinal cord injury: an electroencephalographic study. Neurology 1998, 50:1115-1121.
87. Green A.L., Wang S., Stein J.F., Pereira E.A., Kringelbach M.L., Liu X., Brittain J.S., Aziz T.Z. Neural signatures in patients with neuropathic pain. Neurology 2009, 72:569-571.
88. Griesbach G.S., Hovda D.A., Gomez-Pinilla F. Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation. Brain Res 2009, 1288:105-115.
89. Gustin S.M., Wrigley P.J., Siddall P.J., Henderson L.A. Brain anatomy changes associated with persistent neuropathic pain following spinal cord injury. Cereb Cortex 2010, 20:1409-1419.
90. Gustin S.M., Peck C.C., Cheney L.B., Macey P.M., Murray G.M., Henderson L.A. Pain and plasticity: is chronic pain always associated with somatosensory cortex activity and reorganization?. J Neurosci 2012, 32:14874-14884.
91. Hains B.C., Everhart A.W., Fullwood S.D., Hulsebosch C.E. Changes in serotonin, serotonin transporter expression and serotonin denervation supersensitivity: involvement in chronic central pain after spinal hemisection in the rat. Exp Neurol 2002, 175:347-362.
92. Hains B.C., Saab C.Y., Waxman S.G. Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury. Brain 2005, 128:2359-2371.
93. Hains B.C., Saab C.Y., Waxman S.G. Alterations in burst firing of thalamic VPL neurons and reversal by Na(v)1.3 antisense after spinal cord injury. J Neurophysiol 2006, 95:3343-3352.
94. Hallanger A.E., Levey A.I., Lee H.J., Rye D.B., Wainer B.H. The origins of cholinergic and other subcortical afferents to the thalamus in the rat. J Comp Neurol 1987, 262:105-124.
95. Hallett M. Transcranial magnetic stimulation: a primer. Neuron 2007, 55:187-199.
96. Hangartner T.N., Rodgers M.M., Glaser R.M., Barre P.S. Tibial bone density loss in spinal cord injured patients: effects of FES exercise. J Rehabil Res Dev 1994, 31:50-61.
97. Harkema S.J., Ferreira C.K., van den Brand R.J., Krassioukov A.V. Improvements in orthostatic instability with stand locomotor training in individuals with spinal cord injury. J Neurotrauma 2008, 25:1467-1475.
98. Harkema S.J., Hillyer J., Schmidt-Read M., Ardolino E., Sisto S.A., Behrman A.L. Locomotor training: as a treatment of spinal cord injury and in the progression of neurologic rehabilitation. Arch Phys Med Rehabil 2012, 93:1588-1597.
99. Harkema S.J., Schmidt-Read M., Lorenz D.J., Edgerton V.R., Behrman A.L. Balance and ambulation improvements in individuals with chronic incomplete spinal cord injury using locomotor training-based rehabilitation. Arch Phys Med Rehabil 2012, 93:1508-1517.
100. Hasenstaub A., Sachdev R.N., McCormick D.A. State changes rapidly modulate cortical neuronal responsiveness. J Neurosci 2007, 27:9607-9622.
101. Henderson L.A., Gustin S.M., Macey P.M., Wrigley P.J., Siddall P.J. Functional reorganization of the brain in humans following spinal cord injury: evidence for underlying changes in cortical anatomy. J Neurosci 2012, 31:2630-2637.
102. Higo N., Nishimura Y., Murata Y., Oishi T., Yoshino-Saito K., Takahashi M., Tsuboi F., Isa T. Increased expression of the growth-associated protein 43 gene in the sensorimotor cortex of the macaque monkey after lesioning the lateral corticospinal tract. J Comp Neurol 2009, 516:493-506.
103. Hirata A., Castro-Alamancos M.A. Neocortex network activation and deactivation states controlled by the thalamus. J Neurophysiol 2010, 103:1147-1157.
104. Hobson J.A., McCarley R.W., Wyzinski P.W. Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups. Science 1975, 189:55-58.
105. Hoffman L.R., Field-Fote E.C. Cortical reorganization following bimanual training and somatosensory stimulation in cervical spinal cord injury: a case report. Phys Ther 2007, 87:208-223.
106. Hoffman L.R., Field-Fote E.C. Functional and corticomotor changes in individuals with tetraplegia following unimanual or bimanual massed practice training with somatosensory stimulation: a pilot study. J Neurol Phys Ther 2010, 34:193-201.
107. Hofstetter C.P., Schweinhardt P., Klason T., Olson L., Spenger C. Numb rats walk - a behavioural and fMRI comparison of mild and moderate spinal cord injury. Eur J Neurosci 2003, 18:3061-3068.
108. Hoh D.J., Mercier L.M., Hussey S.P., Lane M.A. Respiration following spinal cord injury: evidence for human neuroplasticity. Respir Physiol Neurobiol 2013, 189:450-464.
109. Holtmaat A., Svoboda K. Experience-dependent structural synaptic plasticity in the mammalian brain. Nat Rev Neurosci 2009, 10:647-658.
110. Humanes-Valera D., Aguilar J., Foffani G. Reorganization of the intact somatosensory cortex immediately after spinal cord injury. PLoS One 2013, 8:e69655.
111. Ilha J., Centenaro L.A., Broetto Cunha N., de Souza D.F., Jaeger M., do Nascimento P.S., Kolling J., Ben J., Marcuzzo S., Wyse A.T., Gottfried C., Achaval M. The beneficial effects of treadmill step training on activity-dependent synaptic and cellular plasticity markers after complete spinal cord injury. Neurochem Res 2011, 36:1046-1055.
112. Inaba M., Maruyama T., Yoshimura Y., Hosoi H., Komatsu Y. Facilitation of low-frequency stimulation-induced long-term potentiation by endogenous noradrenaline and serotonin in developing rat visual cortex. Neurosci Res 2009, 64:191-198.
113. Ivy A.S., Rodriguez F.G., Garcia C., Chen M.J., Russo-Neustadt A.A. Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant. Pharmacol Biochem Behav 2003, 75:81-88.
114. Jain N., Florence S.L., Kaas J.H. Limits on plasticity in somatosensory cortex of adult rats: hindlimb cortex is not reactivated after dorsal column section. J Neurophysiol 1995, 73:1537-1546.
115. Jain N., Catania K.C., Kaas J.H. Deactivation and reactivation of somatosensory cortex after dorsal spinal cord injury. Nature 1997, 386:495-498.
116. Jain N., Florence S.L., Qi H.X., Kaas J.H. Growth of new brainstem connections in adult monkeys with massive sensory loss. Proc Natl Acad Sci U S A 2000, 97:5546-5550.
117. Jain N., Diener P.S., Coq J.O., Kaas J.H. Patterned activity via spinal dorsal quadrant inputs is necessary for the formation of organized somatosensory maps. J Neurosci 2003, 23:10321-10330.
118. Jain N., Qi H.X., Collins C.E., Kaas J.H. Large-scale reorganization in the somatosensory cortex and thalamus after sensory loss in macaque monkeys. J Neurosci 2008, 28:11042-11060.
119. Jiang L., Ji Y., Voulalas P.J., Keaser M., Xu S., Gullapalli R.P., Greenspan J., Masri R. Motor cortex stimulation suppresses cortical responses to noxious hindpaw stimulation after spinal cord lesion in rats. Brain Stimul 2014, 7:182-189.
120. Jitsuki S., Takemoto K., Kawasaki T., Tada H., Takahashi A., Becamel C., Sano A., Yuzaki M., Zukin R.S., Ziff E.B., Kessels H.W., Takahashi T. Serotonin mediates cross-modal reorganization of cortical circuits. Neuron 2011, 69:780-792.
121. Jones L.L., Margolis R.U., Tuszynski M.H. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol 2003, 182:399-411.
122. Jones K.A., Srivastava D.P., Allen J.A., Strachan R.T., Roth B.L., Penzes P. Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling. Proc Natl Acad Sci U S A 2009, 106:19575-19580.
123. Juliano S.L., Ma W., Eslin D. Cholinergic depletion prevents expansion of topographic maps in somatosensory cortex. Proc Natl Acad Sci U S A 1991, 88:780-784.
124. Jurkiewicz M.T., Mikulis D.J., McIlroy W.E., Fehlings M.G., Verrier M.C. Sensorimotor cortical plasticity during recovery following spinal cord injury: a longitudinal fMRI study. Neurorehabil Neural Repair 2007, 21:527-538.
125. Kaas J.H., Qi H.X., Burish M.J., Gharbawie O.A., Onifer S.M., Massey J.M. Cortical and subcortical plasticity in the brains of humans, primates, and rats after damage to sensory afferents in the dorsal columns of the spinal cord. Exp Neurol 2008, 209:407-416.
126. Kambi N., Tandon S., Mohammed H., Lazar L., Jain N. Reorganization of the primary motor cortex of adult macaque monkeys after sensory loss resulting from partial spinal cord injuries. J Neurosci 2011, 31:3696-3707.
127. Kambi N., Halder P., Rajan R., Arora V., Chand P., Arora M., Jain N. Large-scale reorganization of the somatosensory cortex following spinal cord injuries is due to brainstem plasticity. Nat Commun 2014, 5:3602.
128. Kao T., Shumsky J.S., Jacob-Vadakot S., Himes B.T., Murray M., Moxon K.A. Role of the 5-HT2C receptor in improving weight-supported stepping in adult rats spinalized as neonates. Brain Res 2006, 1112:159-168.
129. Kao T., Shumsky J.S., Murray M., Moxon K.A. Exercise induces cortical plasticity after neonatal spinal cord injury in the rat. J Neurosci 2009, 29:7549-7557.
130. Kao T., Shumsky J.S., Knudsen E.B., Murray M., Moxon K.A. Functional role of exercise-induced cortical organization of sensorimotor cortex after spinal transection. J Neurophysiol 2011, 106:2662-2674.
131. Keeler B.E., Liu G., Siegfried R.N., Zhukareva V., Murray M., Houle J.D. Acute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injury. Brain Res 2012, 1438:8-21.
132. Kilgard M.P., Merzenich M.M. Cortical map reorganization enabled by nucleus basalis activity. Science 1998, 279:1714-1718.
133. Kim D., Adipudi V., Shibayama M., Giszter S., Tessler A., Murray M., Simansky K.J. Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection. J Neurosci 1999, 19:6213-6224.
134. Kim B.G., Dai H.N., McAtee M., Vicini S., Bregman B.S. Remodeling of synaptic structures in the motor cortex following spinal cord injury. Exp Neurol 2006, 198:401-415.
135. Kirkwood A. Serotonergic control of developmental plasticity. Proc Natl Acad Sci U S A 2000, 97:1951-1952.
136. Kiser T.S., Reese N.B., Maresh T., Hearn S., Yates C., Skinner R.D., Pait T.G., Garcia-Rill E. Use of a motorized bicycle exercise trainer to normalize frequency-dependent habituation of the H-reflex in spinal cord injury. J Spinal Cord Med 2005, 28:241-245.
137. Kojic L., Gu Q., Douglas R.M., Cynader M.S. Serotonin facilitates synaptic plasticity in kitten visual cortex: an in vitro study. Brain Res Dev Brain Res 1997, 101:299-304.
138. Landry E.S., Lapointe N.P., Rouillard C., Levesque D., Hedlund P.B., Guertin P.A. Contribution of spinal 5-HT1A and 5-HT7 receptors to locomotor-like movement induced by 8-OH-DPAT in spinal cord-transected mice. Eur J Neurosci 2006, 24:535-546.
139. Lauer R.T., Smith B.T., Mulcahey M.J., Betz R.R., Johnston T.E. Effects of cycling and/or electrical stimulation on bone mineral density in children with spinal cord injury. Spinal cord 2011, 49:917-923.
140. Lee H., McKeon R.J., Bellamkonda R.V. Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury. Proc Natl Acad Sci U S A 2010, 107:3340-3345.
141. Legon W., Sato T.F., Opitz A., Mueller J., Barbour A., Williams A., Tyler W.J. Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans. Nat Neurosci 2014, 17:322-329.
142. Levy W.J., Amassian V.E., Traad M., Cadwell J. Focal magnetic coil stimulation reveals motor cortical system reorganized in humans after traumatic quadriplegia. Brain Res 1990, 510:130-134.
143. Lindvall O., Bjorklund A., Nobin A., Stenevi U. The adrenergic innervation of the rat thalamus as revealed by the glyoxylic acid fluorescence method. J Comp Neurol 1974, 154:317-347.
144. Liu G., Keeler B.E., Zhukareva V., Houle J.D. Cycling exercise affects the expression of apoptosis-associated microRNAs after spinal cord injury in rats. Exp Neurol 2010, 226:200-206.
145. Liu G., Detloff M.R., Miller K.N., Santi L., Houle J.D. Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury. Exp Neurol 2012, 233:447-456.
146. Lopez-Garcia J.A., King A.E. Pre- and post-synaptic actions of 5-hydroxytryptamine in the rat lumbar dorsal horn in vitro: implications for somatosensory transmission. Eur J Neurosci 1996, 8:2188-2197.
147. Lotto B., Upton L., Price D.J., Gaspar P. Serotonin receptor activation enhances neurite outgrowth of thalamic neurones in rodents. Neurosci Lett 1999, 269:87-90.
148. Lotze M., Grodd W., Birbaumer N., Erb M., Huse E., Flor H. Does use of a myoelectric prosthesis prevent cortical reorganization and phantom limb pain?. Nat Neurosci 1999, 2:501-502.
149. Lotze M., Laubis-Herrmann U., Topka H. Combination of TMS and fMRI reveals a specific pattern of reorganization in M1 in patients after complete spinal cord injury. Restor Neurol Neurosci 2006, 24:97-107.
150. Lucas J.M., Ji Y., Masri R. Motor cortex stimulation reduces hyperalgesia in an animal model of central pain. Pain 2011, 152:1398-1407.
151. Makin T.R., Scholz J., Filippini N., Henderson Slater D., Tracey I., Johansen-Berg H. Phantom pain is associated with preserved structure and function in the former hand area. Nat Commun 2013, 4:1570.
152. Manduch M., Bezuhly M., Anastakis D.J., Crawley A.P., Mikulis D.J. Serial fMRI of adaptive changes in primary sensorimotor cortex following thumb reconstruction. Neurology 2002, 59:1278-1281.
153. Masri R., Quiton R.L., Lucas J.M., Murray P.D., Thompson S.M., Keller A. Zona incerta: a role in central pain. J Neurophysiol 2009, 102:181-191.
154. Massey J.M., Hubscher C.H., Wagoner M.R., Decker J.A., Amps J., Silver J., Onifer S.M. Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury. J Neurosci 2006, 26:4406-4414.
155. Mattson M.P., Maudsley S., Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 2004, 27:589-594.
156. Maya-Vetencourt J.F., Sale A., Viegi A., Baroncelli L., De Pasquale R., O'Leary O.F., Castren E., Maffei L. The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science 2008, 320:385-388.
157. Maya-Vetencourt J.F., Tiraboschi E., Spolidoro M., Castren E., Maffei L. Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity in rats. Eur J Neurosci 2011, 33:49-57.
158. McKeon R.J., Schreiber R.C., Rudge J.S., Silver J. Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J Neurosci 1991, 11:3398-3411.
159. McKinley P.A., Smith J.L. Age-dependent differences in reorganization of primary somatosensory cortex following low thoracic, (T12) spinal cord transection in cats. J Neurosci 1990, 10:1429-1443.
160. McKinley P.A., Smith J.L. Age-dependent differences in reorganization of primary somatosensory cortex following low thoracic (T12) spinal cord transection in cats. J Neurosci 1990, 10:1429-1443.
161. McKinley P.A., Swyter E. Progressive changes in somatosensory cortical maps in 6-week-old kittens cord-transected at T12. Brain Res 1989, 484:378-382.
162. Merrill L., Girard B., Arms L., Guertin P., Vizzard M.A. Neuropeptide/Receptor expression and plasticity in micturition pathways. Curr Pharm Des 2013, 19:4411-4422.
163. Mikulis D.J., Jurkiewicz M.T., McIlroy W.E., Staines W.R., Rickards L., Kalsi-Ryan S., Crawley A.P., Fehlings M.G., Verrier M.C. Adaptation in the motor cortex following cervical spinal cord injury. Neurology 2002, 58:794-801.
164. Miya D., Giszter S., Mori F., Adipudi V., Tessler A., Murray M. Fetal transplants alter the development of function after spinal cord transection in newborn rats. J Neurosci 1997, 17:4856-4872.
165. Moore C.I., Stern C.E., Dunbar C., Kostyk S.K., Gehi A., Corkin S. Referred phantom sensations and cortical reorganization after spinal cord injury in humans. Proc Natl Acad Sci U S A 2000, 97:14703-14708.
166. Morales-Botello M.L., Aguilar J., Foffani G. Imaging the spatio-temporal dynamics of supragranular activity in the rat somatosensory cortex in response to stimulation of the paws. PLoS One 2012, 7:e40174.
167. Morawietz C., Moffat F. Effects of locomotor training after incomplete spinal cord injury: a systematic review. Arch Phys Med Rehabil 2013, 94:2297-2308.
168. Morrow T.J., Paulson P.E., Brewer K.L., Yezierski R.P., Casey K.L. Chronic, selective forebrain responses to excitotoxic dorsal horn injury. Exp Neurol 2000, 161:220-226.
169. Moruzzi G., Magoun H.W. Brain stem reticular formation and activation of the EEG. Electroencephalogr Clin Neurophysiol 1949, 1:455-473.
170. Musienko P., van den Brand R., Maerzendorfer O., Larmagnac A., Courtine G. Combinatory electrical and pharmacological neuroprosthetic interfaces to regain motor function after spinal cord injury. IEEE Trans Biomed Eng 2009, 56:2707-2711.
171. Neeper S.A., Gomez-Pinilla F., Choi J., Cotman C. Exercise and brain neurotrophins. Nature 1995, 373:109.
172. Neeper S.A., Gomez-Pinilla F., Choi J., Cotman C.W. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res 1996, 726:49-56.
173. Ness T.J., San Pedro E.C., Richards J.S., Kezar L., Liu H.G., Mountz J.M. A case of spinal cord injury-related pain with baseline rCBF brain SPECT imaging and beneficial response to gabapentin. Pain 1998, 78:139-143.
174. Nessler J.A., Timoszyk W., Merlo M., Emken J.L., Minakata K., Roy R.R., de Leon R.D., Edgerton V.R., Reinkensmeyer D.J. A robotic device for studying rodent locomotion after spinal cord injury. IEEE Trans Neural Syst Rehabil Eng 2005, 13:497-506.
175. Nibuya M., Morinobu S., Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 1995, 15:7539-7547.
176. Nishi M., Azmitia E.C. Agonist- and antagonist-induced plasticity of rat 5-HT1A receptor in hippocampal cell culture. Synapse 1999, 31:186-195.
177. Nishimura Y., Onoe H., Morichika Y., Perfiliev S., Tsukada H., Isa T. Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury. Science 2007, 318:1150-1155.
178. Nitsche M.A., Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol 2000, 527(Pt 3):633-639.
179. Normann C., Clark K. Selective modulation of Ca(2+) influx pathways by 5-HT regulates synaptic long-term plasticity in the hippocampus. Brain Res 2005, 1037:187-193.
180. Oliviero A., Mordillo-Mateos L., Arias P., Panyavin I., Foffani G., Aguilar J. Transcranial static magnetic field stimulation of the human motor cortex. J Physiol 2011, 589:4949-4958.
181. Oza C.S., Giszter S.F. Plasticity and alterations of trunk motor cortex following spinal cord injury and non-stepping robot and treadmill training. Exp Neurol 2014, 256:57-69.
182. Paulson P.E., Gorman A.L., Yezierski R.P., Casey K.L., Morrow T.J. Differences in forebrain activation in two strains of rat at rest and after spinal cord injury. Exp Neurol 2005, 196:413-421.
183. Petersen C.C., Hahn T.T., Mehta M., Grinvald A., Sakmann B. Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex. Proc Natl Acad Sci U S A 2003, 100:13638-13643.
184. Peyron R., Schneider F., Faillenot I., Convers P., Barral F.G., Garcia-Larrea L., Laurent B. An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic pain. Neurology 2004, 63:1838-1846.
185. Phillips W.T., Kiratli B.J., Sarkarati M., Weraarchakul G., Myers J., Franklin B.A., Parkash I., Froelicher V. Effect of spinal cord injury on the heart and cardiovascular fitness. Curr Probl Cardiol 1998, 23:641-716.
186. Pindzola R.R., Doller C., Silver J. Putative inhibitory extracellular matrix molecules at the dorsal root entry zone of the spinal cord during development and after root and sciatic nerve lesions. Dev Biol 1993, 156:34-48.
187. Pons T.P., Garraghty P.E., Ommaya A.K., Kaas J.H., Taub E., Mishkin M. Massive cortical reorganization after sensory deafferentation in adult macaques. Science 1991, 252:1857-1860.
188. Priori A. Brain polarization in humans: a reappraisal of an old tool for prolonged non-invasive modulation of brain excitability. Clin Neurophysiol 2003, 114:589-595.
189. Proudfit H.K., Anderson E.G. Influence of serotonin antagonists on bulbospinal systems. Brain Res 1973, 61:331-341.
190. Qi H.X., Jain N., Collins C.E., Lyon D.C., Kaas J.H. Functional organization of motor cortex of adult macaque monkeys is altered by sensory loss in infancy. Proc Natl Acad Sci U S A 2010, 107:3192-3197.
191. Qi H.X., Reed J.L., Gharbawie O.A., Burish M.J., Kaas J.H. Cortical neuron response properties are related to lesion extent and behavioral recovery after sensory loss from spinal cord injury in monkeys. J Neurosci 2014, 34:4345-4363.
192. Ramanathan D., Conner J.M., Tuszynski M.H. A form of motor cortical plasticity that correlates with recovery of function after brain injury. Proc Natl Acad Sci U S A 2006, 103:11370-11375.
193. Ramos A.J., Rubio M.D., Defagot C., Hischberg L., Villar M.J., Brusco A. The 5HT1A receptor agonist, 8-OH-DPAT, protects neurons and reduces astroglial reaction after ischemic damage caused by cortical devascularization. Brain Res 2004, 1030:201-220.
194. Rayegani S.M., Shojaee H., Sedighipour L., Soroush M.R., Baghbani M., Amirani O.B. The effect of electrical passive cycling on spasticity in war veterans with spinal cord injury. Front Neurol 2011, 2:39.
195. Reig R., Sanchez-Vives M.V. Synaptic transmission and plasticity in an active cortical network. PLoS One 2007, 2:e670.
196. Ren Y., Zhang L., Lu Y., Yang H., Westlund K.N. Central lateral thalamic neurons receive noxious visceral mechanical and chemical input in rats. J Neurophysiol 2009, 102:244-258.
197. Rigas P., Castro-Alamancos M.A. Thalamocortical up states: differential effects of intrinsic and extrinsic cortical inputs on persistent activity. J Neurosci 2007, 27:4261-4272.
198. Roelcke U., Curt A., Otte A., Missimer J., Maguire R.P., Dietz V., Leenders K.L. Influence of spinal cord injury on cerebral sensorimotor systems: a PET study. J Neurol Neurosurg Psychiatry 1997, 62:61-65.
199. Russo-Neustadt A., Beard R.C., Cotman C.W. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology 1999, 21:679-682.
200. Russo-Neustadt A.A., Beard R.C., Huang Y.M., Cotman C.W. Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus. Neuroscience 2000, 101:305-312.
201. Sachdev R.N., Ebner F.F., Wilson C.J. Effect of subthreshold up and down states on the whisker-evoked response in somatosensory cortex. J Neurophysiol 2004, 92:3511-3521.
202. Satoh K., Fibiger H.C. Cholinergic neurons of the laterodorsal tegmental nucleus: efferent and afferent connections. J Comp Neurol 1986, 253:277-302.
203. Schmidlin E., Wannier T., Bloch J., Rouiller E.M. Progressive plastic changes in the hand representation of the primary motor cortex parallel incomplete recovery from a unilateral section of the corticospinal tract at cervical level in monkeys. Brain Res 2004, 1017:172-183.
204. Seminowicz D.A., Jiang L., Ji Y., Xu S., Gullapalli R.P., Masri R. Thalamocortical asynchrony in conditions of spinal cord injury pain in rats. J Neurosci 2012, 32:15843-15848.
205. Sharma H., Alilain W.J., Sadhu A., Silver J. Treatments to restore respiratory function after spinal cord injury and their implications for regeneration, plasticity and adaptation. Exp Neurol 2012, 235:18-25.
206. Sheibani V., Farazifard R. Dorsal raphe nucleus stimulation modulates the response of layers IV and V barrel cortical neurons in rat. Brain Res Bull 2006, 68:430-435.
207. Shumsky J.S., Kao T., Amato N., Simansky K., Murray M., Moxon K.A. Partial 5-HT(1A) receptor agonist activity by the 5-HT(2C) receptor antagonist SB 206,553 is revealed in rats spinalized as neonates. Exp Neurol 2005, 191:361-365.
208. Sievert C.F., Neafsey E.J. A chronic unit study of the sensory properties of neurons in the forelimb areas of rat sensorimotor cortex. Brain Res 1986, 381:15-23.
209. Silver J., Miller J.H. Regeneration beyond the glial scar. Nat Rev Neurosci 2004, 5:146-156.
210. Skagerberg G., Bjorklund A. Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat. Neuroscience 1985, 15:445-480.
211. Soler M.D., Kumru H., Pelayo R., Vidal J., Tormos J.M., Fregni F., Navarro X., Pascual-Leone A. Effectiveness of transcranial direct current stimulation and visual illusion on neuropathic pain in spinal cord injury. Brain 2010, 133:2565-2577.
212. Stelzner D.J., Ershler W.B., Weber E.D. Effects of spinal transection in neonatal and weanling rats: survival of function. Exp Neurol 1975, 46:156-177.
213. Steriade M., Datta S., Pare D., Oakson G., Curro Dossi R.C. Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems. J Neurosci 1990, 10:2541-2559.
214. Sydekum E., Ghosh A., Gullo M., Baltes C., Schwab M., Rudin M. Rapid functional reorganization of the forelimb cortical representation after thoracic spinal cord injury in adult rats. Neuroimage 2014, 87:72-79.
215. Tandon S., Kambi N., Lazar L., Mohammed H., Jain N. Large-scale expansion of the face representation in somatosensory areas of the lateral sulcus after spinal cord injuries in monkeys. J Neurosci 2009, 29:12009-12019.
216. Tang X., Davies J.E., Davies S.J. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. J Neurosci Res 2003, 71:427-444.
217. Timoszyk W.K., Nessler J.A., Acosta C., Roy R.R., Edgerton V.R., Reinkensmeyer D.J., de Leon R. Hindlimb loading determines stepping quantity and quality following spinal cord transection. Brain Res 2005, 1050:180-189.
218. Topka H., Cohen L.G., Cole R.A., Hallett M. Reorganization of corticospinal pathways following spinal cord injury. Neurology 1991, 41:1276-1283.
219. Tran Y., Boord P., Middleton J., Craig A. Levels of brain wave activity (8-13 Hz) in persons with spinal cord injury. Spinal cord 2004, 42:73-79.
220. Tropea D., Caleo M., Maffei L. Synergistic effects of brain-derived neurotrophic factor and chondroitinase ABC on retinal fiber sprouting after denervation of the superior colliculus in adult rats. J Neurosci 2003, 23:7034-7044.
221. Turner J.A., Lee J.S., Schandler S.L., Cohen M.J. An fMRI investigation of hand representation in paraplegic humans. Neurorehabil Neural Repair 2003, 17:37-47.
222. Ung R.V., Landry E.S., Rouleau P., Lapointe N.P., Rouillard C., Guertin P.A. Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection. Eur J Neurosci 2008, 28:2231-2242.
223. van Hedel H.J., Dietz V. Rehabilitation of locomotion after spinal cord injury. Restor Neurol Neurosci 2010, 28:123-134.
224. Vaynman S., Gomez-Pinilla F. License to run: exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins. Neurorehabil Neural Repair 2005, 19:283-295.
225. Vaynman S., Ying Z., Gomez-Pinilla F. Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience 2003, 122:647-657.
226. Vaynman S., Ying Z., Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 2004, 20:2580-2590.
227. Vaynman S.S., Ying Z., Yin D., Gomez-Pinilla F. Exercise differentially regulates synaptic proteins associated to the function of BDNF. Brain Res 2006, 1070:124-130.
228. Vessal M., Darian-Smith C. Adult neurogenesis occurs in primate sensorimotor cortex following cervical dorsal rhizotomy. J Neurosci 2010, 30:8613-8623.
229. Vessal M., Aycock A., Garton M.T., Ciferri M., Darian-Smith C. Adult neurogenesis in primate and rodent spinal cord: comparing a cervical dorsal rhizotomy with a dorsal column transection. Eur J Neurosci 2007, 26:2777-2794.
230. Wall P.D., Egger M.D. Formation of new connexions in adult rat brains after partial deafferentation. Nature 1971, 232:542-545.
231. Wang D., Ichiyama R.M., Zhao R., Andrews M.R., Fawcett J.W. Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury. J Neurosci 2011, 31:9332-9344.
232. Wasner G., Lee B.B., Engel S., McLachlan E. Residual spinothalamic tract pathways predict development of central pain after spinal cord injury. Brain 2008, 131:2387-2400.
233. Waterhouse B.D., Moises H.C., Woodward D.J. Interaction of serotonin with somatosensory cortical neuronal responses to afferent synaptic inputs and putative neurotransmitters. Brain Res Bull 1986, 17:507-518.
234. Weber E.D., Stelzner D.J. Behavioral effects of spinal cord transection in the developing rat. Brain Res 1977, 125:241-255.
235. Weishaupt N., Blesch A., Fouad K. BDNF: the career of a multifaceted neurotrophin in spinal cord injury. Exp Neurol 2012, 238:254-264.
236. Weishaupt N., Li S., Di Pardo A., Sipione S., Fouad K. Synergistic effects of BDNF and rehabilitative training on recovery after cervical spinal cord injury. Behav Brain Res 2013, 239:31-42.
237. Wernig A., Muller S., Nanassy A., Cagol E. Laufband therapy based on 'rules of spinal locomotion' is effective in spinal cord injured persons. Eur J Neurosci 1995, 7:823-829.
238. Wessels M., Lucas C., Eriks I., de Groot S. Body weight-supported gait training for restoration of walking in people with an incomplete spinal cord injury: a systematic review. J Rehabil Med 2010, 42:513-519.
239. Whitt J.L., Masri R., Pulimood N.S., Keller A. Pathological activity in mediodorsal thalamus of rats with spinal cord injury pain. J Neurosci 2013, 33:3915-3926.
240. Winchester P., McColl R., Querry R., Foreman N., Mosby J., Tansey K., Williamson J. Changes in supraspinal activation patterns following robotic locomotor therapy in motor-incomplete spinal cord injury. Neurorehabil Neural Repair 2005, 19:313-324.
241. Wrigley P.J., Gustin S.M., Macey P.M., Nash P.G., Gandevia S.C., Macefield V.G., Siddall P.J., Henderson L.A. Anatomical changes in human motor cortex and motor pathways following complete thoracic spinal cord injury. Cereb Cortex 2009, 19:224-232.
242. Wrigley P.J., Press S.R., Gustin S.M., Macefield V.G., Gandevia S.C., Cousins M.J., Middleton J.W., Henderson L.A., Siddall P.J. Neuropathic pain and primary somatosensory cortex reorganization following spinal cord injury. Pain 2009, 141:52-59.
243. Wydenkeller S., Maurizio S., Dietz V., Halder P. Neuropathic pain in spinal cord injury: significance of clinical and electrophysiological measures. Eur J Neurosci 2009, 30:91-99.
244. Yague J.G., Foffani G., Aguilar J. Cortical hyperexcitability in response to preserved spinothalamic inputs immediately after spinal cord hemisection. Exp Neurol 2011, 227:252-263.
245. Yagüe J.G., Humanes-Valera D., Aguilar J., Foffani G. Functional reorganization of the forepaw cortical representation immediately after thoracic spinal cord hemisection in rats. Exp Neurol 2014, 257C:19-24.
246. Yaksh T.L., Wilson P.R. Spinal serotonin terminal system mediates antinociception. J Pharmacol Exp Ther 1979, 208:446-453.
247. Zaaimi B., Edgley S.A., Soteropoulos D.S., Baker S.N. Changes in descending motor pathway connectivity after corticospinal tract lesion in macaque monkey. Brain 2012, 135:2277-2289.
248. Zempleni M.Z., Michels L., Mehnert U., Schurch B., Kollias S. Cortical substrate of bladder control in SCI and the effect of peripheral pudendal stimulation. Neuroimage 2010, 49:2983-2994.