Locomotor Training: As a treatment of spinal cord injury and in the progression of neurologic rehabilitation

Archives of Physical Medicine and Rehabilitation

Volumn 93, Issue 9, 2012, Pages 1588-1597

  Harkema, Susan J ^a,b   Hillyer, Jessica ^a,b   Schmidt Read, Mary ^c   Ardolino, Elizabeth ^d   Sisto, Sue Ann ^e   Behrman, Andrea L ^f  

^a University of Louisville School of Medicine   (United States)

^b Frazier Rehab Institute   (United States)

^c Magee Rehabilitation Hospital   (United States)

^d University of St Augustine   (United States)

^e STONY BROOK UNIVERSITY   (United States)

^f UNIVERSITY OF FLORIDA   (United States)

Author keywords

Clinical trial; Locomotion; Rehabilitation; Spinal cord injuries

Indexed keywords

BLOOD PRESSURE REGULATION; CARDIOVASCULAR FUNCTION; CLINICAL DECISION MAKING; CONVALESCENCE; DAILY LIFE ACTIVITY; DISEASE COURSE; EXOSKELETON (REHABILITATION); FOLLOW UP; HEART RATE; HUMAN; LEG; LOCOMOTION; NERVOUS SYSTEM; OUTCOME ASSESSMENT; PATIENT SATISFACTION; PRACTICE GUIDELINE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REHABILITATION CENTER; REVIEW; SCORING SYSTEM; SPINAL CORD INJURY; STANDING; TREADMILL; WALKING; WALKING SPEED; WEIGHT BEARING;

EID: 84865593677     PISSN: 00039993     EISSN: 1532821X     Source Type: Journal    
DOI: 10.1016/j.apmr.2012.04.032     Document Type: Note

References (147)

1. A.L. Behrman, M.G. Bowden, P.M. Nair Neuroplasticity after spinal cord injury and training: an emerging paradigm shift in rehabilitation and walking recovery Phys Ther 86 2006 1406 1425 (Pubitemid 44497075)
2. M.G. Bowden, E.M. Hannold, P.M. Nair, L.B. Fuller, A.L. Behrman Beyond gait speed: a case report of a multidimensional approach to locomotor rehabilitation outcomes in incomplete spinal cord injury J Neurol Phys Ther 32 2008 129 138
3. A.L. Hicks, K.A. Ginis Treadmill training after spinal cord injury: it's not just about the walking J Rehabil Res Dev 45 2008 241 248
4. A.L. Hicks, M.M. Adams, K. Martin Ginis Long-term body-weight-supported treadmill training and subsequent follow-up in persons with chronic SCI: effects on functional walking ability and measures of subjective well-being Spinal Cord 43 2005 291 298 (Pubitemid 40704991)
5. E.M. Hannold, M.E. Young, M.R. Rittman, M.G. Bowden, A.L. Behrman Locomotor training: experiencing the changing body J Rehabil Res Dev 43 2006 905 916 (Pubitemid 46449931)
6. H. Barbeau, D.A. McCrea, M.J. O'Donovan, S. Rossignol, W.M. Grill, M.A. Lemay Tapping into spinal circuits to restore motor function Brain Res Rev 30 1999 27 51 (Pubitemid 29331514)
7. H. Barbeau Locomotor training in neurorehabilitation: emerging rehabilitation concepts Neurorehabil Neural Repair 17 2003 3 11 (Pubitemid 37102022)
8. V. Dietz, S.J. Harkema Locomotor activity in spinal cord-injured persons J Appl Physiol 96 2004 1954 1960 (Pubitemid 38580025)
9. V. Dietz Body weight supported gait training: from laboratory to clinical setting Brain Res Bull 78 2009 I VI
10. A.W. Dromerick, P.S. Lum, J. Hidler Activity-based therapies NeuroRx 3 2006 428 438 (Pubitemid 44443013)
11. V.R. Edgerton, R.D. de Leon, S.J. Harkema Topical review: retraining the injured spinal cord J Physiol 533 2001 15 22 (Pubitemid 32499352)
12. S.J. Harkema Neural plasticity after human spinal cord injury: application of locomotor training to the rehabilitation of walking Neuroscientist 7 2001 455 468 (Pubitemid 32923760)
13. J. Mehrholz, J. Kugler, M. Pohl Locomotor training for walking after spinal cord injury Cochrane Database Syst Rev 2 2008 66 76
14. R.R. Roy, S.J. Harkema, V.R. Edgerton Basic concepts of activity-based interventions for improved recovery of motor function after spinal cord injury Arch Phys Med Rehabil 93 2012 1487 1497
15. G. Scivoletto, Y. Ivanenko, B. Morganti Plasticity of spinal centers in spinal cord injury patients: new concepts for gait evaluation and training Neurorehabil Neural Repair 21 2007 358 365 (Pubitemid 46871853)
16. M. Wessels, C. Lucas, I. Eriks, S. de Groot Body weight-supported gait training for restoration of walking in people with an incomplete spinal cord injury: a systematic review J Rehabil Med 42 2010 513 519
17. S.J. Harkema, M. Schmidt-Read, A.L. Behrman, A. Bratta, S.A. Sisto, V.R. Edgerton Establishing the NeuroRecovery Network: multisite rehabilitation centers that provide activity-based therapies and assessments for neurologic disorders Arch Phys Med Rehabil 93 2012 1498 1507
18. H. Barbeau, S. Nadeau, C. Garneau Physical determinants, emerging concepts, and training approaches in gait of individuals with spinal cord injury J Neurotrauma 23 2006 571 585 (Pubitemid 43726330)
19. S.J. Harkema Plasticity of interneuronal networks of the functionally isolated human spinal cord Brain Res Rev 57 2008 255 264 (Pubitemid 350213103)
20. H.W. van de Crommert, T. Mulder, J. Duysens Neural control of locomotion: sensory control of the central pattern generator and its relation to treadmill training Gait Posture 7 1998 251 263 (Pubitemid 28327493)
21. S. Grillner Control of locomotion in bipeds, tetrapods, and fish V. Brooks, Handbook of physiology: the nervous system II 1981 American Physiological Society Bethesda 1179 1236
22. J.A. Beres-Jones, T.D. Johnson, S.J. Harkema Clonus after human spinal cord injury cannot be attributed solely to recurrent muscle-tendon stretch Exp Brain Res 149 2003 222 236 (Pubitemid 36315373)
23. J.A. Beres-Jones, S.J. Harkema The human spinal cord interprets velocity-dependent afferent input during stepping Brain 127 2004 2232 2246 (Pubitemid 39382232)
24. G. Colombo, M. Wirz, V. Dietz Effect of locomotor training related to clinical and electrophysiological examinations in spinal cord injured humans Ann N Y Acad Sci 860 1998 536 538 (Pubitemid 29046018)
25. V. Dietz, G. Colombo, L. Jensen Locomotor activity in spinal man Lancet 344 1994 1260 1263 (Pubitemid 24334682)
26. V. Dietz, G. Colombo, L. Jensen, L. Baumgartner Locomotor capacity of spinal cord in paraplegic patients Ann Neurol 37 1995 574 582
27. V. Dietz, M. Wirz, A. Curt, G. Colombo Locomotor pattern in paraplegic patients: training effects and recovery of spinal cord function Spinal Cord 36 1998 380 390 (Pubitemid 28276687)
28. V. Dietz, M. Wirz, G. Colombo, A. Curt Locomotor capacity and recovery of spinal cord function in paraplegic patients: a clinical and electrophysiological evaluation Electroencephalogr Clin Neurophysiol 109 1998 140 153 (Pubitemid 28159977)
29. V. Dietz, K. Nakazawa, M. Wirz, T. Erni Level of spinal cord lesion determines locomotor activity in spinal man Exp Brain Res 128 1999 405 409 (Pubitemid 29450194)
30. B.H. Dobkin, S. Harkema, P. Requejo, V.R. Edgerton Modulation of locomotor-like EMG activity in subjects with complete and incomplete spinal cord injury J Neurol Rehabil 9 1995 183 190
31. T. Erni, G. Colombo Locomotor training in paraplegic patients: a new approach to assess changes in leg muscle EMG patterns Electroencephalogr Clin Neurophysiol 109 1998 135 139
32. S.J. Harkema, S.L. Hurley, U.K. Patel, P.S. Requejo, B.H. Dobkin, V.R. Edgerton Human lumbosacral spinal cord interprets loading during stepping J Neurophysiol 77 1997 797 811 (Pubitemid 27087781)
33. V. Dietz, R. Muller, G. Colombo Locomotor activity in spinal man: significance of afferent input from joint and load receptors Brain 125 Pt 12 2002 2626 2634 (Pubitemid 35423512)
34. C.J. Dy, Y.P. Gerasimenko, V.R. Edgerton, P. Dyhre-Poulsen, G. Courtine, S.J. Harkema Phase-dependent modulation of percutaneously elicited multisegmental muscle responses after spinal cord injury J Neurophysiol 103 2010 2808 2820
35. D.P. Ferris, K.E. Gordon, J.A. Beres-Jones, S.J. Harkema Muscle activation during unilateral stepping occurs in the nonstepping limb of humans with clinically complete spinal cord injury Spinal Cord 42 2004 14 23 (Pubitemid 38174975)
36. M.A. Gorassini, J.A. Norton, J. Nevett-Duchcherer, F.D. Roy, J.F. Yang Changes in locomotor muscle activity after treadmill training in subjects with incomplete spinal cord injury J Neurophysiol 101 2009 969 979
37. R. Grasso, Y.P. Ivanenko, M. Zago Distributed plasticity of locomotor pattern generators in spinal cord injured patients Brain 127 Pt 5 2004 1019 1034 (Pubitemid 38623039)
38. R. Grasso, Y.P. Ivanenko, M. Zago, M. Molinari, G. Scivoletto, F. Lacquaniti Recovery of forward stepping in spinal cord injured patients does not transfer to untrained backward stepping Exp Brain Res 157 2004 377 382 (Pubitemid 39044332)
39. Y.P. Ivanenko, R.E. Poppele, F. Lacquaniti Distributed neural networks for controlling human locomotion: lessons from normal and SCI subjects Brain Res Bull 78 2009 13 21
40. N. Kawashima, D. Nozaki, M.O. Abe, M. Akai, K. Nakazawa Alternate leg movement amplifies locomotor-like muscle activity in spinal cord injured persons J Neurophysiol 93 2005 777 785
41. N. Kawashima, D. Nozaki, M.O. Abe, K. Nakazawa Shaping appropriate locomotive motor output through interlimb neural pathway within spinal cord in humans J Neurophysiol 99 2008 2946 2955
42. L. Lunenburger, M. Bolliger, D. Czell, R. Muller, V. Dietz Modulation of locomotor activity in complete spinal cord injury Exp Brain Res 174 2006 638 646 (Pubitemid 44497436)
43. J.A. Norton, M.A. Gorassini Changes in cortically related intermuscular coherence accompanying improvements in locomotor skills in incomplete spinal cord injury J Neurophysiol 95 2006 2580 2589
44. C.P. Phadke, S.S. Wu, F.J. Thompson, A.L. Behrman Comparison of soleus H-reflex modulation after incomplete spinal cord injury in 2 walking environments: treadmill with body weight support and overground Arch Phys Med Rehabil 88 2007 1606 1613 (Pubitemid 350151389)
45. C.P. Phadke, S.M. Flynn, F.J. Thompson, A.L. Behrman, M.H. Trimble, C.G. Kukulka Comparison of single bout effects of bicycle training versus locomotor training on paired reflex depression of the soleus H-reflex after motor incomplete spinal cord injury Arch Phys Med Rehabil 90 2009 1218 1228
46. S.L. Thomas, M.A. Gorassini Increases in corticospinal tract function by treadmill training after incomplete spinal cord injury J Neurophysiol 94 2005 2844 2855 (Pubitemid 41327380)
47. M.M. Adams, D.S. Ditor, M.A. Tarnopolsky, S.M. Phillips, N. McCartney, A.L. Hicks The effect of body weight-supported treadmill training on muscle morphology in an individual with chronic, motor-complete spinal cord injury: a case study J Spinal Cord Med 29 2006 167 171
48. A.L. Behrman, S.J. Harkema Locomotor training after human spinal cord injury: a series of case studies Phys Ther 80 2000 688 700 (Pubitemid 30441698)
49. A.K. Behrman, A.R. Lawless-Dixon, S.B. Davis Locomotor training progression and outcomes after incomplete spinal cord injury Phys Ther 85 2005 1356 1371 (Pubitemid 41746281)
50. A.L. Behrman, P.M. Nair, M.G. Bowden Locomotor training restores walking in a nonambulatory child with chronic, severe, incomplete cervical spinal cord injury Phys Ther 88 2008 580 590 (Pubitemid 351620007)
51. E.J. Fox, N.J. Tester, C.P. Phadke Ongoing walking recovery 2 years after locomotor training in a child with severe incomplete spinal cord injury Phys Ther 90 2010 793 802
52. A.S. Gorgey, H. Poarch, J. Miller, T. Castillo, D.R. Gater Locomotor and resistance training restore walking in an elderly person with a chronic incomplete spinal cord injury NeuroRehabilitation 26 2010 127 133
53. K.E. Musselman, K. Fouad, J.E. Misiaszek, J.F. Yang Training of walking skills overground and on the treadmill: case series on individuals with incomplete spinal cord injury Phys Ther 89 2009 601 611
54. L.A. Prosser Locomotor training within an inpatient rehabilitation program after pediatric incomplete spinal cord injury Phys Ther 87 2007 1224 1232 (Pubitemid 350194789)
55. E.J. Protas, S.A. Holmes, H. Qureshy, A. Johnson, D. Lee Supported treadmill ambulation training after spinal cord injury: a pilot study Arch Phys Med Rehabil 82 2001 825 831 (Pubitemid 32520795)
56. M.H. Trimble, A.L. Behrman, S.M. Flynn, M.T. Thigpen, F.J. Thompson Acute effects of locomotor training on overground walking speed and H-reflex modulation in individuals with incomplete spinal cord injury J Spinal Cord Med 24 2001 74 80 (Pubitemid 37486207)
57. D.L. Young, H.W. Wallmann, I. Poole, A.J. Threlkeld Body weight supported treadmill training at very low treatment frequency for a young adult with incomplete cervical spinal cord injury NeuroRehabilitation 25 2009 261 270
58. V. Dietz, R. Muller Degradation of neuronal function following a spinal cord injury: mechanisms and countermeasures Brain 127 Pt 10 2004 2221 2231 (Pubitemid 39382231)
59. P.R. Lucareli, M.O. Lima, F.P. Lima, J.G. de Almeida, G.C. Brech, J.M. Greve Gait analysis following treadmill training with body weight support versus conventional physical therapy: a prospective randomized controlled single blind study Spinal Cord 49 2011 1001 1007
60. A. Wernig, S. Mller Laufband locomotion with body weight support improved walking in persons with severe spinal cord injuries Paraplegia 30 1992 229 238
61. A. Wernig, S. Mller, A. Nanassy, E. Cagol Laufband therapy based on "rules of spinal locomotion" is effective in spinal cord injured persons Eur J Neurosci 7 1995 823 829
62. A. Wernig, A. Nanassy, S. Mller Maintenance of locomotor abilities following Laufband (treadmill) therapy in para- and tetraplegic persons: follow-up studies Spinal Cord 36 1998 744 749 (Pubitemid 28515335)
63. A. Wernig Laufband (treadmill) therapy in SCI persons Neurorehabil Neural Repair 13 1999 175 176 (Pubitemid 30152172)
64. A. Wernig, A. Nanassy, S. Muller Laufband (treadmill) therapy in incomplete paraplegia and tetraplegia J Neurotrauma 16 1999 719 726 (Pubitemid 29422797)
65. M. Wirz, G. Colombo, V. Dietz Long term effects of locomotor training in spinal humans J Neurol Neurosurg Psychiatry 71 2001 93 96
66. T. Lam, K. Pauhl, A. Krassioukov, J.J. Eng Using robot-applied resistance to augment body-weight-supported treadmill training in an individual with incomplete spinal cord injury Phys Ther 91 2011 143 151
67. I. Schwartz, A. Sajin, E. Moreh Robot-assisted gait training in multiple sclerosis patients: a randomized trial Mult Scler 18 2012 881 890
68. M. Wirz, D.H. Zemon, R. Rupp Effectiveness of automated locomotor training in patients with chronic incomplete spinal cord injury: a multicenter trial Arch Phys Med Rehabil 86 2005 672 680 (Pubitemid 40487831)
69. N. Alexeeva, C. Sames, P.L. Jacobs Comparison of training methods to improve walking in persons with chronic spinal cord injury: a randomized clinical trial J Spinal Cord Med 34 2011 362 379
70. E.C. Field-Fote Combined use of body weight support, functional electric stimulation, and treadmill training to improve walking ability in individuals with chronic incomplete spinal cord injury Arch Phys Med Rehabil 82 2001 818 824 (Pubitemid 32520794)
71. E.C. Field-Fote, D. Tepavac Improved intralimb coordination in people with incomplete spinal cord injury following training with body weight support and electrical stimulation Phys Ther 82 2002 707 715 (Pubitemid 34728980)
72. E.C. Field-Fote, S.D. Lindley, A.L. Sherman Locomotor training approaches for individuals with spinal cord injury: a preliminary report of walking-related outcomes J Neurol Phys Ther 29 2005 127 137
73. E.C. Field-Fote, K.E. Roach Influence of a locomotor training approach on walking speed and distance in people with chronic spinal cord injury: a randomized clinical trial Phys Ther 91 2011 48 60
74. E. Hardin, R. Kobetic, L. Murray Walking after incomplete spinal cord injury using an implanted FES system: a case report J Rehabil Res Dev 44 2007 333 346 (Pubitemid 47075805)
75. S.J. Harkema, C.K. Ferreira, R.J. van den Brand, A.V. Krassioukov Improvements in orthostatic instability with stand locomotor training in individuals with spinal cord injury J Neurotrauma 25 2008 1467 1475
76. T.G. Hornby, D.H. Zemon, D. Campbell Robotic-assisted, body-weight-supported treadmill training in individuals following motor incomplete spinal cord injury Phys Ther 85 2005 52 66 (Pubitemid 40041547)
77. N.J. Postans, J.P. Hasler, M.H. Granat, D.J. Maxwell Functional electric stimulation to augment partial weight-bearing supported treadmill training for patients with acute incomplete spinal cord injury: a pilot study Arch Phys Med Rehabil 85 2004 604 610 (Pubitemid 38881050)
78. M.F. Sherman, T. Lam, A.W. Sheel Locomotor-respiratory synchronization after body weight supported treadmill training in incomplete tetraplegia: a case report Spinal Cord 47 2009 896 898
79. S. Hesse, C. Werner, A. Bardeleben Electromechanical gait training with functional electrical stimulation: case studies in spinal cord injury Spinal Cord 42 2004 346 352 (Pubitemid 38850542)
80. H. Barbeau, K. Norman, J. Fung, M. Visintin, M. Ladouceur Does neurorehabilitation play a role in the recovery of walking in neurological populations? Ann N Y Acad Sci 860 1998 377 392 (Pubitemid 29045984)
81. H. Barbeau, M. Ladouceur, K. Norman, A. Pepin, A. Lerous Walking after spinal cord injury: evaluation, treatment, and functional recovery Arch Phys Med Rehabil 80 1999 225 235 (Pubitemid 29098418)
82. G.F. Forrest, S.A. Sisto, H. Barbeau Neuromotor and musculoskeletal responses to locomotor training for an individual with chronic motor complete AIS-B spinal cord injury J Spinal Cord Med 31 2008 509 521
83. S. Freivogel, J. Mehrholz, T. Husak-Sotomayor, D. Schmalohr Gait training with the newly developed 'LokoHelp'-system is feasible for non-ambulatory patients after stroke, spinal cord and brain injury A feasibility study Brain Inj 22 2008 625 632 (Pubitemid 351877857)
84. S. Freivogel, D. Schmalohr, J. Mehrholz Improved walking ability and reduced therapeutic stress with an electromechanical gait device J Rehabil Med 41 2009 734 739
85. M.B. Gardner, M.K. Holden, J.M. Leikauskas, R.L. Richard Partial body weight support with treadmill locomotion to improve gait after incomplete spinal cord injury: a single-subject experimental design Phys Ther 78 1998 361 374 (Pubitemid 28191212)
86. C.F. Nooijen, H.N. Ter, E.C. Field-Fote Gait quality is improved by locomotor training in individuals with SCI regardless of training approach J Neuroeng Rehabil 6 2009 36
87. N.J. Tester, D.R. Howland, K.V. Day, S.P. Suter, A. Cantrell, A.L. Behrman Device use, locomotor training and the presence of arm swing during treadmill walking after spinal cord injury Spinal Cord 49 2011 451 456
88. J.F. Yang, J. Norton, J. Nevett-Duchcherer, F.D. Roy, D.P. Gross, M.A. Gorassini Volitional muscle strength in the legs predicts changes in walking speed following locomotor training in people with chronic spinal cord injury Phys Ther 91 2011 931 943
89. T.W. Effing, N.L. van Meeteren, F.W. van Asbeck, A.J. Prevo Body weight-supported treadmill training in chronic incomplete spinal cord injury: a pilot study evaluating functional health status and quality of life Spinal Cord 44 2006 287 296
90. S. Mathias, U.S. Nayak, B. Isaacs Balance in elderly patients: the "get-up and go" test Arch Phys Med Rehabil 67 1986 387 389 (Pubitemid 16055506)
91. D. Podsiadlo, S. Richardson The Timed "Up & Go": a test of basic functional mobility for frail elderly persons J Am Geriatr Soc 39 1991 142 148
92. B. Dobkin, D. Apple, H. Barbeau Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI Neurology 66 2006 484 493
93. B.H. Dobkin, D. Apple, H. Barbeau Methods for a randomized trial of weight-supported treadmill training versus conventional training for walking during inpatient rehabilitation after incomplete traumatic spinal cord injury Neurorehabil Neural Repair 17 2003 153 167 (Pubitemid 37099592)
94. J. Perry, M. Garrett, J. Gromley, S. Mulroy Classification of walking handicap in the stroke population Stroke 26 1995 982 989
95. D.S. Ditor, M.J. Macdonald, M.V. Kamath The effects of body-weight supported treadmill training on cardiovascular regulation in individuals with motor-complete SCI Spinal Cord 43 2005 664 673 (Pubitemid 41718909)
96. S. Coupaud, L.P. Jack, K.J. Hunt, D.B. Allan Muscle and bone adaptations after treadmill training in incomplete spinal cord injury: a case study using peripheral quantitative computed tomography J Musculoskelet Neuronal Interact 9 2009 288 297
97. L.M. Giangregorio, A.L. Hicks, C.E. Webber Body weight supported treadmill training in acute spinal cord injury: impact on muscle and bone Spinal Cord 43 2005 649 657 (Pubitemid 41718907)
98. L.M. Giangregorio, C.E. Webber, S.M. Phillips Can body weight supported treadmill training increase bone mass and reverse muscle atrophy in individuals with chronic incomplete spinal cord injury? Appl Physiol Nutr Metab 31 2006 283 291 (Pubitemid 44152889)
99. A. Jayaraman, P. Shah, C. Gregory Locomotor training and muscle function after incomplete spinal cord injury: case series J Spinal Cord Med 31 2008 185 193 (Pubitemid 351951354)
100. B.G. Stewart, M.A. Tarnopolsky, A.L. Hicks Treadmill training-induced adaptations in muscle phenotype in persons with incomplete spinal cord injury Muscle Nerve 30 2004 61 68 (Pubitemid 38880326)
101. L.M. Cotie, C.L. Geurts, M.M. Adams, M.J. Macdonald Leg skin temperature with body-weight-supported treadmill and tilt-table standing training after spinal cord injury Spinal Cord 49 2011 149 153
102. D.S. Ditor, M.V. Kamath, M.J. Macdonald, J. Bugaresti, N. McCartney, A.L. Hicks Effects of body weight-supported treadmill training on heart rate variability and blood pressure variability in individuals with spinal cord injury J Appl Physiol 98 2005 1519 1525 (Pubitemid 40396531)
103. F. Soyupek, S. Savas, O. Ozturk, E. Ilgun, A. Bircan, A. Akkaya Effects of body weight supported treadmill training on cardiac and pulmonary functions in the patients with incomplete spinal cord injury J Back Musculoskelet Rehabil 22 2009 213 218
104. M. Turiel, S. Sitia, S. Cicala Robotic treadmill training improves cardiovascular function in spinal cord injury patients Int J Cardiol 149 2011 323 329
105. S.M. Phillips, B.G. Stewart, D.J. Mahoney Body-weight-support treadmill training improves blood glucose regulation in persons with incomplete spinal cord injury J Appl Physiol 97 2004 716 724 (Pubitemid 38963146)
106. K.J. Manella, J. Torres, E.C. Field-Fote Restoration of walking function in an individual with chronic complete (AIS A) spinal cord injury J Rehabil Med 42 2010 795 798
107. P. Winchester, R. McColl, R. Querry Changes in supraspinal activation patterns following robotic locomotor therapy in motor-incomplete spinal cord injury Neurorehabil Neural Repair 19 2005 313 324 (Pubitemid 41705659)
108. D.S. Ditor, A.E. Latimer, K.A. Ginis, K.P. Arbour, N. McCartney, A.L. Hicks Maintenance of exercise participation in individuals with spinal cord injury: effects on quality of life, stress and pain Spinal Cord 41 2003 446 450 (Pubitemid 36976465)
109. R.N. Sturt, A.E. Holland, P.W. New Walking ability at discharge from inpatient rehabilitation in a cohort of non-traumatic spinal cord injury patients Spinal Cord 47 2009 763 768
110. J.F. Ditunno Jr, H. Barbeau, B.H. Dobkin Validity of the walking scale for spinal cord injury and other domains of function in a multicenter clinical trial Neurorehabil Neural Repair 21 2007 539 550 (Pubitemid 47585198)
111. P. Winchester, P. Smith, N. Foreman A prediction model for determining over ground walking speed after locomotor training in persons with motor incomplete spinal cord injury J Spinal Cord Med 32 2009 63 71
112. J.J. Buehner, G.F. Forrest, M. Schmidt-Read, S. White, K. Tansey, D.M. Basso Relationship between ASIA examination and functional outcomes in the NeuroRecovery Network locomotor training program Arch Phys Med Rehabil 93 2012 1530 1540
113. D.J. Lorenz, S. Datta, S.J. Harkema Longitudinal patterns of functional recovery in patients with incomplete spinal cord injury receiving activity-based rehabilitation Arch Phys Med Rehabil 93 2012 1541 1552
114. S. Kirshblum, S. Millis, W. McKinley, D. Tulsky Late neurologic recovery after traumatic spinal cord injury Arch Phys Med Rehabil 85 2004 1811 1817 (Pubitemid 39441139)
115. R.L. Waters, R.H. Adkins, J.S. Yakura, I. Sie Motor and sensory recovery following incomplete paraplegia Arch Phys Med Rehabil 75 1994 67 72 (Pubitemid 24038829)
116. R.L. Waters, R.H. Adkins, J.S. Yakura, I. Sie Motor and sensory recovery following incomplete tetraplegia Arch Phys Med Rehabil 75 1994 306 311 (Pubitemid 24099564)
117. F.H. Geisler, W.P. Coleman, G. Grieco, D. Poonian Measurements and recovery patterns in a multicenter study of acute spinal cord injury Spine 26 24 Suppl 2001 S68 S86
118. M.B. Bracken, M.J. Shepard, T.R. Holford Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study JAMA 277 1997 1597 1604 (Pubitemid 27231191)
119. H.J. Van Hedel, V. Dietz Rehabilitation of locomotion after spinal cord injury Restor Neurol Neurosci 28 2010 123 134
120. J. Fung, J.E. Stewart, H. Barbeau The combined effects of clonidine and cyproheptadine with interactive training on the modulation of locomotion in spinal cord injured subjects J Neurol Sci 100 1990 85 93
121. E. Swinnen, S. Duerinck, J.P. Baeyens, R. Meeusen, E. Kerckhofs Effectiveness of robot-assisted gait training in persons with spinal cord injury: a systematic review J Rehabil Med 42 2010 520 526
122. D. Aoyagi, W.E. Ichinose, S.J. Harkema, D.J. Reinkensmeyer, J.E. Bobrow A robot and control algorithm that can synchronously assist in naturalistic motion during body-weight-supported gait training following neurologic injury IEEE Trans Neural Syst Rehabil Eng 15 2007 387 400 (Pubitemid 47460412)
123. J.A. Galvez, A. Budovitch, S.J. Harkema, D.J. Reinkensmeyer Trainer variability during step training after spinal cord injury: implications for robotic gait-training device design J Rehabil Res Dev 48 2011 147 160
124. T.G. Hornby, D.J. Reinkensmeyer, D. Chen Manually-assisted versus robotic-assisted body weight-supported treadmill training in spinal cord injury: what is the role of each? PM R 2 2010 214 221
125. L.L. Cai, G. Courtine, A.J. Fong, J.W. Burdick, R.R. Roy, V.R. Edgerton Plasticity of functional connectivity in the adult spinal cord Philos Trans R Soc Lond B Biol Sci 361 2006 1635 1646 (Pubitemid 44450215)
126. A.L. Behrman, E. Ardolino, L.R. VanHiel Assessment of functional improvement without compensation reduces variability of outcome measures after human spinal cord injury Arch Phys Med Rehabil 93 2012 1518 1529
127. J.D. Steeves, D. Lammertse, A. Curt Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures Spinal Cord 45 2007 206 221 (Pubitemid 46340849)
128. M.S. Alexander, K.D. Anderson, F. Biering-Sorensen Outcome measures in spinal cord injury: recent assessments and recommendations for future directions Spinal Cord 47 2009 582 591
129. S.A. Sisto, T. Dyson-Hudson Dynamometry testing in spinal cord injury J Rehabil Res Dev 44 2007 123 136 (Pubitemid 46890066)
130. S.A. Sisto, D.J. Lorenz, K. Hutchinson Cardiovascular status of individuals with incomplete spinal cord injury from 7 NeuroRecovery Network rehabilitation centers Arch Phys Med Rehabil 93 2012 1578 1587
131. S.A. Morrison, G.F. Forrest, L.R. VanHiel, M. Dav, D. D'Urso NeuroRecovery Network provides standardization of locomotor training for persons with incomplete spinal cord injury Arch Phys Med Rehabil 93 2012 1574 1577
132. S.J. Harkema, M. Schmidt-Read, D.J. Lorenz, V.R. Edgerton, A.L. Behrman Balance and ambulation improvements in individuals with chronic incomplete spinal cord injury using locomotor training-based rehabilitation Arch Phys Med Rehabil 93 2012 1508 1517
133. G.F. Forrest, D.J. Lorenz, K. Hutchinson Ambulation and balance outcomes measure different aspects of recovery in individuals with chronic incomplete spinal cord injury Arch Phys Med Rehabil 93 2012 1553 1564
134. S. Datta, D.J. Lorenz, S.J. Harkema Dynamic longitudinal evaluation of the utility of the Berg Balance Scale in individuals with motor incomplete spinal cord injury Arch Phys Med Rehabil 93 2012 1565 1573
135. E.M. Ardolino, K.J. Hutchinson, G.P. Zipp, M. Clark, S.J. Harkema The ABLE scale: the development and psychometric properties of an outcome measure for the spinal cord injury population Phys Ther 2012 Jun 14 [Epub ahead of print]
136. V. Dietz Neuronal plasticity after a human spinal cord injury: positive and negative effects Exp Neurol 235 2012 110 115
137. B.J. Kaplan, G. Giesbrecht, S. Shannon, K. McLeod Evaluating treatments in health care: the instability of a one-legged stool BMC Med Res Methodol 11 2011 65
138. H. Walach, T. Falkenberg, V. Fonnebo, G. Lewith, W. Jonas Circular instead of hierarchical: methodological principles for the evaluation of complex interventions BMC Med Res Methodol 6 2006 29
139. J. Concato, N. Shah, R.I. Horwitz Randomized, controlled trials, observational studies, and the hierarchy of research designs N Engl J Med 342 2000 1887 1892 (Pubitemid 30419054)
140. V.R. Edgerton Invited commentary Phys Ther 88 2008 590 591
141. A. Apeldoorn, H. Bosselaar, R. Ostelo Identification of patients with chronic low back pain who might benefit from additional psychological assessment Clin J Pain 28 2012 23 31
142. G. Dejong, C.H. Hsieh, K. Putman, R.J. Smout, S.D. Horn, W. Tian Physical therapy activities in stroke, knee arthroplasty, and traumatic brain injury rehabilitation: their variation, similarities, and association with functional outcomes Phys Ther 91 2011 1826 1837
143. S.D. Horn, G. Dejong, D.K. Ryser, P.J. Veazie, J. Teraoka Another look at observational studies in rehabilitation research: going beyond the holy grail of the randomized controlled trial Arch Phys Med Rehabil 86 12 Suppl 2 2005 S8 S15
144. S.A. Maulden, J. Gassaway, S.D. Horn, R.J. Smout, G. Dejong Timing of initiation of rehabilitation after stroke Arch Phys Med Rehabil 86 12 Suppl 2 2005 S34 S40
145. S. Ghaemi A clinician's guide to statistics and epidemiology in mental health; measuring truth and uncertainty 2009 Cambridge University Pr Cambridge
146. B. Giesser, J. Beres-Jones, A. Budovitch, E. Herlihy, S. Harkema Locomotor training using body weight support on a treadmill improves mobility in persons with multiple sclerosis: a pilot study Mult Scler 13 2007 224 231 (Pubitemid 46592776)
147. K.J. Sullivan, B.J. Knowlton, B.H. Dobkin Step training with body weight support: effect of treadmill speed and practice paradigms on poststroke locomotor recovery Arch Phys Med Rehabil 83 2002 683 691 (Pubitemid 34498887)