Functional MRI of the brain detects neuropathic pain in experimental spinal cord injury

Pain

Volumn 138, Issue 2, 2008, Pages 292-300

  Endo, Toshiki ^a,b   Spenger, Christian ^a   Hao, Jingxia ^a   Tominaga, Teiji ^b   Wiesenfeld Hallin, Zsuzsanna ^a   Olson, Lars ^a   Xu, Xiao Jun ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

fMRI; Naloxone; Neuropathic pain; Somatosensory; Spinal cord injury

Indexed keywords

NALOXONE;

ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN MAPPING; CONTROLLED STUDY; ELECTROSTIMULATION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; MECHANICAL STIMULATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SOMATOSENSORY CORTEX; SPINAL CORD INJURY; THERMAL STIMULATION;

ANIMALS; BRAIN; BRAIN MAPPING; FEMALE; MAGNETIC RESONANCE IMAGING; NEURALGIA; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES;

EID: 49049083855     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2007.12.017     Document Type: Article

References (39)

1. Apkarian A.V., Bushnell M.C., Treede R.D., and Zubieta J.K. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 9 (2005) 463-484
2. Bushnell M.C., Duncan G.H., Hofbauer R.K., Ha B., Chen J.I., and Carrier B. Pain perception: is there a role for primary somatosensory cortex?. Proc Natl Acad Sci USA 96 (1999) 7705-7709
3. Chang C., and Shyu B.C. A fMRI study of brain activations during non-noxious and noxious electrical stimulation of the sciatic nerve of rats. Brain Res 897 (2001) 71-81
4. Coghill R.C., Sang C.N., Maisog J.M., and Iadarola M.J. Pain intensity processing within the human brain: a bilateral, distributed mechanism. J Neurophysiol 82 (1999) 1934-1943
5. Craig A.D. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci 3 (2002) 655-666
6. Curt A., Alkadhi H., Crelier G.R., Boendermaker S.H., Hepp-Reymond M.C., and Kollias S.S. Changes of non-affected upper limb cortical representation in paraplegic patients as assessed by fMRI. Brain 125 (2002) 2567-2578
7. Drew G.M., Siddall P.J., and Duggan A.W. Responses of spinal neurones to cutaneous and dorsal root stimuli in rats with mechanical allodynia after contusive spinal cord injury. Brain Res 893 (2001) 59-69
8. Gauriau C., and Bernard J.F. Posterior triangular thalamic neurons convey nociceptive messages to the secondary somatosensory and insular cortices in the rat. J Neurosci 24 (2004) 752-761
9. Hao J.X., Yu W., Xu X.J., and Wiesenfeld-Hallin Z. Capsaicin-sensitive afferents mediate chronic cold, but not mechanical, allodynia-like behavior in spinally injured rats. Brain Res 722 (1996) 177-180
10. Hao J.X., Yu W., and Xu X.J. Evidence that spinal endogenous opioidergic systems control the expression of chronic pain-related behaviors in spinally injured rats. Exp Brain Res 118 (1998) 259-268
11. Hao J.X., Kupers R.C., and Xu X.J. Response characteristics of spinal cord dorsal horn neurons in chronic allodynic rats after spinal cord injury. J Neurophysiol 92 (2004) 1391-1399
12. Hargreaves K., Dubner R., Brown F., Flores C., and Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32 (1988) 77-88
13. Hess A., Sergejeva M., Budinsky L., Zeilhofer H.U., and Brune K. Imaging of hyperalgesia in rats by functional MRI. Eur J Pain 11 (2007) 109-119
14. Hofstetter C.P., Schweinhardt P., Klason T., Olson L., and Spenger C. Numb rats walk - a behavioural and fMRI comparison of mild and moderate spinal cord injury. Eur J Neurosci 18 (2003) 3061-3068
15. Hoheisel U., Scheifer C., Trudrung P., Unger T., and Mense S. Pathophysiological activity in rat dorsal horn neurones in segments rostral to a chronic spinal cord injury. Brain Res 974 (2003) 134-145
16. Johansen J.P., Fields H.L., and Manning B.H. The affective component of pain in rodents: direct evidence for a contribution of the anterior cingulate cortex. Proc Natl Acad Sci USA 98 (2001) 8077-8082
17. Lilja J., Endo T., Hofstetter C., Westman E., Young J., Olson L., et al. Blood oxygenation level-dependent visualization of synaptic relay stations of sensory pathways along the neuroaxis in response to graded sensory stimulation of a limb. J Neurosci 26 (2006) 6330-6336
18. Lowe A.S., Beech J.S., and Williams S.C. Small animal, whole brain fMRI: innocuous and nociceptive forepaw stimulation. Neuroimage 35 (2007) 719-728
19. Luttinger D. Determination of antinociceptive efficacy of drugs in mice using different water temperatures in a tail-immersion test. J Pharmacol Methods 13 (1985) 351-357
20. Malisza K.L., and Docherty J.C. Capsaicin as a source for painful stimulation in functional MRI. J Magn Reson Imaging 14 (2001) 341-347
21. Moylan Governo R.J., Morris P.G., William Prior M.J., Marsden C.A., and Chapman V. Capsaicin-evoked brain activation and central sensitization in anaesthetised rats: a functional magnetic resonance imaging study. Pain 126 (2006) 35-45
22. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates, the new coronal set (2005), Academic Press, New York
23. Petrovic P., Ingvar M., Stone-Elander S., Petersson K.M., and Hansson P. A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy. Pain 83 (1999) 459-470
24. Peyron R., Garcia-Larrea L., Gregoire M.C., Convers P., Lavenne F., Veyre L., et al. Allodynia after lateral-medullary (Wallenberg) infarct. A PET study. Brain 121 (1998) 345-356
25. Peyron R., Laurent B., and Garcia-Larrea L. Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiol Clin 30 (2000) 263-288
26. Peyron R., Schneider F., Faillenot I., Convers P., Barral F.G., Garcia-Larrea L., et al. An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic pain. Neurology 63 (2004) 1838-1846
27. Randall L.O., and Selitto J.J. A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn Ther 111 (1957) 409-419
28. Schweinhardt P., Fransson P., Olson L., Spenger C., and Andersson J.L. A template for spatial normalisation of MR images of the rat brain. J Neurosci Methods 129 (2003) 105-113
29. Schweinhardt P., Glynn C., Brooks J., McQuay H., Jack T., Chessell I., et al. An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients. Neuroimage 32 (2006) 256-265
30. Siddall P.J., Yezierski R.P., and Loser D.J. Taxonomy and epidemiology of spinal cord injury pain. In: Yezierski R.P., and Burchiel K. (Eds). Spinal cord injury pain: assessment, mechanisms, management (2002), IASP Press, Seattle, WA 9-24
31. Spenger C., Josephson A., Klason T., Hoehn M., Schwindt W., Ingvar M., et al. Functional MRI at 4.7 tesla of the rat brain during electric stimulation of forepaw, hindpaw, or tail in single- and multislice experiments. Exp Neurol 166 (2000) 246-253
32. Takahashi Y., and Nakajima Y. Dermatomes in the rat limbs as determined by antidromic stimulation of sensory C-fibers in spinal nerves. Pain 67 (1996) 197-202
33. Treede R.D., Kenshalo D.R., Gracely R.H., and Jones A.K. The cortical representation of pain. Pain 79 (1999) 105-111
34. Tuor U.I., Malisza K., Foniok T., Papadimitropoulos R., Jarmasz M., Somorjai R., et al. Functional magnetic resonance imaging in rats subjected to intense electrical and noxious chemical stimulation of the forepaw. Pain 87 (2000) 315-324
35. Vogt B.A. Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 6 (2005) 533-544
36. Waxman S.G., and Hains B.C. Fire and phantoms after spinal cord injury: Na+ channels and central pain. Trends Neurosci 29 (2006) 207-215
37. Xu X.J., Hao J.X., Aldskogius H., Seiger A., and Wiesenfeld-Hallin Z. Chronic pain-related syndrome in rats after ischemic spinal cord lesion: a possible animal model for pain in patients with spinal cord injury. Pain 48 (1992) 279-290
38. Xu X.J., Hao J.X., Seiger A., Hughes J., Hokfelt T., and Wiesenfeld-Hallin Z. Chronic pain-related behaviors in spinally injured rats: evidence for functional alterations of the endogenous cholecystokinin and opioid systems. Pain 56 (1994) 271-277
39. Xu X.J., Hao J.X., and Wiesenfeld-Hallin Z. Physiological and pharmacological characterization of a rat model of spinal cord injury pain after spinal ischemia. In: Yezierski R.P., and Burchiel K. (Eds). Spinal cord injury pain: assessment, mechanisms, management (2002), IASP Press, Seattle, WA 175-188