Pre- and post-synaptic actions of 5-hydrpxytryptamine in the rat lumbar dorsal horn in vitro: Implications for somatosensory transmission

European Journal of Neuroscience

Volumn 8, Issue 10, 1996, Pages 2188-2197

  Lopez Garcia, J A ^a,b   King, A E ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

5 carboxamidotryptamine; 5 HT; Dorsal horn neurons; Primary afferent depolarization; Somatosensory system; Spinal cord; Synaptic transmission

Indexed keywords

5 CARBAMOYLTRYPTAMINE; BIOCYTIN; PRESYNAPTIC RECEPTOR; SEROTONIN; SEROTONIN AGONIST;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; EXCITATORY POSTSYNAPTIC POTENTIAL; INTERNEURON; LUMBAR SPINE; NEUROTRANSMISSION; NEWBORN; NONHUMAN; PRIMARY AFFERENT DEPOLARIZATION; PRIORITY JOURNAL; RAT; SENSORY NERVE; SOMATOSENSORY SYSTEM; SPINAL CORD DORSAL HORN; SYNAPTIC TRANSMISSION;

AFFERENT PATHWAYS; ANIMALS; EVOKED POTENTIALS, SOMATOSENSORY; LUMBOSACRAL REGION; MEMBRANE POTENTIALS; NEURONS; RATS; SEROTONIN; SEROTONIN AGONISTS; SPINAL CORD; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 0029860371     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1996.tb00740.x     Document Type: Article

References (25)

1. Alhaider, A. A., Lei, S. Z. and Wilkox, G. L. (1991) Spinal 5-HT3 receptormediated antinociception: possible release of GABA. J. Neurosci., 11, 1881-1888.
2. Anwyl, R. (1990) Neurophysiological actions of 5-hydroxytryptamine in the vertebrate nervous system. Prog. Neurobiol., 35, 451-468.
3. Bagust, J., Forsythe, Y. D. and Kerkut, G. A. (1985) An investigation of the dorsal root reflex using an in vitro preparation of the hamster spinal cord. Brain Res., 331, 315-325.
4. Belcher, G., Ryall, R. W. and Schaffner, R. (1978) The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurones in the cat. Brain Res., 151, 307-321.
5. Besson, J. M. and Chaouch, A. (1987) Peripheral and spinal mechanisms of nociception. Physiol. Rev., 67, 67-172.
6. Besson, J. M. (1990) Serotonin and Pain. Elsevier Science Publishers B. V. (Biomedical Division).
7. Bowery, N.G., Hill, D.R., Doble, A., Middlemiss, D.N., Shaw, J. and Tumbull, M. (1980) (-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature (Lond.), 283, 92-94.
8. Cardenas, C. G. and Scroggs, R. S. (1994) Serotonin inhibits calcium currents in acutely isolated capsaicin sensitive C-type rat sensory neurons. Soc.Neurosci. Abstr.; 20, 759.
9. Carstens, E., Klumpp, D., Randic M. and Zimmermann, M. (1981) Effect of iontophoretically applied 5-hydroxytryptamine on the excitability of single primary afferent C- and A-fibres in the cat spinal cord. Brain Res., 220, 151-158.
10. Carstens, E., Gilly, H., Schreiber, H. and Zimmermann, M. (1987) Effects of midbrain stimulation and iontophoretic application of Serotonin, noradrenaline and GABA on electrical thresholds of afferent C- and Afibre terminals in cat spinal cord. Neuroscience, 21, 395-406.
11. Curtis, J. C. and Appenteng, K. (1993) The electrical geometry, electrical properties and synaptic connections onto rat V motoneurons in vitro. J. Physiol. (Lond.), 465, 85-119.
12. Dahlstrom, A. and Fuxe, K. (1965) Evidence for the existence of monoamine neurons in the central nervous system. Acta. Physiol. Scand., 64, 1-30.
13. 1 binding sites on primary afferent fibres in the dorsal horn of the rat spinal cord. Neurosci. Lett., 83, 71-76.
14. Eccles, J. R., Eccles, R. M. and Magni, F. (1961) Central inhibitory action attributable to presynaptic depolarization produced by muscle afferent volleys. J. Physiol. (Lond.), 159, 147-166.
15. Eccles, J. C., Kostyuk, P. G. and Schmidt, R. F. (1962) Central pathways responsible for depolarization of primary afferent fibres. J. Physiol. (Land.), 161, 237-257.
16. Eccles, J. C., Schmidt, R. F. and Willis, W. D. (1963) Pharmacological studies on presynaptic inhibition. J. Physiol. (Lond.), 168, 500-530.
17. El-Yasir, N., Fleetwood-Walker, S. M. and Mitchell, R. (1988) Heterogeneous effects of 5-hydroxytryptamine in' the dorsal horn of rat, the involvement of 5-hydroxytryptamine 1 receptor subtypes. Brain Res., 456, 147-158.
18. Evans, R. H. (1989) The pharmacology of segmental transmission in the spinal cord. Prog. Neurobiol, 33, 255-79.
19. Evans, R. H. and Long, S. K. (1989) Primary afferent depolarization in the rat spinal cord is mediated by pathways utilising NMDA and non-NMDA receptors. Neurosci. Lett., 100, 231-236.
20. Glaum, S. R. E., Proudfit, H. K. and Anderson, G. (1988) Reversal of the antinociceptive effects of intrathecaly administered serotonin in the rat by a selective 5-HT3 antagonist. Neurosci. Lett., 95, 313-317.
21. Grudt, T. J., Williams, J. T. and Travagli, R.A. (1995) Inhibition by 5hydroxytryptamine and noradrenaline in the substantia gelatinosa of the guinea pig spinal trigeminal nucleus. J. Physiol. (Lond.), 485, 113-120
22. 3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord. Eur. J. Pharmacol., 164, 315-322.
23. Headley, P. M., Duggan, A. W. and Griersmith, B.T. (1978) Selective reduction by noradrenaline and serotonin of nociceptive responses of cat dorsal horn neurons. Brain Res., 145, 185-189.
24. Hentall, I. D. and Fields, H. L. (1983) Actions of opiates, substance P and serotonin on the excitability of primary afferent terminals and observations on interneuronal activity in the neonatal rat's dorsal horn in vitro. Neuroscience, 9, 521-528.
25. Hoffert, M. J., Miletic, V., Ruda, M.A. and Dubner, R. (1983) Immunocytochemical identification of serotonin axonal contacts on characterized neurons in lamina I and II of the cat dorsal horn. Brain Res., 267, 361-364.