Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant

Pharmacology Biochemistry and Behavior

Volumn 75, Issue 1, 2003, Pages 81-88

  Ivy, A S ^a   Rodriguez, F G ^a   Garcia, C ^a   Chen, M J ^a   Russo Neustadt, A A ^a  

^a CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

5 HT1A; 5 HT2A 2C; Exercise; Neurotrophins; Adrenoceptors

Indexed keywords

ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; TRANYLCYPROMINE;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ARTICLE; DENTATE GYRUS; EXERCISE; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SEROTONINERGIC SYSTEM;

EID: 0037621531     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(03)00044-3     Document Type: Article

References (56)

1. Altar C.A. Neurotrophins and depression. Trends Pharmacol. Sci. 20:1999;59-61.
2. Berchtold N.C., Oliff H.S., Isackson P., Cotman C.W. Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. Brain Res. Mol. Brain Res. 71:1999;11-22.
3. Bergles D.E., Doze V.A., Madison D.V., Smith S.J. Excitatory actions of norepinephrine on multiple classes of hippocampal CA1 interneurons. J. Neurosci. 16:1996;572-585.
4. Bijak M., Misgeld U. Adrenergic modulation of hilar neuron activity and granule cell inhibition in the guinea-pig hippocampal slice. Neuroscience. 67:1995;541-550.
5. Brown B.S., Payne T., Kim C., Moore G., Krebs P., Martin W. Chronic response of rat brain norepinephrine and serotonin levels to endurance training. J. Appl. Physiol. 46:1979;19-23.
6. Chaouloff F. Physical exercise and brain monoamines: a review. Acta Physiol. Scand. 137:1989;1-13.
7. Chaouloff F. Influence of physical exercise on 5-HT1A receptor- and anxiety-related behaviours. Neurosci. Lett. 176:1994;226-230.
8. Chaouloff F. Effects of acute physical exercise on central serotonergic systems. Med. Sci. Sports Exerc. 29:1997;58-62.
9. Chaouloff F., Laude D., Guezennec Y., Elghozi J.L. Motor activity increases tryptophan, 5-hydroxyindoleacetic acid, and homovanillic acid in ventricular cerebrospinal fluid of the conscious rat. J. Neurochem. 46:1986;1313-1316.
10. Cirulli F., Berry A., Alleva E. Intracerebroventricular administration of brain-derived neurotrophic factor in adult rats affects analgesia and spontaneous behaviour but not memory retention in a Morris Water Maze task. Neurosci. Lett. 287:2000;207-210.
11. Dey S. Physical exercise as a novel antidepressant agent: possible role of serotonin receptor subtypes. Physiol. Behav. 55:1994;323-329.
12. Dey S., Singh R.H., Dey P.K. Exercise training: significance of regional alterations in serotonin metabolism of rat brain in relation to antidepressant effect of exercise. Physiol. Behav. 52:1992;1095-1099.
13. Dishman R.K. Brain monoamines, exercise, and behavioral stress: animal models. Med. Sci. Sports Exerc. 29:1997;63-74.
14. Dishman R.K., Renner K.J., White-Welkley J.E., Burke K.A., Bunnell B.N. Treadmill exercise training augments brain norepinephrine response to familiar and novel stress. Brain Res. Bull. 52:2000;337-342.
15. Duman R.S. Novel therapeutic approaches beyond the serotonin receptor. Biol. Psychiatry. 44:1998;324-335.
16. Duman R.S., Heninger G.R., Nestler E.J. A molecular and cellular theory of depression. Arch. Gen. Psychiatry. 54:1997;597-606.
17. Duman R.S., Malberg J., Nakagawa S., D'Sa C. Neuronal plasticity and survival in mood disorders. Biol. Psychiatry. 48:2000;732-739.
18. Duman R.S., Nakagawa S., Malberg J. Regulation of adult neurogenesis by antidepressant treatment. Neuropsychopharmacology. 25:2001;836-844.
19. Dunn A.L., Reigle T.G., Youngstedt S.D., Armstrong R.B., Dishman R.K. Brain norepinephrine and metabolites after treadmill training and wheel running in rats. Med. Sci. Sports Exerc. 28:1996;204-209.
20. Fornal C.A., Metzler C.W., Gallegos R.A., Veasey S.C., McCreary A.C., Jacobs B.L. WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135. J. Pharmacol. Exp. Ther. 278:1996;752-762.
21. Forster E.A., Cliffe I.A., Bill D.J., Dover G.M., Jones D., Reilly Y.et al. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur. J. Pharmacol. 281:1995;81-88.
22. Freund T.F., Gulyas A.I., Acsady L., Gorcs T., Toth K. Serotonergic control of the hippocampus via local inhibitory interneurons. Proc. Natl. Acad. Sci. USA. 87:1990;8501-8505.
23. Fujimaki K., Morinobu S., Duman R.S. Administration of a cAMP phosphodiesterase 4 inhibitor enhances antidepressant-induction of BDNF mRNA in rat hippocampus. Neuropsychopharmacology. 22:2000;42-51.
24. Gartside S.E., Umbers V., Sharp T. Inhibition of 5-HT cell firing in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1A autoreceptors and noradrenergic mechanisms. Psychopharmacology (Berl). 130:1997;261-268.
25. Goodman G.A., Rall T.W., Nies A.S. P. T. Goodman and Gilman's the phamacological basis of therapeutics. 8th ed. 1990;Pergamon, New York.
26. 2 receptors. Eur. J. Pharmacol. 154:1988;285-291.
27. Invernizzi R., Velasco C., Bramante M., Longo A., Samanin R. Effect of 5-HT1A receptor antagonists on citalopram-induced increase in extracellular serotonin in the frontal cortex, striatum and dorsal hippocampus. Neuropharmacology. 36:1997;467-473.
28. Janssen P.A.J. 5-HT2 receptor blockade to study serotonin-induced pathology. Trends Pharmacol. Sci. 4:1983;198-206.
29. Jensen J., Mikkelsen J., Mørk A. Increased adenylyl cyclase type 1 mRNA, but not adenylyl cyclase type 2 in the rat hippocampus following antidepressant treatment. Eur. Neuropsychopharmacol. 10:2000;105-111.
30. Lapchak P.A., Hefti F. BDNF and NGF treatment in lesioned rats: effects on cholinergic function and weight gain. NeuroReport. 3:1992;405-408.
31. Lopez J.F., Chalmers D.T., Little K.Y., Watson S.J. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. (A.E. Bennett Research Award) Biol. Psychiatry. 43:1998;547-573.
32. Mamounas L.A., Blue M.E., Siuciak J.A., Altar C.A. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J. Neurosci. 15:1995;7929-7939.
33. Martin-Iverson M.T., Todd K.G., Altar C.A. Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine. J. Neurosci. 14:1994;1262-1270.
34. McEwen B.S. Stress and hippocampal plasticity. Annu. Rev. Neurosci. 22:1999;105-122.
35. McEwen B.S. Effects of adverse experiences for brain structure and function. Biol. Psychiatry. 48:2000;721-731.
36. Meeusen R., De Meirleir K. Exercise and brain neurotransmission. Sports Med. 20:1995;160-188.
37. Morinobu S., Fujimaki K., Okuyama N., Takahashi M., Duman R.S. Stimulation of adenylyl cyclase and induction of brain-derived neurotrophic factor and TrkB mRNA by NKH477, a novel and potent forskolin derivative. J. Neurochem. 72:1999;2198-2205.
38. Nestler E., Terwilliger R., Duman R. Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex. J. Neurochem. 53:1989;1644-1647.
39. Nibuya M., Morinobu S., Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 15:1995;7539-7547.
40. Nibuya M., Nestler E.J., Duman R.S. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J. Neurosci. 16:1996;2365-2372.
41. Oliff H.S., Berchtold N.C., Isackson P., Cotman C.W. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Brain Res. Mol. Brain Res. 61:1998;147-153.
42. Pelleymounter M.A., Cullen M.J., Wellman C.L. Characteristics of BDNF-induced weight loss. Exp. Neurol. 131:1995;229-238.
43. Piguet P., Galvan M. Transient and long-lasting actions of 5-HT on rat dentate gyrus neurones in vitro. J. Physiol. 481:1994;629-639.
44. Pompeiano M., Palacios J.M., Mengod G. Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res. Mol. Brain Res. 23:1994;163-178.
45. Romero L., Hervas I., Artigas F. The 5-HT1A antagonist WAY-100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain. Neurosci. Lett. 219:1996;123-126.
46. Russo-Neustadt A., Beard R.C., Cotman C.W. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology. 21:1999;679-682.
47. Russo-Neustadt A.A., Beard R.C., Huang Y.M., Cotman C.W. Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus. Neuroscience. 101:2000;305-312.
48. Russo-Neustadt A., Ha T., Ramirez R., Kesslak J.P. Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model. Behav. Brain Res. 120:2001;87-95.
49. Samorajski T., Rolsten C., Przykorska A., Davis C.M. Voluntary wheel running exercise and monoamine levels in brain, heart and adrenal glands of aging mice. Exp. Gerontol. 22:1987;421-431.
50. Shirayama Y., Chen A.C., Nakagawa S., Russell D.S., Duman R.S. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J. Neurosci. 22:2002;3251-3261.
51. Siuciak J.A., Wong V., Pearsall D., Wiegand S.J., Lindsay R.M. BDNF produces analgesia in the formalin test and modifies neuropeptide levels in rat brain and spinal cord areas associated with nociception. Eur. J. Neurosci. 7:1995;663-670.
52. Siuciak J.A., Boylan C., Fritsche M., Altar C.A., Lindsay R.M. BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration. Brain Res. 710:1996;11-20.
53. Siuciak J.A., Lewis D.R., Wiegand S.J., Lindsay R.M. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol. Biochem. Behav. 56:1997;131-137.
54. Smith M.A., Makino S., Kvetnansky R., Post R.M. Effects of stress on neurotrophic factor expression in the rat brain. Ann. NY Acad. Sci. 771:1995;234-239.
55. Stahl S. 5HT1A receptors and pharmacotherapy. Is serotonin receptor down-regulation linked to the mechanism of action of antidepressant drugs? Psychopharmacol. Bull. 30:1994;39-43.
56. Wright D.E., Seroogy K.B., Lundgren K.H., Davis B.M., Jennes L. Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain. J. Comp. Neurol. 351:1995;357-373.