Role of the 5-HT2C receptor in improving weight-supported stepping in adult rats spinalized as neonates

Brain Research

Volumn 1112, Issue 1, 2006, Pages 159-168

  Kao, Tina ^a   Shumsky, Jed S ^a   Jacob Vadakot, Stacy ^a   Timothy Himes, B ^a   Murray, Marion ^a   Moxon, Karen A ^a,b  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b DREXEL UNIVERSITY   (United States)

Author keywords

Locomotion; m chlorophenylpiperazine; Serotonin; Spinal 5 HT receptor; Spinal cord injury; Transection

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; QUIPAZINE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR; 1,2-DILINOLENOYL-3-(4-AMINOBUTYRYL)PROPANE-1,2,3-TRIOL; 1-(3-CHLOROPHENYL)PIPERAZINE; 3 (4 AMINOBUTYRYL) 1,2 DILINOLENOYLGLYCEROL; 4 AMINOBUTYRIC ACID; DRUG DERIVATIVE; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; TRIACYLGLYCEROL;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENERVATION; DOSE CALCULATION; DOSE RESPONSE; FEMALE; LIMB TREMOR; MOTOR DYSFUNCTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SPINAL CORD INJURY; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL BEHAVIOR; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; DRUG INTERACTION; EXERCISE TEST; METABOLISM; METHODOLOGY; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; SPRAGUE DAWLEY RAT; UPREGULATION; WEIGHT BEARING;

ANIMALIA;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXERCISE TEST; FEMALE; GAMMA-AMINOBUTYRIC ACID; INDOLES; MOTOR ACTIVITY; PIPERAZINES; PSYCHOMOTOR PERFORMANCE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPINAL CORD INJURIES; TRIGLYCERIDES; UP-REGULATION; WEIGHT-BEARING;

EID: 33748437047     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.07.020     Document Type: Article

References (37)

1. Antri M., Orsal D., and Barthe J.Y. Locomotor recovery in the chronic spinal rat: effects of long term treatment with a 5-HT2 agonist. Eur. J. Neurosci. 16 (2002) 467-476
2. 1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat. Eur. J. Neurosci. 18 (2003) 1963-1972
3. Antri M., Barthe J.Y., Mouffle C., and Orsal D. Long-lasting recovery of locomotor function in chronic spinal rat following chronic combined pharmacological stimulation of serotonergic receptors with 8-OHDPAT and quipazine. Neurosci. Lett. 384 1-2 (2005) 162-167
4. Barbeau H., and Rossignol S. The effects of serotonergic drugs on the locomotor pattern and on the cutaneous reflexes of the adult chronic spinal cat. Brain Res. 514 (1990) 55-67
5. Basso D.M., Beattie M.S., and Bresnahan J.C. A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma 12 (1995) 1-21
6. Basura G.J., Zhou S., Walker P.D., and Goshgarian H.G. Distribution of serotonin 2A and 2C receptor mRNA expression in the cervical ventral horn and phrenic motoneurons following spinal cord hemisection. Exp. Neurol. 169 (2001) 255-263
7. Brombridge S.M., Duckworth M., Forbes I.T., Ham P., King F.D., Thewlis K.M., Blaney F.E., Naylor C.B., Blackburn T.P., Kennett G.A., Wood M.D., and Clarke S.E. 6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbomyl]-indole (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist. J. Med. Chem. 40 (1997) 3494-3496
8. Cazalets J.R., Sqalli-Houssaini Y., and Clarac F. Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in the neonatal rat. J. Physiol. (London) 455 (1995) 187-204
9. Clineschmidt B.V., Pierce J.E., and Lovenberg W. Tryptophan hydroxylase and serotonin in spinal cord and brain before and after chronic transection. J. Neurochem. 18 (1971) 1593-1596
10. Germine M., Goddard A.W., Sholomskas D.E., Woods S.W., Charney D.S., and Heninger G.R. Response to meta-chlorophenylpiperazine in panic disorder patients and healthy subjects: influence of reduction in intravenous dosage. Psychiatry Res. 54 (1994) 115-133
11. 2B receptors. Behav. Pharmacol. 12 (2001) 613-620
12. Glennon R.A. Classical hallucinogens. In: Schuster C.R., and Kuhar M.J. (Eds). Pharmacological Aspects of Drug Dependence (1996), Springer, New York 343-371
13. Jackson D.A., and White S.R. Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons. Neuropharmacology 29 (1990) 787-797
14. Kennett G.A., Wood M.D., Bright F., Cilia J., Piper D.C., Gager T., Thomas D.T., Baxter G.S., Forbes I.T., Ham P., and Blackburn T.P. In vitro and in vivo profile of SB 206,553, a potent 5-HT2C/5-HT2B receptor antagonist. Br. J. Pharmacol. 117 (1996) 427-434
15. Kim D., Adipudi V., Shibayama M., Giszter S., Tessler A., Murray M., and Simansky KJ. Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection. J. Neurosci. 19 14 (1999) 6213-6224
16. 2C agonist m-chlorophenylpiperazine increases weight-supported locomotion without development of tolerance in rats with spinal transections. Exp. Neurol. 169 (2001) 496-500
17. Kjaerulff O., and Keihn O. Distribution of networks generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro. J. Neurosci. 16 (1996) 5777-5794
18. Krenz N.R., and Weaver L.C. Sprouting of primary afferent fibers after spinal transection in the rat. Neuroscience 85 2 (1998) 443-458
19. 2 receptor agonists on hindlimb movements in paraplegic mice. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 28 6 (2004) 1053-1060
20. Lucki I., and Wieland S. 5-Hydroxytryptamine1A receptors and behavioral responses. Neuropsychopharmacology 3 (1990) 481-493
21. Lucki I., Ward H.R., and Frazer A. Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifluoro-methylphenyl)piperazine on locomotor activity. J. Pharmacol. Exp. Ther. 249 (1989) 155-164
22. 2 receptors in the rat spinal cord. Brain Res. 550 (1991) 15-23
23. 2C receptor antagonist SB 206,553. Neuropharmacology 36 (1997) 743-745
24. Miya D., Giszter S., Mori F., Adipudi V., Tessler A., and Murray M. Fetal transplants alter the development of function after spinal cord transection in newborn rats. J. Neurosci. 17 12 (1997) 4856-4872
25. 2C receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 359 (1999) 1-6
26. Nothias J.M., Mitsui T., Shumsky J.S., Fischer I., Atonnacci M.D., and Murray M. Combined effects of neurotrophin secreting transplants, exercise and serotonergic drug challenge improve function in spinal rats. Neurorehabilitation Neural Repair 19 4 (2005) 296-312
27. Pearson K.G., and Ramirez J.M. Sensory modulation of pattern generating circuits. In: Stein P.S.G., Grillner S., Selverston A.I., and Stuart D.G. (Eds). Neurons, Networks, and Motor Behavior (1997), MIT Press, Cambridge, Massachusetts 225-236
28. 2C receptors. Brain Res. Mol. Brain Res. 23 (1994) 163-178
29. Rossignol S., Giroux N., Chau C., Marcoux J., Brustein E., and Reader T.A. Pharmacological aids to locomotor training after spinal injury in the cat. J. Physiol. 533 (2001) 65-74
30. Schmidt B.J., and Jordan L.M. The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord. Brain Res. Bull. 53 5 (2000) 689-710
31. Sharma A., Punhani T., and Fone K.C.F. Distribution of the 5-hydroxytryptamine 2C receptor protein in adult rat brain and spinal cord determined using a receptor-directed antibody: effect of 5,7-dihydroxytryptamine. Synapse 27 (1997) 450-456
32. Shumsky J.S., Kao T., Amato N., Simansky K., Murray M., and Moxon K.A. Partial 5-HT1A receptor agonist activity by the 5-HT2C receptor antagonist SB 206,553 is revealed in rats spinalized as neonates. Exp. Neurol. 191 (2005) 361-365
33. Sillar K.T., Kiehn O., and Kudo N. Chemical modulation of vertebrate motor circuits. In: Stein P.S.G., Grillner S., Selverston A.I., and Stuart D.G. (Eds). Sensory Modulation of Pattern Generating Circuits. Neurons, Networks, and Motor Behavior (1997), MIT Press, Cambridge, Massachusetts 183-194
34. Stelzner D.J., Erschler W.B., and Weber E.D. Effects of spinal transection in neonatal and weanling rats. Exp. Neurol. 46 (1975) 156-177
35. Thor K.B., Nickolaus S., and Helke C.J. Autoradiographic localization of 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites in the rat spinal cord. Neuroscience 55 (1993) 235-252
36. Weber E.D., and Stelzner D.J. Behavioral effects of spinal cord transection in the developing rat. Brain Res. 125 (1997) 241-255
37. Yi D.K., Adipudi V., Anderson M., Simansky K.N., and Murray K.J. Transplant mediated locomotion is improved by selective serotonergic agonists. Ann. N. Y. Acad. Sci. 860 (1998) 524-527